An anti-c-Fms antibody inhibits osteoclastogenesis in a mouse periodontitis model

Oral Diseases

Volumn 20, Issue 3, 2014, Pages 319-324

  Kimura, K ^a   Kitaura, H ^a   Fujii, T ^a   Ishida, M ^a   Hakami, Zw ^a   Takano Yamamoto, T ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Anti c Fms antibody; LPS; M CSF; Osteoclast; Periodontitis

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; C FMS PROTEIN; COLONY STIMULATING FACTOR 1; LIPOPOLYSACCHARIDE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY AFS98; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; UNCLASSIFIED DRUG; ANTIBODY; COLONY STIMULATING FACTOR RECEPTOR;

ALVEOLAR BONE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CELL COUNT; CONTROLLED STUDY; GINGIVA; INHIBITION KINETICS; MALE; MANDIBLE; MOLAR TOOTH; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; PERIODONTITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING; TISSUE SECTION; ANIMAL; C57BL MOUSE; CELL DIFFERENTIATION; DISEASE MODEL; IMMUNOLOGY; PHYSIOLOGY;

ANIMALS; ANTIBODIES; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; MALE; MICE; MICE, INBRED C57BL; OSTEOCLASTS; PERIODONTITIS; RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR;

EID: 84896078758     PISSN: 1354523X     EISSN: 16010825     Source Type: Journal    
DOI: 10.1111/odi.12117     Document Type: Article

References (28)

1. Abu-Amer Y, Ross FP, Edwards J, Teitelbaum SL (1997). Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor. J Clin Invest 100: 1557-1565.
2. Azuma Y, Kaji K, Katogi R, Takeshita S, Kudo A (2000). Tumor necrosis factor-alpha induces differentiation of and bone resorption by osteoclasts. J Biol Chem 275: 4858-4864.
3. Bostanci N, Allaker RP, Belibasakis GN et al (2007). Porphyromonas gingivalis antagonises Campylobacter rectus induced cytokine production by human monocytes. Cytokine 39: 147-156.
4. Chiang CY, Kyritsis G, Graves DT, Amar S (1999). Interleukin-1 and tumor necrosis factor activities partially account for calvarial bone resorption induced by local injection of lipopolysaccharide. Infect Immun 67: 4231-4236.
5. Fuller K, Murphy C, Kirstein B, Fox SW, Chambers TJ (2002). TNF alpha potently activates osteoclasts, through a direct action independent of and strongly synergistic with RANKL. Endocrinology 143: 1108-1118.
6. Garlet GP, Cardoso CR, Silva TA et al (2006). Cytokine pattern determines the progression of experimental periodontal disease induced by Actinobacillus actinomycetemcomitans through the modulation of MMPs, RANKL, and their physiological inhibitors. Oral Microbiol Immunol 21: 12-20.
7. Inada M, Matsumoto C, Uematsu S, Akira S, Miyaura C (2006). Membrane-bound prostaglandin E synthase-1-mediated prostaglandin E2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation. J Immunol 177: 1879-1885.
8. Ji JD, Park-Min KH, Shen Z et al (2009). Inhibition of RANK Expression and Osteoclastogenesis by TLRs and IFN-γ in Human Osteoclast Precursors. J Immunol 183: 7223-7233.
9. Kajiya M, Giro G, Taubman MA, Han X, Mayer MP, Kawai T (2010). Role of periodontal pathogenic bacteria in RANKL-mediated bone destruction in periodontal disease. J Oral Microbiol 2: 5532-5547.
10. Kimble RB, Srivastava S, Ross FP, Matayoshi A, Pacifici R (1996). Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an interleukin-1 and tumor necrosis factor-mediated stimulation of macrophage colony-stimulating factor production. J Biol Chem 271: 28890-28897.
11. Kimura K, Kitaura H, Fujii T, Hakami ZW, Takano-Yamamoto T (2012). Anti-c-Fms antibody inhibits lipopolysaccharide-induced osteoclastogenesis in vivo. FEMS Immunol Med Microbiol 64: 219-227.
12. Kitaura H, Sands MS, Aya K et al (2004). Marrow stromal cells and osteoclast precursors differentially contribute to TNF-alpha-induced osteoclastogenesis in vivo. J Immunol 173: 4838-4846.
13. Kitaura H, Zhou P, Kim HJ, Novack DV, Ross FP, Teitelbaum SL (2005). M-CSF mediates TNF-induced inflammatory osteolysis. J Clin Invest 115: 3418-3427.
14. Kobayashi K, Takahashi N, Jimi E et al (2000). Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction. J Exp Med 191: 275-286.
15. Merkel KD, Erdmann JM, McHugh KP, Abu-Amer Y, Ross FP, Teitelbaum SL (1999). Tumor necrosis factor-alpha mediates orthopedic implant osteolysis. Am J Pathol 154: 203-210.
16. Moriyama H, Ukai T, Hara Y (2002). Interferon-gamma production changes in parallel with bacterial lipopolysaccharide induced bone resorption in mice: an immunohistometrical study. Calcif Tissue Int 71: 53-58.
17. Mormann M, Thederan M, Nackchbandi I, Giese T, Wagner C, Hansch GM (2008). Lipopolysaccharides (LPS) induce the differentiation of human monocytes to osteoclasts in a tumour necrosis factor (TNF) alpha-dependent manner: a link between infection and pathological bone resorption. Mol Immunol 45: 3330-3337.
18. Redlich K, Hayer S, Ricci R et al (2002). Osteoclasts are essential for TNF-alpha-mediated joint destruction. J Clin Invest 110: 1419-1427.
19. Sakuma Y, Tanaka K, Suda M et al (2000). Impaired bone resorption by lipopolysaccharide in vivo in mice deficient in the prostaglandin E receptor EP4 subtype. Infect Immun 68: 6819-6825.
20. Schwartz Z, Goultschin J, Dean DD, Boyan BD (1997). Mechanisms of alveolar bone destruction in periodontitis. Periodontol 2000 14: 158-172.
21. Slots J, Genco RJ (1984). Black-pigmented Bacteroides species, Capnocytophaga species, and Actinobacillus actinomycetemcomitans in human periodontal disease: virulence factors in colonization, survival, and tissue destruction. J Dent Res 63: 412-421.
22. Srivastava S, Weitzmann MN, Kimble RB et al (1998). Estrogen blocks M-CSF gene expression and osteoclast formation by regulating phosphorylation of Egr-1 and its interaction with Sp-1. J Clin Invest 102: 1850-1859.
23. Sudo T, Nishikawa S, Ogawa M et al (1995). Functional hierarchy of c-kit and c-fms in intramarrow production of CFU-M. Oncogene 11: 2469-2476.
24. Takei I, Takagi M, Ida H, Ogino T, Santavirta S, Konttinen YT (2000). High macrophage-colony stimulating factor levels in synovial fluid of loose artificial hip joints. J Rheumatol 27: 894-899.
25. Taubman MA, Valverde P, Han X, Kawai T (2005). Immune response: the key to bone resorption in periodontal disease. J Periodontol 76: 2033-2041.
26. Teitelbaum SL (2000). Bone resorption by osteoclasts. Science 289: 1504-1508.
27. Yang PT, Kasai H, Xiao WG et al (2006). Increased expression of macrophage colony-stimulating factor in ankylosing spondylitis and rheumatoid arthritis. Ann Rheum Dis 65: 1671-1672.
28. Zou W, Bar-Shavit Z (2002). Dual modulation of osteoclast differentiation by lipopolysaccharide. J Bone Miner Res 17: 1211-1218.