Recent advances in childhood arterial ischemic stroke

Current Atherosclerosis Reports

Volumn 12, Issue 4, 2010, Pages 217-224

  Fox, Christine K ^a   Fullerton, Heather J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Arterial ischemic stroke; Cerebral arteriopathy; Childhood stroke; Stroke outcomes; Thrombolysis

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; TISSUE PLASMINOGEN ACTIVATOR;

BRAIN ARTERY; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CEREBRAL ARTERY DISEASE; CEREBROVASCULAR ACCIDENT; CHILDHOOD DISEASE; CLINICAL TRIAL; DELAYED DIAGNOSIS; DOPPLER ECHOGRAPHY; EPILEPSY; HEALTH CARE COST; HIGH RISK PATIENT; HUMAN; MEDICAL CARE; NEUROIMAGING; PROGNOSIS; RECURRENT DISEASE; REINFECTION; REVIEW; RISK FACTOR; RISK REDUCTION; SICKLE CELL ANEMIA; BRAIN; CHILD; FEMALE; ISCHEMIA; MALE; STROKE; VASCULARIZATION;

BRAIN; CHILD; FEMALE; HUMANS; INTRACRANIAL ARTERIAL DISEASES; ISCHEMIA; MALE; RISK FACTORS; STROKE;

EID: 77955943926     PISSN: 15233804     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11883-010-0113-8     Document Type: Review

References (50)

