Comparative Protein Composition of the Brains of PACAP-Deficient Mice Using Mass Spectrometry-Based Proteomic Analysis

Journal of Molecular Neuroscience

Volumn 54, Issue 3, 2014, Pages 310-319

  Maasz, G ^a,b   Pirger, Z ^b,c   Reglodi, D ^b   Petrovics, D ^a   Schmidt, J ^a,b   Kiss, P ^b   Rivnyak, A ^b   Hashimoto, H ^d   Avar, P ^a   Jambor, E ^a   Tamas, A ^b   Gaszner, B ^b   Mark, L ^a,b  

^a UNIVERSITY OF PÉCS   (Hungary)

^b UNIVERSITY OF PÉCS   (Hungary)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

Knockout; MALDI; PACAP; Proteomics

Indexed keywords

HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; PROTEOME;

ANIMAL; ANTIBODY SPECIFICITY; BRAIN; DEFICIENCY; ENZYMOLOGY; GENETICS; METABOLISM; MOUSE;

ANIMALS; BRAIN; MICE; ORGAN SPECIFICITY; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; PROTEOME;

EID: 84896416999     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-014-0264-0     Document Type: Article

References (31)

1. Armstrong BD, Abad C, Chhith S et al (2008) Impaired nerve regeneration and enhanced neuroinflammatory response in mice lacking pituitary adenylyl cyclase activating peptide. Neuroscience 151:63–73
2. Atlasz T, Babai N, Kiss P et al (2007) Pituitary adenylate cyclase activating polypeptide is protective in bilateral carotid occlusion-induced retinal lesion in rats. Gen Comp Endocrinol 153:108–114
3. Atlasz T, Szabadfi K, Kiss P et al (2008) PACAP-mediated neuroprotection of neurochemically identified cell types in MSG-Induced retinal degeneration. J Mol Neurosci 36:97–104
4. Brown D, Tamas A, Reglödi D, Tizabi Y (2013) PACAP protects against salsolinol-induced toxicity in dopaminergic SH-SY5Y cells: implication for Parkinson’s disease. J Mol Neurosci 50:600–607
5. Endo K, Nakamachi T, Seki T et al (2011) Neuroprotective effect of PACAP against NMDA-induced retinal damage in the mouse. J Mol Neurosci 43:22–29
6. Fabian E, Reglodi D, Mester L et al (2012) Effects of PACAP on intracellular signaling pathways in human retinal pigment epithelial cells exposed to oxidative stress. J Mol Neurosci 48:493–500
7. Ferencz A, Kiss P, Weber G et al (2010a) Comparison of intestinal warm ischemic injury in PACAP knockout and wild-type mice. J Mol Neurosci 42:435–442
8. Ferencz A, Weber G, Helyes Z, Hashimoto H, Baba A, Reglodi D (2010b) Presence of endogenous PACAP-38 ameliorated intestinal cold preservation tissue injury. J Mol Neurosci 42:428–434
9. Girard BA, Lelievre V, Braas KM et al (2006) Noncompensation in peptide/receptor gene expression and distinct behavioral phenotypes in VIP- and PACAP-deficient mice. J Neurochem 99:499–513
10. Hashimoto H, Shintani N, Tanaka K et al (2001) Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP). Proc Natl Acad Sci U S A 98:13355–13360
11. Hashimoto H, Hashimoto R, Shintani N et al (2009) Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone. J Neurochem 110:595–602
12. Hori M, Nakamachi T, Rakwal R et al (2012) Transcriptomics and proteomics analyses of the PACAP38 influenced ischemic brain in permanent middle cerebral artery occlusion model mice. J Neuroinflammation 9:256
13. Horvath G, Mark L, Brubel R et al (2010) Mice deficient in pituitary adenylate cyclase activating polypeptide display increased sensitivity to renal oxidative stress in vitro. Neurosci Lett 469:70–74
14. Lebon A, Seyer D, Cosette P et al (2006) Identification of proteins regulated by PACAP in PC12 cells by 2D gel electrophoresis coupled to mass spectrometry. Ann NY Acad Sci 1070:380–387
15. Miyata A, Arimura A, Dahl RR et al (1989) Isolation of a novel 38 residue-hypothalamic polypeptide which stimulated adenylate cyclase in pituitary cells. Biochem Biophys Res Commun 164:567–574
16. Ogawa T, Nakamachi T, Ohtaki H et al (2005) Monoaminergic neuronal development is not affected in PACAP-gene-deficient mice. Regul Pept 126:103–108
17. Ohtaki H, Nakamachi T, Dohi K et al (2006) Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6. Proc Natl Acad Sci U S A 103:7488–7493
18. Ohtaki H, Nakamachi T, Dohi K, Shioda S (2008) Role of PACAP in ischemic neural death. J Mol Neurosci 36:16–25
19. Ohtaki H, Satoh A, Nakamachi T et al (2010) Regulation of oxidative stress by pituitary adenylate cyclase-activating polypeptide (PACAP) mediated by PACAP receptor. J Mol Neurosci 42:397–403
20. Reglodi D, Tamás A, Somogyvári-Vigh A et al (2002) Effects of pretreatment with PACAP on the infarct size and functional outcome in rat permanent focal cerebral ischemia. Peptides 23:2227–2234
21. Reglodi D, Kiss P, Szabadfi K et al (2012) PACAP is an endogenous protective factor-insights from PACAP-deficient mice. J Mol Neurosci 48:482–492
22. Szabadfi K, Atlasz T, Kiss P et al (2012) Mice deficient in pituitary adenylate cyclase activating polypeptide (PACAP) are more susceptible to retinal ischemic injury in vivo. Neurotox Res 21:41–48
23. Tan YV, Abad C, Lopez R et al (2009) Targeted gene deletion reveals that pituitary adenylyl cyclase activating polypeptide is an intrinsic regulator of Treg abundance in mice and plays a protective role in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 106:2012–2017
24. Tsuchikawa D, Nakamachi T, Tsuchida M et al (2012) Neuroprotective effect of endogenous pituitary adenylate cyclase-activating polypeptide on spinal cord injury. J Mol Neurosci 48:508–517
25. Vaudry D, Hamelink C, Damadzic R, Eskay RL, Gonzalez B, Eiden LE (2005) Endogenous PACAP acts as a stress response peptide to protect cerebellar neurons from ethanol or oxidative insult. Peptides 26:2518–2524
26. Vaudry D, Falluel-Morel A, Bourgault S et al (2009) Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery. Pharmacol Rev 61:283–357
27. Wada Y, Nakamachi T, Endo K et al (2013) PACAP attenuates NMDA-induced retinal damage in association with modulation of the microglia/macrophage status into an acquired deactivation subtype. J Mol Neurosci 51:493–502
28. Wang SL, Liu CY, Liu FM, Ren LP (2012) IL-USA-DLLME method to simultaneously extract and determine four phenylurea herbicides in water samples. Curr Anal Chem 8:357–364
29. Watson MB, Nobuta H et al (2013) PACAP deficiency sensitizes nigrostriatal dopaminergic neurons to paraquat-induced damage and modulates central and peripheral inflammatory activation in mice. Neuroscience 240:277–286
30. Zaman K, Ryu H, Hall D et al (1999) Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin. J Mol Neurosci 19:9821–9830
31. Zhang YF, Lee HK (2012) Ionic liquid-based ultrasound-assisted dispersive liquid-liquid microextraction followed high-performance liquid chromatography for the determination of ultraviolet filters in environmental water samples. Anal Chim Acta 750:120–126