Evolution and pharmacological modulation of the arrhythmogenic wave dynamics in canine pulmonary vein model

Europace

Volumn 16, Issue 3, 2014, Pages 416-423

  Colman, Michael A ^a   Varela, Marta ^b   Hancox, Jules C ^c   Zhang, Henggui ^a   Aslanidi, Oleg V ^b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Atrial arrhythmias; Computational modelling; Drug effects; Pulmonary veins; Re entrant waves

Indexed keywords

AMIODARONE; ION CHANNEL;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANISOTROPY; ARRHYTHMOGENESIS; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; DOG; ELECTRIC CONDUCTIVITY; GAP JUNCTION; HEART ATRIUM FIBRILLATION; ION CURRENT; NONHUMAN; PRIORITY JOURNAL; PULMONARY VEIN; QUANTITATIVE ANALYSIS; SIMULATION; THREE DIMENSIONAL IMAGING;

ATRIAL ARRHYTHMIAS; COMPUTATIONAL MODELLING; DRUG EFFECTS; PULMONARY VEINS; RE-ENTRANT WAVES;

ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; BIOLOGICAL CLOCKS; COMPUTER SIMULATION; DISEASE MODELS, ANIMAL; DOGS; HEART CONDUCTION SYSTEM; HEART RATE; HUMANS; MODELS, CARDIOVASCULAR; PULMONARY VEINS;

EID: 84895759396     PISSN: 10995129     EISSN: 15322092     Source Type: Journal    
DOI: 10.1093/europace/eut349     Document Type: Article

References (45)

