Improved recurrence-free survival with ARCON for anemic patients with laryngeal cancer

Clinical Cancer Research

Volumn 20, Issue 5, 2014, Pages 1345-1354

  Janssens, Geert O ^a   Rademakers, Saskia E ^a   Terhaard, Chris H ^b   Doornaert, Patricia A ^c   Bijl, Hendrik P ^e   Van Den Ende, Piet ^f   Chin, Alim ^g   Takes, Robert P ^a   De Bree, Remco ^d   Hoogsteen, Ilse J ^a   Bussink, Johan ^a   Span, Paul N ^a   Kaanders, Johannes H ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c Departments of Radiation Oncology   (Netherlands)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^f MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^g LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOGEN; HEMOGLOBIN; NICOTINAMIDE; PIMONIDAZOLE;

ACCELERATED RADIOTHERAPY COMBINED WITH CARBOGEN BREATHING AND NICOTINAMIDE; ADULT; AGED; ANEMIA; ARTICLE; CANCER CONTROL; CANCER PROGNOSIS; CANCER STAGING; CANCER THERAPY; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; FOLLOW UP; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN TISSUE; LARYNX CANCER; MAJOR CLINICAL STUDY; MALE; OPEN STUDY; OUTCOME ASSESSMENT; OXYGENATION; PATIENT MONITORING; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; RADIATION DOSE FRACTIONATION; RANDOMIZED CONTROLLED TRIAL; RECURRENCE FREE SURVIVAL; TREATMENT DURATION; TREATMENT RESPONSE; TUMOR BIOPSY;

ADULT; AGED; AGED, 80 AND OVER; ANEMIA; ANOXIA; BIOLOGICAL MARKERS; CARBON DIOXIDE; FEMALE; HEMOGLOBINS; HUMANS; LARYNGEAL NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; NIACINAMIDE; OXYGEN; PROGNOSIS; RADIATION-SENSITIZING AGENTS; RADIOTHERAPY; TREATMENT OUTCOME;

EID: 84895788001     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-13-1730     Document Type: Article

References (34)

