In vivo and in vitro evidence for placental DNA damage in preeclampsia

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Tadesse, Serkalem ^a,b   Kidane, Dawit ^c   Guller, Seth ^c   Luo, Tianmeng ^b   Norwitz, Nicholas G ^c   Arcuri, Felice ^d   Toti, Paolo ^d   Norwitz, Errol R ^a,b  

^a TUFTS MEDICAL CENTER   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF SIENA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GAMMA HISTONE H2AX; HISTONE H2AX; HYDROGEN PEROXIDE; UNCLASSIFIED DRUG;

ARTICLE; CELL HYPOXIA; CONTROLLED STUDY; CYTOTROPHOBLAST; DECIDUA; DNA DAMAGE; DNA REPAIR; EMBRYO; EXCISION REPAIR; FEMALE; FETOPLACENTAL UNIT; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PLACENTA; PREECLAMPSIA; PROTECTION; PROTEIN EXPRESSION; REPERFUSION; STROMA CELL; TISSUE SPECIFICITY; TROPHOBLAST;

ADULT; ANALYSIS OF VARIANCE; BLOTTING, WESTERN; CELL NUCLEUS; DECIDUA; DNA DAMAGE; FEMALE; HISTONES; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; MICROSCOPY, CONFOCAL; PRE-ECLAMPSIA; PREGNANCY; REACTIVE OXYGEN SPECIES; STROMAL CELLS; TROPHOBLASTS;

EID: 84896460542     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086791     Document Type: Article

References (42)

