Identification of streptococcal M-protein cardiopathogenic epitopes in experimental autoimmune valvulitis

Journal of Cardiovascular Translational Research

Volumn 7, Issue 2, 2014, Pages 172-181

  Kirvan, Christine A ^a   Galvin, Jeffrey E ^b   Hilt, Silvia ^a   Kosanke, Stanley ^c   Cunningham, Madeleine W ^c  

^a CALIFORNIA STATE UNIVERSITY   (United States)

^b ZOETIS   (United States)

^c UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Autoimmunity; M protein; Rheumatic heart disease; T cells

Indexed keywords

M PROTEIN; VASCULAR CELL ADHESION MOLECULE 1;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; BIOTINYLATION; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CROSS REACTION; EPITOPE MAPPING; EXPERIMENTAL AUTOIMMUNE VALVULITIS; FEMALE; IMMUNOHISTOCHEMISTRY; NONHUMAN; PATHOGENESIS; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; RAT; RHEUMATIC PANCARDITIS; STREPTOCOCCUS; T LYMPHOCYTE; UPREGULATION;

RATTUS; STREPTOCOCCUS SP. 'GROUP A';

ANIMALS; ANTIGENS, BACTERIAL; AUTOIMMUNE DISEASES; BACTERIAL OUTER MEMBRANE PROTEINS; CARRIER PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CHEMOTAXIS, LEUKOCYTE; CYTOKINES; DISEASE MODELS, ANIMAL; EPITOPE MAPPING; EPITOPES, T-LYMPHOCYTE; FEMALE; HEART VALVE DISEASES; PEPTIDE FRAGMENTS; RATS; RATS, INBRED LEW; RHEUMATIC HEART DISEASE; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84896402338     PISSN: 19375387     EISSN: 19375395     Source Type: Journal    
DOI: 10.1007/s12265-013-9526-4     Document Type: Article

References (50)

