메뉴 건너뛰기




Volumn 150, Issue , 2014, Pages 66-72

The synthetic progestin megestrol acetate adversely affects zebrafish reproduction

Author keywords

Endocrine disruption; Hypothalamic pituitary gonadal axis; Progestin; Reproduction

Indexed keywords

11 KETO TESTOSTERONE; ANDROGEN; ESTRADIOL; MEGESTROL ACETATE; TESTOSTERONE; UNCLASSIFIED DRUG;

EID: 84896109883     PISSN: 0166445X     EISSN: 18791514     Source Type: Journal    
DOI: 10.1016/j.aquatox.2014.02.020     Document Type: Article
Times cited : (48)

References (46)
  • 1
    • 79956289710 scopus 로고    scopus 로고
    • Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception
    • Africander D., Verhoog N., Hapgood J.P. Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception. Steroids 2011, 76:636-652.
    • (2011) Steroids , vol.76 , pp. 636-652
    • Africander, D.1    Verhoog, N.2    Hapgood, J.P.3
  • 2
    • 0034819875 scopus 로고    scopus 로고
    • Description and evaluation of a short-term reproduction test with the fathead minnow (Pimephales promelas)
    • Ankley G.T., Jensen K.M., Kahl M.D., Korte J.J., Makynen E.A. Description and evaluation of a short-term reproduction test with the fathead minnow (Pimephales promelas). Environ. Toxicol. Chem. 2001, 20:1276-1290.
    • (2001) Environ. Toxicol. Chem. , vol.20 , pp. 1276-1290
    • Ankley, G.T.1    Jensen, K.M.2    Kahl, M.D.3    Korte, J.J.4    Makynen, E.A.5
  • 4
    • 84877111452 scopus 로고    scopus 로고
    • A new look at an old drug for the treatment of cancer cachexia: megestrol acetate
    • Argiles J.M., Anguera A., Stemmler B. A new look at an old drug for the treatment of cancer cachexia: megestrol acetate. Clin. Nutr. 2013, 32:319-324.
    • (2013) Clin. Nutr. , vol.32 , pp. 319-324
    • Argiles, J.M.1    Anguera, A.2    Stemmler, B.3
  • 5
    • 0037603395 scopus 로고    scopus 로고
    • Effects of progesterone and estradiol on the reproductive axis in immature diploid and triploid rainbow trout
    • Atteke C., Vetillard A., Fostier A., Garnier D.H., Jego P., Bailhache T. Effects of progesterone and estradiol on the reproductive axis in immature diploid and triploid rainbow trout. Comp. Biochem. Physiol. 2003, 134A:693-705.
    • (2003) Comp. Biochem. Physiol. , vol.134 A , pp. 693-705
    • Atteke, C.1    Vetillard, A.2    Fostier, A.3    Garnier, D.H.4    Jego, P.5    Bailhache, T.6
  • 7
    • 70450016380 scopus 로고    scopus 로고
    • Determination and source apportionment of five classes of steroid hormones in urban rivers
    • Chang H., Wan Y., Hu J. Determination and source apportionment of five classes of steroid hormones in urban rivers. Environ. Sci. Technol. 2009, 43:7691-7698.
    • (2009) Environ. Sci. Technol. , vol.43 , pp. 7691-7698
    • Chang, H.1    Wan, Y.2    Hu, J.3
  • 8
    • 78650417547 scopus 로고    scopus 로고
    • Occurrence of androgens and progestogens in wastewater treatment plants and receiving river waters: comparison to estrogens
    • Chang H., Wan Y., Wu S., Fan Z., Hu J. Occurrence of androgens and progestogens in wastewater treatment plants and receiving river waters: comparison to estrogens. Water Res. 2011, 45:732-740.
    • (2011) Water Res. , vol.45 , pp. 732-740
    • Chang, H.1    Wan, Y.2    Wu, S.3    Fan, Z.4    Hu, J.5
  • 9
    • 84860825337 scopus 로고    scopus 로고
    • Alterations in retinoid status after long-term exposure to PBDEs in zebrafish (Danio rerio)
    • Chen L., Hu C., Huang C., Wang Q., Wang X., Yang L., Zhou B. Alterations in retinoid status after long-term exposure to PBDEs in zebrafish (Danio rerio). Aquat. Toxicol. 2012, 120-121:11-18.
