Long-term immune reconstitution and infection burden after mismatched hematopoietic stem cell transplantation

Biology of Blood and Marrow Transplantation

Volumn 20, Issue 4, 2014, Pages 507-517

  Servais, Sophie ^a,c   Lengline, Etienne ^a   Porcher, Raphaël ^a   Carmagnat, Maryvonnick ^a   Peffault de Latour, Régis ^a   Robin, Marie ^a   Sicre de Fontebrune, Flore ^a   Clave, Emmanuel ^a   Maki, Guitta ^a   Granier, Clémence ^a   Xhaard, Alienor ^a   Dhedin, Nathalie ^a   Molina, Jean Michel ^a,b   Toubert, Antoine ^a,b   Moins Teisserenc, Hélène ^a,b   Socie, Gérard ^a,b  

^a SAINT LOUIS HOSPITAL   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Hematopoietic stem cell transplantation; Immune reconstitution; Infection

Indexed keywords

ACUTE CHOLECYSTITIS; ADENOVIRUS INFECTION; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; B LYMPHOCYTE; BACTEREMIA; BACTERIAL INFECTION; BACTERIAL PNEUMONIA; BACTERIAL SKIN DISEASE; BACTEROIDES INFECTION; CANDIDEMIA; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULITIS; COLITIS; CYTOMEGALOVIRUS INFECTION; EFFECTOR CELL; ENTEROBACTERIACEAE INFECTION; ENTEROCOCCAL INFECTION; EPSTEIN BARR VIRUS INFECTION; ESCHERICHIA COLI INFECTION; FEMALE; GRAFT VERSUS HOST REACTION; GRAM NEGATIVE INFECTION; HAEMOPHILUS INFECTION; HERPES SIMPLEX; HIGH RISK POPULATION; HLA MATCHING; HUMAN; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; IMMUNOPHENOTYPING; INFECTION; INFECTION RATE; INFECTION RISK; INFLUENZA; KLEBSIELLA PNEUMONIAE INFECTION; LUNG ASPERGILLOSIS; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MEMORY T LYMPHOCYTE; MORTALITY; MYCOSIS; NATURAL KILLER CELL; PARAINFLUENZA VIRUS INFECTION; PATHOGEN LOAD; PNEUMOCOCCAL INFECTION; PROSPECTIVE STUDY; PROTEUS INFECTION; PSEUDOMONAS INFECTION; REGULATORY T LYMPHOCYTE; RESPIRATORY SYNCYTIAL VIRUS INFECTION; SEPTIC SHOCK; SKIN ABSCESS; STREPTOCOCCUS VIRIDANS INFECTION; SURVIVAL TIME; SYSTEMIC MYCOSIS; T LYMPHOCYTE SUBPOPULATION; TOXOPLASMOSIS; UMBILICAL CORD BLOOD; UNRELATED DONORS; UPPER RESPIRATORY TRACT INFECTION; URINARY TRACT INFECTION; VIRUS INFECTION; YOUNG ADULT;

HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNE RECONSTITUTION; INFECTION;

ADOLESCENT; ADULT; BACTERIAL INFECTIONS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHILD; GRAFT SURVIVAL; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOCOMPATIBILITY TESTING; HLA ANTIGENS; HUMANS; IMMUNOLOGIC MEMORY; KILLER CELLS, NATURAL; LYMPHOCYTE COUNT; MIDDLE AGED; MYCOSES; T-LYMPHOCYTE SUBSETS; TISSUE DONORS; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME; VIRUS DISEASES;

EID: 84895785554     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2014.01.001     Document Type: Article

References (44)

