Evaluation of antibiotic-impregnated microspheres for the prevention of implant-associated orthopaedic infections

Journal of Bone and Joint Surgery

Volumn 96, Issue 2, 2014, Pages 128-134

  Ambrose, Catherine G ^a   Clyburn, Terry A ^a   Mika, Joerg ^a   Gogola, Gloria R ^b   Kaplan, Heidi B ^a   Wanger, Audrey ^a   Mikos, Antonios G ^c  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b Shriners Hospital Houston   (United States)

^c Rice University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICROSPHERE; TOBRAMYCIN; TOBRAMYCIN SULFATE; ANTIINFECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; BONE INFECTION; BONE RADIOGRAPHY; CONTROLLED STUDY; IMPLANT ASSOCIATED ORTHOPAEDIC INFECTION; INFECTION PREVENTION; INFECTION RATE; MALE; MEDICAL DEVICE COMPLICATION; NONHUMAN; ORTHOPEDIC IMPLANT; PRIORITY JOURNAL; REVIEW; STAPHYLOCOCCUS AUREUS; SURGICAL INFECTION; TRABECULAR BONE; ANIMAL; ARTICLE; DISEASE MODEL; DRUG DELIVERY SYSTEM; EVALUATION STUDY; IMPLANTATION; INFECTION; METHODOLOGY; PROSTHESES AND ORTHOSES; RABBIT; RANDOMIZATION; REFERENCE VALUE; SENSITIVITY AND SPECIFICITY; STAPHYLOCOCCUS INFECTION; TREATMENT OUTCOME;

ANIMALS; ANTI-BACTERIAL AGENTS; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; MALE; MICROSPHERES; PROSTHESES AND IMPLANTS; PROSTHESIS IMPLANTATION; PROSTHESIS-RELATED INFECTIONS; RABBITS; RANDOM ALLOCATION; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; STAPHYLOCOCCAL INFECTIONS; TOBRAMYCIN; TREATMENT OUTCOME;

EID: 84896304474     PISSN: 00219355     EISSN: 15351386     Source Type: Journal    
DOI: 10.2106/JBJS.L.01750     Document Type: Review

References (39)

