The efficacy of disulfiram: A review of outcome studies

Addiction

Volumn 92, Issue 4, 1997, Pages 381-395

  Hughes, Julian C ^a   Cook, Christopher C H ^b  

^a CHURCHILL HOSPITAL   (United Kingdom)

^b UNIVERSITY OF KENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DISULFIRAM;

ALCOHOL CONSUMPTION; ALCOHOLISM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG IMPLANTATION; HUMAN; MAJOR CLINICAL STUDY; MEDICAL INFORMATION; META ANALYSIS; METHODOLOGY; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL; REVIEW; SINGLE BLIND PROCEDURE;

EID: 0030966158     PISSN: 09652140     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1360-0443.1997.tb03370.x     Document Type: Review

References (81)

1. WILLIAMS, E. E. (1937) Effects of alcohol on workers with carbon disulfide, Journal of the American Medical Association, 109, 1472-1473.
2. HALD, J. & JACOBSEN, E. (1948) A drug sensitising the organism to ethyl alcohol, Lancet, 255, 1001-1004.
3. LUNDWALL, L. & BAEKELAND, F. (1971) Disulfiram treatment of alcoholism. A review, The Journal of Nervous and Mental Disease, 153, 381-394.
4. PEACHEY, J. E. (1984) Clinical uses of the alcohol-sensitising drugs, in: EDWARDS, G. & LITTLETON, J. (Eds) Pharmacological Treatments for Alcoholism, pp. 531-557 (London, Croom Helm).
5. GELDER, M., GATH, D. MAYOU,. R. & COWEN, P. (1996) Oxford Textbook of Psychiatry, 3rd edn (Oxford, Oxford University Press).
6. HEATHER, N. (1989) Disulfiram treatment for alcoholism: deserves re-examination, British Medical Journal, 299, 471-472.
7. CHICK. J. (1990) Alcohol dependence: what treatment works? in: HAWTON, K. & COWEN, R. (Eds) Dilemmas and Difficulties in the Management of Psychiatric Patients, pp. 171-182 (Oxford, Oxford University Press).
8. BREWER, C. (1993a) Recent developments in disulfiram treatment, Alcohol and Alcoholism, 28, 383-395.
9. BREWER, C. (1993b) What the textbooks say about disulfiram: a review of recent publications, in: BREWER, C. (Ed.) Treatment Options in Addiction. Medical management of alcohol and opiate abuse, pp. 29-37 (London, Gaskell).
10. TENNANT, F. S. JR. (1986) Disulfiram will reduce medical complications but not cure alcoholism, Journal of the American Medical Association, 256, 1489.
11. WALLERSTEIN, R. S. (1957) Hospital Treatment of Alcoholism: a comparative, experimental study (London, Imago).
12. BOURNE, P. G., ALFORD, J. A. & BOWCOCK, J. Z. (1966) Treatment of skid-row alcoholics with disulfiram, Quarterly Journal of Studies on Alcohol, 21, 42-48.
13. GALLANT, D. M., BISHOP, M. P., FAULKNER, M. A. et al. (1968) A comparative evaluation of compulsory (group therapy and/or antabuse) and voluntary treatment of the chronic alcoholic municipal court offender, Psychosomatics, 9, 306-310.
14. BREWER, C. (1986) Supervised disulfiram in alcoholism, British Journal of Hospital Medicine, 35, 116-119.
15. KNOX, W. J. (1972) Four-year follow-up of veterans treated on a small alcoholism treatment ward, Quarterly Journal of Studies on Alcoholism, 33, 105-110.
16. HAYNES, S. N. (1973) Contingency management in a municipally-administered Antabuse program for alcoholics, Journal of Behaviour Therapy and Experimental Psychiatry, 4, 31-32.
17. GERREIN, J. R., ROSENBERG, C. M. & MANOHAR, V. (1973) Disulfiram maintenance in outpatient treatment of alcoholism, Archives of General Psychiatry, 28, 798-802.
18. EDWARDS, J. D. Si Dux, J. E. (1974) Alcoholism clinic in a military setting: a combined disulfiram and group therapy outpatient program, Military Medicine, 139, 206-209.
19. ROSENBERG, C. M. (1974) Drug maintenance in the outpatient treatment of chronic alcoholism, Archives of General Psychiatry, 30, 373-377.
