Naphthoquinone-mediated inhibition of lysine acetyltransferase KAT3B/p300, basis for non-toxic inhibitor synthesis

Journal of Biological Chemistry

Volumn 289, Issue 11, 2014, Pages 7702-7717

  Vasudevarao, Mohankrishna Dalvoy ^a   Mizar, Pushpak ^a   Kumari, Sujata ^a   Mandal, Somnath ^a   Siddhanta, Soumik ^a   Swamy, Mahadeva M M ^a   Kaypee, Stephanie ^a   Kodihalli, Ravindra C ^a   Banerjee, Amrita ^b   Naryana, Chandrabhas ^a   Dasgupta, Dipak ^b   Kundu, Tapas K ^a  

^a JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

^b SAHA INSTITUTE OF NUCLEAR PHYSICS   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS;

1 ,4-NAPHTHOQUINONES; ACETYL TRANSFERASE; ACETYLTRANSFERASE ACTIVITY; ADDUCT FORMATION; NAPHTHOQUINONE; REDOX CYCLING; REVERSIBLE BINDING; THIOL REACTIVITY;

KETONES;

1,4 NAPHTHOQUINONE DERIVATIVE; 5 HYDROXY 2,3 DIMETHYLNAPHTHALENE 1,4 DIONE; AMINO ACID ACETYLTRANSFERASE; LYSINE ACETYLTRANSFERASE KAT3B P300; PLUMBAGIN; REACTIVE OXYGEN METABOLITE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; HISTONE ACETYLATION; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; NUCLEOPHILICITY; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ENZYME INACTIVATION; ENZYME INHIBITORS; HISTONE ACETYLASE; LYSINE ACETYLTRANSFERASE; N-ACETYL CYSTEINE; PLUMBAGIN; REACTIVE OXYGEN SPECIES (ROS); STRUCTURE-ACTIVITY RELATIONSHIP; THIOL; TOXICITY;

BINDING SITES; CELL LINE, TUMOR; CELL SURVIVAL; E1A-ASSOCIATED P300 PROTEIN; ENZYME INHIBITORS; HEK293 CELLS; HELA CELLS; HUMANS; KINETICS; LYSINE; NAPHTHOQUINONES; OXIDATION-REDUCTION; PROTEIN STRUCTURE, TERTIARY; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS;

EID: 84896281725     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.486522     Document Type: Article

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