1. Mader JT, Landon GC, Calhoun J. Antimicrobial treatment of osteomyelitis. Clin Orthop Relat Res. 1993 Oct;295: 87-95.
2. Buchholz HW, Elson RA, Engelbrecht E, Lodenkǎmper H, Rôttger J, Siegel A. Management of deep infection of total hip replacement. J Bone Joint Surg Br. 1981;63(3): 342-53.
3. Wininger DA, Fass RJ. Antibiotic-impregnated cement and beads for orthopedic infections. Antimicrob Agents Chemother. 1996 Dec;40(12): 2675-9.
4. Henry SL, Seligson D, Mangino P, Popham GJ. Antibiotic-impregnated beads. Part I: bead implantation versus systemic therapy. Orthop Rev. 1991 Mar;20(3): 242-7.
5. Penner MJ, Duncan CP, Masri BA. The in vitro elution characteristics of antibiotic-loaded CMW and Palacos-R bone cements. J Arthroplasty. 1999 Feb; 14(2): 209-14.
6. Wang J, Calhoun JH, LeFrock J, Mader JT. The roles and effectiveness of adjunctive therapy in the management of musculoskeletal infections. In: Calhoun J, Mader JT, editors. Musculoskeletal Infections. New York: Marcel Dekker; 2003: 513-40.
7. Garvin K, Feschuk C. Polylactide-polyglycolide antibiotic implants. Clin Orthop Relat Res. 2005 Aug;437: 105-10.
8. Brin YS, Golenser J, Mizrahi B, Maoz G, Domb AJ, Peddada S, Tuvia S, Nyska A, Nyska M. Treatment of osteomyelitis in rats by injection of degradable polymer releasing gentamicin. J Control Release. 2008 Oct 21;131(2): 121-7. Epub 2008 Jul 20.
9. Kanellakopoulou K, Giamarellos-Bourboulis EJ. Carrier systems for the local delivery of antibiotics in bone infections. Drugs. 2000 Jun;59(6): 1223-32.
10. Kundu B, Soundrapandian C, Nandi SK, Mukherjee P, Dandapat N, Roy S, Datta BK, Mandal TK, Basu D, Bhattacharya RN. Development of new localized drug delivery system based on ceftriaxone-sulbactam composite drug impregnated porous hydroxyapatite: A systematic approach for in vitro and in vivo animal trial. Pharm Res. 2010 Aug;27(8): 1659-76. Epub 2010 May 13.
11. Ambrose CG, Gogola GR, Clyburn TA, Raymond AK, Peng AS, Mikos AG. Antibiotic microspheres: preliminary testing for potential treatment of osteomyelitis. Clin Orthop Relat Res. 2003 Oct;415: 279-85.
12. Ambrose CG, Clyburn TA, Louden K, Joseph J, Wright J, Gulati P, Gogola GR, Mikos AG. Effective treatment of osteomyelitis with biodegradable microspheres in a rabbit model. Clin Orthop Relat Res. 2004 Apr;421: 293-9.
13. Zimmerli W, Waldvogel FA, Vaudaux P, Nydegger UE. Pathogenesis of foreign body infection: description and characteristics of an animal model. J Infect Dis. 1982 Oct;146(4): 487-97.
14. Nelson CL, McLaren AC, McLaren SG, Johnson JW, Smeltzer MS. Is aseptic loosening truly aseptic? Clin Orthop Relat Res. 2005 Aug;437: 25-30.
15. Costerton JW. Biofilm theory can guide the treatment of device-related orthopaedic infections. Clin Orthop Relat Res. 2005 Aug;437: 7-11.
16. Palmer M, Costerton W, Sewecke J, Altman D. Molecular techniques to detect biofilm bacteria in long bone nonunion: A case report. Clin Orthop Relat Res. 2011 Nov;469(11): 3037-42.
17. Zimmerli W, Moser C. Pathogenesis and treatment concepts of orthopaedic biofilm infections. FEMS Immunol Med Microbiol. 2012 Jul;65(2): 158-68. Epub 2012 Mar 15.
18. Stoodley P, Ehrlich GD, Sedghizadeh PP, Hall-Stoodley L, Baratz ME, Altman DT, Sotereanos NG, Costerton JW, Demeo P. Orthopaedic biofilm infections. Curr Orthop Pract. 2011 Nov;22(6): 558-63.
19. Jiranek WA, Hanssen AD, Greenwald AS. Antibiotic-loaded bone cement for infection prophylaxis in total joint replacement. J Bone Joint Surg Am. 2006 Nov;88(11): 2487-500.
20. Block JE, Stubbs HA. Reducing the risk of deep wound infection in primary joint arthroplasty with antibiotic bone cement. Orthopedics. 2005 Nov;28(11): 1334-45.
21. Dunbar MJ. Antibiotic bone cements: Their use in routine primary total joint arthroplasty is justified. Orthopedics. 2009 Sep;32(9).
