Population impact of familial and environmental risk factors for schizophrenia: A nationwide study

Schizophrenia Research

Volumn 153, Issue 1-3, 2014, Pages 214-219

  Sørensen, Holger J ^a,c   Nielsen, Philip R ^b,c   Pedersen, Carsten B ^b,c   Benros, Michael E ^a,b,c   Nordentoft, Merete ^a,c   Mortensen, Preben B ^b,c  

^a Mental Health Services CPH   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c Aarhus   (Denmark)

Author keywords

Environmental risk factors; Psychiatric family history; Register based; Schizophrenia; Urban birth

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; ATTRIBUTABLE RISK; BIRTHPLACE; CHILD; COHORT ANALYSIS; ENVIRONMENTAL FACTOR; FAMILY HISTORY; FEMALE; HUMAN; IMMIGRATION; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; MIDDLE AGED; PARENTAL DEPRIVATION; PATERNAL AGE; PREDICTIVE VALUE; PRIORITY JOURNAL; PROGENY; RISK ASSESSMENT; RISK FACTOR; SCHIZOPHRENIA; URBAN AREA; YOUNG ADULT; AGE DISTRIBUTION; AGED; DENMARK; ENVIRONMENT; FAMILY HEALTH; GENETICS; MIGRATION; PARENT; REGRESSION ANALYSIS; STATISTICS AND NUMERICAL DATA; URBANIZATION;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; CHILD; DENMARK; EMIGRATION AND IMMIGRATION; ENVIRONMENT; FAMILY HEALTH; FEMALE; HUMANS; MALE; MIDDLE AGED; PARENTS; REGRESSION ANALYSIS; RISK FACTORS; SCHIZOPHRENIA; URBANIZATION; YOUNG ADULT;

EID: 84895807096     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2014.01.008     Document Type: Article

References (32)

