Bacterial respiratory tract infections are promoted by systemic hyperglycemia after severe burn injury in pediatric patients

Burns

Volumn 40, Issue 3, 2014, Pages 428-435

  Kraft, Robert ^e   Herndon, David N ^b,c   Mlcak, Ronald P ^b   Finnerty, Celeste C ^b,c,d   Cox, Robert A ^b   Williams, Felicia N ^b   Jeschke, Marc G ^a  

^a Canada   (Canada)

^b SHRINERS HOSPITALS FOR CHILDREN   (United States)

^c Department of Surgery ^*  (United States)

^d UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^e Klinikum Memmingen   (Germany)

Author keywords

Airway glucose threshold; Bacterial growth; Hyperglycemia; Pneumonia; Respiratory tract infections

Indexed keywords

GLUCOSE; INSULIN; FLUCONAZOLE; PIPERACILLIN PLUS TAZOBACTAM; VANCOMYCIN;

ADOLESCENT; ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; ARTIFICIAL VENTILATION; ATELECTASIS; BACTERIAL INFECTION; BURN; CHILD; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; INCIDENCE; INFANT; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NEWBORN; PNEUMONIA; PRESCHOOL CHILD; RESPIRATORY TRACT INFECTION; SCHOOL CHILD; SEPSIS; AIRWAY; ANTIBIOTIC THERAPY; BACTERIAL RESPIRATORY TRACT INFECTION; BLOOD SAMPLING; CHI SQUARE TEST; CLINICAL ASSESSMENT; COHORT ANALYSIS; CONTROLLED STUDY; CRITICALLY ILL PATIENT; INJURY SEVERITY; PARAMETERS; PEDIATRICS; POSITIVE END EXPIRATORY PRESSURE; PREDICTIVE VALUE; RESPIRATORY FUNCTION; STUDENT T TEST;

AIRWAY GLUCOSE THRESHOLD; BACTERIAL GROWTH; HYPERGLYCEMIA; PNEUMONIA; RESPIRATORY TRACT INFECTIONS;

ADOLESCENT; BURNS; BURNS, INHALATION; CHILD; CHILD, PRESCHOOL; FEMALE; GLUCOSE; HUMANS; HYPERGLYCEMIA; INFANT; INJURY SEVERITY SCORE; MALE; PNEUMONIA, BACTERIAL; RESPIRATORY DISTRESS SYNDROME, ADULT; RESPIRATORY TRACT INFECTIONS; SEPSIS;

EID: 84896091979     PISSN: 03054179     EISSN: 18791409     Source Type: Journal    
DOI: 10.1016/j.burns.2013.07.007     Document Type: Article

References (36)

