Treatment of osteomyelitis in rats by injection of degradable polymer releasing gentamicin

Journal of Controlled Release

Volumn 131, Issue 2, 2008, Pages 121-127

  Brin, Yaron S ^a,b   Golenser, Jacob ^c   Mizrahi, Boaz ^d   Maoz, Guy ^a,b   Domb, Abraham J ^d   Peddada, Shyamal ^e   Tuvia, Shmuel ^f   Nyska, Abraham ^b,g   Nyska, Meir ^a,b  

^a MEIR MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^d HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^e NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^f BIOLINERX LTD   (Israel)

^g Toxicologic Pathology   (Israel)

Author keywords

Delivery vehicle; Gentamicin; Injectable degradable polymer; Osteomyelitis; Poly(sebacic co ricinoleic ester anhydride); S. aureus

Indexed keywords

ABS RESINS; ESTERS; HYDRAULIC STRUCTURES; ORGANIC COMPOUNDS; PHOTODEGRADATION; POLYMERS; RADIOGRAPHY; SIMULATED ANNEALING;

DELIVERY VEHICLE; GENTAMICIN; INJECTABLE DEGRADABLE POLYMER; OSTEOMYELITIS; POLY(SEBACIC-CO-RICINOLEIC-ESTER-ANHYDRIDE); S. AUREUS;

RATS;

GENTAMICIN; POLY(SEBACIC CO RICINOLEIC ESTER ANHYDRIDE); POLYMER; UNCLASSIFIED DRUG;

ABSCESS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HISTOLOGY; NONHUMAN; OSTEOMYELITIS; PRIORITY JOURNAL; RADIOGRAPHY; RAT; STAPHYLOCOCCUS AUREUS; TIBIA; X RAY;

ANIMALS; ANTI-BACTERIAL AGENTS; BIOCOMPATIBLE MATERIALS; DECANOIC ACIDS; DISEASE MODELS, ANIMAL; DRUG CARRIERS; DRUG COMPOUNDING; FEMALE; GENTAMICINS; INJECTIONS, INTRALESIONAL; OSTEOMYELITIS; POLYMERS; RATS; RATS, INBRED F344; RICINOLEIC ACIDS; SOLUBILITY; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; TIBIA;

EID: 53249154659     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2008.07.022     Document Type: Article

References (51)

