Telomere attrition and decreased fetuin-A levels indicate accelerated biological aging and are implicated in the pathogenesis of colorectal cancer

Clinical Cancer Research

Volumn 17, Issue 17, 2011, Pages 5573-5581

  Maxwell, Fraser ^a   McGlynn, Liane M ^a   Muir, Hannah C ^a   Talwar, Dinesh ^b   Benzeval, Michaela ^c   Robertson, Tony ^c   Roxburgh, Campbell S ^a   McMillan, Donald C ^a   Horgan, Paul G ^a   Shiels, Paul G ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b NHS Greater Glasgow and Clyde Clinical Biochemistry Service   (United Kingdom)

^c MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ALPHA TOCOPHEROL; C REACTIVE PROTEIN; CALCIUM; FETUIN A; INTERLEUKIN 10; INTERLEUKIN 6; RETINOL; VASCULOTROPIN; XANTHOPHYLL;

ADULT; AGED; AGING; ARTICLE; CALCIUM HOMEOSTASIS; CANCER TISSUE; COLON; COLON CARCINOGENESIS; COLORECTAL CARCINOMA; CONTROLLED STUDY; FEMALE; GENE DOSAGE; HUMAN; HUMAN TISSUE; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TELOMERE;

AGED; AGED, 80 AND OVER; AGING; ALPHA-2-HS-GLYCOPROTEIN; CALCIUM; COLORECTAL NEOPLASMS; DNA; FEMALE; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; OXIDATION-REDUCTION; RECTAL NEOPLASMS; RISK FACTORS; TELOMERE; TELOMERE SHORTENING; TUMOR MARKERS, BIOLOGICAL;

EID: 80052468934     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-10-3271     Document Type: Article

References (46)

1. CancerStats: Bowel cancer. 2010. Available from: http://info. cancerresearchuk. org/cancerstats/types/bowel/index.htm?script=true.
2. Lamb KJ, Shiels PG. Telomeres, ageing and oxidation. SEB Exp Biol Ser 2009;62:117-37.
3. Moyzis RK, Buckingham JM, Cram LS, Dani M, Deaven LL, Jones MD, et al. A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci U S A 1988;85:6622-6.
4. Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990;345:458-60.
5. Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res 1961;25:585-621.
6. Misri S, Pandita S, Kumar R, Pandita TK. Telomeres, histone code, and DNA damage response. Cytogenet Genome Res 2008;122: 297-307.
7. Slagboom PE, Droog S, Boomsma DI. Genetic determination of telomere size in humans: a twin study of three age groups. Am J Hum Genet 1994;55:876-82.
8. Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, DePinho RA, et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997;91:25-34.
9. Samper E, Flores JM, Blasco MA. Restoration of telomerase activity rescues chromosomal instability and premature aging in terc-/- mice with short telomeres. EMBO Rep 2001;2:800-7.
10. Saretzki G, Von Zglinicki T. Replicative aging, telomeres, and oxidative stress. Ann N Y Acad Sci 2002;959:24-9.
11. von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem Sci 2002;27:339-44.
12. Starr JM, Shiels PG, Harris SE, Pattie A, Pearce MS, Relton CL, et al. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. Mech Ageing Dev 2008;129:745-51.
13. Carrero JJ, Stenvinkel P, Fellstrom B, Qureshi AR, Lamb K, Heimburger O, et al. Telomere attrition is associated with inflammation, low fetuin-A levels and high mortality in prevalent haemodialysis patients. J Intern Med 2008;263:302-12.
14. Blasco MA. Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet 2005;6:611-22.
15. Brouilette SW, Moore JS, McMahon AD, Thompson JR, Ford I, Shepherd J, et al. Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study. Lancet 2007;369:107-14.
16. Savale L, Chaouat A, Bastuji-Garin S, