Structural changes in the bronchial mucosa of young children at risk of developing asthma

Pediatric Allergy and Immunology

Volumn 25, Issue 2, 2014, Pages 136-142

  Berankova, Katarina ^a   Uhlik, Jiri ^b   Honkova, Lenka ^a   Pohunek, Petr ^a  

^a UNIVERSITY HOSPITAL MOTOL   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Basement membrane; Bronchial asthma; Collagen IV; Laminin; Remodelling; Tenascin

Indexed keywords

COLLAGEN TYPE 4; LAMININ; TENASCIN;

ARTICLE; ASTHMA; ASTHMA PREDICTIVE INDEX; BASEMENT MEMBRANE; BRONCHUS BIOPSY; BRONCHUS MUCOSA; CHILD; CLINICAL ARTICLE; DISEASE COURSE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPE; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; PRESCHOOL CHILD; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; RISK FACTOR; AGE; AIRWAY REMODELING; BIOPSY; BRONCHOSCOPY; BRONCHUS; CASE CONTROL STUDY; CHEMISTRY; EARLY DIAGNOSIS; INFANT; METABOLISM; PATHOLOGY; PREDICTIVE VALUE; RESPIRATORY TRACT MUCOSA;

AGE FACTORS; AIRWAY REMODELING; ASTHMA; BASEMENT MEMBRANE; BIOPSY; BRONCHI; BRONCHOSCOPY; CASE-CONTROL STUDIES; CHILD, PRESCHOOL; COLLAGEN TYPE IV; EARLY DIAGNOSIS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; LAMININ; MALE; PREDICTIVE VALUE OF TESTS; RESPIRATORY MUCOSA; RISK FACTORS; TENASCIN;

EID: 84896122535     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/pai.12119     Document Type: Article

References (26)

1. Asher MI, Montefort S, Björkstén B, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet 2006: 368: 733-743.
2. Holgate ST, Arshad HS, Roberts GC, Howarth PH, Thurner P, Davies DE. A new look at the pathogenesis of asthma. Clin Sci 2009: 118: 439-450.
3. Jeffery PK. Remodeling in asthma and chronic obstructive lung disease. Am J Respir Crit Care Med 2001: 164: S28-S38.
4. Bai TR, Knight DA. Structural changes in the airways in asthma: observations and consequences. Clin Sci 2005: 108: 463-477.
5. Pohunek P, Warner JO, Turzikova J, Kudrmann J, Roche WR. Markers of eosinophilic inflammation and tissue re-modelling in children before clinically diagnosed bronchial asthma. Pediatr Allergy Immunol 2005: 16: 43-51.
6. Saglani S, Payne DN, Zhu J, et al. Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers. Am J Respir Crit Care Med 2007: 176: 858-864.
7. Bergeron C, Tulic MK, Hamid Q. Airway remodelling in asthma: from benchside to clinical practice. Can Respir J 2010: 17: e85-e93.
8. Castro-Rodriguez JA, Holberg CJ, Wright AL, Martinez FD. A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med 2000: 162: 1403-1406.
9. Fedorov IA, Wilson SJ, Davies DE, Holgate ST. Epithelial stress and structural remodelling in childhood asthma. Thorax 2005: 60: 389-394.
10. Sacco O, Silvestri M, Sabatini F, Sale R, Defilippi AC, Rossi GA. Epithelial cells and fibroblasts: structural repair and remodelling in the airways. Paediatr Respir Rev 2004: 5: S35-S40.
11. Durbeej M. Laminins. Cell Tissue Res 2010: 339: 259-268.
12. Aumailley M, Smyth N. The role of laminins in basement membrane function. J Anat 1998: 193: 1-21.
13. Leblond CP, Inoue S. Structure, composition, and assembly of basement membrane. Am J Anat 1989: 185: 367-390.
14. Christie PE, Jonas M, Tsai CH, Chi EY, Henderson WR Jr. Increase in laminin expression in allergic airway remodelling and decrease by dexamethasone. Eur Respir J 2004: 24: 107-115.
15. Liesker JJ, Ten Hacken NH, Zeinstra-Smith M, Rutgers SR, Postma DS, Timens W. Reticular basement membrane in asthma and COPD: similar thickness, yet different composition. Int J Chron Obstruct Pulmon Dis 2009: 4: 127-135.
16. Amenta PS, Gil J, Martinez-Hernandez A. Connective tissue of rat lung. II: ultrastructural localization of collagen types III, IV, and VI. J Histochem Cytochem 1988: 36: 1167-1173.
17. Kuo C, Lim S, King NJ, et al. Rhinovirus infection induces extracellular matrix protein deposition in asthmatic and nonasthmatic airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2011: 300: L951-L957.
18. Phipps S, Benyahia F, Ou TT, Barkans J, Robinson DS, Kay AB. Acute allergen-induced airway remodeling in atopic asthma. Am J Respir Cell Mol Biol 2004: 31: 626-632.
19. Karjalainen EM, Lindqvist A, Laitinen LA, et al. Airway inflammation and basement membrane tenascin in newly diagnosed atopic and nonatopic asthma. Respir Med 2003: 97: 1045-1051.
20. Laitinen A, Altraja A, Kämpe M, Linden M, Virtanen I, Laitinen LA. Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid. Am J Respir Crit Care Med 1997: 156: 951-958.
21. Lambrecht BN, Hammad H. The airway epithelium in asthma. Nat Med 2012: 18: 684-692.
22. Lopes-Guisa JM, Powers C, File D, Cochrane E, Jimenez N, Debley JS. Airway epithelial cells from asthmatic children differentially express proremodeling factors. J Allergy Clin Immunol 2012: 129: 990-997.
23. Le Cras TD, Acciani TH, Mushaben IM, et al. Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma. Am J Physiol Lung Cell Mol Physiol 2011: 300: L414-L421.
24. Swindle EJ, Collins JE, Davies DE. Breakdown in epithelial barrier function in patients with asthma: identification of novel therapeutic approaches. J Allergy Clin Immunol 2009: 124: 23-34.
25. Crosby LM, Waters CM. Epithelial repair mechanisms in the lung. Am J Physiol Lung Cell Mol Physiol 2010: 298: L715-L731.
26. Guilbert TW, Morgan WJ, Zeiger RS, et al. Long-term inhaled corticosteroids in preschool children at high risk for asthma. N Engl J Med 2006: 354: 1985-1997.