An evaluation of immune system cell infiltrate in the cervical stroma of patients with grade III cervical intraepithelial neoplasia after treatment with intralesional alpha-2B interferon

European Journal of Gynaecological Oncology

Volumn 35, Issue 1, 2014, Pages 20-25

  Machado, F A ^a   Abdalla, D R ^a   Montes, L ^a   Etchebehere, R M ^a   Michelin, M A ^a   Murta, E F C ^a  

^a FEDERAL UNIVERSITY OF TRIÂNGULO MINEIRO   (Brazil)

Author keywords

Cervical intraepithelial neoplasia; Immune response; Immunotherapy

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; PERFORIN; RECOMBINANT ALPHA2B INTERFERON;

ADULT; ARTICLE; B LYMPHOCYTE; CANCER IMMUNOTHERAPY; CANCER PATIENT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CERVICAL STROMA; CLINICAL ARTICLE; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MIDDLE AGED; NATURAL KILLER CELL; STROMA; UTERINE CERVIX CARCINOMA IN SITU; YOUNG ADULT;

ADULT; ANTIGENS, CD; CERVICAL INTRAEPITHELIAL NEOPLASIA; FEMALE; HUMANS; INJECTIONS, INTRALESIONAL; INTERFERON-ALPHA; MIDDLE AGED; NEOPLASM GRADING; PROSPECTIVE STUDIES; RECOMBINANT PROTEINS; TREATMENT FAILURE; UTERINE CERVICAL NEOPLASMS;

EID: 84895829872     PISSN: 03922936     EISSN: None     Source Type: Journal    
DOI: 10.12892/ejgo23872014     Document Type: Article

References (28)