1. Agrawal N, Johnston SC, Wu YW, et al. Imaging data reveal a higher pediatric stroke incidence than prior US estimates. Stroke 2009;40:3415-3421.
2. Lo W, Stephens J, Fernandez S. Pediatric stroke in the United States and the impact of risk factors. J Child Neurol 2009;24:194-203.
3. Golomb MR, Fullerton HJ, Nowak-Gottl U, Deveber G. Male predominance in childhood ischemic stroke: Findings from the international pediatric stroke study. Stroke 2009;40:52-57.
4. Normann S, de Veber G, Fobker M, et al. Role of endogenous testosterone concentration in pediatric stroke. Ann Neurol 2009;66:754-758.
5. Mackay M, Wiznitzer M, Benedict S, et al. Risk factors for childhood arterial ischemic stroke: Results from the International Pediatric Stroke Study [abstract]. Presented at International Stroke Conference 2010. San Antonio, TX; February 24-26, 2010.
6. Fullerton HJ, Wu YW, Sidney S, Johnston SC. Risk of recurrent childhood arterial ischemic stroke in a population-based cohort: The importance of cerebrovascular imaging. Pediatrics 2007;119:495-501.
7. Amlie-Lefond C, Bernard TJ, Sebire G, et al. Predictors of cerebral arteriopathy in children with arterial ischemic stroke: Results of the International Pediatric Stroke Study. Circulation 2009;119:1417-1423 Results from the International Pediatric Stroke Study of 525 children with vascular imaging after an arterial ischemic stroke demonstrate the importance of arteriopathies. The term "focal cerebral arteriopathy" is suggested to describe the common finding of focal cerebral arterial stenosis with no apparent cause. Prior upper respiratory infection was associated with focal cerebral arteriopathy, supporting the role of infection in childhood stroke.
8. Rea D, Brandsema JF, Armstrong D, et al. Cerebral arteriopathy in children with neurofibromatosis type 1. Pediatrics 2009 (in press).
9. Chabrier S, Rodesch G, Lasjaunias P, et al. Transient cerebral arteriopathy: A disorder recognized by serial angiograms in children with stroke. J Child Neurol 1998;13:27-32.
10. Ganesan V, Chong WK, Cox TC, et al. Posterior circulation stroke in childhood: Risk factors and recurrence. Neurology 2002;59:1552-1556.
11. Bernard TJ, Goldenberg NA, Tripputi M, et al. Anticoagulation in childhood-onset arterial ischemic stroke with non-moyamoya arteriopathy: Findings from the Colorado and German (COAG) collaboration. Stroke 2009;40:2869-2871.
12. Nagel MA, Cohrs RJ, Mahalingam R, et al. The varicella zoster virus vasculopathies: Clinical, CSF, imaging, and virologic features. Neurology 2008;70:853-860.
13. Miravet E, Danchaivijitr N, Basu H, et al. Clinical and radiological features of childhood cerebral infarction following varicella zoster virus infection. Dev Med Child Neurol 2007;49:417-422.
14. Donahue JG, Kieke BA, Yih WK, et al. Varicella vaccination and ischemic stroke in children: Is there an association? Pediatrics 2009;123:e228-e234.
15. Ohene-Frempong K, Weiner SJ, Sleeper LA, et al. Cerebrovascular accidents in sickle cell disease: Rates and risk factors. Blood 1998;91:288-294.
16. Adams R, McKie V, Nichols F, et al. The use of transcranial ultrasonography to predict stroke in sickle cell disease. N Engl J Med 1992;326:605-610.
17. Adams RJ, McKie VC, Hsu L, et al. Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. N Engl J Med 1998;339:5-11.
18. Mirre E, Brousse V, Berteloot L, et al. Feasibility and efficacy of chronic transfusion for stroke prevention in children with sickle cell disease. Eur J Haematol 2005;84:259-265.
19. Colombatti R, Meneghetti G, Ermani M, et al. Primary stroke prevention for sickle cell disease in north-east Italy: The role of ethnic issues in establishing a Transcranial Doppler screening program. Ital J Pediatr 2009;35:15.
20. Armstrong-Wells J, Grimes B, Sidney S, et al. Utilization of TCD screening for primary stroke prevention in children with sickle cell disease. Neurology 2009;72:1316-1321.
21. Dowling MM, Lee N, Quinn CT, et al. Prevalence of intracardiac shunting in children with sickle cell disease and stroke. J Pediatr 2009 (in press).
22. Roach ES, Golomb MR, Adams R, et al. Management of stroke in infants and children: A scientific statement from a Special Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young. Stroke 2008;39:2644-2691 The American Heart Association Stroke counsel provides a statement of evidencebased recommendations for management of pediatric stroke in various subpopulations of children, including perinatal stroke, childhood arterial ischemic stroke, sickle cell disease, moyamoya disease, cervicocephalic arterial dissection, and cardiogenic embolism. Protocols for dosing of heparin and warfarin in children are suggested.
23. Chen J, Zimmerman RA, Jarvik GP, et al. Perioperative stroke in infants undergoing open heart operations for congenital heart disease. Ann Thorac Surg 2009;88:823-829.
24. Morita DC, Donaldson A, Butterfield RJ, et al. Methylenetetrahydrofolate reductase gene polymorphism and childhood stroke. Pediatr Neurol 2009;41:247-249.
