Disulfiram efficacy in the treatment of alcohol dependence: A meta-analysis

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Skinner, Marilyn D ^a   Lahmek, Pierre ^a   Pham, Héloïse ^b   Aubin, Henri Jean ^c  

^a Hôpitaux Universitaires Henri Mondor   (France)

^b Centre Médical Marmottan Paris   (France)

^c HÔPITAL PAUL BROUSSE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACAMPROSATE; ALCOHOL; COCAINE; DISULFIRAM; NALTREXONE; PLACEBO;

ALCOHOL ABUSE; ALCOHOLISM; ARTICLE; DRUG EFFICACY; DRUG SAFETY; EFFECT SIZE; HUMAN; INTERMETHOD COMPARISON; OPEN STUDY; POPULATION RESEARCH; RANDOMIZED CONTROLLED TRIAL (TOPIC); SYSTEMATIC REVIEW; TREATMENT DURATION;

ADOLESCENT; ADULT; AGED; ALCOHOL DETERRENTS; ALCOHOLISM; CASE-CONTROL STUDIES; COCAINE; DISULFIRAM; ENDPOINT DETERMINATION; FEMALE; HUMANS; MALE; MIDDLE AGED; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME;

EID: 84895734743     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0087366     Document Type: Article

References (66)

1. Azrin NH, Sisson RW, Meyers R, Godley M (1982) Alcoholism treatment by disulfiram and community reinforcement therapy. J Behav Ther Exp Psychiatry 13: 105-112. (Pubitemid 12052939)
2. Brewer C, Meyers R, Johnson J (2000) Does disulfiram help to prevent relapse in alcohol abuse? CNS Drugs 14: 329-341.
3. Wright C, Moore RD (1990) Disulfiram treatment of alcoholism. Am J Med 88: 647-655. (Pubitemid 20192282)
4. Wilson A, Blanchard R, Davidson W, McRae L, Maini K (1984) Disulfiram implantation: a dose response trial. J Clin Psychiatry 45: 242-247. (Pubitemid 14113562)
5. Fuller R, Gordis E (2004) Does disulfiram have a role in alcoholism treatment today? Addiction 99: 21-24. (Pubitemid 38142216)
6. Skinner M, Coudert M, Berlin I, Passeri E, Michel L, et al. (2010) Effect of the threat of a disulfiram-ethanol reaction on cue reactivity in alcoholics Drug Alcohol Depend.
7. Johnson BA (2010) Medication treatment of different types of alcoholism. Am J Psychiatry 167: 630-639.
8. Swift RM (1999) Drug therapy for alcohol dependence. N Engl J Med 340: 1482-1490.
9. Weinshenker D (2010) Cocaine sobers up. Nat Med 16: 969-970.
10. Carroll KM, Fenton LR, Ball SA, Nich C, Frankforter TL, et al. (2004) Efficacy of disulfiram and cognitive behavior therapy in cocaine-dependent outpatients: a randomized placebo-controlled trial. Arch Gen Psychiatry 61: 264-272. (Pubitemid 38295828)
11. Gossop M, Carroll KM (2006) Disulfiram, cocaine, and alcohol: two outcomes for the price of one? Alcohol Alcohol 41: 119-120.
12. Mutschler J, Buhler M, Grosshans M, Diehl A, Mann K, et al. (2010) Disulfiram, an option for the treatment of pathological gambling? Alcohol Alcohol 45: 214- 216.
13. Grassi MC, Cioce AM, Giudici FD, Antonilli L, Nencini P (2007) Short-term efficacy of Disulfiram or Naltrexone in reducing positive urinalysis for both cocaine and cocaethylene in cocaine abusers: A pilot study. Pharmacological Research 55: 117-121. (Pubitemid 46201774)
14. Petrakis IL, Carroll KM, Nich C, Gordon LT, McCance-Katz EF, et al. (2000) Disulfiram treatment for cocaine dependence in methadone-maintained opioid addicts. Addiction 95: 219-228. (Pubitemid 30111242)
15. Yao L, Fan P, Arolfo M, Jiang Z, Olive MF, et al. (2010) Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of dopamine synthesis. Nat Med 16: 1024-1028.
16. Gaval-Cruz M, Weinshenker D (2009) mechanisms of disulfiram-induced cocaine abstinence: antabuse and cocaine relapse. Mol Interv 9: 175-187.
17. Hughes JC, Cook CC (1997) The efficacy of disulfiram: a review of outcome studies. Addiction 92: 381-395. (Pubitemid 27183253)
18. Suh JJ, Pettinati HM, Kampman KM, O'Brien CP (2006) The status of disulfiram: a half of a century later. J Clin Psychopharmacol 26: 290-302. (Pubitemid 43804621)
19. Jorgensen CH, Pedersen B, Tonnesen H (2011) The Efficacy of Disulfiram for the Treatment of Alcohol Use Disorder. Alcohol Clin Exp Res.
20. Tønnesen H, Rosenberg J, Nielsen HJ, Rasmussen V, Hauge C, et al. (1999) Effect of preoperative abstinence on poor postoperative outcome in alcohol misusers: randomised controlled trial. BMJ 318: 1311-1316. (Pubitemid 29219042)