1. Chambers H.F. The changing epidemiology of S. aureus. Emerg. Infect. Dis. 7 (2001) 178-182
2. Rubin R.J., Harrington C.A., and Poon A. The economic impact of S. aureus infection in NY City hospitals. Emerg. Infect. Dis. 5 (1999) 9-17
3. Mader J.T., Cripps M.W., and Calhoun J.H. Adult posttraumatic osteomyelitis of the tibia. Clin. Orthop. 360 (1999) 14-21
4. Crémieux A.C., and Carbon C. Experimental models of bone and prosthetic joint infections. Clin. Infect. Dis. 25 (1997) 1295-1302
5. Waldvogel F.A., Medoff G., and Swartz M.N. Osteomyelitis: a review of clinical features, therapeutic considerations and unusual aspects. N. Engl. J. Med. 282 (1970) 198-206
6. Costerton J.W. Biofilm theory can guide the treatment of device-related orthopaedic infections. Clin. Orthop. 437 (2005) 7-11
7. Lazzarini L., Mader J.T., and Calhoun J.H. Osteomyelitis in long bones. J. Bone Jt. Surg. Am. 86-A 10 (2004) 2305-2318
8. Walenkamp G.H., Kleijn L.L., and de Leeuw M. Osteomyelitis treated with gentamicin-PMMA beads: 100 patients followed for 1-12 years. Acta Orthop. Scand. 69 (1998) 518-522
9. Sasaki T., Ishibashi Y., Katano H., Nagumo A., and Toh S. In vitro elution of vancomycin from calcium phosphate cement. J. Arthroplast. 20 (2005) 1055-1059
10. Stern J.A., and Clemens J.Q. Osteomyelitis of the pubis: a complication of a chronic indwelling catheter. Urology 61 (2003) 4621-4622
11. Wong M.W., and Hui M. Development of gentamicin resistance after gentamicin-PMMA beads for treatment of foot osteomyelitis: report of two cases. Foot Ankle Int. 26 (2005) 1093-1105
12. Schmidt C., Wenz R., and Nies B. Antibiotic in vivo/in vitro release, histocompatability and degradation of gentamicin implants based on lactic acid and copolymers. J. Control. Release 37 (1995) 83-94
13. Domb A.J., Rosenberg A.E., and Hanff P. Bioerodible polyanhydrides for antibiotic drug delivery: in vivo osteomyelitis treatment in a rat model system. J. Orthop. Res. 1 (1993) 256-262
14. Li L.C., Deng J., and Stephens D. Polyanhydride implant for antibiotic delivery-from the bench to the clinic. Adv. Drug Deliv. Rev. 54 (2002) 963-986
15. Overbeck J.P., Winckler S.T., and Meffert R. Penetration of ciprofloxacin into bone: a new bioabsorbable implant. J. Invest. Surg. 8 (1995) 155-162
16. Garvin K.L., Miyano J.A., and Robinson D. Polylactide/polyglycolide antibiotic implants in the treatment of osteomyelitis. A canine model. J. Bone Jt. Surg. Am. 76 (1994) 1500-1506
17. Leyh R.G., Bartels C., and Sievers H.H. Adjuvant treatment of deep sternal wound infection with collagenous gentamicin. Ann. Thorac. Surg. 68 (1999) 1648-1651
18. Aimin C., Chunlin H., and Juliang B. Antibiotic loaded chitosan bar. An in vitro, in vivo study of a possible treatment for osteomyelitis. Clin. Orthop. 366 (1999) 239-247
19. Gursel I., Korkusuz F., and Turesin F. In vivo application of biodegradable controlled antibiotic release systems for the treatment of implant-related osteomyelitis. Biomaterials 22 (2001) 73-80
20. Shikanov B., Vaisman M.Y., Krasko A., Nyska A., and Domb J. Poly(sebacic acid-co-ricinoleic acid biodegradable carrier for paclitaxel: in vitro release and in vivo toxicity. J. Biomed. Mater. Res. 69 (2004) 47-54
21. Gracia E., Lacleriga A., Monzon M., Levia J., Oteiza C., and Amorena B. Application of a rat osteomyelitis model to compare in vivo and in vitro the antibiotic efficacy against bacteria with high capacity to form biofilms. J. Surg. Res. 79 2 (1998) 146-153
22. Shikanov A., Ezra A., and Domb A.J. Poly(sebacic acid-co-ricinoleic acid) biodegradable carrier for paclitaxel-effect of additives. J. Control. Release 105 1-2 (2005) 52-67
23. Teomim D., and Domb A.J. Nonlinear fatty acid terminated polyanhydrides. Biomacromolecules 2 1 (2001) 37-44
24. Sampath S.S., and Robinson D.H. Comparison of new and existing spectrophotometric methods for the analysis of tobramycin and other aminoglycosides. J. Pharm. Sci. 79 5 (1990) 428-431
25. Zak O., Zak F., Rich R., Tosch W., Kradolfer F., and Sheld W.M. Experimental staphylococcal osteomyelitis in rats: therapy with rifampin and cloxacillin, alone or in combination. In: Perity P., and Grassi G.G. (Eds). Current Chemotherapy and Immunotherapy (1982), American Society for Microbiology, Washington 973-974
26. Lucke M., Schmidmajer G., Sadoni S., Widemann B., Haas N.P., and Rasche M. Gentamicin coating of metallic implants reduces implant-related osteomyelitis in rats. Bone 32 5 (2003) 521-531