    • (2012) Aquat. Toxicol. , pp. 11-18
    • Chen, L.1    Hu, C.2    Huang, C.3    Wang, Q.4    Wang, X.5    Yang, L.6    Zhou, B.7
  • 11
    • 75449087350 scopus 로고    scopus 로고
    • Highly active human pharmaceuticals in aquatic systems: A concept for their identification based on their mode of action
    • Christen V., Hickmann S., Rechenberg B., Fent K. Highly active human pharmaceuticals in aquatic systems: A concept for their identification based on their mode of action. Aquat. Toxicol. 2010, 96:167-181.
    • (2010) Aquat. Toxicol. , vol.96 , pp. 167-181
    • Christen, V.1    Hickmann, S.2    Rechenberg, B.3    Fent, K.4
  • 13
    • 0141993014 scopus 로고    scopus 로고
    • Effects of dietary methylmercury on reproductive endocrinology of fathead minnows
    • Drevnick P.E., Sandheinrich M.B. Effects of dietary methylmercury on reproductive endocrinology of fathead minnows. Environ. Sci. Technol. 2003, 37:4390-4396.
    • (2003) Environ. Sci. Technol. , vol.37 , pp. 4390-4396
    • Drevnick, P.E.1    Sandheinrich, M.B.2
  • 15
    • 77950365917 scopus 로고    scopus 로고
    • Characterization and expression of the nuclear progestin receptor in zebrafish gonads and brain
    • Hanna R.N., Daly S.C., Pang Y., Anglade I., Kah O., Thomas P., Zhu Y. Characterization and expression of the nuclear progestin receptor in zebrafish gonads and brain. Biol. Reprod. 2010, 82:112-122.
    • (2010) Biol. Reprod. , vol.82 , pp. 112-122
    • Hanna, R.N.1    Daly, S.C.2    Pang, Y.3    Anglade, I.4    Kah, O.5    Thomas, P.6    Zhu, Y.7
  • 16
    • 60449089110 scopus 로고    scopus 로고
    • Expression of membrane progestin receptors in zebrafish (Danio rerio) oocytes, testis and pituitary
    • Hanna R.N., Zhu Y. Expression of membrane progestin receptors in zebrafish (Danio rerio) oocytes, testis and pituitary. Gen. Comp. Endocrinol. 2009, 161:153-157.
    • (2009) Gen. Comp. Endocrinol. , vol.161 , pp. 153-157
    • Hanna, R.N.1    Zhu, Y.2
  • 17
    • 79953311092 scopus 로고    scopus 로고
    • Controls of meiotic signaling by membrane or nuclear progestin receptor in zebrafish follicle-enclosed oocytes
    • Hanna R.N., Zhu Y. Controls of meiotic signaling by membrane or nuclear progestin receptor in zebrafish follicle-enclosed oocytes. Mol. Cell. Endocrinol. 2011, 337:80-88.
    • (2011) Mol. Cell. Endocrinol. , vol.337 , pp. 80-88
    • Hanna, R.N.1    Zhu, Y.2
  • 18
    • 84859881520 scopus 로고    scopus 로고
    • The synthetic progestogen, Levonorgestrel, but not natural progesterone, affects male mate calling behavior of Xenopus laevis
    • Hoffmann F., Kloas W. The synthetic progestogen, Levonorgestrel, but not natural progesterone, affects male mate calling behavior of Xenopus laevis. Gen. Comp. Endocrinol. 2012, 176:385-390.
    • (2012) Gen. Comp. Endocrinol. , vol.176 , pp. 385-390
    • Hoffmann, F.1    Kloas, W.2
  • 19
    • 84881420196 scopus 로고    scopus 로고
    • Effects of bisphenol S exposure on endocrine functions and reproduction of zebrafish
    • Ji K., Hong S., Kho Y., Choi K. Effects of bisphenol S exposure on endocrine functions and reproduction of zebrafish. Environ. Toxicol. Chem. 2013, 47:8793-8800.
    • (2013) Environ. Toxicol. Chem. , vol.47 , pp. 8793-8800
    • Ji, K.1    Hong, S.2    Kho, Y.3    Choi, K.4
  • 20
    • 33748744630 scopus 로고    scopus 로고
    • The Ultraviolet filter 3-benzylidene camphor adversely affects reproduction in fathead minnow (Pimephales promelas)
    • Kunz P.Y., Gries T., Fent K. The Ultraviolet filter 3-benzylidene camphor adversely affects reproduction in fathead minnow (Pimephales promelas). Toxicol. Sci. 2006, 93:311-321.