20. BIGELOW, G., STRICKLER, D., LIEBSON, I. & GRIFFITHS, R. (1976) Maintaining disulfiram ingestion among outpatient alcoholics: a security-deposit contingency contracting procedure, Behavior Research and Therapy, 14, 378-381.
21. AZRIN, N. H. (1976) Improvements in the community-reinforcement approach to alcoholism, Behavior Research and Therapy, 14, 339-348.
22. AZRIN, N. H., SISSON, R. W., MEYERS, R. & GODLEY, M. (1982) Alcoholism treatment by disulfiram and community reinforcement therapy, Journal of Behavior Therapy and Experimental Psychiatry, 13, 105-112.
23. HUNT, G. M. & AZRIN, N. H. (1973) A community-reinforcement approach to alcoholism, Behavior Research and Therapy, 11, 91-104.
24. LIEBSON, I. A., TOMMASELLO, A. & BIGELOW, G. E. (1978) A behavioral treatment of alcoholic methadone patients, Annals of Internal Medicine, 89, 342-344.
25. ROBICHAUD, C., STRICKLER, D., BIGELOW, G. & LIEBSON, I. (1979) Disulfiram maintenance employee alcoholism treatment: a three-phase evaluation, Behavior Research and Therapy, 17, 618-621.
26. LING, W., WEISS, D. G., CHARUVASTRA, C. & O'BRIEN, C. P. (1983) Use of disulfiram for alcoholics in methadone maintenance programs, Archives of General Psychiatry, 40, 851-854.
27. BREWER, C. & SMITH, J. (1983) Probation linked supervised disulfiram in the treatment of habitual drunken offenders: results of a pilot study, British Medical Journal, 287, 1282-1283.
28. BREWER, C. & SMITH, J. (1983) Probation linked disulfiram treatment (Letter), British Medical Journal, 287, 1795.
29. KEANE, T. M., FOY, D. W., NUNN, B. & RYCHTARIK, R. G. (1984) Spouse contracting to increase antabuse compliance in alcoholic veterans, Journal of Clinical Psychology, 40, 340-344.
30. POWELL, B. J., PENICK, E. C., READ, M. R. & LUDWIG, A. M. (1985) Comparison of three outpatient treatment interventions: a twelve-month follow-up of men alcoholics, Journal of Studies on Alcohol, 46, 309-312.
31. CHICK, J., GOUGH, K., FALKOWSKI et al. (1992) Disulfiram treatment of alcoholism, British Journal of Psychiatry, 161, 84-89.
32. SCHUCKIT, M. A. (1985) A one-year follow-up of men alcoholics given disulfiram, Journal of Studies on Alcohol, 46, 191-195.
33. SERENY, G., SHARMA, V., HOLT, J. & GORDIS, E. (1986) Mandatory supervised Antabuse therapy in an outpatient alcoholism program: a pilot study, Alcoholism: Clinical and Experimental Research, 10, 290-292.
34. FULLER, R. K. & ROTH, H. P. (1979) Disulfiram for the treatment of alcoholism: an evaluation in 128 men, Annals of Internal Medicine, 90, 901-904.
35. FULLER, R. K. & WILLIFORD, W. O. (1980) Life-table analysis of abstinence in a study evaluating the efficacy of disulfiram, Alcoholism: Clinical and Experimental Research, 4, 298-301.
36. FULLER, R. K., BRANCHEY, L., BRIGHTWELL, D. R. et al. (1986) Disulfiram treatment of alcoholism: a Veterans Administration cooperative study, Journal of the American Medical Association, 256, 1449-1455.
37. HEATHER, N. (1993) Disulfiram treatment for alcohol problems: is it effective and, if so, why? in: BREWER, C. (Ed.) Treatment Options in Addiction. Medical management of alcohol and opiate abuse, pp 1-18 (London, Gaskell).
38. DUCKERT, F. & JOHNSEN, J. (1987) Behavioral use of disulfiram in the treatment of problem drinking, The International Journal of the Addictions, 22, 445-454.
39. ÖJEHAGEN, A., SKJÆRRIS, A. & BERGLUND, M. (1991) Long-term use of aversive drugs in outpatient alcoholism treatment, Acta Psychiatrica Scandinavica, 84, 185-190.
40. MAYER, J. & MYERSON, D. J. (1971) Outpatient treatment of alcoholics: effects of status, stability and nature of treatment, Quarterly Journal of Studies on Alcohol, 32, 620-627.
