Paracetamol (acetaminophen): A blessing or a hidden curse?

Inflammopharmacology

Volumn 22, Issue 1, 2014, Pages 63-65

  Whitehouse, M W ^a,b   Butters, D E ^b  

^a GRIFFITH UNIVERSITY   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Analgesics; Conditional pharmacology toxicology; Gastrotoxicity; Hepatotoxicity; Sulphur nutrition

Indexed keywords

CAFFEINE; PARACETAMOL; PHENACETIN;

ANALGESIC ACTIVITY; ARTHRITIS; DEACETYLATION; DRUG EFFICACY; DRUG METABOLISM; HUMAN; HYDROXYLATION; INFLAMMATION; LIVER TOXICITY; METABOLIC SYNDROME X; OXIDATIVE STRESS; PRIORITY JOURNAL; SHORT SURVEY; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; HUMANS; INFLAMMATION;

EID: 84895878863     PISSN: 09254692     EISSN: 15685608     Source Type: Journal    
DOI: 10.1007/s10787-013-0189-1     Document Type: Short Survey

References (18)

1. Blumenthal M (2000) Snr editor, Herbal Medicine: expanded commission E monographs. Integrative Medicine Communications Newton MA p 518
2. Boutaud O, Aronoff DM, Richardson JH, Marnett LJ, Oates JA et al (2002) Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H2 synthases. Proc Natl Acad Sci (Washington) 99:7130-7135 (Pubitemid 34526267)
3. Brodie BB, Axelrod J (1949) The fate of acetophenetidin (phenacten) in man. J Pharmacol Exp Therap 97:58-67
4. Butters D, Whitehouse M (2009) Beyond conventional DMARDs: extending TNF-regulant therapies to the vast majority/less privileged who do need them. Int J Rheum Dis 12:299-307
5. Ecclesiastes (300-500 BCE) Holy Bible, Chapter 3, Verses 1-8
6. Fiorucci S, Antonelli E, Distrutti E, Rizzo G, Mencarelli A, Orlandi S et al (2005) Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs. Gastroenterology 129:1210-1224 (Pubitemid 41446861)
7. Gonzalez-Perez A, Rodriguez LAG (2006) Upper gastrointestinal complications among users of paracetamol. Basic Clin Pharmacol Toxicol 98:297-303
8. Graham GG, Davies MJ, Day RO, Mohamudally A, Scott KF et al (2013) The modern pharmacology of paracetamol. Inflammopharmacol 21:201-232
9. Lassak EV, McCarthy T (1997) Australian medicinal plants. Reed Books, Australia. 2nd edn 2011, p 240, 303
10. Lester D, Greenberg LA, Carroll RP (1947) The metabolic fate of acetanilide and other aniline derivatives. J Pharmacol Exp Therap 90:68-75
11. Li Voti G, Acierno C, Tulone V, Cataliotti F et al (1997) Relationship between upper gastrointestinal bleeding and nonsteroidal anti-inflammatory drugs in children. Pediatr Surg Int 12:264-265 (Pubitemid 27183268)
12. Mowrey DB (1993) Herbal tonic therapies. Wings Books, New York, p 400
13. Mills S, Bone K (2000) Principles and practise of Phytotherapy. Modern herbal medicine. 1st edn Edinburgh. Churchill Livingstone p 643 [2nd edn 2013 in press]
14. Rahme E, Pettitt D, Le Lorier J (2002) Determinants and sequelae associated with utilization of acetaminophen versus traditional NSAIDs in an elderly population. Arthritis Rheum 46:3046-3054 (Pubitemid 35315900)
15. Rainsford KD (2004) Analgesic abuse syndrome in Aspirin and related drugs. Taylor & Francis, London, pp 454-456
16. Rainsford KD, Whitehouse MW (2006) Paracetamol (acetaminophen)-induced gastrotoxicity; revealed by hyperacidity in combination with acute or chronic inflammation. Inflammopharmacol 14:150-154 (Pubitemid 44358281)
17. Whitehouse MW (2005) Prostanoids as friends not foes: further evidence from the interference by cyclooxygenase-inhibitory drugs when inducing tolerance to experimental arthritigens in rats. Inflammopharmacol 12:481-492
18. Whitehouse MW, Rainsford KS, Ghosh P (2008) How safe is paracetamol as an alternative analgesic to NSAIDs? Int Med J 38 (suppl 2) ARP9 (p.A12)