1. Ballen K.K., Koreth J., Chen Y.B., et al. Selection of optimal alternative graft source: mismatched unrelated donor, umbilical cord blood, or haploidentical transplant. Blood 2012, 119:1972-1980.
2. Abrahamsen I.W., Somme S., Heldal D., et al. Immune reconstitution after allogeneic stem cell transplantation: the impact of stem cell source and graft-versus-host disease. Haematologica 2005, 90:86-93.
3. Auletta J.J., Lazarus H.M. Immune restoration following hematopoietic stem cell transplantation: an evolving target. Bone Marrow Transplant 2005, 35:835-857.
4. Wingard J.R. Opportunistic infections after blood and marrow transplantation. Transpl Infect Dis 1999, 1:3-20.
5. Brown J.A., Boussiotis V.A. Umbilical cord blood transplantation: basic biology and clinical challenges to immune reconstitution. Clin Immunol 2008, 127:286-297.
6. Geddes M., Storek J. Immune reconstitution following hematopoietic stem-cell transplantation. Best Pract Res Clin Haematol 2007, 20:329-348.
7. Jacobson C.A., Turki A.T., McDonough S.M., et al. Immune reconstitution after double umbilical cord blood stem cell transplantation: comparison with unrelated peripheral blood stem cell transplantation. Biol Blood Marrow Transplant 2011, 18:565-574.
8. Bacigalupo A., Ballen K., Rizzo D., et al. Defining the intensity of conditioning regimens: working definitions. Biol Blood Marrow Transplant 2009, 15:1628-1633.
9. Arai S., Jagasia M., Storer B., et al. Global and organ-specific chronic graft-versus-host disease severity according to the 2005 NIH Consensus Criteria. Blood 2011, 118:4242-4249.
10. Calandra T., Cohen J. The international sepsis forum consensus conference on definitions of infection in the intensive care unit. Crit Care Med 2005, 33:1538-1548.
11. Robin M., Porcher R., De Castro Araujo R., et al. Risk factors for late infections after allogeneic hematopoietic stem cell transplantation from a matched related donor. Biol Blood Marrow Transplant 2007, 13:1304-1312.
12. Copelan E., Casper J.T., Carter S.L., et al. Ascheme for defining cause of death and its application in the T cell depletion trial. Biol Blood Marrow Transplant 2007, 13:1469-1476.
13. Corre E., Carmagnat M., Busson M., et al. Long-term immune deficiency after allogeneic stem cell transplantation: B-cell deficiency is associated with late infections. Haematologica 2012, 95:1025-1029.
14. Purves R.D. Optimum numerical integration methods for estimation of area-under-the-curve (AUC) and area-under-the-moment-curve (AUMC). JPharmacokinet Biopharm 1992, 20:211-226.
15. Kalbeisch J.D., Prentice R.L. The Statistical Analysis of Failure Time Data 1980, John Wiley & Sons, New York.
16. Gray R. Aclass of k-sample tests for comparing the cumulative incidence of a competing risk. Ann Stat 1988, 16:1141-1154.
17. Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. JRoy Stat Soc 1995, 57:289-300.
18. Prentice R.L., Williams B.J., Peterson A.V. On the regression analysis of multivariate failure time data. Biometrika 1981, 68:373-379.
19. Wulfsohn M.S., Tsiatis A.A. Ajoint model for survival and longitudinal data measured with error. Biometrics 1997, 53:330-339.
20. Peters S.A., Bots M.L., den Ruijter H.M., et al. Multiple imputation of missing repeated outcome measurements did not add to linear mixed-effects models. JClin Epidemiol 2012, 65:686-695.
21. Twisk J., de Boer M., de Vente W., Heymans M. Multiple imputation of missing values was not necessary before performing a longitudinal mixed-model analysis. JClin Epidemiol 2013, 66:1022-1028.
22. Prentice R.L., Kalbeisch J.D., Peterson A.V., Flournoy N., et al. The analysis of failure times in the presence of competing risks. Biometrics 1978, 34:541-554.
23. Grambsch P., Therneau T. Proportional hazards tests and diagnostics based on weighted residual. Biometrika 1994, 81:515-556.
24. R: A Language and Environment for Statistical Computing 2012, R, R Foundation for Statistical ComputingVienna, Austria, ISBN 3-900051-07-0 2012. Available at. http://wwwr-projectorg/.
25. Rizopoulos D. An R package for the joint modelling of longitudinal and time-to-event data. JStat Software 2010, 35:1-33.