41. OBITZ, F. W. (1978) Control orientation and disulfiram, Journal of Studies on Alcohol, 39, 1297-1298.
42. O'NEIL, P.M., ROITZSCH, J. C., GIACINTO, J. P. & MILLER, W. C. (1982) Disulfiram acceptors and refusers: do they differ? Addictive Behaviors, 7, 207-209.
43. BAEKELAND, F., LUNDWALL, L., KISSIN, B. & SHANAHAN, T. (1971) Correlates of outcome in disulfiram treatment of alcoholism, Journal of Nervous and Mental Disease, 153, 1-9.
44. BANYS, P. (1988) The clinical use of disulfiram (Antabuse): a review, Journal of Psychoactive Drugs, 20, 243-261.
45. MALLA, A. (1988) An outcome study comparing refusers and acceptors of treatment for alcoholism, Canadian Journal of Psychiatry, 33, 183-187.
46. BROMET, E., Moos, R., Buss, F. & WUTHMANN, C. (1977) Posttreatment functioning of alcoholic patients: its relation to program participation, Journal of Consulting and Clinical Psychology, 45, 829-842.
47. FULLER, R. K., WILLIFORD, W. O., LEE, K. K. & DERMAN, R. (1984) Veterans Administration cooperative study of disulfiram in the treatment of alcoholism: study design and methodological considerations, Controlled Clinical Trials, 5, 263-273.
48. WRIGHT, C. & MOORE, R. D. (1990) Disulfiram treatment of alcoholism, American Journal of Medicine, 88, 647-655.
49. O'FARRELL, T. J., CUTTER, H. S. G. & FLOYD, F. J. (1985) Evaluating behavioral marital therapy for male alcoholics: effects on marital adjustment and communication from before to after therapy, Behavior Therapy, 16, 147-167.
50. O'FARRELL, T. J. & BAYOG, R. D. (1986) Antabuse contracts for married alcoholics and their spouses: a method to maintain Antabuse ingestion and decrease conflict about drinking, Journal of Substance Abuse Treatment, 3, 1-8.
51. NEIDERHISER, D. H., FULLER, R. K., HEJDUK L. J. & ROTH, H. P. (1976) Method for the detection of diethylamine, a metabolite of disulfiram, in urine, Journal of Chromatography, 117, 187-192.
52. FULLER, R. K. & NEIDERHISER, D. H. (1981) Evaluation and application of a urinary diethylamine method to measure compliance with disulfiram therapy, Journal of Studies on Alcohol, 42, 202-206.
53. PAULSON, S. M., KRAUSE, S. & IBER, F. L. (1977) Development and evaluation of a compliance test for patients taking disulfiram, Johns Hopkins Medical Journal, 141, 119-125.
54. KOFOED, L. L. (1987) Chemical monitoring of disulfiram compliance: a study of alcoholic outpatients, Alcoholism: Clinical and Experimental Research, 11, 481-485.
55. KRANZLER, H. R., DOLINSKY, Z. & KAPLAN, R. F. (1990) Giving ethanol to alcoholics in a research setting: its effect on compliance with disulfiram treatment, British Journal of Addiction, 85, 119-123.
56. MARIE, C. (1955) A propos d'un nouveau mode de traitement de l'alcoolisme chronique par implantation de disulfure de tétra-éthyle-thiouramne, thesis (Faculty of Medicine, University of Paris).
57. KELLAM, A. M. P. & WESOLKOWSKI, J. (1968) A case of alcoholism treated by disulfiram implantation, Journal of Alcoholism, 3, 38-40.
58. WILSON, A. (1975) Disulfiram implantation in alcoholism treatment: a review, Journal of Studies on Alcohol, 36, 555-565.
59. HUSSAIN, M. Z. & HARINATH, M. (1972) Helping alcoholics abstain: an implantable substance (Letter), American Journal of Psychiatry, 129, 363.
60. MALCOLM, M. T. & MADDEN, J. S. (1973) The use of disulfiram implantation in alcoholism, British Journal of Psychiatry, 123, 41-45.
61. WHYTE, C. R. & O'BRIEN, P. M. J. (1974) Disulfiram implant: a controlled trial, British Journal of Psychiatry, 124, 42-44.
