Risk Factors for Late Infections after Allogeneic Hematopoietic Stem Cell Transplantation from a Matched Related Donor

Biology of Blood and Marrow Transplantation

Volumn 13, Issue 11, 2007, Pages 1304-1312

  Robin, Marie ^a   Porcher, Raphaël ^a   De Castro Araujo, Renato ^a   de Latour, Régis Peffault ^a   Devergie, Agnès ^a   Rocha, Vanderson ^a   Larghero, Jérome ^a   Adès, Lionel ^a   Ribaud, Patricia ^a   Mary, Jean Yves ^a   Socié, Gérard ^a  

^a SAINT LOUIS HOSPITAL   (France)

Author keywords

Bone marrow transplantation; Late infection

Indexed keywords

BUSULFAN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; METHOTREXATE; STEROID;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; APLASTIC ANEMIA; ARTICLE; ASPERGILLOSIS; BACTERIAL INFECTION; CAUSE OF DEATH; CHILD; CHRONIC MYELOID LEUKEMIA; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; FEMALE; FOLLOW UP; GRAFT VERSUS HOST REACTION; HEPATITIS C; HERPES VIRUS INFECTION; HIGH RISK PATIENT; HLA MATCHING; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; INFECTION; INFECTION RISK; IRRADIATION; LEUKEMIA RELAPSE; LIVING DONOR; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; MORBIDITY; MORTALITY; MYCOSIS; PARASITOSIS; PROPORTIONAL HAZARDS MODEL; RETROSPECTIVE STUDY; RISK FACTOR; VARICELLA ZOSTER VIRUS; VIRUS INFECTION; WHOLE BODY RADIATION;

ADOLESCENT; ADULT; ANEMIA, APLASTIC; BACTERIAL INFECTIONS; FEMALE; FRANCE; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INCIDENCE; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; LEUKEMIA, MYELOID, ACUTE; MALE; MYCOSES; RETROSPECTIVE STUDIES; RISK FACTORS; SURVIVORS; TRANSPLANTATION, HOMOLOGOUS; VIRUS DISEASES;

EID: 35348832315     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2007.07.007     Document Type: Article

References (38)

