The synthetic gestagen levonorgestrel disrupts sexual development in Xenopus laevis by affecting gene expression of pituitary gonadotropins and gonadal steroidogenic enzymes

Toxicological Sciences

Volumn 124, Issue 2, 2011, Pages 311-319

  Lorenz, Claudia ^a   Contardo Jara, Valeska ^a,b   Trubiroha, Achim ^a   Krüger, Angela ^a   Viehmann, Viola ^a   Wiegand, Claudia ^c   Pflugmacher, Stephan ^a,b   Nützmann, Gunnar ^a   Lutz, Ilka ^a   Kloas, Werner ^a,d  

^a LEIBNIZ INSTITUTE OF FRESHWATER ECOLOGY AND INLAND FISHERIES   (Germany)

^b TECHNISCHE UNIVERSITÄT BERLIN   (Germany)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^d HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Amphibian; Aromatase; Fsh; Gonad histology; Lh; Progestin; Star

Indexed keywords

FOLLITROPIN BETA SUBUNIT; GONADOTROPIN; LEVONORGESTREL; LUTEINIZING HORMONE; MESSENGER RNA; STEROID 5ALPHA REDUCTASE; STEROIDOGENIC FACTOR 1;

ANIMAL TISSUE; ARTICLE; FEMALE; GENE EXPRESSION; GONAD; HISTOPATHOLOGY; MALE; METAMORPHOSIS; MORPHOLOGY; NONHUMAN; SEXUAL DEVELOPMENT; XENOPUS LAEVIS;

3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; ANIMALS; FEMALE; FOLLICLE STIMULATING HORMONE, BETA SUBUNIT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GONADOTROPINS; GONADS; LARVA; LEVONORGESTREL; LUTEINIZING HORMONE, BETA SUBUNIT; MALE; PITUITARY GLAND; POLYMERASE CHAIN REACTION; PROGESTINS; SEXUAL DEVELOPMENT; XENOPUS LAEVIS;

EID: 81855199721     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr241     Document Type: Article

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