1. Harrison L, Shasha D, Shiaova L, White C, Ramdeen B, Portenoy R. Prevalence of anemia in cancer patients undergoing radiation therapy. Semin Oncol 2001;28:54-9.
2. Grau C, Overgaard J. Significance of hemoglobin concentration for treatment outcome. In:Molls M, Vaupel P, editors. Blood perfusion and microenvironment of human tumors. Berlin/Heidelberg/New York: Springer-Verlag; 1998. p. 101-12.
3. Hoff CM, Lassen P, Eriksen JG, Hansen HS, Specht L, Overgaard M, et al. Does transfusion improve the outcome for HNSCC patients treated with radiotherapy?-Results from the randomized DAHANCA 5 and 7 trials. Acta Oncol 2011;50:1006-14.
4. Henke M, Sindlinger F, Ikenberg H, Gerds T, Schumacher M. Blood hemoglobin level and treatment outcome of early breast cancer. Strahlenther Onkol 2004;180:45-51.
5. Henke M, Laszig R, Rübe C, Schäfer U, Haase KD, Schilcher B, et al. Erythropoietin to treat head and neck cancer patients with anemia undergoing radiotherapy: randomized, double-blind, placebo-controlled trial. Lancet 2003;362:1255-60.
6. Leyland-Jones B. Breast cancer trial with erythropoietin terminated unexpectedly. Lancet Oncol 2003;4:459-60.
7. Lambin P, Ramaekers BL, van Mastrigt GA, van den Ende P, de Jong J, De Ruysscher DK, et al. Erythropoietin as an adjuvant treatment with (chemo) radiation therapy for head and neck cancer (review). Cochrane Database Syst Rev 2009;3:1-30.
8. Hoogsteen IJ, Pop LA, Marres HA, Merkx MA, van den Hoogen FJ, van der Kogel AJ, et al. Oxygen-modifying treatment with ARCON reduces the prognostic significance of hemoglobin in squamous cell carcinoma of the head and neck. Int J Radiat Biol Phys 2006;64:83-9.
9. Kaanders JH, Bussink J, van der Kogel AJ. ARCON: a novel biology-based approach in radiotherapy. Lancet Oncol 2002;3: 728-37.
10. Janssens GO, Terhaard CH, Doornaert PA, Bijl HP, van den Ende P, Chin A, et al. Acute toxicity profile and compliance to ARCON for clinical stage T2-4 laryngeal cancer: results of a phase III randomized trial. Int J Radiat Oncol Biol Phys 2012;82: 532-8.
11. Janssens GO, Rademakers SE, Terhaard CH, Doornaert PA, Bijl HP, van den Ende P, et al. Accelerated radiotherapy with carbogen and nicotinamide for laryngeal cancer: Results of a phase III randomized trial. J Clin Oncol 2012;30:1777-82.
12. Henk JM, Kunkler PB, Smith CW. Radiotherapy and hyperbaric oxygen in head and neck cancer. Final report of first controlled clinical trial. Lancet 1977;2:101-3.
13. Haustermans K, van der Kogel AJ, Vanacker B, van der Schueren E. Influence of combined use of nicotinamide and carbogen on rat spinal cord radiation tolerance. Radiother Oncol 1994;31: 123-8.
14. Hoogsteen IJ, Lok J, Marres HA, Takes RP, Rijken PF, van der Kogel AJ, et al. Hypoxia in larynx carcinomas assessed by pimonidazole binding and the value of CA-IX and vascularity as surrogate markers of hypoxia. Eur J Cancer 2009;45:2906-14.
15. Vaupel P. Hypoxia and aggressive tumor phenotype: implications for therapy and prognosis. Oncologist 2008;13:21-6.
16. Becker A, Stadler P, Lavey RS, Hänsgen G, Kuhnt T, Lautenschlaäger C, et al. Severe anemia is associated with poor tumor oxygenation in head and neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys 2000;46:459-66.
17. Henke M, Mattern D, Pepe M, Bezay C, Weissenberger C, Werner M, et al. Do erythropoietin receptors on cancer cells explain unexpected clinical findings? J Clin Oncol 2006;24:4708-13.
18. Varlotto J, Stevenson MA. Anemia, tumor hypoxemia, and the cancer patient. Int J Radiat Oncol Biol Phys 2005;63:25-36.
19. Prosnitz RG, Yao B, Farrell CL, Clough R, Brizel DM. Pretreatment anemia is correlated with reduced effectiveness of radiation and concurrent chemotherapy in advanced head and neck cancer. Int J Radiat Oncol Biol Phys 2005;61:1087-95.
20. Denis F, Garaud P, Bardet E, Alfonsi M, Sire C, Germain T, et al. Final results of the 94-01 French head and neck oncology and radiotherapy group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma. J Clin Oncol 2004;22:69-76.
21. Hirst DG. Anemia: a problem or an opportunity in radiotherapy? Int J Radiat Biol Phys 1986;12:2009-17.
22. Tannock IF. Effects of pO2 on cell proliferation kinetics. In:Bond VP, Suit HD, Marcial V, editors. Time and dose relationships in radiation biology as applied to radiotherapy. Upton, Brookhaven National Laboratory; 1970. p. 215-24.
23. Hirst DG, Wood PJ. The adaptive response of mouse tumors to anemia and retransfusion. Int J Radiat Biol Rel Stud Phys Chem Med 1987;51:597-609.
24. Overgaard J. Hypoxic modification of radiotherapy in squamous cell carcinoma of the head and neck: a systematic review and metaanalysis. Radiother Oncol 2011;100:22-32.
25. Dische S, Anderson PJ, Sealy R, Watson ER. Carcinoma of the cervix-anaemia, radiotherapy and hyperbaric oxygen. Br J Radiol 1983;56: 251-5.
26. McCormack M, Nias AH, Smith E. Chronic anaemia, hyperbaric oxygen and tumour radiosensitivity. Br J Radiol 1990;63:752-9.
27. Harrison L, Blackwell K. Hypoxia and anemia: factors in decreased sensitivity to radiation therapy and chemotherapy? Oncologist 2004; 9:31-40.
28. Kelleher DK, Matthiensen Thews O, Vaupel P. Blood flow, oxygenation, and bioenergetic status of tumors after erythropoietin treatment in normal and anemic rats. Cancer Res 1996;56:4728-34.
29. Nordsmark M, Bentzen SM, Rudat V, Brizel D, Lartigau E, Stadler P, et al. Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy: an international multi-center study. Radiother Oncol 2005;77:18-24.
30. Rudat V, VanselowB, Wollensack P, Bettscheider C, Osman-Ahmet S, Eble MJ, et al. Repeatability and prognostic impact of the pretreatment pO2 histography in patients with advanced head and neck cancer. Radiother Oncol 2000;57:31-7.
31. Kim JW, Dang CV. Cancer's molecular sweet tooth and the Warburg effect. Cancer Res 2006;66:8927-30.
32. Meijer TW, Kaanders JH, Span PN, Bussink J. Targeting hypoxia, HIF-1 and tumor glucose metabolism to improve radiotherapy efficacy. Clin Cancer Res 2012;18:5585-94.
33. Bron D, Meuleman N, Mascaux C. Biological basis of anemia. Semin Oncol 2001;28:1-6.
34. Forastiere AA, Goepfert H, Maor M, Pajak TF, Weber R, Morrison W, et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 2003;349: 2091-8.