Dopamine mediates vagal modulation of the immune system by electroacupuncture

Nature Medicine

Volumn 20, Issue 3, 2014, Pages 291-295

  Torres Rosas, Rafael ^a,b   Yehia, Ghassan ^a   Peña, Geber ^a   Mishra, Priya ^a   Del Rocio Thompson Bonilla, Maria ^a,c   Moreno Eutimio, Mario Adán ^d   Arriaga Pizano, Lourdes Andrea ^b   Isibasi, Armando ^b   Ulloa, Luis ^a,e  

^a RUTGERS UNIVERSITY   (United States)

^b Medical Research Unit on Immunochemistry National Medical Center Siglo XXI   (Mexico)

^c Institute for Social Security and Services for the State's Employees Research Institute   (Mexico)

^d HOSPITAL JUÁREZ DE MÉXICO   (Mexico)

^e Rutgers The State University of New Jersey   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC LEVO AMINO ACID DECARBOXYLASE; CATECHOLAMINE; DOPAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE RECEPTOR STIMULATING AGENT;

ADRENAL GLAND; ADRENAL INSUFFICIENCY; ADRENAL MEDULLA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; ELECTROACUPUNCTURE; IMMUNE SYSTEM; MALE; MOUSE; NONHUMAN; PERITONITIS; PRIORITY JOURNAL; SCIATIC NERVE; VAGUS NERVE;

MUS;

ADRENAL GLANDS; ANIMALS; CATECHOLAMINES; CYTOKINES; DOPA DECARBOXYLASE; DOPAMINE; ELECTROACUPUNCTURE; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; NEURONS; PERITONITIS; RECEPTORS, DOPAMINE D1; SCIATIC NERVE; SEPSIS; VAGUS NERVE;

EID: 84896119053     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3479     Document Type: Article

References (39)