1. Campos L.M.F.R, Dias F.L., Antunes L.M.G., Murta E.F.C.: "Prevalence of micronuclei in exfoliated uterine cervical cells from patients with risk factors for cervical cancer". Sao Paulo Med J., 2008, 126, 323.
2. Selva L., Gonzalez-Bosquet E., Rodriguez-Plata M.T., Esteva C., Suñol M., Muñoz-Almagro C.: "Detection of human papillomavirus infection in women attending a colposcopy clinic". Diagn. Microbiol. Infect. Dis., 2009, 64, 416.
3. Schawarz T.F., Spaczynski M., Schneider A., Wysocki J., Galaj A., Perona P., et al.: "Immunogenicity and tolerability of an HPV-13/18 ASO4-adjuvanted prophylactic cervical cancer vaccine in women aged 15-55 years". Vaccine, 2009, 27, 581.
4. Gravitt P.E., Jamshidi R.: "Diagnosis and Management of Oncogenic Cervical Human Papillomavirus Infection". Infect. Dis. Clin. N. Am., 2005, 19, 429.
5. WHO/ICO Information Centre on HPV and Cervical Cancer (HPV Information Centre). Human Papillomavirus and Related Cancers in Brazil. Summary Report 2010. Accessed: June 2010, www.who.int/hpv-centre
6. Tindle R.W.: "Immune evasion in human papillomavirus-associated cervical cancer". Nat. Rev. Cancer, 2002, 2, 59.
7. Richart R.M., Shingleton H.M., Wiener J., Spiro D.: "Human cervical intraepithelial neoplasia: fine structure of dysplasia and carcinoma in situ". Cancer Res., 1968, 28, 695.
8. Kristensen J., Langhoff-Roos J., Kristensen F.B.: "Increased Risk of Preterm Birth in Women With Cervical Conization". Obstet. Gynecol., 1993, 81, 3632.
9. Murta E.F.C., Tavares Murta B.M.: "Successful pregnancy after vaginal cancer treated with interferon". Tumori, 2004, 90, 247.
10. Ramos M.C., Mardegan M.C., Peghini B.C., Adad S.J., Michelin M.A., Murta E.F.: "Expression of cytokines in cervical stroma in patients with high-grade cervical intraepithelial neoplasia after treatment with intralesional interferon alpha-2b". Eur. J. Gynaecol. Oncol., 2010, 31, 522.
11. Misson D.R., Abdalla D.R., Borges A.M., Shimba D.S., Adad S.J., Michelin M.A., Murta E.F.C.: "Cytokine serum levels in patients with cervical intraepithelial neoplasia grade II-III treated with intralesional interferon-α 2b". Tumori, 2011, 97, 578.
12. Machado P.R.L., Araújo M.I.A.S., Carvalho L., Carvalho E.M.: "Immune response mechanisms to infections". An. bras. Dermatol, 2004, 79, 647.
13. Stanley M.A.: "Immunobiology of HPV and HPV vaccines". Gynecol Oncol, 2008, 109, S15.
14. Georgiannos S.N., Renault A., Goode A.W., Sheaff M.: "The immunophenotype and activation status of the lymphocytic infiltrate in human breast cancers, the role of the major histocompatibility complex in cell-mediated immune mechanisms, and their association with prognostic indicators". Surgery, 2003, 134, 827.
15. Borden E.C., Sem G.C., Uzé G., Silverman R.H., Ransohoff R.M., Foster G.R., et al.: "Interferons at age 50: past, current and future impact on biomedicine". Nat. Rev. Drug Discov., 2007, 6, 975.
16. Nomelini R.S., Mardegan M.C., Murta E.F.C.: "Utilization of Interferon in Gynecologic and Breast Cancer". Clinical Medicine: Oncology, 2007, 1, 111.??
17. Choo Y.C., Seto W.H., Hsu C., Tany Y.H., Ma H.K., Ng M.H.: "Cervical intraepithelial neoplasia treated by perilesional injection of interferon". Br. J. Obstet. Gynaecol., 1986, 93, 372.
18. Dunham A.M., MCcartney J.C., Mccance D.J., Taylor R.W.: "Effect of perilesional injection of alpha-interferon on cervical intraepithelial neoplasia and associated human papillomavirus infection". J. R. Soc. Med., 1990, 83, 490.
19. Stellato G.: "Intralesional recombinant alpha 2B interferon in the treatment of human papillomavirus-associated cervical intraepithelial neoplasia". Sex. Transm. Dis., 1992, 19, 124.
20. Byrne M.A., Moller B.R., Taylor-Robinson D., Harris J.R., Wickenden C., Malcolm A.D., et al.: "The effect of interferon on human papillomaviruses associated with cervical intraepithelial neoplasia". Br. J. Obstet. Gynaecol., 1986, 93, 1136.
21. Frost L., Skajaa K., Hvidman L.E., Fay S.J., Larsen P.M.: "No effect of intralesional injection of interferon on moderate cervical intraepithelial neoplasia". Br. J. Obstet. Gynaecol., 1990, 97, 626.
22. Petry K.U., Scheffel D., Bode U., Gabrysiak T., Köchel H., Kupsch E., et al.: "Cellular immunodeficiency enhances the progression of human papillomavirus-associated cervical lesions". Int. J. Cancer, 1994, 57, 836.
23. Ellerbrock T.V., Chiasson M.A., Bush T.J., Sun X.W., Sawo D., Brudney K., et al.: "Incidence of cervical squamous intraepithelial lesions in HIV-infected women". JAMA, 2000, 283, 1031.
24. Arany I., Tyring S.K.: "Status of local cellular immunity in interferon-responsive and -nonresponsive human papillomavirus-associated lesions". Sex. Transm. Dis., 1996, 23, 475.
25. Mardegan M.C., Ramos M.C., Adad S.J., Michelin M.A., Shimba D., Murta E.F.C.: "Immunological evaluation of vaginal secretion in patients with high-grade cervical intra-epithelial neoplasia treated with intralesional interferon-α 2b". Eur. J. Gynaecol. Oncol., 2011, 32, 297.
26. Maluf P.J., Michelin M.A., Etchebehere, R.M., Adad S.J., Murta E.F.C.: "T lymphocytes (CD3) may participate in the recurrence of cervical intraepithelial neoplasia grade III". Arch. Gynecol. Obstet., 2008, 278, 525. doi: 10.1007/s00404-008-0621-8. Epub 2008 Mar 15.
27. Silva C.S., Michelin M.A., Etchebehere R.M., Adad S.J., Murta E.F.C.: "Local lymphocytes and nitric oxide synthase in the uterine cervical stroma of patients with grade III cervical intraepithelial neoplasia". Clinics, 2010, 65, 575.
28. Law R.H., Lukoyanova N., Voskoboinik I., Caradoc-Davies T.T., Baran K., Dunstone M.A., et al.: "The structural basis for membrane binding and pore formation by lymphocyte perforin". Nature, 2010, 468, 447.