22. Bourne RB. Prophylactic use of antibiotic bone cement: An emerging standard-in the affirmative. J Arthroplasty. 2004 Jun;19(4)(Suppl 1): 69-72.
23. Adams CS, Antoci V Jr, Harrison G, Patal P, Freeman TA, Shapiro IM, Parvizi J, Hickok NJ, Radin S, Ducheyne P. Controlled release of vancomycin from thin sol-gel films on implant surfaces successfully controls osteomyelitis. J Orthop Res. 2009 Jun;27(6): 701-9.
24. Alt V, Bitschnau A, Bôhner F, Heerich KE, Magesin E, Sewing A, Pavlidis T, Szalay G, Heiss C, Thormann U, Hartmann S, Pabst W, Wenisch S, Schnettler R. Effects of gentamicin and gentamicin-RGD coatings on bone ingrowth and biocompatibility of cementless joint prostheses: An experimental study in rabbits. Acta Biomater. 2011 Mar;7(3): 1274-80. Epub 2010 Dec 01.
25. Moojen DJ, Vogely HC, Fleer A, Nikkels PG, Higham PA, Verbout AJ, Castelein RM, Dhert WJ. Prophylaxis of infection and effects on osseointegration using a tobramycin-periapatite coating on titanium implants-An experimental study in the rabbit. J Orthop Res. 2009 Jun;27(6): 710-6.
26. Vester H, Wildemann B, Schmidmaier G, Stôckle U, Lucke M. Gentamycin delivered from a PDLLA coating of metallic implants: In vivo and in vitro characterisation for local prophylaxis of implant-related osteomyelitis. Injury. 2010 Oct;41(10): 1053-9.
27. Stewart RL, Cox JT, Volgas D, Stannard J, Duffy L, Waites KB, Chu TM. The use of a biodegradable, load-bearing scaffold as a carrier for antibiotics in an infected open fracture model. J Orthop Trauma. 2010 Sep;24(9): 587-91.
28. Hasegawa M, Sudo A, Komlev VS, Barinov SM, Uchida A. High release of antibiotic from a novel hydroxyapatite with bimodal pore size distribution. J Biomed Mater Res B Appl Biomater. 2004 Aug 15;70(2): 332-9.
29. Smeltzer MS, Thomas JR, Hickmon SG, Skinner RA, Nelson CL, Griffith D, Parr TR Jr, Evans RP. Characterization of a rabbit model of staphylococcal osteomyelitis. J Orthop Res. 1997 May;15(3): 414-21.
30. Cleek RL, Ting KC, Eskin SG, Mikos AG. Microparticles of poly(DL-lacticco-glycolic acid)/poly(ethylene glycol) blends for controlled drug delivery. J Control Release. 1997;48(2-3): 259-68.
31. Ambrose CG, Clanton TO. Bioabsorbable implants: review of clinical experience in orthopedic surgery. Ann Biomed Eng. 2004 Jan;32(1): 171-7.
32. Bobyn JD, Stackpool GJ, Hacking SA, Tanzer M, Krygier JJ. Characteristics of bone ingrowth and interface mechanics of a new porous tantalum biomaterial. J Bone Joint Surg Br. 1999 Sep;81(5): 907-14.
33. Bobyn JD, Toh KK, Hacking SA, Tanzer M, Krygier JJ. Tissue response to porous tantalum acetabular cups: A canine model. J Arthroplasty. 1999 Apr; 14(3): 347-54.
34. Donath K, Breuner G. A method for the study of undecalcified bones and teeth with attached soft tissues. The Sǎge-Schliff (sawing and grinding) technique. J Oral Pathol. 1982 Aug;11(4): 318-26.
35. Parvizi J, Saleh KJ, Ragland PS, Pour AE, Mont MA. Efficacy of antibioticimpregnated cement in total hip replacement. Acta Orthop. 2008 Jun;79(3): 335-41.
36. Schmidmaier G, Lucke M, Wildemann B, Haas NP, Raschke M. Prophylaxis and treatment of implant-related infections by antibiotic-coated implants: A review. Injury. 2006 May;37(Suppl 2): S105-12.
37. Gosselin RA, Roberts I, Gillespie WJ. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. 2004;1: CD003764.
38. Wright BA, Roberts CS, Seligson D, Malkani AL, McCabe SJ. Cost of antibiotic beads is justified: A study of open fracture wounds and chronic osteomyelitis. J Long Term Eff Med Implants. 2007;17(3): 181-5.
39. Gardner MJ, Mehta S, Barei DP, Nork SE. Treatment protocol for open AO/OTA type C3 pilon fractures with segmental bone loss. J Orthop Trauma. 2008 Aug;22(7): 451-7.