Naive CD4 T-cell activation identifies MS patients having rapid transition to progressive MS

Neurology

Volumn 82, Issue 8, 2014, Pages 681-690

  Zastepa, Evelyn ^a   Fitz Gerald, Leslie ^a   Hallett, Michael ^a   Antel, Jack ^b   Bar Or, Amit ^b   Baranzini, Sergio ^c   Lapierre, Yves ^b   Haegert, David G ^a  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1A INTERFERON; CD28 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD45RA ANTIGEN; CHEMOKINE RECEPTOR CCR1; CYCLOPHOSPHAMIDE; INTERFERON BETA SERINE; INTERFERON REGULATORY FACTOR 5; INTERFERON REGULATORY FACTOR 7; MEMBRANE PROTEIN; MESSENGER RNA; METHOTREXATE; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; T LYMPHOCYTE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; DEMYELINATING DISEASE; DISEASE COURSE; DISEASE DURATION; DOWN REGULATION; EXPANDED DISABILITY STATUS SCALE; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE ONTOLOGY; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; HUMAN; IMMUNOGENETICS; IMMUNOSUPPRESSIVE TREATMENT; INNATE IMMUNITY; MALE; MEMORY T LYMPHOCYTE; MICROARRAY ANALYSIS; MIDDLE AGED; MONOCYTE; MULTIPLE SCLEROSIS; NERVE DEGENERATION; OVERLAPPING GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; UPREGULATION;

ADULT; CD4-POSITIVE T-LYMPHOCYTES; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION; HUMANS; IMMUNITY, INNATE; LYMPHOCYTE ACTIVATION; MIDDLE AGED; MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; RECEPTORS, ANTIGEN, T-CELL;

EID: 84895791295     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0000000000000146     Document Type: Article

References (35)