    • (2006) Toxicol. Sci. , vol.93 , pp. 311-321
    • Kunz, P.Y.1    Gries, T.2    Fent, K.3
  • 21
    • 0141780915 scopus 로고    scopus 로고
    • Quantification of steroid hormones with pheromonal properties in municipal wastewater effluent
    • Kolodziej E.P., Gray J.L., Sedlak D.L. Quantification of steroid hormones with pheromonal properties in municipal wastewater effluent. Environ. Toxicol. Chem. 2003, 22:2622-2629.
    • (2003) Environ. Toxicol. Chem. , vol.22 , pp. 2622-2629
    • Kolodziej, E.P.1    Gray, J.L.2    Sedlak, D.L.3
  • 22
    • 79952350029 scopus 로고    scopus 로고
    • Early life progestin exposure causes arrested oocyte development, oviductal agenesis and sterility in adult Xenopus tropicalis frogs
    • Kvarnryd M., Grabic R., Brandt I., Berg C. Early life progestin exposure causes arrested oocyte development, oviductal agenesis and sterility in adult Xenopus tropicalis frogs. Aquat. Toxicol. 2011, 103:18-24.
    • (2011) Aquat. Toxicol. , vol.103 , pp. 18-24
    • Kvarnryd, M.1    Grabic, R.2    Brandt, I.3    Berg, C.4
  • 23
    • 53149136166 scopus 로고    scopus 로고
    • An investigation into the role of prostaglandins in zebrafish oocyte maturation and ovulation
    • Lister A.L., Van Der Kraak G. An investigation into the role of prostaglandins in zebrafish oocyte maturation and ovulation. Gen. Comp. Endocrinol. 2008, 159:46-57.
    • (2008) Gen. Comp. Endocrinol. , vol.159 , pp. 46-57
    • Lister, A.L.1    Van Der Kraak, G.2
  • 24
    • 79951513972 scopus 로고    scopus 로고
    • Trace analysis of 28 steroids in surface water, wastewater and sludge samples by rapid resolution liquid chromatography-electrospray ionization tandem mass spectrometry
    • Liu S., Ying G.G., Zhao J.L., Chen F., Yang B., Zhou L.J., Lai H.J. Trace analysis of 28 steroids in surface water, wastewater and sludge samples by rapid resolution liquid chromatography-electrospray ionization tandem mass spectrometry. J. Chromatogr. A 2011, 1218:1367-1378.
    • (2011) J. Chromatogr. A , vol.1218 , pp. 1367-1378
    • Liu, S.1    Ying, G.G.2    Zhao, J.L.3    Chen, F.4    Yang, B.5    Zhou, L.J.6    Lai, H.J.7
  • 25
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 26
    • 80655149045 scopus 로고    scopus 로고
    • Influence of progesterone on oocyte quality and embryo development in cows
    • Lonergan P. Influence of progesterone on oocyte quality and embryo development in cows. Theriogenology 2011, 76:1594-1601.
    • (2011) Theriogenology , vol.76 , pp. 1594-1601
    • Lonergan, P.1
  • 27
    • 81855199721 scopus 로고    scopus 로고
    • The synthetic gestagen Levonorgestrel disrupts sexual development in Xenopus laevis by affecting gene expression of pituitary gonadotropins and gonadal steroidogenic enzymes
    • Lorenz C., Contardo-Jara V., Trubiroha A., Kruger A., Viehmann V., Wiegand C., Pflugmacher S., Nutzmann G., Lutz I., Kloas W. The synthetic gestagen Levonorgestrel disrupts sexual development in Xenopus laevis by affecting gene expression of pituitary gonadotropins and gonadal steroidogenic enzymes. Toxicol. Sci. 2011, 124:311-319.
    • (2011) Toxicol. Sci. , vol.124 , pp. 311-319
    • Lorenz, C.1    Contardo-Jara, V.2    Trubiroha, A.3    Kruger, A.4    Viehmann, V.5    Wiegand, C.6    Pflugmacher, S.7    Nutzmann, G.8    Lutz, I.9    Kloas, W.10
  • 28
    • 79955770646 scopus 로고    scopus 로고
    • Effects of progesterone on sperm motility in fathead minnow (Pimephales promelas)
    • Murack P.J., Parrish J., Barry T.P. Effects of progesterone on sperm motility in fathead minnow (Pimephales promelas). Aquat. Toxicol. 2011, 104:121-125.