1. Angus, D.C. & van Der Poll, T. Severe sepsis and septic shock. N. Engl. J. Med. 369, 840-851 (2013
2. Ulloa, L. & Tracey, K.J. The 'cytokine profile': A code for sepsis. Trends Mol. Med. 11, 56-63 (2005
3. Ulloa, L. The vagus nerve and the nicotinic anti-inflammatory pathway. Nat. Rev. Drug Discov. 4, 673-684 (2005
4. Annane, D. Adrenal insufficiency in sepsis. Curr. Pharm. Des. 14, 1882-1886 (2008
5. Tracey, K.J. et al. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature 330, 662-664 (1987
6. Riedemann, N.C., Guo, R.F. & Ward, P.A. Novel strategies for the treatment of sepsis. Nat. Med. 9, 517-524 (2003
7. Ulloa, L., Brunner, M., Ramos, L. & Deitch, E.A. Scientific and clinical challenges in sepsis. Curr. Pharm. Des. 15, 1918-1935 (2009
8. Nathan, C. Points of control in inflammation. Nature 420, 846-852 (2002
9. Abraham, E. et al. Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: A randomized, double-blind, placebo-controlled, multicenter phase III trial with 1,342 patients. Crit. Care Med. 29, 503-510 (2001
10. Borovikova, L.V. et al. Vagus nerve stimulation attenuates the systemic inflammatory response to LPS. Nature 405, 458-462 (2000
11. Huston, J.M. et al. Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis. J. Exp. Med. 203, 1623-1628 (2006
12. Peña, G. et al. Cholinergic regulatory lymphocytes re-establish neuromodulation of innate immune responses in sepsis. J. Immunol. 187, 718-725 (2011
13. Bernik, T.R. et al. Cholinergic antiinflammatory pathway inhibition of tumor necrosis factor during ischemia reperfusion. J. Vasc. Surg. 36, 1231-1236 (2002
14. Altavilla, D. et al. Activation of the cholinergic anti-inflammatory pathway reduces NF-kappab activation, blunts TNF-A production, and protects againts splanchic artery occlusion shock. Shock 25, 500-506 (2006
15. Cai, B. et al. a7 cholinergic-Agonist prevents systemic inflammation and improves survival during resuscitation. J. Cell. Mol. Med. 13, 3774-3785 (2009
16. van Westerloo, D.J. et al. The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice. Gastroenterology 130, 1822-1830 (2006
17. Pullan, R.D. et al. Transdermal nicotine for active ulcerative colitis. N. Engl. J. Med. 330, 811-815 (1994
18. Wang, H. et al. Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat. Med. 10, 1216-1221 (2004
19. van Westerloo, D.J. et al. The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis. J. Infect. Dis. 191, 2138-2148 (2005
20. Vickers, A.J. et al. Acupuncture for chronic pain: Individual patient data meta-Analysis. Arch. Intern. Med. 172, 1444-1453 (2012
21. Lee, A. & Done, M.L. Stimulation of the wrist acupuncture point P6 for preventing postoperative nausea and vomiting. Cochrane Database Syst. Rev. CD003281 (2004
22. Napadow, V. & Kaptchuk, T.J. Patient characteristics for outpatient acupuncture in Beijing, China. J. Altern. Complement. Med. 10, 565-572 (2004
23. Wu, H.M. et al. Acupuncture for stroke rehabilitation. Cochrane Database Syst. Rev. CD004131 (2006
24. Goldman, N. et al. Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. Nat. Neurosci. 13, 883-888 (2010
25. Ernst, E., Lee, M.S. & Choi, T.Y. Acupuncture: Does it alleviate pain and are there serious risks? A review of reviews. Pain 152, 755-764 (2011
26. Vida, G. et al. β2-Adrenoreceptors of regulatory lymphocytes are essential for vagal neuromodulation of the innate immune system. FASEB J. 25, 4476-4485 (2011
27. Coupland, R.E., Parker, T.L., Kesse, W.K. & Mohamed, A.A. The innervation of the adrenal gland. III. Vagal innervation. J. Anat. 163, 173-181 (1989
28. Wang, H. et al. Nicotinic acetylcholine receptor a7 subunit is an essential regulator of inflammation. Nature 421, 384-388 (2003
29. Vida, G., Peña, G., Deitch, E.A. & Ulloa, L. a7-nicotinic receptor mediates vagal induction of splenic norepinephrine. J. Immunol. 186, 4340-4346 (2011
30. Grenader, A. & Healy, D.P. Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells. J. Pharmacol. Exp. Ther. 258, 193-198 (1991
31. Weber, R.R. et al. Pharmacokinetic and pharmacodynamic properties of intravenous fenoldopam, a dopamine1-receptor agonist, in hypertensive patients. Br. J. Clin. Pharmacol. 25, 17-21 (1988
32. Denef, C., Manet, D. & Dewals, R. Dopaminergic stimulation of prolactin release. Nature 285, 243-246 (1980
33. Gorissen, H. & Laduron, P. Solubilisation of high-Affinity dopamine receptors. Nature 279, 72-74 (1979
34. Morelli, A. et al. Prophylactic fenoldopam for renal protection in sepsis: A randomized, double-blind, placebo-controlled pilot trial. Crit. Care Med. 33, 2451-2456 (2005
35. Sorkin, L.S. & Yaksh, T.L. Behavioral models of pain states evoked by physical injury to the peripheral nerve. Neurotherapeutics 6, 609-619 (2009
36. Richner, M., Bjerrum, O.J., Nykjaer, A. & Vaegter, C.B. The spared nerve injury (SNI) model of induced mechanical allodynia in mice. J. Vis. Exp. 3092 (2011
37. Kadl, A., Pontiller, J., Exner, M. & Leitinger, N. Single bolus injection of bilirubin improves the clinical outcome in a mouse model of endotoxemia. Shock 28, 582-588 (2007
38. Panayotis, N. et al. Morphological and functional alterations in the substantia nigra pars compacta of the Mecp2-null mouse. Neurobiol. Dis. 41, 385-397 (2011
39. Ulloa, L., Doody, J. & Massague, J. Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway. Nature 397, 710-713 (1999