Cross-Reactivity between Erythropoietin and Thrombopoietin at the Level of Mpl Does Not Account for the Thrombocytosis Seen in Iron Deficiency [2]

Journal of Pediatric Hematology/Oncology

Volumn 25, Issue 11, 2003, Pages 919-920

  Geddis, Amy E ^a   Kaushansky, Kenneth ^a  

^a UCSD MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; THROMBOPOIETIN;

AMINO ACID SEQUENCE; CROSS REACTION; DRUG RECEPTOR BINDING; IRON DEFICIENCY; LETTER; MEGAKARYOPOIESIS; PRIORITY JOURNAL; STEM CELL; THROMBOCYTE COUNT; THROMBOCYTOSIS;

EID: 0242524441     PISSN: 10774114     EISSN: None     Source Type: Journal    
DOI: 10.1097/00043426-200311000-00020     Document Type: Letter

References (7)

1. Bilic E, Bilic E. Amino acid sequence homology of thrombopoietin and erythropoietin may explain thrombocytosis in children with iron deficiency anemia. J Pediatr Hematol Oncol. 2003;25:675-676.
2. Akan H, Guven N, Aydogdu I, et al. Thrombopoietic cytokines in patients with iron deficiency anemia with or without thrombocytosis. Acta Haematol. 2000;103:152-156.
3. Broudy VC, Lin N, Sabath D, et al. Human platelets display high-affinity receptors for thrombopoietin. Blood. 1997;89:1896-1904.
4. Broudy VC, Lin N, Kaushansky K. Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood. 1995;85:1719-1726.
5. Metcalf D, Di Rago L, Mifsud S. Synergistic and inhibitory interactions in the in vitro control of murine megakaryocyte colony formation. Stem Cells. 2002;20:552-560.
6. Perlman MK, Schwab JG, Nachman JB, et al. Thrombocytopenia in children with severe iron deficiency. J Pediatr Hematol Oncol. 2002;24: 380-384.
7. Shibata J, Hasegawa J, Siemens H, et al. Hemostasis and coagulation at a hematocrit level of 0.85: functional consequences of erythrocytosis. Blood. 2003;101:4416-4422.