1. Dekker A., and Engelhard D. Clinical Bone Marrow and Blood Stem Cell Transplantation. Bacterial Infection. 3rd ed. Vol. 73 (2004), Cambridge University Press, Melbourne, Australia 1158-1179
2. Atkinson K., Farewell V., Storb R., et al. Analysis of late infections after human bone marrow transplantation: role of genotypic nonidentity between marrow donor and recipient and of nonspecific suppressor cells in patients with chronic graft-versus-host disease. Blood 60 (1982) 714-720
3. Ochs L., Shu X.O., Miller J., et al. Late infections after allogeneic bone marrow transplantations: comparison of incidence in related and unrelated donor transplant recipients. Blood 86 (1995) 3979-3986
4. Kulkarni S., Powles R., Treleaven J., et al. Chronic graft versus host disease is associated with long-term risk for pneumococcal infections in recipients of bone marrow transplants. Blood 95 (2000) 3683-3686
5. Hoyle C., and Goldman J.M. Life-threatening infections occurring more than 3 months after BMT. 18 UK Bone Marrow Transplant Teams. Bone Marrow Transplant 14 (1994) 247-252
6. Peffault de Latour R., Levy V., Asselah T., et al. Long-term outcome of hepatitis C infection after bone marrow transplantation. Blood 103 (2004) 1618-1624
7. Strasser S.I., Sullivan K.M., Myerson D., et al. Cirrhosis of the liver in long-term marrow transplant survivors. Blood 93 (1999) 3259-3266
8. Boeckh M., Kim H.W., Flowers M.E., Meyers J.D., and Bowden R.A. Long-term acyclovir for prevention of varicella zoster virus disease after allogeneic hematopoietic cell transplantation-a randomized double-blind placebo-controlled study. Blood 107 (2006) 1800-1805
9. Robin M., Guardiola P., Dombret H., et al. Allogeneic bone marrow transplantation for acute myeloblastic leukaemia in remission: risk factors for long-term morbidity and mortality. Bone Marrow Transplant 31 (2003) 877-887
10. Ades L., Mary J.Y., Robin M., et al. Long-term outcome after bone marrow transplantation for severe aplastic anemia. Blood 103 (2004) 2490-2497
11. Robin M., Guardiola P., Devergie A., et al. A 10-year median follow-up study after allogeneic stem cell transplantation for chronic myeloid leukemia in chronic phase from HLA-identical sibling donors. Leukemia 19 (2005) 1613-1620
12. Ljungman P., Engelhard D., de la Camara R., et al. Vaccination of stem cell transplant recipients: recommendations of the Infectious Diseases Working Party of the EBMT. Bone Marrow Transplant 35 (2005) 737-746
13. Calandra T., and Cohen J. The international sepsis forum consensus conference on definitions of infection in the intensive care unit. Crit Care Med 33 (2005) 1538-1548
14. Goldstein B., Giroir B., and Randolph A. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 6 (2005) 2-8
15. Shulman H.M., Sullivan K.M., Weiden P.L., et al. Chronic graft-versus-host syndrome in man. A long-term clinicopathologic study of 20 Seattle patients. Am J Med 69 (1980) 204-217
16. Glucksberg H., Storb R., Fefer A., et al. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation 18 (1974) 295-304
17. Kalbfleisch J., and Prentice R. The Statistical Analysis of Failure Time Data (2002), Wiley-Interscience, New York
18. Grambsch P., and Therneau T. Proportional hazards tests and diagnostics based on weighted residuals. Biometrika 81 (1994) 515-526
19. Maury S., Mary J.Y., Rabian C., et al. Prolonged immune deficiency following allogeneic stem cell transplantation: risk factors and complications in adult patients. Br J Haematol 115 (2001) 630-641
20. Socie G., Salooja N., Cohen A., et al. Nonmalignant late effects after allogeneic stem cell transplantation. Blood 101 (2003) 3373-3385
21. Kalhs P., Panzer S., Kletter K., et al. Functional asplenia after bone marrow transplantation. A late complication related to extensive chronic graft-versus-host disease. Ann Intern Med 109 (1988) 461-464
22. Clave E., Rocha V., Talvensaari K., et al. Prognostic value of pretransplantation host thymic function in HLA-identical sibling hematopoietic stem cell transplantation. Blood 105 (2005) 2608-2613
23. Socie G., Stone J.V., Wingard J.R., et al. Long-term survival and late deaths after allogeneic bone marrow transplantation. Late Effects Working Committee of the International Bone Marrow Transplant Registry. N Engl J Med 341 (1999) 14-21
24. Knecht H., Jost R., Gmur J., Burger J., and Fehr J. Functional hyposplenia after allogeneic bone marrow transplantation is detected by epinephrine stimulation test and splenic ultrasonography. Eur J Haematol 41 (1988) 382-387
25. Jantunen E., Itala M., Siitonen T., et al. Late non-relapse mortality among adult autologous stem cell transplant recipients: a nation-wide analysis of 1,482 patients transplanted in 1990-2003. Eur J Haematol 77 (2006) 114-119
26. Broers A.E., van Der Holt R., van Esser J.W., et al. Increased transplant-related morbidity and mortality in CMV-seropositive patients despite highly effective prevention of CMV disease after allogeneic T-cell-depleted stem cell transplantation. Blood 95 (2000) 2240-2245
27. Ljungman P., Brand R., Einsele H., Frassoni F., Niederwieser D., and Cordonnier C. Donor CMV serologic status and outcome of CMV-seropositive recipients after unrelated donor stem cell transplantation: an EBMT megafile analysis. Blood 102 (2003) 4255-4260
28. Meyers J.D., Flournoy N., and Thomas E.D. Risk factors for cytomegalovirus infection after human marrow transplantation. J Infect Dis 153 (1986) 478-488
29. Grob J.P., Grundy J.E., Prentice H.G., et al. Immune donors can protect marrow-transplant recipients from severe cytomegalovirus infections. Lancet 1 (1987) 774-776
30. Nichols W.G., Corey L., Gooley T., Davis C., and Boeckh M. High risk of death due to bacterial and fungal infection among cytomegalovirus (CMV)-seronegative recipients of stem cell transplants from seropositive donors: evidence for indirect effects of primary CMV infection. J Infect Dis 185 (2002) 273-282
31. Paulin T., Ringden O., and Lonnqvist B. Faster immunological recovery after bone marrow transplantation in patients without cytomegalovirus infection. Transplantation 39 (1985) 377-384
32. Wagner J.A., Ross H., Hunt S., et al. Prophylactic ganciclovir treatment reduces fungal as well as cytomegalovirus infections after heart transplantation. Transplantation 60 (1995) 1473-1477
33. Noel D.R., Witherspoon R.P., Storb R., et al. Does graft-versus-host disease influence the tempo of immunologic recovery after allogeneic human marrow transplantation?. An observation on 56 long-term survivors. Blood 51 (1978) 1087-1105
34. Witherspoon R.P., Storb R., Ochs H.D., et al. Recovery of antibody production in human allogeneic marrow graft recipients: influence of time posttransplantation, the presence or absence of chronic graft-versus-host disease, and antithymocyte globulin treatment. Blood 58 (1981) 360-368
35. Paulin T., Ringden O., and Nilsson B. Immunological recovery after bone marrow transplantation: role of age, graft-versus-host disease, prednisolone treatment and infections. Bone Marrow Transplant 1 (1987) 317-328
36. Koc Y., Miller K.B., Schenkein D.P., et al. Varicella zoster virus infections following allogeneic bone marrow transplantation: frequency, risk factors, and clinical outcome. Biol Blood Marrow Transplant 6 (2000) 44-49
37. Ljungman P., Lonnqvist B., Gahrton G., Ringden O., Sundqvist V.A., and Wahren B. Clinical and subclinical reactivations of varicella-zoster virus in immunocompromised patients. J Infect Dis 153 (1986) 840-847
38. Steer C.B., Szer J., Sasadeusz J., Matthews J.P., Beresford J.A., and Grigg A. Varicella-zoster infection after allogeneic bone marrow transplantation: incidence, risk factors and prevention with low-dose aciclovir and ganciclovir. Bone Marrow Transplant 25 (2000) 657-664