Caerulein precursor fragment (CPF) peptides from the skin secretions of Xenopus laevis and Silurana epitropicalis are potent insulin-releasing agents

Biochimie

Volumn 95, Issue 2, 2013, Pages 429-435

  Srinivasan, Dinesh ^a   Mechkarska, Milena ^b   Abdel Wahab, Yasser H A ^a   Flatt, Peter R ^a   Conlon, J Michael ^b  

^a UNIVERSITY OF ULSTER   (United Kingdom)

^b UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

Author keywords

Caerulein precursor fragment; Frog skin; Insulin releasing peptide; Silurana; Xenopus

Indexed keywords

AMINO ACID DERIVATIVE; ANTIDIABETIC AGENT; CERULEIN PRECURSOR FRAGMENT PEPTIDE; CERULETIDE; GLYCINELEUCINE AMIDE; INSULIN; MAGAININ DERIVATIVE; UNCLASSIFIED DRUG; XENOPSIN; XENOPSIN PRECURSOR FRAGMENT; XENOPUS PROTEIN;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DRUG MECHANISM; INSULIN RELEASE; NONHUMAN; PEPTIDOMICS; PROTEIN DETERMINATION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; RAT; SILURANA EPITROPICALIS; SKIN SECRETION; XENOPUS; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; CAERULEIN; CALCIUM; CELL LINE; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN-SECRETING CELLS; L-LACTATE DEHYDROGENASE; MAGAININS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PEPTIDES; PIPIDAE; PROTEIN PRECURSORS; RATS; SKIN; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS; XENOPUS PROTEINS;

ANURA; PIPIDAE; RATTUS; SILURANA; XENOPUS (GENUS); XENOPUS EPITROPICALIS; XENOPUS LAEVIS;

EID: 84872789091     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2012.10.026     Document Type: Article

References (37)

