Blood flow, oxygenation, and bioenergetic status of tumors after erythropoietin treatment in normal and anemic rats

Cancer Research

Volumn 56, Issue 20, 1996, Pages 4728-4734

  Kelleher, Debra K ^a   Matthiensen, Ulrike ^a   Thews, Oliver ^a   Vaupel, Peter ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT ERYTHROPOIETIN;

ANEMIA; ANIMAL EXPERIMENT; ARTICLE; CANCER RADIOTHERAPY; CONTROLLED STUDY; DRUG EFFECT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SARCOMA; TUMOR BLOOD FLOW; TUMOR GROWTH;

ANEMIA; ANIMALS; DRUG SCREENING ASSAYS, ANTITUMOR; ERYTHROPOIETIN, RECOMBINANT; HEMOGLOBIN A; MALE; NEOPLASMS, EXPERIMENTAL; OXYGEN; RATS; RATS, SPRAGUE-DAWLEY; REGIONAL BLOOD FLOW;

EID: 0029795885     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Vaupel, P., Kallinowski, F., and Okunieff, P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res., 49: 6449-6465, 1989
2. Vaupel, P Pathophysiological mechanisms of hyperthermia in cancer therapy. In: M. Gautherie (ed ), Biological Basis of Oncologic Thermotherapy, pp. 73-134. Berlin: Springer-Verlag, 1990.
3. Vaupel, P. W. Oxygenation of solid tumors In: B. A Teicher (ed.), Drug Resistance in Oncology, pp. 53-85. New York: Marcel Dekker, Inc., 1993
4. Bush, R S Current status of treatment of localized disease and future aspects. Int. J. Radiat. Oncol. Biol. Phys., 10: 1165-1174, 1984
5. Bush, R S , Jenkin, R D. T , Allt, W. E. C , Beale, F A , Bean, H , Dembo, A. J., and Pringle, J F Definitive evidence for hypoxic cells influencing cure in cancer therapy. Br J Cancer, 37 (Suppl. 3): 302-306, 1978
6. Dische, S., Anderson, P. J , Sealy, R., and Watson, E. R. Carcinoma of the cervix: anaemia, radiotherapy and hyperbaric oxygen. Br. J. Radiol , 56. 251-255, 1983
7. Hoeckel, M , Schlenger, K , Mitze, M., Schaeffer, U., and Vaupel, P. Hypoxia and radiation response in human tumors. Semin. Radiat. Oncol., 6: 1-8, 1996.
8. Graeber, T. G , Osmanian, C , Jacks, T , Housman, D E , Koch, C. J., Lowe, S. W., and Giaccia, A. J Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours Nature (Lond ), 379: 88-91, 1996.
9. Cartwright, G. E. The anemia of chronic disorders. Semin Hematol., 3: 351-375, 1966
10. Levine, E. A., and Vijayakumar, S. Blood transfusion in patients receiving radical radiotherapy a reappraisal Onkologie, 16: 79-87, 1993.
11. Blumberg, N , and Heal, J M Transfusion and recipient immune function. Arch. Pathol. Lab. Med , 113: 246-253, 1989.
12. Brunson, M. E., and Alexander, J. W. Mechanisms of transfusion-induced immunosuppression. Transfusion (Arlingt ), 30: 651-658, 1990
13. Francis, D M. A Relationship between blood transfusion and tumour behaviour. Br J. Surg , 78: 1420-1428, 1991.
14. Heiss, M. M , Mempel, W., Delanoff, C., Jauch, K-W., Gabka, C., Mempel, M , Dieterich, H-J., Eissner, H-J , and Schildberg, F-W. Blood transfusion-modulated tumor recurrence: first results of a randomized study of autologous versus allogeneic blood transfusion in colorectal cancer surgery J Clin Oncol., 12 1859-1867, 1994
15. Case, D C , Bukowski, R. M , Carey, R W , Fishkin, E H , Henry, D H , Jacobson, R J , Jones, S E , Keller, A M., Kugler, J. W , Nichols, C R., Salmon, S E., Silver, R T , Storniolo, A M., Wampler, G. L , Dooley, C M , Larholt, K. M , Nelson, R A., and Abels, R. I. Recombinant human erythropoietin therapy for anemic cancer patients on combination chemotherapy J. Natl Cancer Inst , 85: 801-806, 1993
16. Miller, C. B , Platanias, L. C , Mills, S R , Zahurak, M L , Ratain, M J., Ettinger, D S., and Jones, R. J Phase I-II trial of erythropoietin in the treatment of cisplatin-associated anemia. J. Natl Cancer Inst , 84: 98-103, 1992
17. Bajetta, E., Di Bartolomeo, M , Buzzoni, R., Bochiechio, A M., and Colleoni, M Recombinant human erythropoietin (rHuEPO) in the treatment of anemia associated with solid tumors with or without bone marrow infiltration. Int J. Oncol., 3: 1121-1126, 1993.
18. Abels, R. I , Larholt, K. M., Krantz, K D , and Bryant, E. C Recombinant human erythropoietin (r-HuEPO) for the treatment of the anemia of cancer. In: M. J. Murphy (ed.), Blood Cell Growth Factors: Their Present and Future Use in Hematology and Oncology, pp 121-141. Dayton, OH: AlphaMed Press, 1991.
19. Vijayakumar, S., Roach, M , Wara, W., Chan, S. K., Ewing, C., Rubin, S , Sutton, H., Halpern, H , Awan, A., Houghton, A., Quiet, C., and Weichselbaum, R. Effect of subcutaneous recombinant human erythropoietin in cancer patients receiving radiotherapy: preliminary results of a randomized, open-labeled, phase II trial. Int. J Radiat. Oncol. Biol Phys., 26: 721-729, 1993.
