Differential expression and functional characterization of system L amino acid transporters in human normal osteoblast cells and osteogenic sarcoma cells

Anticancer Research

Volumn 26, Issue 3 A, 2006, Pages 1989-1996

  Kim, Su Gwan ^a   Kim, Hyun Ho ^a   Kim, Hak Kyun ^a   Kim, Chang Hyun ^a   Chun, Hong Sung ^a   Kanai, Yoshikatsu ^b   Endou, Hitoshi ^b   Kim, Do Kyung ^a  

^a Chosun University   (South Korea)

^b KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Antitumor therapy; Essential amino acids; L type amino acid transporter; Osteoblast cells; Osteogenic sarcoma cells

Indexed keywords

2 AMINOBICYCLO (2,2,1) HEPTANE 2 CARBOXYLIC ACID; AMINO ACID DERIVATIVE; AMINO ACID TRANSPORTER; ANTINEOPLASTIC AGENT; CARBOXYLIC ACID DERIVATIVE; LEUCINE; LEUCINE C 14; PROTEIN LAT1; PROTEIN LAT2; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ARTICLE; BINDING AFFINITY; DRUG INHIBITION; DRUG MECHANISM; HUMAN; HUMAN CELL; OOCYTE; OSTEOBLAST; OSTEOSARCOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; XENOPUS;

AMINO ACID TRANSPORT SYSTEM L; AMINO ACID TRANSPORT SYSTEM Y+; AMINO ACIDS; AMINO ACIDS, CYCLIC; ANIMALS; ANTIGENS, CD98 LIGHT CHAINS; BONE NEOPLASMS; CARBON RADIOISOTOPES; CELL LINE, TUMOR; HUMANS; LARGE NEUTRAL AMINO ACID-TRANSPORTER 1; LEUCINE; OSTEOBLASTS; OSTEOSARCOMA; STEREOISOMERISM; XENOPUS;

EID: 33745616802     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Christensen HN: Role of amino acid transport and countertransport in nutrition and metabolism. Physiol Rev 70: 43-77, 1990.
2. McGivan JD and Pastor-Anglada M: Regulatory and molecular aspects of mammalian amino acid transport. Biochem J 299: 321-334, 1994.
3. Oxender DL and Christensen HN: Evidence for two types of mediation of neutral amino acid transport in Ehrlich cells. Nature 197: 765-767, 1963.
4. Kanai Y, Segawa H, Miyamoto K, Uchino H, Takeda E and Endou H: Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). J Biol Chem 273: 23629-23632, 1998.
5. Yanagida O, Kanai Y, Chairoungdua A et al: Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines. Biochim Biophys Acta 1514: 291-302, 2001.
6. +-independent neutral amino acid transporter with broad substrate selectivity. J Biol Chem 274: 19745-19751, 1999.
7. Mannion BA, Kolesnikova TV, Lin SH, Thompson NL and Hemler ME: The light chain of CD98 is identified as E16/TA1 protein. J Biol Chem 273: 33127-33129, 1998.
8. Mastroberardino L, Spindler B, Pfeiffer R et al: Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family. Nature 395: 288-291, 1998.
9. Pfeiffer R, Spindler B, Loffing J, Skelly PJ, Shoemaker CB and Verrey F: Functional heterodimeric amino acid transporters lacking cysteine residues involved in disulfide bond. FEBS Lett 439: 157-162, 1998.
10. Nakamura E, Sato M, Yang H et al: 4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer. J Biol Chem 274: 3009-3016, 1999.
11. Prasad PD, Wang H, Huang H et al: Human LAT1, a subunit of system L amino acid transporter: molecular cloning and transport function. Biochem Biophys Res Commun 255: 283-288, 1999.
12. Sang J, Lim YP, Panzia MA, Finch P and Thompson NL: TA1, a highly conserved oncofetal complementary DNA from rat hepatoma, encodes an integral membrane protein associated with liver development, carcinogenesis, and cell activation. Cancer Res 55: 1152-1159, 1995.
13. Wolf DA, Wang S, Panzia MA, Bassily NH and Thompson NL: Expression of a highly conserved oncofetal gene, TA1/E16, in human colon carcinoma and other primary cancers: homology to Schistosoma mansoni amino acid permease and Caenorhabditis elegans gene products. Cancer Res 56: 5012-5022, 1996.
14. Uchino H, Kanai Y, Kim DK et al: Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition. Mol Pharmacol 61: 729-737, 2002.
15. Pineda M, Fernandez E, Torrents D et al: Identification of a membrane protein, LAT-2, that co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids. J Biol Chem 274: 19738-19744, 1999.
16. Rossier G, Meier C, Bauch C et al: LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine. J Biol Chem 274: 34948-34954, 1999.
17. +-independent, broad-specific neutral amino acid transporter from mammalian intestine. Biochim Biophys Acta 1463: 6-14, 2000.
18. Kanai Y and Endou H: Heterodimeric amino acid transporters: molecular biology and pathological and pharmacological relevance. Curr Drug Metab 2: 339-354, 2001.
19. Kim DK, Kanai Y, Choi HW et al: Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells. Biochim Biophys Acta 1565: 112-121, 2002.
20. Katsui K, Kuroda M, Wang Y et al: Cepharanthin enhances adriamycin sensitivity by synergistically accelerating apoptosis for adriamycin-resistant osteosarcoma cell lines, SaOS2-AR and SaOS2 F-AR. Int J Oncol 25: 47-56, 2004.
21. Komatsu M, Kuroda M, Wang Y et al: Manganese superoxide dismutase overexpression changes plating efficiency bidirectionally according to change in redox for SaOS2 human osteosarcoma cell line. Int J Oncol 26: 853-862, 2005.
22. Yoon JH, Kim YB, Kim MS et al: Expression and functional characterization of the system L amino acid transporter in KB human oral epidermoid carcinoma cells. Cancer Lett 205: 215-226, 2004.
23. Chairoungdua A, Segawa H, Kim JY et al: Identification of an amino acid transporter associated with the cystinuria-related type II membrane glycoprotein. J Biol Chem 274: 28845-28848, 1999.
24. +-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. J Biol Chem 276: 17221-17228, 2001.
25. Mizoguchi K, Cha SH, Chairoungdua A et al: Human cystinuria-related transporter: localization and functional characterization. Kidney Int 59: 1821-1833, 2001.
26. Yoon JH, Kim IJ, Kim H et al: Amino acid transport system L is differently expressed in human normal oral keratinocytes and human oral cancer cells. Cancer Lett 222: 237-245, 2005.
27. Christensen HN, Handlogten ME, Lam I, Tager HS and Zand R: A bicyclic amino acid to improve discriminations among transport systems. J Biol Chem 244: 1510-1520, 1969.
28. 0,+. J Biol Chem 274: 23740-23745, 1999.