Mortality, attempted suicide, re-hospitalisation and prescription refill for clozapine and other antipsychotics in Sweden-a register-based study

Pharmacoepidemiology and Drug Safety

Volumn 23, Issue 3, 2014, Pages 290-298

  Ringbäck Weitoft, Gunilla ^a   Berglund, Mats ^b   Lindström, Eva A ^c   Nilsson, Mikael ^d,e   Salmi, Peter ^a   Rosén, Måns ^d,e  

^a NATIONAL BOARD OF HEALTH AND WELFARE   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^d Swedish Council on Health Technology Assessment   (Sweden)

^e KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Antipsychotics; Epidemiology; Mortality; Pharmacoepidemiology; Re hospitalisation; Suicide; Suicide attempts

Indexed keywords

ANTIDEPRESSANT AGENT; ARIPIPRAZOLE; CLOZAPINE; FLUPENTIXOL; HALOPERIDOL; NEUROLEPTIC AGENT; OLANZAPINE; PERPHENAZINE; QUETIAPINE; RISPERIDONE; ZIPRASIDONE; ZUCLOPENTHIXOL;

ADULT; AGRANULOCYTOSIS; ARTICLE; CARDIOVASCULAR DISEASE; CAUSE OF DEATH; CONTROLLED STUDY; ETIOLOGIC FRACTION; FEMALE; FOLLOW UP; HOSPITAL READMISSION; HUMAN; INTOXICATION; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH CARE; MIDDLE AGED; MORTALITY; NEOPLASM; POPULATION BASED CASE CONTROL STUDY; PRESCRIPTION; PRIORITY JOURNAL; PSYCHIATRIC DIAGNOSIS; REGISTER; RESPIRATORY TRACT DISEASE; RISK REDUCTION; SCHIZOPHRENIA; SUICIDE; SUICIDE ATTEMPT; SWEDEN; ADOLESCENT; AGED; CASE CONTROL STUDY; COHORT ANALYSIS; EPIDEMIOLOGY; HOSPITALIZATION; PSYCHOLOGY; SUICIDE, ATTEMPTED; TRENDS; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANTIPSYCHOTIC AGENTS; CASE-CONTROL STUDIES; CLOZAPINE; COHORT STUDIES; DRUG PRESCRIPTIONS; FEMALE; HOSPITALIZATION; HUMANS; MALE; MIDDLE AGED; MORTALITY; SUICIDE, ATTEMPTED; SWEDEN; YOUNG ADULT;

EID: 84895506968     PISSN: 10538569     EISSN: 10991557     Source Type: Journal    
DOI: 10.1002/pds.3567     Document Type: Article

References (23)

1. Tiihonen J, Lönnqvist J, Wahlbeck K, et al. 11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study). Lancet 2009; 374: 620-627.
2. Tiihonen J, Wahlbeck K, Lönnqvist J, et al. Effectiveness of antipsychotic treatment in a nationwide cohort of patients in community care after first hospitalization due to schizophrenia and schizoaffective disorder: observational follow-up study. BMJ 2006. doi:10.1136/bmj.38881.382755.2F.
3. Asenjo Lobos C, Komossa K, Rummel-Kluge C, et al. Clozapine versus other typical antipsychotics for schizophrenia. Review. Cochrane Library 2010, Issue 12.
4. Casey DE. Neuroleptic drug-induced extrapyramidal syndromes and tardive dyskinesia. Schiz Res 1991; 4: 109-120.
5. Kane J, Honigfeld G, Singer J, Meltzer H. Clozapine for the treatment-resistant schizophrenic. Arch Gen Psychiatry 1988; 45: 789-796.
6. Lindström LH. The effect of long-term treatment with clozapine in schizophrenia: a retrospective study in 96 patients treated with clozapine up to 13 years. Acta Psychiatr Scand 1988; 77: 524-529.
7. Wettermark B, Hammar N, Fored M, et al. The new Swedish prescribed drug register - opportunities for pharmacoepidemiological research and experience from the first six months. Pharmacoepidemiol Drug Saf 2007; 16: 726-735.
8. Ludvigsson JF, Andersson E, Ekbom A, et al. External review and validation of the Swedish national inpatient register. BMC Public Health 2011; 11: 450-465.
9. th Revision (ICD-10) Version for 2010 (http://apps.who.int/classifications/icd10/browse/2010/en#/V, accessed 18 Nov 2013).
10. WHO Collaborating Centre for Drug statistics Methodology. ATC/DDD Index 2013 (http://www.whocc.no/atc_ddd_index/, accessed 18 Nov 2013).
11. Meltzer HY, Alphs L, Green AI, et al. Clozapine treatment for suicidality in schizophrenia: International Suicide Prevention Trial (InterSePT). Arch Gen Psychiatry 2003; 60: 82-91.
12. Haukka J, Tiihonen J, Harkanen T, Lönnqvist J. Association between medication and risk of suicide, attempted suicide and death in nationwide cohort of suicidal patients with schizophrenia. Pharmacoepidemiol Drug Saf 2008; 17: 686-696.
13. Walker AM, Lanza LL, Arellano F, Rothman KJ. Mortality in current and former users of clozapine. Epidemiology 1997; 8: 671-677.
14. Kiviniemi M, Svisaari J, Koivumaa-Honkanen H, Hääkinen U, Isohanni M, Hakko H. Antipsychotics and mortality in first-onset schizophrenia: prospective Finnish register study with 5-year follow-up. Schizophrenia Res 2013; 150: 274-80.
15. McEvoy JP, Lieberman JA, Stroup TS, et al. For the CATIE investigators. Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment. Am J Psychiatry 2006; 163: 600-610.
16. Tidemalm D, Långström N, Lichtenstein P, Runeson B. Risk of suicide after suicide attempt according to coexisting psychiatric disorder: Swedish cohort study with long follow-up. BMJ 2008; 337: a2205. doi:10.1136/bmj.a2205.
17. Nordentoft M, Mortensen PB, Böcker PC. Absolute risk of suicide after first hospital contact in mental disorder. Arch Gen Psychiatry 2011; 68: 1058-1064.
18. Blonde L, Kan HJ, Gutterman EM, et al. Predicted risk of diabetes and coronary heart disease in patients with schizophrenia; aripiprazole versus standard of care. J Clin Psychiatry 2008; 69: 741-748.
19. Stroup TS, McEvoy JP, Ring KD, et al. Schizophrenia Trials Network. A randomized trial examining the effectiveness of switching from olanzapine, quetiapine, or risperidone to aripiprazole to reduce metabolic risk: comparison of antipsychotics for metabolic problems (CAMP). Am J Psychiatry 2011; 168: 882-884.
20. Hor K, Taylor M. Suicide and schizophrenia: a systematic review of rates and risk factors. J Psychopharmacol 2010; 24(4 supl): 81-90.
21. Meltzer HY. Suicide and schizophrenia: clozapine and the InterSePT study. International Clozapine/Leponex Suicide Prevention Trial. J Clin Psychiatry 1999; 60(Suppl 12): 4750.
22. Copolov DL, Bell WR, Benson WJ, et al. Clozapine treatment in Australia: a review of haematological monitoring. Med J Aust 1998; 168: 495-7.
23. Alvir JM, Lieberman JA. Agranulocytosis: incidence and risk factors. J Clin Psychiatry 1994; 55(Suppl B): 137-138.