21. Carroll C, Ziedonis D, O'Malley S, McCance-Katz E, Gordon L, et al. (1993) Pharmacologic interventions for alcohol and cocaine abusing individuals - a pilot study of disulfiram and naltrexone. American Journal on Addictions 2: 77-79.
22. Bardeleben UK, H.; Biedert, E.; Ihde, T.; Ladewig, D. (1999) Randomized open efficacy study of naltrexone vs. acamprosate vs. disulfiram combined with cognitive-behavioral psychotherapy in preventing alcohol relapse. In: Ladewig D, editor. Basic and Clinical Science of Substance Related Disorders. Basel: Karger. pp. 45-48.
23. Chick J, Gough K, Falkowski W, Kershaw P, Hore B, et al. (1992) Disulfiram treatment of alcoholism. Br J Psychiatry 161: 84-89.
24. De Sousa A, Jagtap J (2009) An open label trial of naltrexone versus disulfiram in elderly patients with alcohol dependence. JPPS 6: 85-89.
25. Gerrein JR, Rosenberg CM, Manohar V (1973) Disulfiram maintenance in outpatient treatment of alcoholism. Arch Gen Psychiatry 28: 798-802.
26. Pettinati HM, Kampman KM, Lynch KG, Xie H, Dackis C, et al. (2008) A double blind, placebo-controlled trial that combines disulfiram and naltrexone for treating co-occurring cocaine and alcohol dependence. Addict Behav 33: 651-667.
27. Fuller RK, Branchey L, Brightwell DR, Derman RM, Emrick CD, et al. (1986) Disulfiram treatment of alcoholism. A Veterans Administration cooperative study. JAMA 256: 1449-1455. (Pubitemid 16014332)
28. Cohen J (1988) Statistical Power Analysis for the Behavioral Sciences: Lawrence Erlbaum Associates.
29. Higgins J, Green Se (2011) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 The Cochrane Collaboration.
30. Oliveto A, Poling J, Mancino MJ, Feldman Z, Cubells JF, et al. (2011) Randomized, double blind, placebo-controlled trial of disulfiram for the treatment of cocaine dependence in methadone-stabilized patients. Drug Alcohol Depend 113: 184-191.
31. Carroll KM, Nich C, Ball SA, McCance E, Rounsavile BJ (1998) Treatment of cocaine and alcohol dependence with psychotherapy and disulfiram. Addiction 93: 713-727. (Pubitemid 28230603)
32. Ling W, Weiss DG, Charuvastra VC, O'Brien CP (1983) Use of disulfiram for alcoholics in methadone maintenance programs. A Veterans Administration Cooperative Study. Arch Gen Psychiatry 40: 851-854. (Pubitemid 13025218)
33. De Sousa A, De Sousa A (2008) An open randomized trial comparing disulfiram and naltrexone in adolescents with alcohol dependence. Journal of Substance Use 13: 382-388.
34. Niederhofer H, Staffen W (2003) Comparison of disulfiram and placebo in treatment of alcohol dependence of adolescents. Drug Alcohol Rev 22: 295-297. (Pubitemid 37394836)
35. De Sousa A, De Sousa A (2004) A one-year pragmatic trial of naltrexone vs disulfiram in the treatment of alcohol dependence. Alcohol Alcohol 39: 528-531. (Pubitemid 39534536)
36. De Sousa A, De Sousa A (2005) An open randomized study comparing disulfiram and acamprosate in the treatment of alcohol dependence. Alcohol Alcohol 40: 545-548. (Pubitemid 41600008)
37. De Sousa AA, De Sousa J, Kapoor H (2008) An open randomized trial comparing disulfiram and topiramate in the treatment of alcohol dependence. J Subst Abuse Treat 34: 460-463. (Pubitemid 351609293)
38. Petrakis IL, Poling J, Levinson C, Nich C, Carroll K, et al. (2005) Naltrexone and disulfiram in patients with alcohol dependence and comorbid psychiatric disorders. Biol Psychiatry 57: 1128-1137. (Pubitemid 40615774)
39. Fuller RK, Roth HP (1979) Disulfiram for the treatment of alcoholism. An evaluation in 128 men. Ann Intern Med 90: 901-904. (Pubitemid 9229637)
40. Laaksonen E, Koski-Jannes A, Salaspuro M, Ahtinen H, Alho H (2008) A randomized, multicentre, open-label, comparative trial of disulfiram, naltrexone and acamprosate in the treatment of alcohol dependence. Alcohol Alcohol 43: 53-61.
41. Nava F, Premi S, Manzato E, Lucchini A (2006) Comparing treatments of alcoholism on craving and biochemical measures of alcohol consumptionst. J Psychoactive Drugs 38: 211-217. (Pubitemid 44759957)
42. Ulrichsen J, Nielsen MK, Ulrichsen M (2010) Disulfiram in severe alcoholism-an open controlled study. Nord J Psychiatry 64: 356-362.
