Real-time image-based investigation of spheronization and drying phenomena using different pellet formulations

European Journal of Pharmaceutical Sciences

Volumn 44, Issue 5, 2011, Pages 635-642

  Burggraeve, A ^a   Sandler, N ^b   Heinamaki J ^c,d   Raikkonen H ^c   Remon, J P ^a   Vervaet, C ^a   De Beer, T ^a   Yliruusi, J ^c  

^a GHENT UNIVERSITY   (Belgium)

^b ÅBO AKADEMI UNIVERSITY   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d UNIVERSITY OF TARTU   (Estonia)

Author keywords

Brightness; Extrusion spheronization; Fluid bed drying; Particle size and shape (distribution); Photometric stereo imaging; Visualisation

Indexed keywords

ARTICLE; CHEMICAL PROCEDURES; DRUG FORMULATION; DRUG PELLET; FLUID BED DRYING; PARTICLE SIZE; PELLET EXTRUSION; PHASE TRANSITION; PRIORITY JOURNAL; RAMAN SPECTROMETRY; SOLID STATE; SPHERONIZATION;

CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DESICCATION; PARTICLE SIZE; SPECTRUM ANALYSIS, RAMAN; THEOPHYLLINE; WATER;

EID: 82155162349     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.10.011     Document Type: Article

References (25)

1. S. Airaksinen, M. Karjalainen, E. Räsänen, J. Rantanen, and J. Yliruusi Comparison of the effects of two drying methods on polymorphism of theophylline Int. J. Pharm. 276 2004 129 141 (Pubitemid 38542994)
2. L. Baert, and J.P. Remon Influence of amount of granulation liquid on the drug-release rate from pellets made by extrusion spheronization Int. J. Pharm. 95 1993 135 141 (Pubitemid 23203146)
3. A.B.B. Bashaiwoldu, F. Podczeck, and M. Newton A study on the effect of drying techniques on the mechanical properties of pellets and compacted pellets Eur. J. Pharm. Sci. 21 2004 119 129 (Pubitemid 38165319)
4. K.E. Fielden, J.M. Newton, and R.C. Rowe The influence of lactose particle size on spheronization of extrudate processed by a ram extruder Int. J. Pharm. 81 1992 205 224
5. K.E. Fielden, J.M. Newton, and R.C. Rowe The influence of moisture-content on spheronization of extrudate processed by a ram extruder Int. J. Pharm. 97 1993 79 92 (Pubitemid 23242369)
6. L. Hasznos, I. Langer, and M. Gyarmathy Some factors influencing pellet characteristics made by an extrusion/spheronisation process. Part I: effects on size characteristics and moisture content decrease of pellets Drug Dev. Ind. Pharm. 18 1992 409 437
7. L. Hellén, and J. Yliruusi Process variables of instant granulator and spheroniser. III. Shape and shape distribution of pellets Int. J. Pharm. 96 1993 217 223 (Pubitemid 23233288)
8. L. Hellén, J. Yliruusi, and E. Kristoffersson Process variables of instant granulator and spheroniser. II. Size and size distributions of pellets Int. J. Pharm. 96 1993 205 216 (Pubitemid 23233287)
9. L. Hellén, J. Yliruusi, P. Merkku, and E. Kristoffersson Process variables of instant granulator and spheroniser. I. Physical properties of granules, extrudate and pellets Int. J. Pharm. 96 1993 197 204 (Pubitemid 23233286)
10. M. Koester, and M. Thommes New insights into the pelletization mechanism by extrusion/spheronization AAPS Pharm. Sci. Technol. 11 2010 1549 1551
11. J.M. Newton, S.R. Chapman, and R.C. Rowe The influence of process variables on the preparation and properties of spherical granules by the process of extrusion and spheronisation Int. J. Pharm. 120 1995 101 109
12. E. Räsänen, J. Rantanen, A. Jørgensen, M. Karjalainen, T. Paakkari, and J. Yliruusi Novel identification of pseudopolymorphic changes of theophylline during wet granulation using near infrared spectroscopy J. Pharm. Sci. 90 2001 389 396
13. A. Reynolds A new technique for the production of spherical particles Manuf. Chem. Aerosol News 41 1970 40 43
14. M. Römer, J. Heinämäki, I. Miroshnyk, N. Kivikero, N. Sandler, J. Rantanen, and J. Yliruusi Phase transformation of erythromycin A dihydrate during fluid bed drying J. Pharm. Sci. 97 2008 4020 4029
15. M. Römer, J. Heinämäki, I. Miroshnyk, N. Sandler, J. Rantanen, and J. Yliruusi Phase transformations of erythromycin A dihydrate during pelletisation and drying Eur. J. Pharm. Biopharm. 67 2007 246 252 (Pubitemid 46991315)
16. R.C. Rowe Spheronization: a novel pill-making process? Pharm. Int. 6 1985 119 123
17. N. Sandler Photometric imaging in particle size measurement and surface visualization Int. J. Pharm. 417 2011 227 234
18. N. Sandler, J. Rantanen, J. Heinämäki, M. Römer, M. Marvola, and J. Yliruusi Pellet manufacturing by extrusion-spheronization using process analytical technology AAPS Pharm. Sci. Technol. 6 2005 E174 E183
19. D. Sonaglio, B. Bataille, C. Ortigosa, and M. Jacob Factorial design in the feasibility of producing microcel MC-101 pellets by extrusion spheronization Int. J. Pharm. 115 1995 53 60
20. I. Soppela, S. Airaksinen, J. Hatara, H. Raikkonen, O. Antikainen, J. Yliruusi, and N. Sandler Rapid particle size measurement using 3D surface imaging AAPS Pharm. Sci. Technol. 12 2011 476 484
21. J.J. Sousa, A. Sousa, F. Podczeck, and J.M. Newton Influence of process conditions on drug release from pellets Int. J. Pharm. 144 1996 159 169 (Pubitemid 27043033)
22. N.R. Trivedi, M.G. Rajan, J.R. Johnson, and A.J. Shukla Pharmaceutical approaches to preparing pelletized dosage forms using the extrusion- spheronization process Crit. Rev. Ther. Drug 24 2007 1 40 (Pubitemid 46653058)
23. C. Vervaet, and J.P. Remon Influence of impeller design, method of screen perforation and perforation geometry on the quality of pellets made by extrusion-spheronisation Int. J. Pharm. 133 1996 29 37 (Pubitemid 26163329)
24. L.S.C. Wan, P.W.S. Heng, and C.V. Liew Spheronization conditions on spheroid shape and size Int. J. Pharm. 96 1993 59 65 (Pubitemid 23233270)
25. R.J. Woodham Photometric-method for determining surface orientation from multiple images Opt. Eng. 19 1980 139 144