1. P.R. Flatt, C.J. Bailey, and B.D. Green Recent advances in antidiabetic drug therapies targeting the enteroinsular axis Curr. Drug Metab. 10 2009 125 137
2. V.A. Fonseca, B. Zinman, M.A. Nauck, A.B. Goldfine, and J. Plutzky Confronting the type 2 diabetes epidemic: the emerging role of incretin-based therapies Am. J. Med. 123 2010 S2 S10
3. B.D. Green, and P.R. Flatt Incretin hormone mimetics and analogues in diabetes therapeutics Best Pract. Res. Clin. Endocrinol. Metab. 21 2007 497 516
4. O.O. Ojo, P.R. Flatt, Y.H.A. Abdel-Wahab, J.M. Conlon, Insulin-releasing peptides, in: A.J. Kastin (Ed.), Handbook of Biologically Active Peptides, Elsevier, San Diego, CA, 2013, in press.
5. M. Mechkarska, O.O. Ojo, M.A. Meetani, L. Coquet, T. Jouenne, Y.H. Abdel-Wahab, P.R. Flatt, J.D. King, and J.M. Conlon Peptidomic analysis of skin secretions from the bullfrog Lithobates catesbeianus (Ranidae) identifies multiple peptides with potent insulin-releasing activity Peptides 32 2011 203 208
6. Y.H. Abdel-Wahab, G.J. Power, M.T. Ng, P.R. Flatt, and J.M. Conlon Insulin-releasing properties of the frog skin peptide pseudin-2 and its [Lys18]-substituted analogue Biol. Chem. 389 2008 143 148
7. J.M. Conlon, G.J. Power, Y.H. Abdel-Wahab, P.R. Flatt, H. Jiansheng, L. Coquet, J. Leprince, T. Jouenne, and H. Vaudry A potent, non-toxic insulin-releasing peptide isolated from an extract of the skin of the Asian frog, Hylarana guentheri (Anura:Ranidae) Regul. Pept. 151 2008 153 159
8. O.O. Ojo, Y.H. Abdel-Wahab, P.R. Flatt, M. Mechkarska, and J.M. Conlon Tigerinin-1R: a potent, non-toxic insulin-releasing peptide isolated from the skin of the Asian frog, Hoplobatrachus rugulosus Diabetes Obes. Metab. 13 2011 1114 1122
9. Y.H. Abdel-Wahab, G.J. Power, P.R. Flatt, D.C. Woodhams, L.A. Rollins-Smith, and J.M. Conlon A peptide of the phylloseptin family from the skin of the frog Hylomantis lemur (Phyllomedusinae) with potent in vitro and in vivo insulin-releasing activity Peptides 29 2008 2136 2143
10. Y.H. Abdel-Wahab, S. Patterson, P.R. Flatt, and J.M. Conlon Brevinin-2-related peptide and its [D4K] analogue stimulate insulin release in vitro and improve glucose tolerance in mice fed a high fat diet Horm. Metab. Res. 42 2010 652 656
11. J. Eng, W.A. Kleinman, L. Singh, G. Singh, and J.P. Raufman Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom J. Biol. Chem. 267 1992 7402 7405
12. D.R. Frost Amphibian Species of the World: An Online Reference. Version 5.5 Electronic database accessible at: 2011 American Museum of Natural History New York, USA http://research.amnh.org/herpetology/amphibia/index.php
13. B.J. Evans, D.B. Kelley, R.C. Tinsley, D.J. Melnick, and D.C. Cannatella A mitochondrial DNA phylogeny of African clawed frogs: phylogeography and implications for polyploid evolution Mol. Phylogenet. Evol. 33 2004 197 213
14. J.M. Conlon, M. Mechkarska, and J.D. King Host-defense peptides in skin secretions of African clawed frogs (Xenopodinae, Pipidae) Gen. Comp. Endocrinol. 176 2012 513 518
15. M.G. Giovannini, L. Poulter, B.W. Gibson, and D.H. Williams Biosynthesis and degradation of peptides derived from Xenopus laevis prohormones Biochem. J. 243 1987 113 120
16. M. Zasloff Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms and partial cDNA sequence of a precursor Proc. Natl. Acad. Sci. U. S. A. 84 1987 5449 5453
17. B.W. Gibson, L. Poulter, D.H. Williams, and J.E. Maggio Novel peptide fragments originating from PGLa and the caerulein and xenopsin precursors from Xenopus laevis J. Biol. Chem. 261 1986 5341 5349
18. D. Andreu, H. Aschauer, G. Kreil, and R.B. Merrifield Solid-phase synthesis of PYLa and isolation of its natural counterpart, PGLa [PYLa-(4-24)] from skin secretion of Xenopus laevis Eur. J. Biochem. 149 1985 531 535
19. W. Hoffmann, T.C. Bach, H. Seliger, and G. Kreil Biosynthesis of caerulein in the skin of Xenopus laevis: partial sequences of precursors as deduced from cDNA clones EMBO J. 2 1983 111 114
20. T. Wakabayashi, and H. Kato S.Tachibana, Complete nucleotide sequence of mRNA for caerulein precursor from Xenopus skin: the mRNA contains an unusual repetitive structure Nucleic Acids Res. 13 1985 1817 1828
