Iron deficiency anemia as a risk factor for cerebrovascular events in early childhood: A case-control study

Annals of Hematology

Volumn 93, Issue 4, 2014, Pages 571-576

  Azab, Seham F A ^a   Abdelsalam, Sanaa M ^a   Saleh, Safaa H A ^a   Elbehedy, Rabab M ^a   Lotfy, Sabah M ^a   Esh, Asmaa M H ^b   Srea, Mona A ^a   Aziz, Khalid A ^a  

^a ZAGAZIG UNIVERSITY   (Egypt)

^b Zagazig University   (Egypt)

Author keywords

Cerebrovascular; Childhood; Iron deficiency anemia

Indexed keywords

ANTITHROMBIN III; BLOOD CLOTTING FACTOR 5 LEIDEN; FERRITIN; HEMOGLOBIN S; IRON; LUPUS ANTICOAGULANT; PROTEIN C; PROTEIN S; PROTHROMBIN; TRANSFERRIN;

ARTICLE; BRAIN ISCHEMIA; CASE CONTROL STUDY; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FERRITIN BLOOD LEVEL; GENE; GENE MUTATION; HUMAN; INFANT; IRON BINDING CAPACITY; IRON BLOOD LEVEL; IRON DEFICIENCY ANEMIA; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PHLEBOGRAPHY; PRESCHOOL CHILD; PRIORITY JOURNAL; RISK FACTOR; SCREENING TEST; THROMBOCYTOSIS; TRANSFERRIN BLOOD LEVEL;

ANEMIA, IRON-DEFICIENCY; BRAIN ISCHEMIA; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; EARLY DIAGNOSIS; FEMALE; HUMANS; INFANT; MALE; RISK FACTORS; STROKE;

EID: 84896376382     PISSN: 09395555     EISSN: 14320584     Source Type: Journal    
DOI: 10.1007/s00277-013-1922-y     Document Type: Article

References (34)