1. H. Takahashi, Y. Tsuda, D. Takeuchi, M. Kobayashi, D.N. Herndon, and F. Suzuki Influence of systemic inflammatory response syndrome on host resistance against bacterial infections Crit Care Med 32 2004 1879 1885
2. M.G. Jeschke, D.L. Chinkes, C.C. Finnerty, G. Kulp, O.E. Suman, and W.B. Norbury et al. Pathophysiologic response to severe burn injury Ann Surg 248 2008 387 401
3. W. Xiao-Wu, D.N. Herndon, M. Spies, A.P. Sanford, and S.E. Wolf Effects of delayed wound excision and grafting in severely burned children Arch Surg 137 2002 1049 1054
4. R.P. Mlcak, O.E. Suman, and D.N. Herndon Respiratory management of inhalation injury Burns 33 2007 2 13
5. D. Church, S. Elsayed, O. Reid, B. Winston, and R. Lindsay Burn wound infections Clin Microbiol Rev 19 2006 403 434
6. P.J. Mathews, and L.M. Mathews Reducing the risks of ventilator- associated infections Dimens Crit Care Nurs 19 2000 17 21
7. R.A. Cox, R.P. Mlcak, D.L. Chinkes, S. Jacob, P. Enkhbaatar, and J. Jaso et al. Upper airway mucus deposition in lung tissue of burn trauma victims Shock 29 2008 356 361
8. K. Murakami, R. McGuire, R.A. Cox, J.M. Jodoin, F.C. Schmalstieg, and L.D. Traber et al. Recombinant antithrombin attenuates pulmonary inflammation following smoke inhalation and pneumonia in sheep Crit Care Med 31 2003 577 583
9. K.K. Kalsi, E.H. Baker, O. Fraser, Y.L. Chung, O.J. Mace, and E. Tarelli et al. Glucose homeostasis across human airway epithelial cell monolayers: role of diffusion, transport and metabolism Pflugers Arch 457 2009 1061 1070
10. D.M. Wood, A.L. Brennan, B.J. Philips, and E.H. Baker Effect of hyperglycaemia on glucose concentration of human nasal secretions Clin Sci (Lond) 106 2004 527 533
11. B.J. Philips, J.X. Meguer, J. Redman, and E.H. Baker Factors determining the appearance of glucose in upper and lower respiratory tract secretions Intens Care Med 29 2003 2204 2210
12. B.J. Philips, J. Redman, A. Brennan, D. Wood, R. Holliman, and D. Baines et al. Glucose in bronchial aspirates increases the risk of respiratory MRSA in intubated patients Thorax 60 2005 761 764
13. D.N. Herndon, D.W. Hart, S.E. Wolf, D.L. Chinkes, and R.R. Wolfe Reversal of catabolism by beta-blockade after severe burns N Engl J Med 345 2001 1223 1229
14. M.G. Jeschke, R.P. Mlcak, C.C. Finnerty, W.B. Norbury, G.G. Gauglitz, and G.A. Kulp et al. Burn size determines the inflammatory and hypermetabolic response Crit Care 11 2007 R90
15. L.K. Branski, R. Mittermayr, D.N. Herndon, W.B. Norbury, O.E. Masters, and M. Hofmann et al. A porcine model of full-thickness burn, excision and skin autografting Burns 34 2008 1119 1127
16. D.W. Hart, S.E. Wolf, D.L. Chinkes, D.C. Gore, R.P. Mlcak, and R.B. Beauford et al. Determinants of skeletal muscle catabolism after severe burn Ann Surg 232 2000 455 465
17. D.W. Hart, S.E. Wolf, R. Mlcak, D.L. Chinkes, P.I. Ramzy, and M.K. Obeng et al. Persistence of muscle catabolism after severe burn Surgery 128 2000 312 319
18. R.P. Mlcak, M.G. Jeschke, R.E. Barrow, and D.N. Herndon The influence of age and gender on resting energy expenditure in severely burned children Ann Surg 244 2006 121 130
19. J.J. Gallagher, L.K. Branski, N. Williams-Bouyer, C. Villarreal, and D.N. Herndon Treatment of infection in burns D.N. Herndon, Total burn care 4th ed. 2012 Saunder-Elsevier China 137 156
20. M.M. Levy, M.P. Fink, J.C. Marshall, E. Abraham, D. Angus, and D. Cook et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference Crit Care Med 31 2003 1250 1256
21. R.C. Bone, W.J. Sibbald, and C.L. Sprung The ACCP-SCCM consensus conference on sepsis and organ failure Chest 101 1992 1481 1483
22. M.G. Jeschke, C.C. Finnerty, O.E. Suman, G. Kulp, R.P. Mlcak, and D.N. Herndon The effect of oxandrolone on the endocrinologic, inflammatory, and hypermetabolic responses during the acute phase postburn Ann Surg 246 2007 351 362
23. G. Van den Berghe, A. Wilmer, G. Hermans, W. Meersseman, P.J. Wouters, and I. Milants et al. Intensive insulin therapy in the medical ICU N Engl J Med 354 2006 449 461
24. X. Wu, S.J. Thomas, D.N. Herndon, A.P. Sanford, and S.E. Wolf Insulin decreases hepatic acute phase protein levels in severely burned children Surgery 135 2004 196 202
25. M.G. Jeschke, D. Klein, and D.N. Herndon Insulin treatment improves the systemic inflammatory reaction to severe trauma Ann Surg 239 2004 553 560
26. E.J. Pierre, R.E. Barrow, H.K. Hawkins, T.T. Nguyen, Y. Sakurai, and M. Desai et al. Effects of insulin on wound healing J Trauma 44 1998 342 345
27. F.M. Brunkhorst, C. Engel, F. Bloos, A. Meier-Hellmann, M. Ragaller, and N. Weiler et al. Intensive insulin therapy and pentastarch resuscitation in severe sepsis N Engl J Med 358 2008 125 139
28. S. Finfer, D.R. Chittock, S.Y. Su, D. Blair, D. Foster, and V. Dhingra et al. Intensive versus conventional glucose control in critically ill patients N Engl J Med 360 2009 1283 1297
29. J.C. Preiser, P. Devos, S. Ruiz-Santana, C. Melot, D. Annane, and J. Groeneveld et al. A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the glucontrol study Intens Care Med 35 2009 1738 1748
30. M.G. Jeschke, R. Kraft, F. Emdad, G.A. Kulp, F.N. Williams, and D.N. Herndon Glucose control in severely thermally injured pediatric patients: what glucose range should be the target? Ann Surg 252 2010 521 528
31. R.P. Dellinger, M.M. Levy, A. Rhodes, D. Annane, H. Gerlach, and S.M. Opal et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012 Crit Care Med 41 2013 580 637
32. M.G. Cree, R.Y. Fram, D. Barr, D. Chinkes, R.R. Wolfe, and D.N. Herndon Insulin resistance, secretion and breakdown are increased 9 months following severe burn injury Burns 35 2009 63 69
33. G.S. Hotamisligil Inflammatory pathways and insulin action Int J Obes Relat Metab Disord 27 Suppl. 3 2003 S53 S55
34. A. Yao-Borengasser, V. Varma, A.M. Bodles, N. Rasouli, B. Phanavanh, and M.J. Lee et al. Retinol binding protein 4 expression in humans: relationship to insulin resistance, inflammation, and response to pioglitazone J Clin Endocrinol Metab 92 2007 2590 2597
35. G. Saumon, G. Martet, and P. Loiseau Glucose transport and equilibrium across alveolar-airway barrier of rat Am J Physiol 270 1996 L183 L190
36. A.L. Brennan, K.M. Gyi, D.M. Wood, J. Johnson, R. Holliman, and D.L. Baines et al. Airway glucose concentrations and effect on growth of respiratory pathogens in cystic fibrosis J Cyst Fibros 6 2007 101 109