1. Stollerman, G. H. (2001). Rheumatic fever in the 21st century. Clinical Infectious Diseases, 33 (6), 806-14.
2. Stollerman, G. H. (1997). Rheumatic Fever. Lancet, 349, 935-942.
3. Cunningham, M. W. (2000). Pathogenesis of acute rheumatic fever. In D. S. Stevens & E. H. Kaplan (Eds.), Streptococcal diseases (1st ed., pp. 102-132). New York, NY: Oxford Press.
4. Cunningham, M. W. (2012). Streptococcus and Rheumatic Fever. Current Opinion in Rheumatology, 24, 408-416.
5. Dajani, A. S. (1992). Guidelines for the diagnosis of rheumatic fever (Jones criteria, 1992 update). Journal of the American Medical Association, 268, 2069-2073.
6. Kaur, S., et al. (1998). Ethnic differences in expression of susceptibility marker(s) in rheumatic fever/rheumatic heart disease patients. International Journal of Cardiology, 64, 9-14. (Pubitemid 28161133)
7. Veasy, L. G., Tani, L. Y., & Hill, H. R. (1994). Persistence of acute rheumatic fever in the intermountain area of the United States. Journal of Pediatrics, 124, 9-16. (Pubitemid 24027280)
8. Veasy, L. G., Wiedmeier, S. E., & Orsmond, G. S. (1987). Resurgence of acute rheumatic fever in the intermountain area of the United States. New England Journal of Medicine, 316 (8), 421-427. (Pubitemid 17035568)
9. Veasy, L. G., et al. (2004). Temporal association of the appearance of mucoid strains of Streptococcus pyogenes with a continuing high incidence of rheumatic fever in Utah. Pediatrics, 113 (3 Pt 1), e168-72.
10. Kaplan, M. H., Johnson, D. R., & Cleary, P. P. (1989). Group A streptococcal serotypes isolated from patients and sibling contacts during the resurgence of rheumatic fever in the United states in the mid-1980's. Journal of Infectious Diseases, 159, 101-103. (Pubitemid 19022001)
11. Bisno, A. L. (2001). Acute pharyngitis. New England Journal of Medicine, 344 (3), 205-11.
12. Unny, S.K. and Middlebrooks B.L. (1983) Streptococcal rheumatic carditis, Microbiological Reviews, 47 (1), 97-120. (Pubitemid 13081192)
13. Cunningham, M. W. (1996). Streptococci and rheumatic fever. In N. R. Rose & H. Friedman (Eds.), Microorganisms and autoimmune disease (pp. 13-66). New York: Plenum.
14. Zabriskie, J. B., Hsu, K. C., & Seegal, B. C. (1970). Heart-reactive antibody associated with rheumatic fever: characterization and diagnostic significance. Clinical and Experimental Immunology, 7, 147-159.
15. Krisher, K., & Cunningham, M. W. (1985). Myosin: a link between streptococci and heart. Science, 227 (4685), 413-5. (Pubitemid 15153497)
16. Galvin, J. E., et al. (2001). Induction of myocarditis and valvulitis in Lewis rats by different epitopes of cardiac myosin and its implications in rheumatic carditis. American Journal of Pathology, 160, 297-306. (Pubitemid 34052290)
17. Martins, T. B., et al. (2008). Comprehensive analysis of antibody responses to streptococcal and tissue antigens in patients with acute rheumatic fever. International Immunology, 20 (3), 445-52. (Pubitemid 351321252)
18. Kemeny, E., et al. (1989). Identification of mononuclear cells and T cell subsets in rheumatic valvulitis. Clinical Immunology and Immunopathology, 52, 225-237. (Pubitemid 19177746)
19. Fraser, W., et al. (1997). Rheumatic Aschoff nodules revisited: II. Cytokine expression corroborates recently proposed sequential stages. Histopathology, 31, 460-464. (Pubitemid 27505363)
20. Roberts, S., et al. (2001). Immune mechanisms in rheumatic carditis: focus on valvular endothelium. Journal of Infectious Diseases, 183, 507-511. (Pubitemid 32105611)
21. Raizada, V., et al. (1983). Tissue distribution of lymphocytes in rheumatic heart valves as defined by monoclonal anti-T cell antibodies. American Journal of Medicine, 74, 90-96. (Pubitemid 13221611)
22. Guilherme, L., et al. (1995). Human heart-filtrating Tcell clones from rheumatic heart disease patients recognize both streptococcal and cardiac proteins. Circulation, 92, 415-420.
23. Grundtman, C. (2010). H.I., Førre OT, Saatvedt K, Mikkelsen K, Lundberg IE., Cardiovascular disease in patients with inflammatory rheumatic disease is associated with up-regulation of markers of inflammation in cardiac microvessels and cardiomyocytes. Arthritis and Rheumatism, 62, 667-73.
24. Fae, K. C., et al. (2006). Mimicry in recognition of cardiac myosin peptides by heart-intralesional T cell clones from rheumatic heart disease. Journal of Immunology, 176 (9), 5662-70.
25. Ellis, N.M. J., et al. (2005). T cell mimicry and epitope specificity of crossreactive T cell clones from rheumatic heart disease. Journal of Immunology, 175, 5448-5456. (Pubitemid 41456431)
26. Cunningham, M. W. (2003). Autoimmunity and molecular mimicry in the pathogenesis of post-streptococcal heart disease. Frontiers in Bioscience, 8, s533-43.
27. Cunningham, M. W. (2000). Group A streptococcal sequelae and molecular mimicry. In M. W. Cunningham & R. S. Fujinami (Eds.), Effects of microbes on the immune system (1st ed., pp. 123-149). Philadelphia, PA: Lippincott, Williams and Wilkins.
