Determination of antiplasmodial activity and binding affinity of curcumin and demethoxycurcumin towards PfTrxR

Natural Product Research

Volumn 28, Issue 6, 2014, Pages 359-364

  Munigunti, Ranjith ^a   Gathiaka, Symon ^b   Acevedo, Orlando ^b   Sahu, Rajnish ^c   Tekwani, Babu ^c   Calderón, Angela I ^a  

^a AUBURN UNIVERSITY   (United States)

^b AUBURN UNIVERSITY   (United States)

^c UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

liquid chromatography mass spectrometry based assays; molecular modelling; Plasmodium falciparum thioredoxin reductase (PfTrxR)

Indexed keywords

ANTIMALARIAL AGENT; CURCUMIN; DEMETHOXYCURCUMIN; DIMER; OXIDOREDUCTASE INHIBITOR; PLASMODIUM FALCIPARUM THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ANTIPLASMODIAL ACTIVITY; ARTICLE; BINDING AFFINITY; COMPUTER MODEL; CONTROLLED STUDY; DRUG BINDING; DRUG CYTOTOXICITY; DRUG SCREENING; ENZYME INHIBITION; IC 50; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR MODEL; NONHUMAN; PLASMODIUM FALCIPARUM; VERO CELL;

PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; CERCOPITHECUS AETHIOPS; CURCUMA; CURCUMIN; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PLASMODIUM FALCIPARUM; THIOREDOXIN-DISULFIDE REDUCTASE; VERO CELLS;

EID: 84896405419     PISSN: 14786419     EISSN: 14786427     Source Type: Journal    
DOI: 10.1080/14786419.2013.866112     Document Type: Article

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