26. Chao N.J., Emerson S.G., Weinberg K.I. Stem cell transplantation (cord blood transplants). Hematology Am Soc Hematol Educ Program 2004, 354-371.
27. Komanduri K.V., St John L.S., de Lima M., et al. Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing. Blood 2007, 110:4543-4551.
28. Parody R., Martino R., Rovira M., et al. Severe infections after unrelated donor allogeneic hematopoietic stem cell transplantation in adults: comparison of cord blood transplantation with peripheral blood and bone marrow transplantation. Biol Blood Marrow Transplant 2006, 12:734-748.
29. Sauter C., Abboud M., Jia X., et al. Serious infection risk and immune recovery after double-unit cord blood transplantation without antithymocyte globulin. Biol Blood Marrow Transplant 2011, 17:1460-1471.
30. Mikulska M., Raiola A.M., Bruzzi P., et al. CMV infection after transplant from cord blood compared to other alternative donors: the importance of donor-negative CMV serostatus. Biol Blood Marrow Transplant 2012, 18:92-99.
31. Walker C.M., van Burik J.A., De For T.E., Weisdorf D.J. Cytomegalovirus infection after allogeneic transplantation: comparison of cord blood with peripheral blood and marrow graft sources. Biol Blood Marrow Transplant 2007, 13:1106-1115.
32. Hamza N.S., Lisgaris M., Yadavalli G., et al. Kinetics of myeloid and lymphocyte recovery and infectious complications after unrelated umbilical cord blood versus HLA-matched unrelated donor allogeneic transplantation in adults. Br J Haematol 2004, 124:488-498.
33. Burke M.J., Vogel R.I., Janardan S.K., et al. Early lymphocyte recovery andoutcomes after umbilical cord blood transplantation (UCBT) for hematologic malignancies. Biol Blood Marrow Transplant 2011, 17:831-840.
34. Atsuta Y., Morishima Y., Suzuki R., et al. Comparison of unrelated cord blood transplantation and HLA-mismatched unrelated bone marrow transplantation for adults with leukemia. Biol Blood Marrow Transplant 2013, 18:780-787.
35. Laughlin M.J., Eapen M., Rubinstein P., et al. Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. NEngl J Med 2004, 351:2265-2275.
36. Ringden O., Okas M., Uhlin M., et al. Unrelated cord blood and mismatched unrelated volunteer donor transplants, two alternatives in patients who lack an HLA-identical donor. Bone Marrow Transplant 2008, 42:643-648.
37. Ponce D.M., Zheng J., Gonzales A.M., et al. Reduced late mortality risk contributes to similar survival after double-unit cord blood transplantation compared with related and unrelated donor hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2011, 17:1316-1326.
38. Chen Y.B., Aldridge J., Kim H.T., et al. Reduced-intensity conditioning stemcell transplantation: comparison of double umbilical cord blood and unrelated donor grafts. Biol Blood Marrow Transplant 2012, 18:805-812.
39. Kanda J., Chiou L.W., Szabolcs P., et al. Immune recovery in adult patients after myeloablative dual umbilical cord blood, matched sibling, and matched unrelated donor hematopoietic cell transplantation. Biol Blood Marrow Transplant 2012, 18:1664-1676.e1661.
40. Talvensaari K., Clave E., Douay C., et al. Abroad T-cell repertoire diversity and an efficient thymic function indicate a favorable long-term immune reconstitution after cord blood stem cell transplantation. Blood 2002, 99:1458-1464.
41. Beaudette-Zlatanova B.C., Le P.T., Knight K.L., et al. Apotential role for Bcells in suppressed immune responses in cord blood transplant recipients. Bone Marrow Transplant 2012, 48:85-93.
42. Renard C., Barlogis V., Mialou V., et al. Lymphocyte subset reconstitution after unrelated cord blood or bone marrow transplantation in children. Br J Haematol 2012, 152:322-330.
43. Szabolcs P., Niedzwiecki D. Immune reconstitution in children after unrelated cord blood transplantation. Biol Blood Marrow Transplant 2008, 14:66-72.
44. Bartelink I.H., Belitser S.V., Knibbe C.A., et al. Immune reconstitution kinetics as an early predictor for mortality using various hematopoietic stem cell sources in children. Biol Blood Marrow Transplant 2013, 19:305-313.