Improvement of functional recovery of donor heart following cold static storage with doxycycline cardioplegia

Cardiovascular Toxicology

Volumn 14, Issue 1, 2014, Pages 64-73

  Ozcinar, Evren ^a   Okatan, Esma N ^b   Tuncay, Erkan ^b   Eryilmaz, Sadik ^b   Turan, Belma ^b  

^a MINISTRY OF HEALTH   (Turkey)

^b ANKARA UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Cardioplegia; Cold storage; Heart function; Ischemia; Matrix metalloproteinases; Reperfusion

Indexed keywords

DOXYCYCLINE; GELATINASE A;

ANIMAL TISSUE; AORTA FLOW; APOPTOSIS; ARTICLE; CARDIOPLEGIA; CONTROLLED STUDY; CRYOPRESERVATION; ENZYME ACTIVITY; HEART LEFT VENTRICLE FUNCTION; HEART PERFUSION; HEART PRESERVATION; HEART PROTECTION; HEART RATE; MALE; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; QUALITY CONTROL; RAT; TISSUE HOMOGENATE; WEIGHT GAIN;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CARDIOPLEGIC SOLUTIONS; COLD ISCHEMIA; COLD TEMPERATURE; CYTOPROTECTION; DOXYCYCLINE; HEART ARREST, INDUCED; HEART TRANSPLANTATION; MALE; MATRIX METALLOPROTEINASE 2; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; RECOVERY OF FUNCTION; TIME FACTORS; TISSUE AND ORGAN HARVESTING; VENTRICULAR FUNCTION, LEFT;

EID: 84895801697     PISSN: 15307905     EISSN: 15590259     Source Type: Journal    
DOI: 10.1007/s12012-013-9231-1     Document Type: Article

References (44)

