Longer telomeres are associated with cancer risk in MMR-proficient hereditary non-polyposis colorectal cancer

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Seguí, Nuria ^a   Guinó, Elisabet ^a   Pineda, Marta ^a   Navarro, Matilde ^a   Bellido, Fernando ^a   Lázaro, Conxi ^a   Blanco, Ignacio ^a   Moreno, Victor ^a,b   Capellá, Gabriel ^a   Valle, Laura ^a  

^a CATALAN INSTITUTE OF ONCOLOGY   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

MISMATCH REPAIR PROTEIN;

ADULT; ARTICLE; CANCER RISK; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE MUTATION; GENETIC ASSOCIATION; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HUMAN; MAJOR CLINICAL STUDY; MALE; MMR GENE; MULTIPLEX POLYMERASE CHAIN REACTION; POLYMERASE CHAIN REACTION; QUANTITATIVE ANALYSIS; RETROSPECTIVE STUDY; TELOMERE HOMEOSTASIS; BLOOD; FAMILY HEALTH; GENETICS; HETEROZYGOTE; MIDDLE AGED; MISMATCH REPAIR; MUTATION; PROCEDURES; RISK ASSESSMENT; RISK FACTOR; TELOMERE; TELOMERE SHORTENING;

ADULT; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA MISMATCH REPAIR; FAMILY HEALTH; FEMALE; HETEROZYGOTE; HUMANS; MALE; MIDDLE AGED; MUTATION; POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; TELOMERE; TELOMERE HOMEOSTASIS; TELOMERE SHORTENING;

EID: 84895474576     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086063     Document Type: Article

References (22)

1. Lynch HT, Lynch PM, Lanspa SJ, Snyder CL, Lynch JF, et al. (2009) Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications. Clin Genet 76: 1-18.
2. Ku CS, Cooper DN, Wu M, Roukos DH, Pawitan Y, et al. (2012) Gene discovery in familial cancer syndromes by exome sequencing: prospects for the elucidation of familial colorectal cancer type X. Mod Pathol 25: 1055-1068.
3. Blasco MA (2005) Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet 6: 611-622. (Pubitemid 41044298)
4. Stewart JA, Chaiken MF, Wang F, Price CM (2012) Maintaining the end: roles of telomere proteins in end-protection, telomere replication and length regulation. Mutat Res 730: 12-19.
5. Hou L, Zhang X, Gawron AJ, Liu J (2012) Surrogate tissue telomere length and cancer risk: shorter or longer? Cancer Lett 319: 130-135.
6. Alter BP, Giri N, Savage SA, Rosenberg PS (2009) Cancer in dyskeratosis congenita. Blood 113: 6549-6557.
7. Blasco MA (2005) Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging. Embo J 24: 1095-1103. (Pubitemid 40516594)
8. Prescott J, Wentzensen IM, Savage SA, De Vivo I (2012) Epidemiologic evidence for a role of telomere dysfunction in cancer etiology. Mutat Res 730: 75-84.
9. Zee RY, Castonguay AJ, Barton NS, Buring JE (2009) Mean telomere length and risk of incident colorectal carcinoma: a prospective, nested case-control approach. Cancer Epidemiol Biomarkers Prev 18: 2280-2282.
10. Pooley KA, Sandhu MS, Tyrer J, Shah M, Driver KE, et al. (2010) Telomere length in prospective and retrospective cancer case-control studies. Cancer Res 70: 3170-3176.
11. Lee IM, Lin J, Castonguay AJ, Barton NS, Buring JE, et al. (2010) Mean leukocyte telomere length and risk of incident colorectal carcinoma in women: a prospective, nested case-control study. Clin Chem Lab Med 48: 259-262.
12. Bozzao C, Lastella P, Ponz de Leon M, Pedroni M, Di Gregorio C, et al. (2011) Analysis of telomere dynamics in peripheral blood cells from patients with Lynch syndrome. Cancer 117: 4325-4335.
13. Maxwell F, McGlynn LM, Muir HC, Talwar D, Benzeval M, et al. (2011) Telomere attrition and decreased fetuin-A levels indicate accelerated biological aging and are implicated in the pathogenesis of colorectal cancer. Clin Cancer Res 17: 5573-5581.
14. Jones AM, Beggs AD, Carvajal-Carmona L, Farrington S, Tenesa A, et al. (2012) TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres. Gut 61: 248-254.
15. Cui Y, Cai Q, Qu S, Chow WH, Wen W, et al. (2012) Association of leukocyte telomere length with colorectal cancer risk: nested case-control findings from the Shanghai Women's Health Study. Cancer Epidemiol Biomarkers Prev 21: 1807-1813.
16. Segui N, Pineda M, Guino E, Borras E, Navarro M, et al. (2013) Telomere length and genetic anticipation in lynch syndrome. PLoS One 8: e61286.
17. Cawthon RM (2009) Telomere length measurement by a novel monochrome multiplex quantitative PCR method. Nucleic Acids Res 37: e21.
18. Martinez-Delgado B, Yanowsky K, Inglada-Perez L, Domingo S, Urioste M, et al. (2011) Genetic anticipation is associated with telomere shortening in hereditary breast cancer. PLoS Genet 7: e1002182.
19. Savage SA, Gadalla SM, Chanock SJ (2013) The long and short of telomeres and cancer association studies. J Natl Cancer Inst 105: 448-449.
20. Lan Q, Cawthon R, Shen M, Weinstein SJ, Virtamo J, et al. (2009) A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of non-Hodgkin lymphoma. Clin Cancer Res 15: 7429-7433.
21. Bisoffi M, Heaphy CM, Griffith JK (2006) Telomeres: prognostic markers for solid tumors. Int J Cancer 119: 2255-2260. (Pubitemid 44546943)
22. Hu J, Hwang SS, Liesa M, Gan B, Sahin E, et al. (2012) Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell 148: 651-663.