The fungal metabolite galiellalactone interferes with the nuclear import of NF-κB and inhibits HIV-1 replication

Chemico-Biological Interactions

Volumn 214, Issue 1, 2014, Pages 69-76

  Pérez, Moisés ^a   Soler Torronteras, Rafael ^a   Collado, Juan A ^a   Limones, Carmen G ^a   Hellsten, Rebecka ^b   Johansson, Martin ^b   Sterner, Olov ^b   Bjartell, Anders ^b   Calzado, Marco A ^a   Muñoz, Eduardo ^a  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Galiellalactone; HIV 1; Importins; LTR; NF B

Indexed keywords

ANTIVIRUS AGENT; GALIELLALACTONE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMPORTIN ALPHA3; KARYOPHERIN; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ACETYLATION; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; BIOTINYLATION; CONTROLLED STUDY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; INHIBITION KINETICS; LONG TERMINAL REPEAT; NONHUMAN; NUCLEAR IMPORT; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; VESICULAR STOMATITIS VIRUS; VIRUS CELL INTERACTION; VIRUS INHIBITION; VIRUS REPLICATION;

GALIELLALACTONE; HIV-1; IMPORTINS; LTR; NF-ΚB;

ALPHA KARYOPHERINS; ASCOMYCOTA; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; CELL NUCLEUS; HIV-1; HUMANS; LACTONES; NF-KAPPA B; VIRUS REPLICATION;

EID: 84896475169     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2014.02.012     Document Type: Article

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