    • (2011) Aquat. Toxicol. , vol.104 , pp. 121-125
    • Murack, P.J.1    Parrish, J.2    Barry, T.P.3
  • 29
    • 0031034684 scopus 로고    scopus 로고
    • 17 alpha,20 beta-dihydroxy-4-pregnen-3-one, a maturation-inducing hormone in fish oocytes: mechanisms of synthesis and action
    • Nagahama Y. 17 alpha,20 beta-dihydroxy-4-pregnen-3-one, a maturation-inducing hormone in fish oocytes: mechanisms of synthesis and action. Steroids 1997, 62:190-196.
    • (1997) Steroids , vol.62 , pp. 190-196
    • Nagahama, Y.1
  • 30
    • 44249092617 scopus 로고    scopus 로고
    • Regulation of oocyte maturation in fish
    • Nagahama Y., Yamashita M. Regulation of oocyte maturation in fish. Dev. Growth Differ. 2008, 50(Suppl. 1):S195L S219.
    • (2008) Dev. Growth Differ. , vol.50 , Issue.SUPPL. 1
    • Nagahama, Y.1    Yamashita, M.2
  • 31
    • 77955556274 scopus 로고    scopus 로고
    • Reproductive responses in fathead minnow and Japanese medaka following exposure to a synthetic progestin, Norethindrone
    • Paulos P., Runnalls T.J., Nallani G., La Point T., Scott A.P., Sumpter J.P., Huggett D.B. Reproductive responses in fathead minnow and Japanese medaka following exposure to a synthetic progestin, Norethindrone. Aquat. Toxicol. 2010, 99:256-262.
    • (2010) Aquat. Toxicol. , vol.99 , pp. 256-262
    • Paulos, P.1    Runnalls, T.J.2    Nallani, G.3    La Point, T.4    Scott, A.P.5    Sumpter, J.P.6    Huggett, D.B.7
  • 32
    • 52949145243 scopus 로고    scopus 로고
    • Trace analysis of contraceptive drug levonorgestrel in wastewater samples by a newly developed indirect competitive enzyme-linked immunosorbent assay (ELISA) coupled with solid phase extraction
    • Pu C., Wu Y.-F., Yang H., Deng A.-P. Trace analysis of contraceptive drug levonorgestrel in wastewater samples by a newly developed indirect competitive enzyme-linked immunosorbent assay (ELISA) coupled with solid phase extraction. Anal. Chim. Acta 2008, 628:73-79.
    • (2008) Anal. Chim. Acta , vol.628 , pp. 73-79
    • Pu, C.1    Wu, Y.-F.2    Yang, H.3    Deng, A.-P.4
  • 33
    • 84874029024 scopus 로고    scopus 로고
    • Several synthetic progestins with different potencies adversely affect reproduction of fish
    • Runnalls T.J., Beresford N., Losty E., Scott A.P., Sumpter J.P. Several synthetic progestins with different potencies adversely affect reproduction of fish. Environ. Sci. Technol. 2013, 47:2077-2084.
    • (2013) Environ. Sci. Technol. , vol.47 , pp. 2077-2084
    • Runnalls, T.J.1    Beresford, N.2    Losty, E.3    Scott, A.P.4    Sumpter, J.P.5
  • 34
    • 78650285954 scopus 로고    scopus 로고
    • Pharmaceuticals in the aquatic environment: Steroids and anti-steroids as high priorities for research
    • Runnalls T.J., Margiotta-Casaluci L., Kugathas S., Sumpter J.P. Pharmaceuticals in the aquatic environment: Steroids and anti-steroids as high priorities for research. Hum. Ecol. Risk Assess. 2010, 16:1318-1338.
    • (2010) Hum. Ecol. Risk Assess. , vol.16 , pp. 1318-1338
    • Runnalls, T.J.1    Margiotta-Casaluci, L.2    Kugathas, S.3    Sumpter, J.P.4
  • 35
    • 84875079683 scopus 로고    scopus 로고
    • Disrupted oogenesis in the frog Xenopus tropicalis after exposure to environmental progestin concentrations
    • Safholm M., Norder A., Fick J., Berg C. Disrupted oogenesis in the frog Xenopus tropicalis after exposure to environmental progestin concentrations. Biol. Reprod. 2012, 86(126):1-7.
    • (2012) Biol. Reprod. , vol.86 , Issue.126 , pp. 1-7
    • Safholm, M.1    Norder, A.2    Fick, J.3    Berg, C.4
  • 37
    • 76449085306 scopus 로고    scopus 로고
    • The role of the maturation-inducing steroid, 17,20beta-dihydroxypregn-4-en-3-one, in male fishes: a review
    • Scott A.P., Sumpter J.P., Stacey N. The role of the maturation-inducing steroid, 17,20beta-dihydroxypregn-4-en-3-one, in male fishes: a review. J. Fish Biol. 2010, 76:183-224.