28. Guilherme, L. and Kalil, J. (2004). Rheumatic fever: howstreptococcal throat 637Q4 infection triggers an autoimmune disease. Y. Schoenfeld, N.R. Rose (Eds.), Infection and autoimmu-638 nity (pp 321-331) New York: Elsevier.
29. Manjula, B. N., Trus, B. L., & Fischetti, V.A. (1985). Presence of two distinct regions in the coiled-coil structure of the streptococcal Pep M5 protein: relationship to mammalian coiled-coil proteins and implications to its biological properties. Proceedings of the National Academy of Sciences of the United States of America, 82 (4), 1064-8. (Pubitemid 15100495)
30. Manjula, B. N., & Fischetti, V. A. (1980). Tropomyosin-like seven residue periodicity in three immunologically distinct streptococcalM proteins and its implications for the antiphagocytic property of the molecule. Journal of Experimental Medicine, 151 (3), 695-708. (Pubitemid 10143850)
31. Bronze, M. S., et al. (1987). Protective and heart-cross-reactive epitopes of type 19 streptococcal M protein. Transactions of the Association of American Physicians, 100, 80-4.
32. Bisno, A. L. (1980). The concept of rheumatogenic and nonrheumatogenic group A streptococci. In S. E. Read & J. B. Zabriskie (Eds.), Streptococcal diseases and the immune response (pp. 789-803). New York: Academic Press.
33. Bisno, A. L. (1995). Streptococcus pyogenes . In G. L. Mandell, R. G. Bennett, & R. Dolin (Eds.), Principles and practice of infectious diseases (pp. 1786-1799). New York: Churchill Livingstone.
34. Fischetti, V. A. (1989). Streptococcal M protein: molecular design and biological behavior. Clinical Microbiology Reviews, 2 (3), 285-314.
35. Huber, S. A.,& Cunningham,M.W. (1996). StreptococcalMprotein peptide with similarity to myosin induces CD4+ T cell-dependent myocarditis in MRL/++ mice and induces partial tolerance against coxsackieviral myocarditis. Journal of Immunology, 156 (9), 3528-34. (Pubitemid 26123570)
36. Cunningham, M. W. (2004). T cell Mimicry in inflammatory heart disease. Molecular Immunology, 40, 1121-1127.
37. Fae, K., et al. (2004). Heart infiltrating Tcell clones from a rheumatic heart disease patient display a common TCR usage and a degenerate antigen recognition pattern. Molecular Immunology, 40 (14-15), 1129-35. (Pubitemid 38221195)
38. Lymbury, R. S., et al. (2003). Induction of autoimmune valvulitis in Lewis rats following immunization with peptides from the conserved region of group A streptococcalMprotein. Journal of Autoimmunity, 20 (3), 211-7. (Pubitemid 36561486)
39. Quinn, A., et al. (2001). Induction of autoimmune valvular heart disease by recombinant streptococcal M protein. Infection and Immunity, 69 (6), 4072-4078. (Pubitemid 32493331)
40. Gorton, D., Govan, B. L., & Ketheesan, N. (2009). B and T cell responses in group A streptococcal M protein/peptide induced experimental carditis. Infection and Immunity, 77, 2177-2183.
41. Gorton, D. E., et al. (2010). An alternative technique for the induction of autoimmune valvulitis in a rat model of rheumatic heart disease. Journal of Immunological Methods, 15 (355), 80-85.
42. Cunningham, M. W. (1992). Group A streptococci: molecular mimicry, autoimmunity and infection. In M. Hook & L. S. Switalski (Eds.), Microbial adhesion and invasion (pp. 147-167). New York: Springer.
43. Quinn, A., et al. (1995). Autoantibody germ-line gene segment encodes VH and VL regions of a human anti-streptococcal monoclonal antibody recognizing streptococcal M protein and human cardiac myosin epitopes. Journal of Immunology, 154 (8), 4203-12.
44. Guilherme, L., et al. (2004). Rheumatic heart disease: proinflammatory cytokines play a role in the progression and maintenance of valvular lesions. American Journal of Pathology, 165, 1583-1591. (Pubitemid 39435157)
45. Guilherme, L., et al. (2001). T-cell reactivity against streptococcal antigens in the periphery mirrors reactivity of heart-infiltrating T lymphocytes in rheumatic heart disease patients. Infection and Immunity, 69 (9), 5345-51. (Pubitemid 32786466)
46. Ellis, N. M. J., et al. (2010). Priming the immune system for heart disease: a perspective on group A streptococci. Journal of Infectious Diseases, 202, 1059-1067.
47. Cunningham, M. W., et al. (1997). Molecular analysis of human cardiac myosin-cross-reactive B- and T-cell epitopes of the group A streptococcal M5 protein. Infection and Immunity, 65, 3913-3923. (Pubitemid 27398159)
48. Adderson, E. E., et al. (1998). Molecular analysis of polyreactive monoclonal antibodies from rheumatic carditis: human anti-N -acetylglucosamine/ anti-myosin antibody V region genes. Journal of Immunology, 161, 2020-2031. (Pubitemid 28387628)
49. Guilherme, L., Kalil, J., & Cunningham, M. (2006). Molecular mimicry in the autoimmune pathogenesis of rheumatic heart disease. Autoimmunity, 39 (1), 31-9. (Pubitemid 43878518)
50. McNamara, C., et al. (2008). Coiled-coil irregularities and instabilities in group A streptococcus M1 are required for virulence. Science, 319, 1405-1408. (Pubitemid 351354878)