27. Krasko M.Y., Golenser J., Nyska A., Nyska M., Brin Y.S., and Domb A.J. Gentamicin extended release from an injectable polymeric implant. J. Control. Release 117 1 (2007) 90-96
28. Patzakis M.J., Mazur K., Wilkins J., Sherman R., and Holtom P. Septopal beads and autogenous bone grafting for bone defects in patients with chronic osteomyelitis. Clin. Orthop. Relat. Res. 295 (1993) 112-118
29. Calhoun J.H., Henry S.L., Anger D.M., Cobos J.A., and Mader J.T. The treatment of infected nonunions with gentamicin-polymethylmethacrylate antibiotic beads. Clin. Orthop. 295 (1993) 23-27
30. DeSilva G.L., Fritzler A., and DeSilva S.P. Antibiotic-impregnated cement spacer for bone defects of the forearm and hand. Tech. Hand Up. Extrem. Surg. 11 2 (2007) 163-167
31. Holtom P.D. Antibiotic prophylaxis: current recommendations. J. Am. Acad. Orthop. Surg. 14 10 (2006) S98-S100
32. Buchholz H.W., and Engelbrecht H. Depot effects of various antibiotics mixed with Palacos resins. Chirurg 41 (1970) 511-515
33. Evans R.P., and Nelson C.L. Gentamicin-impregnated polymethylmethacrylate beads compared with systemic antibiotic therapy in the treatment of chronic osteomyelitis. Clin. Orthop. Relat. Res. 295 (1993) 37-42
34. Jenny G. Local antibiotic therapy using gentamicin-PMMA chains in post-traumatic bone infections. Short and long-term results. Reconstr. Surg. Traumatol. 20 (1988) 36-46
35. Klemm K.W. Antibiotic bead chains. Clin. Orthop. Relat. Res. 295 (1993) 63-76
36. Klemm K.W. Gentamicin-PMMA chains (Septopal chains) for the local antibiotic treatment of chronic osteomyelitis. Reconstr. Surg. Traumatol. 20 (1988) 11-35
37. Ambrose C.G., Clyburn T.A., Louden K., Joseph J., Wright J., Gulati P., Gogola G.R., and Mikos A.G. Effective treatment of osteomyelitis with biodegradable microspheres in a rabbit model. Clin. Orthop. Relat. Res. 421 (2004) 293-299
38. van de Belt H., Neut D., Schenk W., van Horn J.R., van der Mei H.C., and Bussscher H.J. Gentamicin release from polymethylmethacrylate bone cements and Staphylococcus aureus biofilm formation. Acta Orthop. Scand. 71 (2000) 625-629
39. Krasko M.Y., and Domb A.J. Hydrolytic degradation of ricinoleic-sebacic-ester-anhydride copolymers. Biomacromolecules 6 4 (2005) 1877-1884 2005
40. Quick D.J., Macdonald K.K., and Anseth K.S. Delivering DNA from photocrosslinked, surface eroding polyanhydrides. J. Control. Release 97 (2004) 333-343
41. Mclaren A.C., Mclaren S.G., Nelson C.L., Wassell D.L., and Olsen K.M. The effect of sampling method on the elution of tobramycin from calcium sulfate. Clin. Orthop. Relat. Res. 403 (2002) 54-57
42. Jansen J.A., van de Waerden J.P., Wolke J.G., and Groot K. Histologic evaluation of the osseous adaptation to titanium and hydroxyapatite-coated titanium implants. J. Biomed. Mater. Res. 25 (1991) 973-989
43. McLaren A.C., and Miniaci A. Pharmacokinetics of depot administration of tobramycin mixed with morselized cancellous bone. Trans. Orthop. Res. Soc. 12 (1987)
44. Readl H., Schlag G., Stanek G., Hirschl A., and Seelich T. In vitro properties of mixtures of fibrin seal and antibiotics. Biomaterials 4 (1983) 29-32
45. Mendel V., Simanowski H.J., Scholz H.C., and Heymann H. Therapy with gentamicin-PMMA beads, gentamicin-collagen sponge, and cefazolin for experimental osteomyelitis due to Staphylococcus aureus in rats. Arch. Orthop. Trauma Surg. 125 6 (2005) 363-368
46. Zelken J., Wanich T., Gardner M., Griffith M., and Bostrom M. PMMA is superior to hydroxyapatite for colony reduction in induced osteomyelitis. Clin. Orthop. Relat. Res. 462 (2007) 190-194
47. Kamel A.H., and Baddour M.M. Gatifloxacin biodegradable implant for treatment of experimental osteomyelitis: in vitro and in vivo evaluation. Drug Deliv. 14 6 (2007) 349-356
48. Nelson C.L., Hickmon S.G., and Skinner R.A. Treatment of experimental osteomyelitis by surgical debridement and the implantation of biodegradable, polyanhydride-gentamicin beads. J. Orthop. Res. 15 (1997) 249-255
49. Brozsei L., Mintal T., Koos Z., Kocsis B., Helyes Z., Kereskai L., and Nyarady J. Examination of a novel, specified local antibiotic therapy through polymethylmethacrylate capsules in a rabbit osteomyelitis model. Chemotherapy 52 2 (2006) 73-79
50. Perry C.R., Pearson R.L., and Miller G.A. Accuracy of cultures of material from swabbing of the superficial aspect of the wound and needle biopsy in the preoperative assessment of osteomyelitis. J. Bone. Jt. Surg. Am. 73 5 (1991) 745-749
51. Butt W.P. The radiology of infection. Clin. Orthop. 96 (1973) 20-30