20. Lavey, R. S., and Dempsey, W. H. Erythropoietin increases hemoglobin in cancer patients during radiation therapy Int J. Radial. Oncol Biol. Phys , 27: 1147-1152, 1993
21. Adamson, J W., and Spivak, J. L. Physiologic basis for the pharmacologic use of recombinant human erythropoietin in surgery and cancer treatment. Surgery (St. Louis), 115: 7-15, 1994
22. Dusenbery, K. E., McGuire, W. A., Holt, P. J., Carson, L F , Fowler, J M., Twiggs, L. B., and Potish, R. A. Erythropoietin increases hemoglobin during radiation therapy for cervical cancer. Int. J. Radiat. Oncol. Biol Phys., 29: 1079-1084, 1994.
23. Kluge, M., Elger, B., Engel, T., Schaefer, C , Seega, J, and Vaupel, P. Acute effects of tumor necrosis factor α or lymphotoxin on global blood flow, laser Doppler flux, and bioenergetic status of subcutaneous rodent tumors. Cancer Res., 52: 2167-2173, 1992.
24. Bork, R., Vaupel, P., and Thews, G. Atemgas-pH-Nomogramme fur das Rattenblut bei 37°C Anaesthesist, 24: 84-90, 1975.
25. Menke, H , and Vaupel, P. Effect of injectable or inhalational anesthetics and of neuroleptic, neuroleptanalgesic, and sedative agents on tumor blood flow Radiat Res., 114: 64-76, 1988.
26. 133xenon in water, saline, lipids, and blood. Scand. J. Clin. Lab. Invest., 29: 127-242, 1972.
27. 2 tension measurements. Cancer Res., 51: 3316-3322, 1991.
28. Krueger, W , Mayer, W-K , Schaefer, C., Stohrer, M , and Vaupel, P. Acute changes of systemic parameters in tumor-bearing rats, and of tumor glucose, lactate, and ATP levels upon local hyperthermia and/or hyperglycaemia. J. Cancer Res. Clin. Oncol., 117: 409-415, 1991.
29. Vaupel, P. W. Blood flow, oxygenation, tissue pH distribution, and bioenergetic status of tumors, Lecture 23 Berlin: Ernst Schering Research Foundation, 1994
30. 2 predicts survival in advanced cancer of the uterine cervix. Radiother Oncol., 26: 45-50, 1993.
31. Nordsmark, M., Overgaard, M , and Overgaard, J. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother. Oncol , in press, 1996.
32. Brizel, D. M., Scully, S. P., Harrelson, J. M., Layfield, L J., Bean, J. M., Prosnitz, L. R., and Dewhirst, M. W. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res , 56: 941-943, 1996.
33. Joiner, B., Hirst, V. K., McKeown, S. R., McAleer, J. J. A., and Hirst, D. G. The effect of recombinant human erythropoietin treatment on tumour radiosensitivity and cancer-associated anaemia in the mouse. Br J. Cancer, 68: 720-726, 1993.
34. McCormack, M , Nias, A. H. W., and Smith, E. Chronic anaemia, hyperbaric oxygen and tumour radiosensitivity Br. J. Radiol., 63: 752-759, 1990.
35. Tannock, I. F , and Steel, G. G. Tumor growth and cell kinetics in chronically hypoxic animals. J Natl. Cancer Inst., 45. 123-133, 1970
36. Hartveit, F., and Halleraker, B. Effect of subcutaneous transplants of Ehrlich carcinoma on the survival time of mice with intraperitoneal transplants of the same tumor. J Pathol., 105: 85-93, 1971.
37. Bauer, E., Danhauser-Riedl, S., De Riese, W., Raab, H-R., Sandner, S., Meyer, H-J., Neukam, D., Hanauske, U., Freund, M , Poliwoda, H., Rastetter, J , and Hanauske, A-R. Effects of recombinant human erythropoietin on clonogenic growth of primary human tumor specimens in vitro. Onkologie, 15, 254-258, 1992.
38. Mundt, D., Berger, M. R , and Bode, G. Effect of recombinant human erythropoietin on the growth of human tumor cell lines in vitro, Arzneim-Forsch., 42: 92-95, 1992.
39. Rosti, V., Pedrazzoli, P , Ponchio, L , Zibera, C., Novella, A., Luc̀otti, C., Robustelli Della Cuna, G , and Cazzola, M. Effect of recombinant human erythropoietin on hematopoietic and non-hematopoietic malignant cell growth in vitro. Haematologica, 78: 208-212, 1993.
40. Festa, R. S , and Asakura, T Oxygen dissociation curves in children with anemia and malignant disease. Am. J Hematol , 7: 233-244, 1979.
41. Torrance, J , Jacobs, P , Restrepo, A., Eschbach, J., Lenfant, C., and Finch, C. A. Intraerythrocytic adaptation to anemia. N. Engl. J. Med., 283: 165-169, 1970.
42. Rojas, A., Stewart, F. A., Smith, K. A., Soranson, J. A., Randhawa, V S , Stratford, M. R., and Denekamp, J. Effect of anemia on tumor radiosensitivity under normo and hyperbaric conditions. Int. J. Radiat. Oncol. Biol. Phys., 13: 1681-1689, 1987.
43. Sevick, E. M , and Jain, R K. Viscous resistance to blood flow in solid tumors: effect of hematocrit on intratumor blood viscosity. Cancer Res., 49, 3513-3519, 1993.
44. Gerweck, L. E., Seneviratne, T , and Gerweck, K. K. Energy status and radiobiological hypoxia at specified oxygen concentrations Radiat. Res., 135 69-74, 1993.