25. Herak DC, Antolic MR, Krleza JL, et al. Inherited prothrombotic risk factors in children with stroke, transient ischemic attack, or migraine. Pediatrics 2009;123:e653-e660.
26. Zak I, Sarecka-Hujar B, Kopyta I, et al. The T allele of the 677C > T polymorphism of methylenetetrahydrofolate reductase gene is associated with an increased risk of ischemic stroke in Polish children. J Child Neurol 2009;24:1262-1267.
27. Goldenberg NA, Bernard TJ, Fullerton HJ, et al. Antithrombotic treatments, outcomes, and prognostic factors in acute childhoodonset arterial ischaemic stroke: A multicentre, observational, cohort study. Lancet Neurol 2009;8:1120-1127.
28. Monagle P, Chalmers E, Chan A, et al. Antithrombotic therapy in neonates and children: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008;133:887S-968S The American College of Chest Physicians provides clinical practice guidelines for antithrombotic therapy in neonates and children, including guidelines for treatment of acute arterial ischemic stroke with heparin or aspirin.
29. Amlie-Lefond C, deVeber G, Chan AK, et al. Use of alteplase in childhood arterial ischaemic stroke: A multicentre, observational, cohort study. Lancet Neurol 2009;8:530-536.
30. Arnold M, Steinlin M, Baumann A, et al. Thrombolysis in childhood stroke: Report of 2 cases and review of the literature. Stroke 2009;40:801-807.
31. Amlie-Lefond C, Chan AK, Kirton A, et al. Thrombolysis in acute childhood stroke: Design and challenges of the thrombolysis in pediatric stroke clinical trial. Neuroepidemiology 2009;32:279-286.
32. Srinivasan J, Miller SP, Phan TG, Mackay MT. Delayed recognition of initial stroke in children: Need for increased awareness. Pediatrics 2009;124:e227-e234.
33. McGlennan C, Ganesan V. Delays in investigation and management of acute arterial ischaemic stroke in children. Dev Med Child Neurol 2008;50:537-540.
34. Rafay MF, Pontigon AM, Chiang J, et al. Delay to diagnosis in acute pediatric arterial ischemic stroke. Stroke 2009;40:58-64.
35. Hartman AL, Lunney KM, Serena JE. Pediatric stroke: Do clinical factors predict delays in presentation? J Pediatr 2009;154:727-732.
36. Braun KP, Bulder MM, Chabrier S, et al. The course and outcome of unilateral intracranial arteriopathy in 79 children with ischaemic stroke. Brain 2009;132:544-557 The evolution of vascular imaging after childhood arterial ischemic stroke is described in a European cohort. Clinical and imaging characteristics are compared in transient versus progressive cerebral arteriopathies. The majority of children fell under the category of transient cerebral arteriopathy, and recurrent stroke was associated with progressive cerebrovascular disease.
37. Camilo O, Goldstein LB. Seizures and epilepsy after ischemic stroke. Stroke 2004;35:1769-1775.
38. Golomb MR, Garg BP, Carvalho KS, et al. Perinatal stroke and the risk of developing childhood epilepsy. J Pediatr 2007;151:409-413, 13e1-2.
39. Lee JC, Lin KL, Wang HS, et al. Seizures in childhood ischemic stroke in Taiwan. Brain Dev 2009;31:294-299.
40. Everts R, Pavlovic J, Kaufmann F, et al. Cognitive functioning, behavior, and quality of life after stroke in childhood. Child Neuropsychol 2008;14:323-338.
41. Ricci D, Mercuri E, Barnett A, et al. Cognitive outcome at early school age in term-born children with perinatally acquired middle cerebral artery territory infarction. Stroke 2008;39:403-410.
42. Ballantyne AO, Spilkin AM, Hesselink J, Trauner DA. Plasticity in the developing brain: Intellectual, language and academic functions in children with ischaemic perinatal stroke. Brain 2008;131:2975-2985.
43. Beslow LA, Licht DJ, Smith SE, et al. Predictors of outcome in childhood intracerebral hemorrhage: A prospective consecutive cohort study. Stroke 2009;41:313-318.
44. Jordan LC, Kleinman JT, Hillis AE. Intracerebral hemorrhage volume predicts poor neurologic outcome in children. Stroke 2009;40:1666-1671.
45. Guzzetta A, Pizzardi A, Belmonti V, et al. Hand movements at 3 months predict later hemiplegia in term infants with neonatal cerebral infarction. Dev Med Child Neurol 2009 (in press).
46. Kirton A, Shroff M, Visvanathan T, deVeber G. Quantified corticospinal tract diffusion restriction predicts neonatal stroke outcome. Stroke 2007;38:974-980.
47. Domi T, deVeber G, Shroff M, et al. Corticospinal tract prewallerian degeneration: A novel outcome predictor for pediatric stroke on acute MRI. Stroke 2009;40:780-787.
48. Luengo-Fernandez R, Gray AM, Rothwell PM. Costs of stroke using patient-level data: A critical review of the literature. Stroke 2009;40:e18-e23.
49. Perkins E, Stephens J, Xiang H, Lo W. The cost of pediatric stroke acute care in the United States. Stroke 2009;40:2820-2827.
50. Gardner MA, Hills NK, Sidney S, et al. The 5-year direct medical cost of neonatal and childhood stroke in a population-based cohort. Neurology 2009;74:372-378.