Increase in the mediators of asthma in obesity and obesity with type 2 diabetes: Reduction with weight loss

Obesity

Volumn 22, Issue 2, 2014, Pages 356-362

  Dandona, Paresh ^a   Ghanim, Husam ^a   Monte, Scott V ^b   Caruana, Joseph A ^c   Green, Kelly ^a   Abuaysheh, Sanaa ^a   Lohano, Teekam ^a   Schentag, Jerome ^b   Dhindsa, Sandeep ^a   Chaudhuri, Ajay ^a  

^a GATES VASCULAR INSTITUTE AT KALEIDA HEALTH   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ASTHMA; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; FEMALE; FOLLOW-UP STUDIES; GASTRIC BYPASS; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION MEDIATORS; INSULIN RESISTANCE; INTERLEUKIN-4; LEUKOCYTES, MONONUCLEAR; MALE; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; NITRIC OXIDE; OBESITY; OBESITY, MORBID; RECEPTORS, CCR2; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14; WEIGHT LOSS;

EID: 84895900949     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.20524     Document Type: Article

References (27)

1. Beuther DA, Sutherland ER,. Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med 2007; 175: 661-666.
2. Ehrlich SF, Quesenberry CP, Jr, Van Den Eeden SK, et al. Patients diagnosed with diabetes are at increased risk for asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and pneumonia but not lung cancer. Diabet Care 2010; 33: 55-60.
3. Shore SA,. Obesity and asthma: possible mechanisms. J Allergy Clin Immunol 2008; 121: 1087-1093; quiz 1094-1085.
4. Hotamisligil GS, Shargill NS, Spiegelman BM,. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993; 259: 87-91.
5. Dandona P, Weinstock R, Thusu K, et al. Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss. J Clin Endocrinol Metab 1998; 83: 2907-2910.
6. Ghanim H, Aljada A, Hofmeyer D, et al. Circulating mononuclear cells in the obese are in a proinflammatory state. Circulation 2004; 110: 1564-1571.
7. Nathan C,. Epidemic inflammation: pondering obesity. Mol Med 2008; 14: 485-492.
8. Munitz A, Brandt EB, Mingler M, et al. Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis. Proc Natl Acad Sci USA 2008; 105: 7240-7245.
9. Suarez CJ, Parker NJ, Finn PW,. Innate immune mechanism in allergic asthma. Curr Allergy Asthma Rep 2008; 8: 451-459.
10. Galli SJ, Tsai M, Piliponsky AM,. The development of allergic inflammation. Nature 2008; 454: 445-454.
11. Walsh GM,. Emerging drugs for asthma. Expert Opin Emerg Drugs 2008; 13: 643-653.
12. Borish LC, Nelson HS, Corren J, et al. Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. J Allergy Clin Immunol 2001; 107: 963-970.
13. Dandona P, Aljada A, Bandyopadhyay A,. Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol 2004; 25: 4-7.
14. Movahed M, Hashemzadeh M, Jamal M,. Increased prevalence of asthma in patients with type 2 diabetes mellitus. Chest 2006; 130: 160S.
15. de Faria IC, de Faria EJ, Toro AA, et al. Association of TGF-beta1, CD14, IL-4, IL-4R and ADAM33 gene polymorphisms with asthma severity in children and adolescents. J Pediatr (Rio J) 2008; 84: 203-210.
16. Romagnani S,. Cytokines and chemoattractants in allergic inflammation. Mol Immunol 2002; 38: 881-885.
17. Weiss ST, Raby BA, Rogers A,. Asthma genetics and genomics 2009. Curr Opin Genet Dev 2009; 19: 279-282.
18. Kharitonov SA, Barnes PJ,. Effects of corticosteroids on noninvasive biomarkers of inflammation in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc 2004; 1: 191-199.
19. Szefler SJ, Mitchell H, Sorkness CA, et al. Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. Lancet 2008; 372: 1065-1072.
20. Barreto M, Villa MP, Olita C, et al. 8-Isoprostane in exhaled breath condensate and exercise-induced bronchoconstriction in asthmatic children and adolescents. Chest 2009; 135: 66-73.
21. Doherty TA, Soroosh P, Khorram N, et al. The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling. Nat Med 2011; 17: 596-603.
22. Monte SV, Caruana JA, Ghanim H, et al. Reduction in endotoxemia, oxidative and inflammatory stress, and insulin resistance after Roux-en-Y gastric bypass surgery in patients with morbid obesity and type 2 diabetes mellitus. Surgery 2012; 151: 587-593.
23. Ghanim H, Aljada A, Daoud N, et al. Role of inflammatory mediators in the suppression of insulin receptor phosphorylation in circulating mononuclear cells of obese subjects. Diabetologia 2007; 50: 278-285.
24. Godard P, Michel F,. The role of alveolar macrophages in asthma. Allergol Immunopathol (Madr) 1988; 16: 185-186.
25. Martinelli R, Sabroe I, LaRosa G, et al. The CC chemokine eotaxin (CCL11) is a partial agonist of CC chemokine receptor 2b. J Biol Chem 2001; 276: 42957-42964.
26. Bassols J, Moreno-Navarrete JM, Ortega F, et al. LIGHT is associated with hypertriglyceridemia in obese subjects and increased cytokine secretion from cultured human adipocytes. Int J Obes (Lond) 2010; 34: 146-156.
27. Ghanim H, Monte SV, Sia CL, et al. Reduction in inflammation and the expression of amyloid precursor protein and other proteins related to Alzheimer's disease following gastric bypass surgery. J Clin Endocrinol Metab 2012; 97: E1197-E1201.