    • (2010) J. Fish Biol. , vol.76 , pp. 183-224
    • Scott, A.P.1    Sumpter, J.P.2    Stacey, N.3
  • 38
    • 75149136133 scopus 로고    scopus 로고
    • Pharmacological profile of progestins
    • Sitruk-Ware R. Pharmacological profile of progestins. Maturitas 2008, 61:151-157.
    • (2008) Maturitas , vol.61 , pp. 151-157
    • Sitruk-Ware, R.1
  • 39
    • 84874081567 scopus 로고    scopus 로고
    • The synthetic progestin levonorgestrel is a potent androgen in the three-spined stickleback (Gasterosteus aculeatus)
    • Svensson J., Fick J., Brandt I., Brunstrom B. The synthetic progestin levonorgestrel is a potent androgen in the three-spined stickleback (Gasterosteus aculeatus). Environ. Sci. Technol. 2013, 47:2043-2051.
    • (2013) Environ. Sci. Technol. , vol.47 , pp. 2043-2051
    • Svensson, J.1    Fick, J.2    Brandt, I.3    Brunstrom, B.4
  • 40
    • 84891109771 scopus 로고    scopus 로고
    • Environmental concentrations of an androgenic progestin disrupts the seasonal breeding cycle in male three-spined stickleback (Gasterosteus aculeatus).
    • in press.
    • Svensson, J., Fick, J., Brandt, I., Brunstrom, B., 2014. Environmental concentrations of an androgenic progestin disrupts the seasonal breeding cycle in male three-spined stickleback (Gasterosteus aculeatus). Aquat. Toxicol., , in press. doi:10.1016/j.aquatox.2013.12.013.
    • (2014) Aquat. Toxicol.,
    • Svensson, J.1    Fick, J.2    Brandt, I.3    Brunstrom, B.4
  • 41
    • 44549085664 scopus 로고    scopus 로고
    • Functional characteristics of membrane progestin receptor alpha (mPRalpha) subtypes: a review with new data showing mPRalpha expression in seatrout sperm and its association with sperm motility
    • Tubbs C., Thomas P. Functional characteristics of membrane progestin receptor alpha (mPRalpha) subtypes: a review with new data showing mPRalpha expression in seatrout sperm and its association with sperm motility. Steroids 2008, 73:935-941.
    • (2008) Steroids , vol.73 , pp. 935-941
    • Tubbs, C.1    Thomas, P.2
  • 43
    • 33847684354 scopus 로고    scopus 로고
    • Analytical methods for the determination of selected steroid sex hormones and corticosteriods in wastewater
    • Vulliet E., Baugros J.B., Flament-Waton M.M., Grenier-Loustalot M.F. Analytical methods for the determination of selected steroid sex hormones and corticosteriods in wastewater. Anal. Chem. Acta 2007, 387:2143-2151.
    • (2007) Anal. Chem. Acta , vol.387 , pp. 2143-2151
    • Vulliet, E.1    Baugros, J.B.2    Flament-Waton, M.M.3    Grenier-Loustalot, M.F.4
  • 44
    • 79952069487 scopus 로고    scopus 로고
    • Occurrence of pharmaceuticals and hormones in drinking water treated from surface waters
    • Vulliet E., Cren-Olive C., Grenier-Loustalot M.F. Occurrence of pharmaceuticals and hormones in drinking water treated from surface waters. Environ. Chem. Lett. 2011, 9:103-114.
    • (2011) Environ. Chem. Lett. , vol.9 , pp. 103-114
    • Vulliet, E.1    Cren-Olive, C.2    Grenier-Loustalot, M.F.3
  • 46
    • 84860462209 scopus 로고    scopus 로고
    • Progestins and antiprogestins affect gene expression in early development in zebrafish (Danio rerio) at environmental concentrations
    • Zucchi S., Castiglioni S., Fent K. Progestins and antiprogestins affect gene expression in early development in zebrafish (Danio rerio) at environmental concentrations. Environ. Sci. Technol. 2012, 46:5183-5192.
    • (2012) Environ. Sci. Technol. , vol.46 , pp. 5183-5192
    • Zucchi, S.1    Castiglioni, S.2    Fent, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.