1. Walker JJ (2000) Pre-eclampsia. Lancet 356: 1260-1265.
2. Roberts JM, Redman CW (1993) Pre-eclampsia: more than pregnancy-induced hypertension. Lancet 341: 1447-1451. (Pubitemid 23161452)
3. Aplin JD (2000) Hypoxia and human placental development. J Clin Invest 105: 559-560.
4. Kingdom JC, Kaufmann P (1997) Oxygen and placental villous development: origins of fetal hypoxia. Placenta 18: 613-621; discussion 623-616.
5. Wisdom SJ, Wilson R, McKillop JH, Walker JJ (1991) Antioxidant systems in normal pregnancy and in pregnancy-induced hypertension. Am J Obstet Gynecol 165: 1701-1704.
6. Wang Y, Walsh SW (1998) Placental mitochondria as a source of oxidative stress in pre-eclampsia. Placenta 19: 581-586. (Pubitemid 28528845)
7. Kaur G, Mishra S, Sehgal A, Prasad R (2008) Alterations in lipid peroxidation and antioxidant status in pregnancy with preeclampsia. Mol Cell Biochem 313: 37-44.
8. Poranen AK, Ekblad U, Uotila P, Ahotupa M (1996) Lipid peroxidation and antioxidants in normal and pre-eclamptic pregnancies. Placenta 17: 401-405. (Pubitemid 26381677)
9. Brosens JJ, Parker MG, McIndoe A, Pijnenborg R, Brosens IA (2009) A role for menstruation in preconditioning the uterus for successful pregnancy. Am J Obstet Gynecol 200: 615 e611-616.
10. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, et al. (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39: 44-84. (Pubitemid 44566469)
11. Barnes DE, Lindahl T, Sedgwick B (1993) DNA repair. Curr Opin Cell Biol 5: 424-433.
12. Demple B, Harrison L (1994) Repair of oxidative damage to DNA: enzymology and biology. Annu Rev Biochem 63: 915-948. (Pubitemid 24218652)
13. Fortini P, Pascucci B, Parlanti E, D'Errico M, Simonelli V, et al. (2003) The base excision repair: mechanisms and its relevance for cancer susceptibility. Biochimie 85: 1053-1071. (Pubitemid 38142361)
14. Gentil A, Cabral-Neto JB, Mariage-Samson R, Margot A, Imbach JL, et al. (1992) Mutagenicity of a unique apurinic/apyrimidinic site in mammalian cells. J Mol Biol 227: 981-984.
15. Guillet M, Boiteux S (2003) Origin of endogenous DNA abasic sites in Saccharomyces cerevisiae. Mol Cell Biol 23: 8386-8394. (Pubitemid 37377527)
16. Loeb LA, Preston BD (1986) Mutagenesis by apurinic/apyrimidinic sites. Annu Rev Genet 20: 201-230.
17. Ding SZ, O'Hara AM, Denning TL, Dirden-Kramer B, Mifflin RC, et al. (2004) Helicobacter pylori and H2O2 increase AP endonuclease-1/redox factor-1 expression in human gastric epithelial cells. Gastroenterology 127: 845-858. (Pubitemid 39208417)
18. Loeb LA (1985) Apurinic sites as mutagenic intermediates. Cell 40: 483-484.
19. Takagi Y, Nikaido T, Toki T, Kita N, Kanai M, et al. (2004) Levels of oxidative stress and redox-related molecules in the placenta in preeclampsia and fetal growth restriction. Virchows Arch 444: 49-55. (Pubitemid 38200090)
20. Budwit-Novotny DA, McCarty KS, Cox EB, Soper JT, Mutch DG, et al. (1986) Immunohistochemical analyses of estrogen receptor in endometrial adenocarcinoma using a monoclonal antibody. Cancer Res 46: 5419-5425. (Pubitemid 16008326)
21. Snegovskikh VV, Schatz F, Arcuri F, Toti P, Kayisli UA, et al. (2009) Intraamniotic infection upregulates decidual cell vascular endothelial growth factor (VEGF) and neuropilin-1 and -2 expression: implications for infection-related preterm birth. Reprod Sci 16: 767-780.
22. Kliman HJ, Nestler JE, Sermasi E, Sanger JM, Strauss JF, 3rd (1986) Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae. Endocrinology 118: 1567-1582. (Pubitemid 16078536)
23. Rosen T, Schatz F, Kuczynski E, Lam H, Koo AB, et al. (2002) Thrombin-enhanced matrix metalloproteinase-1 expression: a mechanism linking placental abruption with premature rupture of the membranes. J Matern Fetal Neonatal Med 11: 11-17.
24. Lockwood CJ, Arcuri F, Toti P, Felice CD, Krikun G, et al. (2006) Tumor necrosis factor-alpha and interleukin-1beta regulate interleukin-8 expression in third trimester decidual cells: implications for the genesis of chorioamnionitis. Am J Pathol 169: 1294-1302. (Pubitemid 351194364)
25. Norwitz ER, Snegovskikh V, Schatz F, Foyouzi N, Rahman M, et al. (2007) Progestin inhibits and thrombin stimulates the plasminogen activator/inhibitor system in term decidual stromal cells: implications for parturition. Am J Obstet Gynecol 196: 382 e381-388.
26. Jessmon P, Kilburn BA, Romero R, Leach RE, Armant DR (2010) Functionspecific intracellular signaling pathways downstream of heparin-binding EGFlike growth factor utilized by human trophoblasts. Biol Reprod 82: 921-929.
27. Heazell AEP, Moll S.J., Jones C.J.P., Baker P.N. and Crocker I.P. (2007) Formation of Syncytial Knots is Increased by Hyperoxia, Hypoxia and Reactive Oxygen Species. Placenta 28, Supplement A, Trophoblast Research, Vol. 21 S33-S40. (Pubitemid 46506047)
28. Parast MM, Yu H, Ciric A, Salata MW, Davis V, et al. (2009) PPARgamma regulates trophoblast proliferation and promotes labyrinthine trilineage differentiation. PLoS One 4: e8055.
29. Tadesse S, Luo G, Park JS, Kim BJ, Snegovskikh VV, et al. (2011) Intraamniotic infection upregulates neutrophil gelatinase-associated lipocalin (NGAL) expression at the maternal-fetal interface at term: implications for infectionrelated preterm birth. Reprod Sci 18: 713-722.
30. Kubo K, Ide H, Wallace SS, Kow YW (1992) A novel, sensitive, and specific assay for abasic sites, the most commonly produced DNA lesion. Biochemistry 31: 3703-3708.
31. Kow YW, Dare A (2000) Detection of abasic sites and oxidative DNA base damage using an ELISA-like assay. Methods 22: 164-169. (Pubitemid 32896721)
32. Kurisu S, Miya T, Terato H, Masaoka A, Ohyama Y, et al. (2001) Quantitation of DNA damage by an aldehyde reactive probe (ARP). Nucleic Acids Res Suppl: 45-46.
33. Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM (1998) DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 273: 5858-5868. (Pubitemid 28124064)
34. Sharma S, Norris WE, Kalkunte S (2010) Beyond the threshold: an etiological bridge between hypoxia and immunity in preeclampsia. J Reprod Immunol 85: 112-116.
35. Rothkamm K, Kruger I, Thompson LH, Lobrich M (2003) Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol Cell Biol 23: 5706-5715. (Pubitemid 36951334)
36. Rogakou EP, Boon C, Redon C, Bonner WM (1999) Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 146: 905-916.
37. Lei W, Feng XH, Deng WB, Ni H, Zhang ZR, et al. (2012) Progesterone and DNA damage encourage uterine cell proliferation and decidualization through up-regulating ribonucleotide reductase 2 expression during early pregnancy in mice. J Biol Chem 287: 15174-15192.
38. Kajihara T, Tochigi H, Uchino S, Itakura A, Brosens JJ, et al. (2011) Differential effects of urinary and recombinant chorionic gonadotropin on oxidative stress responses in decidualizing human endometrial stromal cells. Placenta 32: 592-597.
39. Kajihara T, Jones M, Fusi L, Takano M, Feroze-Zaidi F, et al. (2006) Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization. Mol Endocrinol 20: 2444-2455. (Pubitemid 44496413)
40. Duguid JR, Eble JN, Wilson TM, Kelley MR (1995) Differential cellular and subcellular expression of the human multifunctional apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme. Cancer Res 55: 6097-6102.
41. Wilson TM, Rivkees SA, Deutsch WA, Kelley MR (1996) Differential expression of the apurinic/apyrimidinic endonuclease (APE/ref-1) multifunctional DNA base excision repair gene during fetal development and in adult rat brain and testis. Mutat Res 362: 237-248. (Pubitemid 26102977)
42. Wilson SH, Kunkel TA (2000) Passing the baton in base excision repair. Nat Struct Biol 7: 176-178. (Pubitemid 30140755)