1. Bruzzi P., Green S.B., Byar D.P., Brinton L.A., Schairer C. Estimating the population attributable risk for multiple risk factors using case-control data. Am. J. Epidemiol. 1985, 122:904-914.
2. Cantor-Graae E., Pedersen C.B. Risk of schizophrenia in second-generation immigrants: a Danish population-based cohort study. Psychol. Med. 2007, 37:485-494.
3. Cantor-Graae E., Pedersen C.B. Full spectrum of psychiatric disorders related to foreign migration: a Danish population-based cohort study. JAMA Psychiatry 2013, 70:427-435.
4. Dean K., Stevens H., Mortensen P.B., Murray R.M., Walsh E., Pedersen C.B. Full spectrum of psychiatric outcomes among offspring with parental history of mental disorder. Arch. Gen. Psychiatry 2010, 67:822-829.
5. El-Saadi O., Pedersen C.B., McNeil T.F., Saha S., Welham J., O'Callaghan E., Cantor-Graae E., Chant D., Mortensen P.B., McGrath J. Paternal and maternal age as risk factors for psychosis: findings from Denmark, Sweden and Australia. Schizophr. Res. 2004, 67:227-236.
6. Gottesman I.I., Laursen T.M., Bertelsen A., Mortensen P.B. Severe mental disorders in offspring with 2 psychiatrically ill parents. Arch. Gen. Psychiatry 2010, 67:252-257.
7. Granville-Grossman K.L. Early bereavement and schizophrenia. Br. J. Psychiatry 1966, 112:1027-1034.
8. Gunawardana L., Zammit S., Lewis G., Gunnell D., Hollis C., Wolke D., Harrison G. Examining the association between maternal analgesic use during pregnancy and risk of psychotic symptoms during adolescence. Schizophr. Res. 2011, 126:220-225.
9. Insel B.J., Schaefer C.A., McKeague I.W., Susser E.S., Brown A.S. Maternal iron deficiency and the risk of schizophrenia in offspring. Arch. Gen. Psychiatry 2008, 65:1136-1144.
10. Kendler K.S., Diehl S.R. The genetics of schizophrenia: a current, genetic-epidemiologic perspective. Schizophr. Bull. 1993, 19:261-285.
11. Kirkbride J.B., Jones P.B. The prevention of schizophrenia-what can we learn from eco-epidemiology?. Schizophr. Bull. 2011, 37:262-271.
12. Kirkbride J., Coid J.W., Morgan C., Fearon P., Dazzan P., Yang M., Lloyd T., Harrison G.L., Murray R.M., Jones P.B. Translating the epidemiology of psychosis into public mental health: evidence, challenges and future prospects. J. Publ. Ment. Health 2010, 9:4-14.
13. Laursen T.M., Munk-Olsen T., Nordentoft M., Bo M.P. A comparison of selected risk factors for unipolar depressive disorder, bipolar affective disorder, schizoaffective disorder, and schizophrenia from a Danish population-based cohort. J. Clin. Psychiatry 2007, 68:1673-1681.
14. Matheson S.L., Shepherd A.M., Laurens K.R., Carr V.J. A systematic meta-review grading the evidence for non-genetic risk factors and putative antecedents of schizophrenia. Schizophr. Res. 2011, 133:133-142.
15. McGrath J.J., Eyles D.W., Pedersen C.B., Anderson C., Ko P., Burne T.H., Norgaard-Pedersen B., Hougaard D.M., Mortensen P.B. Neonatal vitamin D status and risk of schizophrenia: a population-based case-control study. Arch. Gen. Psychiatry 2010, 67:889-894.
16. McGrath J.J., Mortensen P.B., Visscher P.M., Wray N.R. Where GWAS and epidemiology meet: opportunities for the simultaneous study of genetic and environmental risk factors in schizophrenia. Schizophr. Bull. 2013, 39:955-959.
17. Miller B., Messias E., Miettunen J., Alaraisanen A., Jarvelin M.R., Koponen H., Rasanen P., Isohanni M., Kirkpatrick B. Meta-analysis of paternal age and schizophrenia risk in male versus female offspring. Schizophr. Bull. 2011, 37:1039-1047.
18. Mortensen P.B., Norgaard-Pedersen B., Waltoft B.L., Sorensen T.L., Hougaard D., Yolken R.H. Early infections of Toxoplasma gondii and the later development of schizophrenia. Schizophr. Bull. 2007, 33:741-744.
19. Mortensen P.B., Pedersen M.G., Pedersen C.B. Psychiatric family history and schizophrenia risk in Denmark: which mental disorders are relevant?. Psychol. Med. 2010, 40:201-210.
20. Munk-Jorgensen P., Mortensen P.B. The Danish Psychiatric Central Register. Dan. Med. Bull. 1997, 44:82-84.
21. Pedersen C.B. No evidence of time trends in the urban-rural differences in schizophrenia risk among five million people born in Denmark from 1910 to 1986. Psychol. Med. 2006, 36:211-219.
22. Pedersen C.B., Mortensen P.B. Evidence of a dose-response relationship between urbanicity during upbringing and schizophrenia risk. Arch. Gen. Psychiatry 2001, 58:1039-1046.
23. Pedersen C.B., Mortensen P.B. Are the cause(s) responsible for urban-rural differences in schizophrenia risk rooted in families or in individuals?. Am. J. Epidemiol. 2006, 163:971-978.
24. Pedersen C.B., Gotzsche H., Moller J.O., Mortensen P.B. The Danish Civil Registration System. A cohort of eight million persons. Dan. Med. Bull. 2006, 53:441-449.
25. Petersen L., Mortensen P.B., Pedersen C.B. Paternal age at birth of first child and risk of schizophrenia. Am. J. Psychiatry 2011, 168:82-88.
26. Sorensen H.J., Mortensen E.L., Reinisch J.M., Mednick S.A. Association between prenatal exposure to analgesics and risk of schizophrenia. Br. J. Psychiatry 2004, 185:366-371.
27. Sorensen H.J., Mortensen E.L., Reinisch J.M., Mednick S.A. Association between prenatal exposure to bacterial infection and risk of schizophrenia. Schizophr. Bull. 2009, 35:631-637.
28. Sorensen H.J., Nielsen P.R., Pedersen C.B., Mortensen P.B. Association between prepartum maternal iron deficiency and offspring risk of schizophrenia: population-based cohort study with linkage of Danish national registers. Schizophr. Bull. 2011, 37:982-987.
29. Van Os J., Rutten B.P., Poulton R. Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions. Schizophr. Bull. 2008, 34:1066-1082.
30. Weiser M., Werbeloff N., Vishna T., Yoffe R., Lubin G., Shmushkevitch M., Davidson M. Elaboration on immigration and risk for schizophrenia. Psychol. Med. 2008, 38:1113-1119.
31. World Health Organization Manual of the International Statistical Classification of Diseases, Injuries, and Causes of Death (ICD-8) 1967, WHO, Geneva.
32. World Health Organization International Statistical Classification of Diseases and Related Health Problems (ICD-10) 1992, WHO, Geneva.