1. Hunt, S. A. (2006). Taking heart - cardiac transplantation past, present, and future. The New England Journal of Medicine, 355, 231-235.
2. Jahania, M. S.; Sanchez, J. A.; Narayan, P.; Lasley, R. D.; Mentzer, R. M.; Jr. (1999). Heart preservation for transplantation: principles and strategies. The Annals of Thoracic Surgery, 68, 1983-1987.
3. Li, G.; Sullivan, J. A.; Hall, R. I. (1993). Functional recovery in rabbit heart after preservation with a blood cardioplegic solution and perfusion. Journal of Heart and Lung Transplantation, 12, 263-270.
4. Jones, B. U.; Serna, D. L.; Smulowitz, P.; Connolly, P.; Farber, A.; Beckham, G.; et al. (2003). Extended ex vivo myocardial preservation in the beating state using a novel polyethylene glycosylated bovine hemoglobin perfusate based solution. ASAIO Journal, 49, 388-394.
5. Stowe, D. F.; Camara, A. K.; Heisner, J. S.; Aldakkak, M.; Harder, D. R. (2008). Low-flow perfusion of guinea pig isolated hearts with 26 C air-saturated Lifor solution for 20 hours preserves function and metabolism. Journal of Heart and Lung Transplantation, 27, 1008-1015.
6. Parolari, A.; Rubini, P.; Cannata, A.; Bonati, L.; Alamanni, F.; Tremoli, E.; et al. (2002). Endothelial damage during myocardial preservation and storage. The Annals of Thoracic Surgery, 73, 682-690.
7. Maathuis, M. H.; Leuvenink, H. G.; Ploeg, R. J. (2007). Perspectives in organ preservation. Transplantation, 83, 1289-1298.
8. Rudd, D. M.; Dobson, G. P. (2011). Eight hours of cold static storage with adenosine and lidocaine (Adenocaine) heart preservation solutions: toward therapeutic suspended animation. The Journal of Thoracic and Cardiovascular Surgery, 142, 1552-1561.
9. Collins, M. J.; Moainie, S. L.; Griffith, B. P.; Poston, R. S. (2008). Preserving and evaluating hearts with ex vivo machine perfusion: an avenue to improve early graft performance and expand the donor pool. European Journal of Cardio-Thoracic Surgery, 34, 318-325.
10. Ozeki, T.; Kwon, M. H.; Gu, J.; Collins, M. J.; Brassil, J. M.; Miller, M. B.; Jr, et al. (2007). Heart preservation using continuous ex vivo perfusion improves viability and functional recovery. Circulation Journal, 71, 153-159.
11. Rudd, D. M.; Dobson, G. P. (2009). Toward a new and warm nondepolarizing, normokalemic arrest paradigm for orthotopic heart transplantation. The Journal of Thoracic and Cardiovascular Surgery, 137, 198-207.
12. Stoica, S. C.; Satchithananda, D. K.; Dunning, J.; Large, S. R. (2001). Two-decade analysis of cardiac storage for transplantation. European Journal of Cardio-Thoracic Surgery, 20, 792-798.
13. Schulze, R. (2007). Intracellular targets of matrix metalloproteinase-2 in cardiac disease: Rationale and therapeutic approaches. Annual Review of Pharmacology and Toxicology, 47, 211-242.
14. Visse, R.; Nagase, H. (2003). Matrix metalloproteinases and tissue inhibitors of metalloproteinases: Structure, function and biochemistry. Circulation Research, 92, 827-839.
15. Cheung, P. Y.; Sawicki, G.; Wozniak, M.; Wang, W.; Radomski, W. M.; Schulz, R. (2000). Matrix metalloproteinase-2 contributes to ischemia-reperfusion injury in the heart. Circulation, 101, 1833-1839.
16. Zeydanli, E. N.; Kandilci, H. B.; Turan, B. (2011). Doxycycline ameliorates vascular endothelial and contractile dysfunction in the thoracic aorta of diabetic rats. Cardiovascular Toxicology, 11, 134-147.
17. Wagner, F. M. (2011). Donor heart preservation and perfusion. Applied Cardiopulmonary Pathophysiology, 15, 198-206.
18. Demmy, T. L.; Biddle, J. S.; Bennet, L. E.; Walls, J. T.; Schmaltz, R. A.; Curtis, J. J. (1997). Organ preservation solutions in heart transplantation-patterns of usage and related survival. Transplantation, 63, 262-269.
19. George, T. J.; Arnaoutakis, G. J.; Beaty, C. A.; Shah, A. S.; Conte, J. V.; Haluska, M. K. (2012). A novel method of measuring cardiac preservation injury demonstrates University of Wisconsin solution is associated with less ischemic necrosis than Celsior in early cardiac allograft biopsies. The Journal of Heart and Lung Transplantation, 31(4), 410-418.
20. Kukreja, R. C.; Hess, M. L. (1992). The oxygen free radical system: from equations through membrane-protein interactions to cardiovascular injury and protection. Cardiovascular Research, 26, 641-655.
21. Loganathan, S.; Radovits, T.; Hirschberg, K.; Korkmaz, S.; Koch, A.; Karck, M.; et al. (2010). Effects of Custodiol-N, a novel organ preservation solution, on ischemia/reperfusion injury. The Journal of Thoracic and Cardiovascular Surgery, 139, 1048-1056.
22. Radovits, T.; Lin, L. N.; Zotkina, J.; Koch, A.; Rauen, U.; Köhler, G.; et al. (2008). Endothelial dysfunction after long-term cold storage in HTK organ preservation solutions: effects of iron chelators and N-alpha-acetyl-l- histidine. The Journal of Heart and Lung Transplantation, 27, 208-216.
