Insulin-releasing and cytotoxic properties of the frog skin peptide, tigerinin-1R: A structure-activity study

Peptides

Volumn 55, Issue , 2014, Pages 23-31

  Srinivasan, Dinesh ^a   Ojo, Opeolu O ^a   Abdel Wahab, Yasser H A ^a   Flatt, Peter R ^a   Guilhaudis, Laure ^b   Conlon, J Michael ^c  

^a UNIVERSITY OF ULSTER   (United Kingdom)

^b NORMANDIE UNIVERSITÉ   (France)

^c UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

Author keywords

Cytotoxicity, Type 2 diabetes mellitus; Frog skin peptide; Incretin; Tigerinin

Indexed keywords

ALANINE; ANTIDIABETIC AGENT; ARGININE; CALCIUM; DIAZOXIDE; GASTRIC INHIBITORY POLYPEPTIDE; GLUCOSE; INCRETIN; INSULIN; ISOLEUCINE; LACTATE DEHYDROGENASE; LEUCINE; LYSINE; METHANOL; POTASSIUM CHLORIDE; SERINE; TIGERININ 1R; TRIFLUOROETHANOL; TRYPTOPHAN; UNCLASSIFIED DRUG; VERAPAMIL; WATER; [A5W]TIGERININ 1R; [H12K]TIGERININ 1R; [H12R]TIGERININ 1R; [I10W]TIGERININ 1R; [I6W]TIGERININ 1R; [L8W]TIGERININ 1R; [S4K]TIGERININ 1R; [S4R]TIGERININ 1R; AMPHIBIAN PROTEIN; ANTIINFECTIVE AGENT; TIGERININ-1R PEPTIDE, HOPLOBATRACHUS RUGULOSUS;

ABSENCE OF SIDE EFFECTS; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL ACTIVITY; ANURA; ARTICLE; BACTERIAL GROWTH; BLOOD SAMPLING; CALCIUM CELL LEVEL; CELL MEMBRANE; CIRCULAR DICHROISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; CYTOTOXICITY ASSAY; ERYTHROCYTE; ESCHERICHIA COLI; EXTRACELLULAR CALCIUM; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; GROWTH INHIBITION; HEMOLYSIS; HOST RESISTANCE; HUMAN; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN LIKE ACTIVITY; INSULIN RELEASE; INSULIN RESISTANCE; LC 50; LIPID DIET; MALE; MEMBRANE POTENTIAL; MINIMUM INHIBITORY CONCENTRATION; MONOTHERAPY; MOUSE; NONHUMAN; OBESITY; PANCREAS ISLET; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; RAT; SKIN SECRETION; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; ANIMAL; C57BL MOUSE; CALCIUM SIGNALING; CELL LINE; CHEMISTRY; DRUG EFFECTS; MICROBIAL SENSITIVITY TEST; SECRETION (PROCESS);

AMPHIBIAN PROTEINS; ANIMALS; ANTI-BACTERIAL AGENTS; CALCIUM SIGNALING; CELL LINE; ESCHERICHIA COLI; GLUCOSE INTOLERANCE; HUMANS; INCRETINS; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; MEMBRANE POTENTIALS; MICE, INBRED C57BL; MICROBIAL SENSITIVITY TESTS; RATS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84895549308     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2014.02.002     Document Type: Article

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