The expression of HIV-1 Vpu in monocytes causes increased secretion of TGF-β that activates profibrogenic genes in hepatic stellate cells

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Patel, Paresh ^a   Kha, Nabab ^a   Ran, Manjusha ^a   Gupta, Deepti ^a   Jameel, Shahid ^a,b  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^b Wellcome Trust/DBT India Alliance   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CD317 ANTIGEN; CD4 ANTIGEN; COLLAGEN TYPE 1; LYMPHOCYTE ANTIGEN; MACROPHAGE MIGRATION INHIBITION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VPU PROTEIN;

ARTICLE; BINDING AFFINITY; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNE RESPONSE; LIVER FIBROSIS; MONOCYTE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN SYNTHESIS; STELLATE CELL;

BIOLOGICAL MARKERS; CELL LINE; COCULTURE TECHNIQUES; FIBROSIS; GENE EXPRESSION REGULATION; HEPATIC STELLATE CELLS; HUMAN IMMUNODEFICIENCY VIRUS PROTEINS; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MONOCYTES; TRANSCRIPTION FACTOR AP-1; TRANSFORMING GROWTH FACTOR BETA; TRANSGENES; VIRAL REGULATORY AND ACCESSORY PROTEINS;

EID: 84895788719     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0088934     Document Type: Article

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