1. Haïssaguerre M, Jaïs P, Shah DC, Takahashi A, Hocini M, Quiniou G et al. Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N Engl J Med 1998;339:659-66.
2. Nattel S, Shiroshita-Takeshita A, Brundel BJ, Rivard L. Mechanisms of atrial fibrillation: lessons from animal models. Prog Cardiovasc Dis 2005;48:9-28.
3. Calkins H, Kuck KH, Cappato R, Brugada J, Camm AJ, Chen S-A et al. 2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design. Europace 2012;14:528-606.
4. Hocini M, Ho SY, Kawara T, Linnenbank AC, Potse M, Shah D, et al. Electrical conduction in canine pulmonary veins: electrophysiological and anatomic correlation. Circulation 2002;105:2442-8.
5. Arora R, Verheule S, Scott L, Navarrete A, Katari V, Wilson E et al. Arrhythmogenic substrate of the pulmonary veins assessed by high-resolution optical mapping. Circulation 2003;107:1816-21.
6. Aslanidi OV, Colman MA, Varela M, Zhao J, Smaill BH, Hancox JC et al. Heterogeneous and anisotropic integrative model of pulmonary veins: computational study of arrhythmogenic substrate for atrial fibrillation. Interface Focus 2013;3:20120069.
7. Butters TD, Aslanidi OV, Zhao J, Smaill B, Zhang H. A novel computational sheep atria model for the study of atrial fibrillation. Interface Focus 2013;3:20120067.
8. Narayan SM, Krummen DE, Clopton P, Shivkumar K, Miller JM. Direct or coincidental elimination of stable rotors or focal sources may explain successful atrial fibrillation ablation: on-treatment analysis of the confirm (conventional ablation for AF with or without focal impulse and rotor modulation) trial. J Am Coll Cardiol 2013;62:138-47.
9. Kumagai K, Ogawa M, Noguchi H, Yasuda T, Nakashima H, Saku K. Electrophysiologic properties of pulmonary veins assessed using a multielectrode basket catheter. J Am Coll Cardiol 2004;43:2281-9.
10. Colman MA, Aslanidi OV, Kharche S, Boyett MR, Garratt CJ, Hancox JC et al. Pro-arrhythmogenic effects of atrial fibrillation induced electrical remodellinginsights from 3D virtual human atria. J Physiol 2013;591:4249-72.
11. Fareh S, Villemaire C, Nattel S. Importance of refractoriness heterogeneity in the enhanced vulnerability to atrial fibrillation induction caused by tachycardia-induced atrial electrical remodeling. Circulation 1998;98:2202-9.
12. Cha T-J, Ehrlich JR, Zhang L, Chartier D, Leung TK, Nattel S. Atrial tachycardia remodeling of pulmonary vein cardiomyocytes: comparison with left atrium and potential relation to arrhythmogenesis. Circulation 2005;111:728-35.
13. Van Wagoner DR, Nerbonne JM. Molecular basis of electrical remodeling in atrial fibrillation. J Mol Cell Cardiol 2000;32:1101-17.
14. Workman AJ, Kane KA, Rankin AC. The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation. Cardiovasc Res 2001;52:226-35.
15. Dobrev D, Ravens U. Remodeling of cardiomyocyte ion channels in human atrial fibrillation. Basic Res Cardiol 2003;98:137-48.
16. Ausma J, Wijffels M, Thoné F, Wouters L, Allessie M, Borgers M. Structural changes of atrial myocardium due to sustained atrial fibrillation in the goat. Circulation 1997; 96:3157-63.
17. Van der Velden HMW, Jongsma HJ. Cardiac gap junctions and connexins: their role in atrial fibrillation and potential as therapeutic targets. Cardiovasc Res 2002;54:270-9.
18. Severs NJ, Coppen SR, Dupont E, Yeh H-I, Ko Y-S, Matsushita T. Gap junction alterations in human cardiac disease. Cardiovasc Res 2004;62:368-77.
19. Gaspo R, Bosch RF, Talajic M, Nattel S. Functional mechanisms underlying tachycardia-induced sustained atrial fibrillation in a chronic dog model. Circulation 1997;96:4027-35.
20. Camm AJ, Kirchhof P, Lip GYH, Schotten U, Savelieva I, Ernst S et al. Guidelines for the management of atrial fibrillation: the task force for the management of atrial fibrillation of the European Society of Cardiology (ESC). Europace 2010;12:1360-420.
21. Weerasooriya R, Khairy P, Litalien J, Macle L, Hocini M, Sacher F et al. Catheter ablation for atrial fibrillation: are results maintained at 5 years of follow-up? J Am Coll Cardiol 2011;57:160-6.
22. Dobrev D, Nattel S. New antiarrhythmic drugs for treatment of atrial fibrillation. Lancet 2010;375:1212-23.
23. Noble D. Computational models of the heart and their use in assessing the actions of drugs. J Pharmacol Sci 2008;107:107-17.
24. Workman AJ, Smith GL, Rankin AC. Mechanisms of termination and prevention of atrial fibrillation by drug therapy. Pharmacol Ther 2011;131:221-41.
