Immunological evaluation of vaginal secretion in patients with high-grade cervical intraepithelial neoplasia treated with intralesional interferon α-2b

European Journal of Gynaecological Oncology

Volumn 32, Issue 3, 2011, Pages 297-302

  Mardegan, M C ^a   Ramos, M C ^b   Adad, S J ^a   Michelin, M A ^a   Shimba, D ^c   Murta, E F C ^d  

^a UFTM   (Brazil)

^b Federal University of the Triângulo Mineiro UFTM   (Brazil)

^c UFTM ^*  (Brazil)

^d FEDERAL UNIVERSITY OF TRIÂNGULO MINEIRO   (Brazil)

Author keywords

Cervical intraepithelial neoplasia; Cytokines; Human papillomavirus virus; Interferon 2b; Treatment

Indexed keywords

BLAUFERON B; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; RECOMBINANT ALPHA2B INTERFERON; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ASTHENIA; BLOOD CLOTTING; CANCER GRADING; CANCER IMMUNOTHERAPY; CLINICAL ARTICLE; CLINICAL EVALUATION; CLINICAL TRIAL; CYTOKINE PRODUCTION; DRUG FEVER; DRUG TREATMENT FAILURE; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; KIDNEY FUNCTION; LABORATORY TEST; LIVER FUNCTION; MYALGIA; SIDE EFFECT; SMOKING; TREATMENT RESPONSE; UTERINE CERVIX CARCINOMA IN SITU; VAGINA SECRETION; VIRUS LOAD; WART VIRUS;

ADULT; ANTINEOPLASTIC AGENTS; CERVICAL INTRAEPITHELIAL NEOPLASIA; CYTOKINES; DNA, VIRAL; FEMALE; FLOW CYTOMETRY; HUMANS; INTERFERON ALFA-2B; MIDDLE AGED; PAPILLOMAVIRIDAE; PROSPECTIVE STUDIES; UTERINE CERVICAL NEOPLASMS; VAGINA; VAGINAL SMEARS;