1. Muraro PA, Pette M, Bielekova B, McFarland HF, Martin R. Human autoreactive CD41 T cells from naive CD45RA1 and memory CD45RO1 subsets differ with respect to epitope specificity and functional antigen avidity. J Immunol 2000;164:5474-5481.
2. Haegert DG, Hackenbroch JD, Duszczyszyn D, et al. Reduced thymic output and peripheral naive CD4 T-cell alterations in primary progressive multiple sclerosis (PPMS). J Neuroimmunol 2011;233:233-239.
3. Khoruts A, Fraser JM. A causal link between lymphopenia and autoimmunity. Immunol Lett 2005;98:23-31.
4. King C, Ilic A, Koelsch K, Sarvetnick N. Homeostatic expansion of T cells during immune insufficiency generates autoimmunity. Cell 2004;117:265-277.
5. Corvol JC, Pelletier D, Henry RG, et al. Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event. Proc Natl Acad Sci USA 2008;105:11839-11844.
6. Confavreux C, Vukusic S, Adeleine P. Early clinical predictors and progression of irreversible disability in multiple sclerosis: an amnesic process. Brain 2003; 126:770-782.
7. McDonald WI, Compston A, Edan G, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001;50:121-127.
8. Whitney AR, Diehn M, Popper SJ, et al. Individuality and variation in gene expression patterns in human blood. Proc Natl Acad Sci USA 2003;100:1896-1901.
9. Gautier L, Cope L, Bolstad BM, Irizarry RA. Affy: analysis of Affymetrix GeneChip data at the probe level. Bioinformatics 2004;20:307-315.
10. R Development Core Team. R: a language and environment for statistical computing [online]. Available at: http://www. r-project.org/. Accessed February 1, 2011.
11. Yang Y, Paquet A, Dudoit S. Marray: exploratory analysis for two-colour spotted microarray data [online]. Available at: http://www.bioconductor.org/ packages/2.12/bioc/html/ marray.html. Accessed February 10, 2011.
12. Jain A. Data clustering: 50 years beyond K-means. Pattern Recognit Lett 2010;31:651-666.
13. Mootha VK, Lindgren CM, Eriksson KF, et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 2003;34:267-273.
14. Subramanian A, Kuehn H, Gould J, Tamayo P, Mesirov JP. GSEA-P: a desktop application for gene set enrichment analysis. Bioinformatics 2007;23:3251-3253.
15. Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 2008;3: 1101-1108.
16. Suzuki R, Shimodaira H. Pvclust: an R package for hierarchical clustering with p-values [online]. Available at: http://www.is.titech.ac.jp/shimo/prog/ pvclust. Accessed April 15, 2010.
17. Wang M, Windgassen D, Papoutsakis ET. Comparative analysis of transcriptional profiling of CD31, CD41 and CD81 T cells identifies novel immune response players in T-cell activation. BMC Genomics 2008;9:225.
18. Chtanova T, Newton R, Liu SM, et al. Identification of T cell-restricted genes, and signatures for different T cell responses, using a comprehensive collection of microarray datasets. J Immunol 2005;175:7837-7847.
19. Sawcer S, Hellenthal G, Pirinen M, et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 2011;476:214-219.
20. von Essen MR, Kongsbak M, Schjerling P, Olgaard K, Odum N, Geisler C. Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nat Immunol 2010;11:344-349.
21. Gonzalez-Navajas JM, Fine S, Law J, et al. TLR4 signaling in effector CD41 T cells regulates TCR activation and experimental colitis in mice. J Clin Invest 2010;120: 570-581.
22. Komai-Koma M, Jones L, Ogg GS, Xu D, Liew FY. TLR2 is expressed on activated T cells as a costimulatory receptor. Proc Natl Acad Sci USA 2004;101:3029-3034.
23. MacLeod H, Wetzler LM. T cell activation by TLRs: a role for TLRs in the adaptive immune response. Sci STKE 2007;2007:pe48.
24. Wahlstrom J, Berlin M, Skold CM, Wigzell H, Eklund A, Grunewald J. Phenotypic analysis of lymphocytes and monocytes/macrophages in peripheral blood and bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis. Thorax 1999;54:339-346.
25. Tremlett H, Yinshan Z, Devonshire V. Natural history of secondary-progressive multiple sclerosis. Mult Scler 2008; 14:314-324.
26. Gandhi KS, McKay FC, Cox M, et al. The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis. Hum Mol Genet 2010;19:2134-2143.
27. Duszczyszyn DA, Beck JD, Antel J, et al. Altered naive CD4 and CD8 T cell homeostasis in patients with relapsing-remitting multiple sclerosis: thymic versus peripheral (non-thymic) mechanisms. Clin Exp Immunol 2006;143:305-313.
28. Duszczyszyn DA, Williams JL, Mason H, Lapierre Y, Antel J, Haegert DG. Thymic involution and proliferative T-cell responses in multiple sclerosis. J Neuroimmunol 2010;221:73-80.
29. Babu S, Blauvelt CP, Kumaraswami V, Nutman TB. Cutting edge: diminished T cell TLR expression and function modulates the immune response in human filarial infection. J Immunol 2006;176:3885-3889.
30. Linsley PS, Bradshaw J, Urnes M, Grosmaire L, Ledbetter JA. CD28 engagement by B7/BB-1 induces transient down-regulation of CD28 synthesis and prolonged unresponsiveness to CD28 signaling. J Immunol 1993;150:3161-3169.
31. Achiron A, Grotto I, Balicer R, Magalashvili D, Feldman A, Gurevich M. Microarray analysis identifies altered regulation of nuclear receptor family members in the pre-disease state of multiple sclerosis. Neurobiol Dis 2010;38:201-209.
32. Satoh J, Nakanishi M, Koike F, et al. T cell gene expression profiling identifies distinct subgroups of Japanese multiple sclerosis patients. J Neuroimmunol 2006;174: 108-118.
33. Panitch H, Miller A, Paty D, Weinshenker B. Interferon beta-1b in secondary progressive MS: results from a 3-year controlled study. Neurology 2004;63:1788-1795.
34. European Study Group on Interferon Beta-1b in Secondary Progressive MS. Placebo-controlled multicentre randomised trial of interferon beta-1b in treatment of secondary progressive multiple sclerosis. Lancet 1998; 352:1491-1497.
35. Kappos L, Weinshenker B, Pozzilli C, et al. Interferon beta-1b in secondary progressive MS: a combined analysis of the two trials. Neurology 2004;63:1779-1787.