43. Carroll K, Fetnon LR, Bale SA, Nich C, Frankforter TL, et al. (2004) Efficacy of disulfiram and cognitive behavior therapy in cocaine-dependent outpatients. Archives of General Psychiatry 61: 264-272. (Pubitemid 38295828)
44. Higgins JP, Altman DG (2008) Assessing Risk of Bias in Included Studies. In: Higgins JP, Green Se, editors. Cochrane Handbook for Systematic Reviews of Interventions Chichester, UK: John Wiley & Sons.
45. Brewer C, Streel E (2003) Learning the language of abstinence in addiction treatment: some similarities between relapse-prevention with disulfiram, naltrexone, and other pharmacological antagonists and intensive "immersion" methods of foreign language teaching. Subst Abus 24: 157-173. (Pubitemid 37169087)
46. Johnson BA (2008) Update on neuropharmacological treatments for alcoholism: scientific basis and clinical findings. Biochem Pharmacol 75: 34-56.
47. Brewer C (1986) Patterns of compliance and evasion in treatment programmes which include supervised disulfiram. Alcohol Alcohol 21: 385-388.
48. Anton RF (2001) Pharmacologic approaches to the management of alcoholism. J Clin Psychiatry 62 Suppl 20: 11-17.
49. Mutschler J, Eifler S, Dirican G, Grosshans M, Kiefer F, et al. (2013) Functional social support within a medical supervised outpatient treatment program. Am J Drug Alcohol Abuse 39: 44-49.
50. Beattie MC, Longabaugh R (1999) General and alcohol-specific social support following treatment. Addict Behav 24: 593-606. (Pubitemid 29417980)
51. Dobkin PL, De CM, Paraherakis A, Gill K (2002) The role of functional social support in treatment retention and outcomes among outpatient adult substance abusers. Addiction 97: 347-356. (Pubitemid 34250732)
52. Pani PP, Trogu E, Vacca R, Amato L, Vecchi S, et al. (2010) Disulfiram for the treatment of cocaine dependence. Cochrane Database Syst Rev: CD007024.
53. Closser MH, Kosten TR (1992) Alcohol and cocaine abuse. A comparison of epidemiology and clinical characteristics. Recent Dev Alcohol 10: 115-128.
54. Weiss RD, Mirin SM, Griffin ML, Michael JL (1988) Psychopathology in cocaine abusers. Changing trends. J Nerv Ment Dis 176: 719-725. (Pubitemid 19028802)
55. Grant BF, Harford TC (1990) Concurrent and simultaneous use of alcohol with cocaine: results of national survey. Drug Alcohol Depend 25: 97-104. (Pubitemid 20086961)
56. Khalsa H, Paredes A, Anglin MD (1992) The role of alcohol in cocaine dependence. Recent Dev Alcohol 10: 7-35.
57. Regier DA, Farmer ME, Rae DS, Locke BZ, Keith SJ, et al. (1990) Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. JAMA 264: 2511-2518.
58. Carroll KM, Rounsaville BJ, Bryant KJ (1993) Alcoholism in treatment-seeking cocaine abusers: clinical and prognostic significance. J Stud Alcohol 54: 199-208. (Pubitemid 23101826)
59. McCance-Katz EF, Price LH, McDougle CJ, Kosten TR, Black JE, et al. (1993) Concurrent cocaine-ethanol ingestion in humans: pharmacology, physiology, behavior, and the role of cocaethylene. Psychopharmacology (Berl) 111: 39-46. (Pubitemid 23101350)
60. Diehl A, Ulmer L, Mutschler J, Herre H, Krumm B, et al. (2010) Why is Disulfiram Superior to Acamprosate in the Routine Clinical Setting? A Retrospective Long-Term Study in 353 Alcohol-Dependent Patients. Alcohol Alcohol.
61. Brewer C (2001) Disulfiram for alcohol abuse: Why is such an effective drug so under-prescribed? Primary Care in the New NHS Autumn: 227-231.
62. Alharbi FFae-G, N. (2013) The relative safety of disulfiram. Addictive Disorders & Their Treatment 12(3) 12: 140-147.
63. Schuckit MA (1996) Recent developments in the pharmacotherapy of alcohol dependence. J Consult Clin Psychol 64: 669-676. (Pubitemid 26274528)
64. Iber FL, Lee K, Lacoursiere R, Fuller R (1987) Liver toxicity encountered in the Veterans Administration trial of disulfiram in alcoholics. Alcohol Clin Exp Res 11: 301-304. (Pubitemid 18005377)
65. Malcolm R, Olive MF, Lechner W (2008) The safety of disulfiram for the treatment of alcohol and cocaine dependence in randomized clinical trials: guidance for clinical practice. Expert Opin Drug Saf 7: 459-472.
66. Stockwell T, Hodgson R, Edwards G, Taylor C, Rankin H (1979) The development of a questionnaire to measure severity of alcohol dependence. Br J Addict Alcohol Other Drugs 74: 79-87. (Pubitemid 9147690)