62. OBHOLZER, A. M. (1974) A follow-up study of nineteen alcoholic patients treated by means of tetraethyl-thiuram disulfide (Antabuse) implants, British Journal of Addiction, 69, 19-23.
63. KTNGSTONE, E. & KLINE, S. A. (1975) Disulfiram implants in the treatment of alcoholism: some mechanisms of action, International Pharmacopsychiatry, 10, 183-191.
64. LEWIS, M. J., BLAND, R. C. & BAILE, W. (1975) Disulfiram implantation for alcoholism, Canadian Psychiatric Association Journal, 20, 283-286.
65. KLINE, S. A. & KINGSTONE, E. (1977) Disulfiram implants: the right treatment but the wrong drug? Canadian Medical Association Journal, 116, 1382-1383.
66. GOODWIN, D. W. (1973) The use of disulfiram implantation in alcoholism (Letter), British Journal of Psychiatry, 123, 613-614.
67. MALCOLM, M. T., MADDEN, J. S. & WILLIAMS, A. E. (1974) Disulfiram implantation critically evaluated, British Journal of Psychiatry, 125, 485-489.
68. KITSON, T. M. (1978) On the probability of implanted disulfiram's causing a reaction to ethanol, Journal of Studies on Alcohol, 39, 183-186.
69. BERGSTROM, B., ÖHLIN, H., LINDBLOM, P.E. & WADSTEIN, J. (1982) Is disulfiram implantation effective? (Letter), Lancet, i, 49-50.
70. WILSON, A., DAVIDSON, W. .J. & WHITE, J. (1976) Disulfiram implantation: placebo, psychological deterrent, and pharmacological deterrent effects, British Journal of Psychiatry, 129, 277-280.
71. WILSON, A., DAVIDSON, W. J., BLANCHARD, R. & WHITE, J. (1978) Disulfiram implantation: a placebo-controlled trial with two-year follow-up, Journal of Studies on Alcohol, 39, 809-819.
72. WILSON, A., DAVIDSON, W. J. & BLANCHARD, R. (1980) Disulfiram implantation: a trial using placebo implants and two types of controls, Journal of Studies on Alcohol, 41, 429-436.
73. WILSON, A., BLANCHARD, R., DAVIDSON, W., MCRAE, L. & MAINI, K. (1984) Disulfiram implantation: a dose response trial, Journal of Clinical Psychiatry, 45, 242-247.
74. BORG, S., ELTON, M., ERNFORS, C. et al. (1985) Implantation of disulfiram in treatment of alcohol dependence: results of a placebo-controlled one-year study, in: Workshop on Pharmacological Treatment of Alcoholism, National Board of Health and Welfare, pp. 65-88 (Stockholm, Drug Information Committee of Sweden).
75. JOHNSEN, J., STOWELL, A., BACHE-WIIG, J. E., STENSRUD, T., RIPEL, A. & MORLAND, J. (1987) A double-blind placebo controlled study of male alcoholics given a subcutaneous disulfiram implantation, British Journal of Addiction, 82, 607-613.
76. JOHNSEN, J. & MøRLAND, J. (1991) Disulfiram implant: a double-blind placebo controlled followup on treatment outcome, Alcoholism: Clinical and Experimental Research, 15, 532-536.
77. JOHNSEN, J., STOWELL, A., STENSRUD, T., RIPEL, A. & MøRLAND, J. (1990) A double-blind placebo controlled study of healthy volunteers given a subcutaneous disulfiram implantation, Pharmacology and Toxicology, 66, 227-230.
78. JOHNSEN, J. & MØRLAND, J. (1992) Depot preparations of disulfiram: experimental and clinical results, Acta Psychiatrica Scandinavica, 86 (suppl. 396), 27-30.
79. HART, B. W. & FAIMAN, M. D. (1994) In vivo pharmacodynamic studies of the disulfiram metabolite S-methyl N,N-diethylthiolcarbamate sulfoxide: inhibition of liver aldehyde dehydrogenase, Alcoholism: Clinical and Experimental Research, 18, 340-345.
80. PHILLIPS, M. & GRESSER, J. D. (1984) Sustained-release characteristics of a new implantable formulation of disulfiram, Journal of Pharmaceutical Sciences, 73, 1718-1720.
81. PHILLIPS, M. & GREENBERG, J. (1992) Dose-ranging study of depot disulfiram in alcohol abusers, Alcoholism: Clinical and Experimental Research, 16, 964-967.