23. Toledo-Pereyra, L. H.; Toledo, A. H.; Walsh, J.; Lopez-Neblina, F. (2004). Molecular signaling pathways in ischemia/reperfusion. Experimental and Clinical Transplantation, 2(1), 174-177.
24. Shao, Z.; Bhattacharya, K.; Hsich, E.; Park, L.; Walters, B.; Germann, U.; et al. (2006). c-Jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury in vitro and in vivo. Circulation Research, 98(1), 111-118.
25. Shaw, J.; Kirshenbaum, L. A. (2006). Prime time for JNK-mediated Akt reactivation in hypoxia-reoxygenation. Circulation Research, 98(1), 7-9.
26. Matsui, T.; Tao, J.; del Monte, F.; Lee, K. H.; Li, L.; Picard, M.; et al. (2001). Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation, 104(3), 330-335.
27. Pugazhenthi, S.; Nesterova, A.; Sable, C.; Heidenreich, K. A.; Boxer, L. M.; Heasley, L. E.; et al. (2000). Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein. Journal of Biological Chemistry, 275(15), 10761-10766.
28. Kuzuya, M.; Asai, T.; Kanda, S.; Maeda, K.; Cheng, X. W.; Iguchi, A. (2001). Glycation cross-links inhibit matrix metalloproteinase-2 activation in vascular smooth muscle cells cultured on collagen lattice. Diabetologia, 44, 433-436.
29. Radomski, A.; Sawicki, G.; Olson, D. M.; Radomski, M. W. (1998). The role of nitric oxide and metalloproteinases in the pathogenesis of hyperoxia-induced lung injury in newborn rats. British Journal of Pharmacology, 125, 1455-1462.
30. Golub, L. M.; Lee, H. M.; Ryan, M. E.; Giannobile, W. V.; Payne, J.; Sorsa, T. (1998). Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms. Advances in Dental Research, 12, 12-26.
31. Leung, D. W.; Lindlief, L. A.; Laabich, A.; Vissvesvaran, G. P.; Kamat, M.; Lieu, K. L.; et al. (2007). Minocycline protects photoreceptors from light and oxidative stress in primary bovine retinal cell culture. Investigative Ophthalmology & Visual Science, 48, 412-421.
32. Kraus, R. L.; Pasieczny, R.; Lariosa-Willingham, K.; Turner, M. S.; Jiang, A.; Trauger, J. W. (2005). Antioxidant properties of minocycline: neuroprotection in an oxidative stress assay and direct radical-scavenging activity. Journal of Neurochemistry, 94, 819-827.
33. Hoyt, J. C.; Ballering, J.; Numanami, H.; Hayden, J. M.; Robbins, R. A. (2006). Doxycycline modulates nitric oxide production in murine lung epithelial cells. The Journal of Immunology, 176, 567-572.
34. Lai, H. C.; Yeh, Y. C.; Ting, C. T.; Lee, W. L.; Lee, H. W.; Wang, L. C.; et al. (2010). Doxycycline suppresses doxorubicin-induced oxidative stress and cellular apoptosis in mouse hearts. European Journal of Pharmacology, 644, 176-187.
35. Zheng, H.; Tang, M.; Zheng, Q.; Kumarapeli, A. R.; Horak, K. M.; Tian, Z.; et al. (2010). Doxycycline attenuates protein aggregation in cardiomyocytes and improves survival of a mouse model of cardiac proteinopathy. Journal of the American College of Cardiology, 56, 1418-1426.
36. Castro, M. M.; Kandasamy, A. D.; Youssef, N.; Schulz, R. (2011). Matrix metalloproteinase inhibitor properties of tetracyclines: Therapeutic potential in cardiovascular diseases. Pharmacological Research, 64, 551-560.
37. Lalu, M. M.; Pasini, E.; Schulze, C. J.; Ferrari-Vivaldi, M.; Ferrari-Vivaldi, G.; Bachetti, T.; et al. (2005). Ischaemia-reperfusion injury activates matrix metalloproteinases in the human heart. European Heart Journal, 26, 27-35.
38. Butler, T. L.; Egan, J. R.; Graf, F. G.; Au, C. G.; McMahon, A. C.; North, K. N.; et al. (2009). Dysfunction induced by ischemia versus edema: Does edema matter? The Journal of Thoracic and Cardiovascular Surgery, 138, 141-147.
39. Fert-Bober, J.; Leon, H.; Sawicka, J.; Basran, R. S.; Devon, R. M.; Schulz, R.; et al. (2008). Inhibiting matrix metalloproteinase-2 reduces protein release into coronary effluent from isolated rat hearts during ischemia-reperfusion. Basic Research in Cardiology, 103, 431-443.
40. Sutherland, F. J.; Hearse, D. J. (2000). The isolated blood and perfusion fluid perfused heart. Pharmacological Research, 41, 613-627.
41. Huggins, C. E.; Bell, J. R.; Pepe, S.; Delbridge, L. M. D. (2008). Benchmarking ventricular arrhythmias in the Mouse - revisiting the 'Lambeth Conventions' 20 years on. Heart, Lung and Circulation, 17, 445-450.
42. Yang, L.; Yu, T. (2010). Prolonged donor heart preservation with pinacidil: The role of mitochondria and the mitochondrial adenosine triphosphate-sensitive potassium channel. The Journal of Thoracic and Cardiovascular Surgery, 139, 1057-1063.
43. Soory, M. (2008). A role for non-antimicrobial actions of tetracyclines in combating oxidative stress in periodontal and metabolic diseases: A literature review. The Open Dentistry Journal, 2, 5-12.
44. Firatli, E.; Unal, T.; Onan, U.; Sandalli, P. (1994). Antioxidative activities of some chemotherapeutics. A possible mechanism in reducing gingival inflammation. Journal of Clinical Periodontology, 21, 680-683.