25. Zemzemi N, Bernabeu MO, Saiz J, Cooper J, Pathmanathan P, Mirams GR, et al. Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials. Br J Pharmacol 2013;168:718-33.
26. Ramirez RJ, Nattel S, Courtemanche M. Mathematical analysis of canine atrial action potentials: rate, regional factors, and electrical remodeling. Am J Physiol Heart Circ Physiol 2000;279:H1767-85.
27. Aslanidi OV, Butters TD, Ren CX, Ryecroft G, Zhang H. Electrophysiological models for the heterogeneous canine atria: computational platform for studying rapid atrial arrhythmias. Conf Proc IEEE Eng Med Biol Soc 2011;2011:1693-6.
28. Caballero R, de la Fuente MG, Gómez R, Barana A, Amorós I, Dolz-Gaitón P et al. In humans, chronic atrial fibrillation decreases the transient outward current and ultrarapid component of the delayed rectifier current differentially on each atria and increases the slow component of the delayed rectifier current in both. J Am Coll Cardiol 2010;55:2346-54.
29. 2+current downregulation in chronic human atrial fibrillation is associated with increased activity of protein phosphatases. Circulation 2004;110:2651-7.
30. Aslanidi OV, Nikolaidou T, Zhao J, Smaill BH, Gilbert SH, Holden AV et al. Application of micro-computed tomography with iodine staining to cardiac imaging, segmentation, and computational model development. IEEE Trans Med Imaging 2013; 32:8-17.
31. Ho SY, Cabrera JA, Sanchez-Quintana D. Left atrial anatomy revisited. Circ Arrhythm Electrophysiol 2012;5:220-8.
32. Clayton RH, Bernus O, Cherry EM, Dierckx H, Fenton FH, Mirabella L et al. Models of cardiac tissue electrophysiology: progress, challenges and open questions. Prog Biophys Mol Biol 2011;104:22-48.
33. Aslanidi OV, Colman MA, Stott J, Dobrzynski H, Boyett MR, Holden AV et al. 3D virtual human atria: a computational platform for studying clinical atrial fibrillation. Prog Biophys Mol Biol 2011;107:156-68.
34. Aslanidi OV, Boyett MR, Dobrzynski H, Li J, Zhang H. Mechanisms of transition from normal to reentrant electrical activity in a model of rabbit atrial tissue: interaction of tissue heterogeneity and anisotropy. Biophys J 2009;96:798-817.
35. Zhang H, Garratt CJ, Zhu J, Holden AV. Role of up-regulation of IK1 in action potential shortening associated with atrial fibrillation in humans. Cardiovasc Res 2005;66: 493-502.
36. Shinagawa K, Shiroshita-Takeshita A, Schram G, Nattel S. Effects of antiarrhythmic drugs on fibrillation in the remodeled atrium insights into the mechanism of the superior efficacy of amiodarone. Circulation 2003;107:1440-6.
37. Benson AP, Aslanidi OV, Zhang H, Holden AV. The canine virtual ventricular wall: a platform for dissecting pharmacological effects on propagation and arrhythmogenesis. Prog Biophys Mol Biol 2008;96:187-208.
38. Holden AV, Aslanidi OV, Benson AP, Clayton RH, Halley G, Li P et al. The virtual ventricular wall: a tool for exploring cardiac propagation and arrhythmogenesis. J Biol Phys 2006;32:355-68.
39. Allessie MA, de Groot NMS, Houben RPM, Schotten U, Boersma E, Smeets JL et al. Electropathological substrate of long-standing persistent atrial fibrillation in patients with structural heart disease: longitudinal dissociation. Circ Arrhythm Electrophysiol 2010;3:606-15.
40. Verheule S, Tuyls E, van Hunnik A, Kuiper M, Schotten U, Allessie M. Fibrillatory conduction in the atrial free walls of goats in persistent and permanent atrial fibrillation. Circ Arrhythm Electrophysiol 2010;3:590-9.
41. Burashnikov A, Antzelevitch C. Can inhibition of IKur promote atrial fibrillation? Heart Rhythm 2008;5:1304-9.
42. Varela M, Zhao J, Aslanidi OV. Determination of atrial myofibre orientation using structure tensor analysis for biophysical modelling. Lect Note Comput Sci 2013; 7954:425-32.
43. Davies MR, Mistry HB, Hussein L, Pollard CE, Valentin J-P, Swinton J et al. An in silico canine cardiac midmyocardial action potential duration model as a tool for early drug safety assessment. Am J Physiol Heart Circ Physiol 2012;302:H1466-80.
44. Miyauchi Y, Hayashi H, Miyauchi M, Okuyama Y, Mandel WJ, Chen PS et al. Heterogeneous pulmonary vein myocardial cell repolarization implications for reentry and triggered activity. Heart Rhythm 2005;2:1339-45.
45. Ehrlich JR, Cha TJ, Zhang L, Chartier D, Melnyk P, Hohnloser SH et al. Cellular electrophysiology of canine pulmonary vein cardiomyocytes: action potential and ionic current properties. J Physiol 2003;551:801-13.