Damnacanthal is a potent inducer of apoptosis with anticancer activity by stimulating p53 and p21 genes in MCF-7 breast cancer cells

Oncology Letters

Volumn 7, Issue 5, 2014, Pages 1479-1484

  Aziz, Muhammad Yusran Abdul ^a   Omar, Abdul Rahman ^b   Subramani, Tamilselvan ^a   Yeap, Swee Keong ^b   Ho, Wan Yong ^a   Ismail, Nor Hadiani ^c   Ahmad, Syahida ^b   Alitheen, Noorjahan Banu ^a  

^a Department of Cell and Molecular Biology Biomolecular Sciences ^*  (Malaysia)

^b UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^c UNIVERSITI TEKNOLOGI MARA   (Malaysia)

Author keywords

Anticancer; Apoptosis; Caspase; Damnacanthal; MCF 7; P21; P53

Indexed keywords

CASPASE 7; DAMNACANTHAL; ESTROGEN RECEPTOR ALPHA; LIPOCORTIN 5; POTASSIUM IODIDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; X LINKED INHIBITOR OF APOPTOSIS;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER INHIBITION; CELL COUNT; CELL CYCLE ARREST; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; FLOW CYTOMETRY; GENE ACTIVATION; GENE EXPRESSION; GROWTH REGULATION; HUMAN; HUMAN CELL; IC 50; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 84896284890     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2014.1898     Document Type: Article

References (23)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J and Thun MJ: Cancer statistics 2009. CA Cancer J Clin 59: 225-249, 2009.
2. Jovanovic J, Rønneberg JA, Tost J and Kristensen V: The epigenetics of breast cancer. Mol Oncol 4: 242-254, 2010.
3. Wickerham DL: Breast cancer chemoprevention: progress and controversy. Surg Oncol Clin NA 19: 463-473, 2010.
4. Fesik SW: Promoting apoptosis as a strategy for cancer drug discovery. Nat Rev Cancer 5: 876-885, 2005.
5. Hengartner MO: The biochemistry of apoptosis. Nature 407: 770-776, 2000.
6. Hatcher H, Planalp R, Cho J, Torti FM and Torti SV: Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci 65: 1631-1652, 2008.
7. Kawamori T, Lubet R, Steele VE, Kelloff GJ, Kaskey RB, Rao CV and Reddy BS: Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer. Cancer Res 59: 597-601, 1999.
8. Wang MY, West BJ, Jensen CJ, Nowicki D, Su C, Palu AKAnderson G: Morinda citrifolia (Noni): a literature review and recent advances in Noni research. Acta Pharmacol Sin 23: 1127-1141, 2002.
9. Kamiya K, Tanaka Y, Endang H, Umar M and Satake T: New anthraquinone and iridoid from the fruits of Morinda citrifolia. Chem Pharmaceut Bull (Tokyo) 53: 1597-1599, 2005.
10. Alitheen NB, Mashitoh AR, Yeap SK, Shuhaimi M, Manaf AA and Nordin L: Cytotoxic effect of damnacanthal, nordamnacanthal, zerumbone and betulinic acid isolated from Malaysian plant sources. Int Food Res J 17: 711-719, 2010.
11. Ali AM, Ismail NH, Mackeen MM, Yazan LS, Mohamed SM, Ho AS and Lajis NH: Antiviral, cytotoxic and antimicrobial activities of antharaquinones isolated from the roots of morinda elliptica. Pharm Biol 38: 298-301, 2000.
12. Di Salvo J, Nelson SR and Kaplan N: Protein tyrosine phosphorylation in smooth muscle: a potential coupling mechanism between receptor activation and intracellular calcium. Pro Soc Exp Biol Med 214: 285-301, 1997.
13. Hiwasa T, Arase Y, Chen Z, Kita K, Umezawa K, Ito H and Suzuki N: Stimulation of ultraviolet-induced apoptosis of human fibroblast UVr-1 cells by tyrosine kinase inhibitors. FEBS Lett 444: 173-176, 1999.
14. Tosa H, Iinuma M, Asai F, et al: Anthraquinones from Neonauclea calycina and their inhibitory activity against topoisomerase II. Biol Pharm Bull 21: 641-642, 1998.
15. Norsyafini I, Latifah SY and Nordin HL: Nordamnacanthal induced apoptosis and mitotic G2/M arrest with down regulation of bcl-2 in the human breast cancer cell line (MCF-7). Med Health Sci J 2: 27-38, 2010.
16. Latifah SY, Norsyafini I and Nordin HL: BCL-2 was Down regulated in G2/M-Arrest Breast Cancer Cells MCF-7-Treated with Nordamnacanthal. J Pharm Sci Resl 2: 197-207, 2010.
17. Ghobrial IM, Witzig TE and Adjei AA: Targeting apoptosis pathways in cancer therapy. CA Cancer J Clin 55: 178-194, 2005.
18. Strasser A, O'Connor L and Dixit VM: Apoptosis signaling. Ann Rev Biochem 69: 217-245, 2000.
19. Suzuki A, and Shiraki K: Tumor cell 'dead or alive': caspase and surviving regulate cell death, cell cycle and cell survival. Histol Histopathol 16: 583-593, 2001.
20. Green DR and Reed JC: Mitochondria and apoptosis. Science 281: 1309-1312, 1998.
21. Mirzayans R, Andrais B, Scott A and Murray D: New insights into p53 signaling and cancer cell response to DNA damage: implications for cancer therapy. J Biomed Biotechnol 2012: 170325, 2012.
22. Macleod KF, Sherry N, Hannon G, et al: p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev 9: 935-944, 1995.
23. el-Deiry WS, Tokino T, Velculescu VE, et al: WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817-825, 1993.