In-line implementation of an image-based particle size measurement tool to monitor hot-melt extruded pellets

International Journal of Pharmaceutics

Volumn 466, Issue 1-2, 2014, Pages 181-189

  Treffer, Daniel ^a,b   Wahl, Patrick R ^a   Hörmann, Theresa R ^a   Markl, Daniel ^a   Schrank, Simone ^a,b   Jones, Ian ^c   Cruise, Paul ^c   Mürb, Reinhardt Karsten ^d   Koscher, Gerold ^a   Roblegg, Eva ^a,e   Khinast, Johannes G ^a,b  

^a RESEARCH CENTER PHARMACEUTICAL ENGINEERING GMBH   (Austria)

^b GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^c Innopharma Laboratories   (Ireland)

^d Automatik Plastics Machinery GmbH   (Germany)

^e UNIVERSITY OF GRAZ   (Austria)

Author keywords

Hot die face pelletizing; Hot melt extrusion; Measurement position; Particle imaging; Process analytical technology

Indexed keywords

PARACETAMOL; STEARIC ACID; STEARIC ACID DERIVATIVE;

ARTICLE; DRUG PELLET; IMAGE ANALYSIS; LIGHT; MELTING POINT; OPTICAL INSTRUMENTATION; PARTICLE SIZE; PELLET EXTRUSION; PHOTOMETRY; PRIORITY JOURNAL; PROCESS DEVELOPMENT; CHEMISTRY; DEVICES; DRUG FORMULATION; HEAT; IMAGE PROCESSING; ONLINE SYSTEM;

ACETAMINOPHEN; DRUG COMPOUNDING; HOT TEMPERATURE; IMAGE PROCESSING, COMPUTER-ASSISTED; LIGHT; ONLINE SYSTEMS; PARTICLE SIZE; STEARIC ACIDS;

EID: 84896460380     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.03.022     Document Type: Article

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