EID: 79960271555     PISSN: 03922936     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Parkin D.M., Bray F.: "The burden of HPV-related cancers". Vaccine, 2006, 3, S3/11.
2. McCredie M.R., Sharpies K.J., Paul C., Baranyai J., Medley G., Jones R.W., Skegg D.C.: "Natural hitory of cervical neoplasia and risk of invasive cancer in women with cervical Intraepithelial neoplasia 3: a retrospective cohort study". Lancet Oncol., 2008, 9, 425.
3. Woodman C.B., Collins S.I., Young L.S.: "The natural history of cervical HPV infection: unresolved issues". Nat. Rev. Cancer., 2007, 7, 11.
4. Scott M., Stites D.P., Moscicki, A.B.: "Th1 cytokine patterns in cervical human papillomavirus infection". Clin. Diagn. Lab. Immunol., 1999, 6, 751.
5. Frazer I.H., Thomas R., Zhou J., Leggatt G.R., Dunn L., McMillan N. et al.: "Potential strategies utilised by papillomavirus to evade host immunity". Immunol. Rev., 1999, 168, 131.
6. Tindle R.W.: "Immune evasion in human papillomavirus-associated cervical cancer". Nat. Rev. Cancer, 2002, 2, 59.
7. Wu T.C., Kurman R.J.: "Analysis of cytokine profiles in patients with human papillomavirus-associated neoplasms". J. Natl. Cancer Inst., 1997, 89, 245.
8. Gonçalves M.A., Donadi E.: "A immune cellular response to HPV: current concepts". Braz. J. Infect. Dis., 2004, 8, 1.
9. Wright T.C. Jr., Massad L.S., Dunton C.J., Spitzer M., Wilkinson E.J., Solomon D.: American Society for Colposcopy and Cervical Pathology-Sponsored Consensus Conference. "2006 Consensus guidelines for the management of women with cervical intraepithelial neoplasia or adenocarcinoma in situ". Am. J. Obstet. Gynecol., 2007, 197, 340.
10. Jakobsson M., Gissler M., Sainio S., Paavonen J., Tapper A.M.: "Preterm delivery after surgical treatment for cervical intraepithelial neoplasia". Obstet. Gynecol., 2007, 309.
11. Kyrgiou M., Koliopoulos G., Martin-Hirsch P., Arbyn M., Prendiville W., Paraskevaidis E.: "Obstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions: systematic review and meta-analysis". Lancet, 2006, 367, 489.
12. Sadler L., Saftlas A.: "Cervical surgery and preterm birth". J. Perinat. Med., 2007, 35, 5.
13. Sjoborg K.D., Vistad I., Myhr S.S., Svenningsen R., Herzog C., Kloster-Jensen A. et al.: "Pregnancy outcome after cervical cone excision: a case-control study". Acta Obstet. Gynecol. Scand., 2007, 86, 423.
14. Moscicki A.B: "HPV infections in adolescents". Dis. Markers., 2007, 23, 229.
15. Nomelini R.S., Mardegan M.C., Murta E.F.C.: "Utilization of interferon in gynecologic and breast cancer." Clin. Med. Oncol., 2007, 1, 111.
16. Choo Y.C., Seto W.H., Hsu C., Tany Y.H., Ma H.K., Ng M.H.: "Cervical intraepithelial neoplasia treated by perilesional injection of interferon". Br. J. Obstet. Gynaecol., 1986, 93, 372.
17. Dunhan A.M., McCartney J.C., McCance D.J., Taylor R.W.: "Effect of perilesional injection of α-interferon on cervical intraepithelial neoplasia and associated human papillomavirus infection. J. R. Soc. Med., 1990, 83, 490.
18. Stellato G.: "Intralesional recombinant alpha 2B interferon in the treatment of human papillomavirus-associated cervical intraepithelial neoplasia". Sex. Transm. Dis., 1992, 19, 124.
19. Murta E.F.C., Tavares Murta B.M.: "Successful pregnancy after vaginal cancer treated with interferon". Tumori, 2004, 90, 247.
20. Castellsaqué X., Muñoz N.: "Cofactors in human papillomavirus carcinogenesis-role of parity, oral contraceptives, and tobacco smoking". J. Natl. Cancer Inst. Monogr., 2003, 31, 20.
21. Ault K.A.: "Epidemiology and natural history of human papillomavirus infections in the female genital tract". Infect. Dis. Obstet. Gynecol., 2006, suppl. 40470, 1.
22. Byrne M.A., Moller B.R., Taylor-Robinson D., Harris J.R.W., Wickenden C., Ickenden C. et al.: "The effect of interferon on human papilloma virus associated with cervical intraepithelial neoplasia". Br. J. Obstet. Gynaecol., 1986, 93, 1136.
23. Frost L., Skajaa K., Hvidman L.E., Fay S.J., Larsen P.M.: "No effect of intralesional injection of interferon on moderate cervical intraepithelial neoplasia". Br. J. Obstet. Gynecol., 1990, 97, 626.
24. Clerici M., Merola M., Ferrario E., Trabattoni D., Villa M.L., Stefanon B. et al.: "Cytokine production patterns in cervical intraepithelial neoplasia: association with human papillomavirus infection". J. Natl Cancer Inst., 1997, 89, 245.
25. Seo N., Hayakawa S., Takigawa M., Tokura Y.: "Interleukin-10 expressed at early tumour sites induces subsequent generation of CD4(+) T-regulatory cells and systemic collapse of antitumour immunity". Immunology., 2001, 103, 449.
26. Loskog A., Ninalga C., Totterman T.H.: "Dendritic cells engineered to express CD40L continuously produce IL 12 and resist negative signals from Tr1/Th3 dominated tumors". Cancer Immunol. Immunother., 2006, 55, 588.
27. Tavares-Murta B.M., De Resende A.D., Cunha F.Q., Murta E.F.C.: "Local profile of cytokines and nitric oxide in patients with bacterial vaginosis and cervical intraepithelial neoplasia". Eur. J. Obstet. Gynecol. Reprod. Biol., 2008, 138, 93.
28. Wei L.H., Kuo M.L., Chen C.A., Cheng W.F., Cheng S.P., Hsieh F.J., Hsieh C.Y.: "Interleukin-6 in cervical cancer: the relationship with vascular endothelial growth factor". Gynecol. Oncol., 2001, 82, 49.
29. Tjiong M.Y., Van Der Vange N., Ten Kate F.J., Tjong-A-Hung S.P., Ter Schegget J., Burger.M.P., Out T.A.: "Increased IL-6 and IL-8 levels in cervicovaginal secretions of patients with cervical cancer". Gynecol. Oncol., 1999, 73, 285.
30. Fujimoto J., Sakaguchi H., Aoki I., Tamaya T.: "Clinical implications of expression of interleukin 8 related to angiogenesis in uterine cervical cancers". Cancer Res., 2000, 60, 2632.
31. Azar K.K., Tani M., Yasuda H., Sakai A., Inoue M., Sasagawa T.: "Increased secretion patterns of interleukin-10 and tumor necrosis factor-alpha in cervical squamous intraepithelial lesions". Hum. Pathol., 2004, 35,1376.
32. Pardo-Govea T., Callejas D., Núñez-Troconis J., Araujo M., Costa L., Pons H. et al.: "Gamma interferon (IFN-gamma), tumor necrosis factor alpha (TNF-alpha) and interleukins 2, 4 and 6 (IL-2, IL-4, IL-6) in cervical-uterine cells of intraepithelial neoplasia: a preliminary report". Invest. Clin., 2005, 46, 5.
33. Bais A.G., Beckmann I., Ewing P.C., Eijkemans M.J., Meijer C.J., Snijders P.J. et al.: "Cytokine release in HR-HPV(+) women without and with cervical dysplasia (CIN II and III) or carcinoma, comparared with HR- HPV(-) controls". Mediators Inflamm., 2007, 2007, 1.
34. El-Sherif A.M., Seth R., Tighe P.J., Jenkins D.: "Quantitative analysis of IL-10 and IFN-gamma mRNA levels in normal cervix and human papillomavirus type 16 associated cervical precancer". J. Pathol., 2001, 195, 179.
35. Lee B.N., Folien M., Shen D.Y., Malpica A., Adler-Storthz K., Shearer W.T., Reuben J.M.: "Depressed type 1 cytokine synthesis by superantigen-activated CD4+ T cells of women with human papillomavirus-related high-grade squamous intraepithelial lesions". Clin. Diagn. Lab. Immunol., 2004, 11, 239.