1. Hartfield DS, Lowry NJ, Keene DL, Yager JY (1997) Iron deficiency: a cause of stroke in infants and children. Pediatr Neurol 16:50-53
2. Fullerton HJ, Wu YW, Sidney S, Johnston SC (2007) Risk of recurrent childhood arterial ischemic stroke in a population-based cohort: the importance of cerebrovascular imaging. Pediatrics 119:495-501
3. Fox CK, Fullerton HJ (2010) Recent advances in childhood arterial ischemic stroke. Curr Atheroscler Rep 12(4):217-224
4. Fox CK, Johnston SC, Sidney S, Fullerton HJ (2012) High critical care usage due to pediatric stroke: results of a population-based study. Neurology 79(5):420-427
5. Srinivasan J, Miller SP, Phan TG, Mackay MT (2009) Delayed recognition of initial stroke in children: need for increased awareness. Pediatrics 124(2):e227-e234
6. Sébire G, Tabarki B, Saunders DE, Leroy I, Liesner R, Saint-Martin C, Husson B, Williams AN, Wade A, Kirkham FJ (2005) Cerebral venous sinus thrombosis in children: risk factors, presentation, diagnosis and outcome. Brain 128:477-489
7. Amlie-Lefond C, Guillaume S, Fullerton H (2008) Recent developments in childhood arterial ischemic stroke. Lancet Neurol 7:425-435
8. Goodman S, Pavlakis S, Lynch J (2008) Pediatric and newborn stroke. Curr Treatments Neurol 10(6):431-439
9. Zhu A, Kaneshiro M, Kaunitz JD (2010) Evaluation and treatment of iron deficiency anemia: a gastroenterological perspective. Dig Dis Sci 55(3):548-559
10. Lozoff B, Jimenez E, Smith JB (2006) Double burden of iron deficiency in infancy and low socio-economic status: a longitudinal analysis of cognitive test scores to age 19 years. Arch Pediatr Adolesc Med 160(11):1108-1113
11. Lozoff B, Klein NK, Nelson EC, McClish DK, Manuel M, Chacon ME (1998) Behavior of infants with iron-deficiency anemia. Child Dev 69(1):24-36
12. Munot P, De Vile C, Hemingway C et al (2011) Severe iron deficiency anaemia and ischaemic stroke in children. Arch Dis Child 96:276-279
13. Sébire G, Fullerton H, Riou E, de Veber G (2004) Toward the definition of cerebral arteriopathies of childhood. Curr Opin Pediatr 16:617-622
14. Cherian S, Forbes DA, Cook AG, Sanfilippo FM, Kemna EH, Swinkels DW, Burgner DP (2008) An insight into the relationships between hepcidin, anemia, infections and inflammatory cytokines in pediatric refugees: a cross-sectional study. PLoS One 3(12):e4030
15. Zimmermann MB, Hurrell RF (2007) Nutritional iron deficiency. Lancet 370(9586):511-520
16. Dame C, Sutor AH (2005) Primary and secondary thrombocytosis in childhood. Br J Haematol 129(2):165-177
17. Yager JY, Hartfield DS (2002) Neurologic manifestations of iron deficiency in childhood. Pediatr Neurol 27(2):85-92
18. Benedict SL, Bonkowsky JL, Thompson JA, Van Orman CB, Boyer RS, Bale JF Jr, Filloux FM (2004) Cerebral sinovenous thrombosis in children: another reason to treat iron deficiency anemia. J Child Neurol 19(7):526-531
19. El-Arab AM, Mohammad M, El-Sayed M (2009) Evaluation of the daily iron intake by non-breastfed Egyptian infants and young children. Afr J Food Agric Nutr Dev 9(6):1325-1344
20. McLean E, Cogswell M, Egli I, Wojdyla D, de Benoist B (2008) Worldwide prevalence of anaemia, WHO vitamin and mineral nutrition information system, 1993-2005. Public Health Nutr 23:1-11
21. Lutter CK (2008) Iron deficiency in young children in low-income countries and new approaches for its prevention. J Nutr 138(12):2523-2528
22. Lo W, Stephens J, Fernandez S (2009) Pediatric stroke in the United States and the impact of risk factors. J Child Neurol 24:194-203
23. Golomb MR, Fullerton HJ, Nowak-Gottl U, Deveber G (2009) Male predominance in childhood ischemic stroke: findings from the international pediatric stroke study. Stroke 40:52-57
24. Normann S, Veber G, Fobker M et al (2009) Role of endogenous testosterone concentration in pediatric stroke. Ann Neurol 66:754-758
25. Maguire JL, deVeber G, Parkin PC (2007) Association between iron-deficiency anemia and stroke in young children. Pediatrics 120:1053-1057
26. Meena AK, Naidu KS, Murthy JM (2000) Cortical sinovenous thrombosis in a child with nephrotic syndrome and iron deficiency anaemia. Neurol India 48(3):292-294
27. Park MJ, Park PW, Seo YH, Kim KH, Park SH, Jeong JH, Ahn JY (2013) The relationship between iron parameters and platelet parameters in women with iron deficiency anemia and thrombocytosis. Platelets 24(5):348-351
28. Keung YK, Owen J (2004) Iron deficiency and thrombosis: literature review. Clin Appl Thromb Hemost 10(4):387-391
29. Nagai T, Komatsu N, Sakata Y, Miura Y, Ozawa K (2005) Iron deficiency anemia with marked thrombocytosis complicated by central retinal vein occlusion. Intern Med 44(10):1090-1092
30. Bilic E, Bilic E (2003) Amino acid sequence homology of thrombopoietin and erythropoietin may explain thrombocytosis in children with iron deficiency anemia. J Pediatr Hematol Oncol 25(8):675-676
31. Geddis AE, Kaushansky K (2003) Cross-reactivity between erythropoietin and thrombopoietin at the level of Mpl does not account for the thrombocytosis seen in iron deficiency. J Pediatr Hematol Oncol 25:919-920
32. Miravet E, Danchaivitjitr N, Basu H (2007) Clinical and radiographical features of childhood infarction following varicella zoster virus infection. Dev Med Child Neurol 49:417-422
33. Braun KP, BulderMM CS, Kirkham FJ, Uiterwaal CS, Tardieu M et al (2009) The course and outcome of unilateral intracranial arteriopathy in 79 children with ischemic stroke. Brain 132(2):544-557
34. Ganesan V, Prengler M, McShane MA, Wade AM, Kirkham FJ (2003) Investigation of risk factors in children with arterial ischemic stroke. Ann Neurol 53:167-173