21. K. Richter, R. Egger, and G. Kreil Sequence of preprocaerulein cDNAs cloned from skin of Xenopus laevis. A small family of precursors containing one, three, or four copies of the final product J. Biol. Chem. 261 1986 3676 3680
22. R. Vlasak, O. Wiborg, K. Richter, S. Burgschwaiger, J. Vuust, and G. Kreil Conserved exon-intron organization in two different caerulein precursor genes of Xenopus laevis. Additional detection of an exon potentially coding for a new peptide Eur. J. Biochem. 169 1987 53 58
23. J.M. Conlon, N. Al-Ghaferi, E. Ahmed, M.A. Meetani, J. Leprince, and P.F. Nielsen Orthologs of magainin, PGLa, procaerulein-derived, and proxenopsin-derived peptides from skin secretions of the octoploid frog Xenopus amieti (Pipidae) Peptides 31 2010 989 994
24. M. Mechkarska, E. Ahmed, L. Coquet, J. Leprince, T. Jouenne, H. Vaudry, J.D. King, K. Takada, and J.M. Conlon Genome duplications within the Xenopodinae do not increase the multiplicity of antimicrobial peptides in Silurana paratropicalis and Xenopus andrei skin secretions Comp. Biochem. Physiol. Part D Genomics Proteomics 6 2011 206 212
25. M. Mechkarska, E. Ahmed, L. Coquet, J. Leprince, T. Jouenne, H. Vaudry, J.D. King, and J.M. Conlon Antimicrobial peptides with therapeutic potential from skin secretions of the Marsabit clawed frog Xenopus borealis (Pipidae) Comp. Biochem. Physiol. C Toxicol. Pharmacol. 152 2010 467 472
26. J.M. Conlon, M. Mechkarska, E. Ahmed, J. Leprince, H. Vaudry, J.D. King, and K. Takada Purification and properties of antimicrobial peptides from skin secretions of the Eritrea clawed frog Xenopus clivii (Pipidae) Comp. Biochem. Physiol. C Toxicol. Pharmacol. 153 2011 350 354
27. J.D. King, M. Mechkarska, L. Coquet, J. Leprince, T. Jouenne, H. Vaudry, K. Takada, and J.M. Conlon Host-defense peptides from skin secretions of the tetraploid frogs Xenopus petersii and Xenopus pygmaeus, and the octoploid frog Xenopus lenduensis (Pipidae) Peptides 33 2012 35 43
28. M. Mechkarska, E. Ahmed, L. Coquet, J. Leprince, T. Jouenne, H. Vaudry, J.D. King, and J.M. Conlon Peptidomic analysis of skin secretions demonstrates that the allopatric populations of Xenopus muelleri (Pipidae) are not conspecific Peptides 32 2011 1502 1508
29. M.F. Ali, A. Soto, F.C. Knoop, and J.M. Conlon Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae) Biochim. Biophys. Acta 1550 2001 81 89
30. J.M. Conlon, M. Mechkarska, M. Prajeep, A. Sonnevend, L. Coquet, J. Leprince, T. Jouenne, H. Vaudry, and J.D. King Host-defense peptides in skin secretions of the tetraploid frog Silurana epitropicalis with potent activity against methicillin-resistant Staphylococcus aureus (MRSA) Peptides 37 2012 113 119
31. M. Mechkarska, M. Meetani, P. Michalak, Z. Vaksman, K. Takada, and J.M. Conlon Hybridization between the African clawed frogs Xenopus laevis and Xenopus muelleri (Pipidae) increases the multiplicity of antimicrobial peptides in skin secretions of female offspring Comp. Biochem. Physiol. Part D Genomics Proteomics 7 2012 285 291
32. O.K. Zahid, M. Mechkarska, O.O. Ojo, Y.H. Abdel-Wahab, P.R. Flatt, M.A. Meetani, and J.M. Conlon Caerulein-and xenopsin-related peptides with insulin-releasing activities from skin secretions of the clawed frogs, Xenopus borealis and Xenopus amieti (Pipidae) Gen. Comp. Endocrinol. 172 2011 314 320
33. N.H. McClenaghan, and P.R. Flatt Physiological and pharmacological regulation of insulin release: insights offered through exploitation of insulin-secreting cell lines Diabetes Obes. Metab. 1 1999 137 150
34. N.H. McClenaghan, C.R. Barnett, E. Ah-Sing, Y.H. Abdel-Wahab, F.P. O'Harte, T.W. Yoon, S.K. Swanston-Flatt, and P.R. Flatt Characterization of a novel glucose-responsive insulin-secreting cell line, BRIN-BD11, produced by electrofusion Diabetes 45 1996 1132 1140
35. P.R. Flatt, and C.J. Bailey Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice Diabetelogia 20 1981 573 577
36. G. Bocchinfuso, A. Palleschi, B. Orioni, G. Grande, F. Formaggio, C. Toniolo, Y. Park, K.S. Hahm, and L. Stella Different mechanisms of action of antimicrobial peptides: insights from fluorescence spectroscopy experiments and molecular dynamics simulations J. Pept. Sci. 15 2009 550 558
37. J.H. Kim, J.O. Lee, J.H. Jung, S.K. Lee, G.Y. You, S.H. Park, and H.S. Kim Gaegurin-6 stimulates insulin secretion through calcium influx in pancreatic beta Rin5mf cells Regul. Pept. 159 2010 123 128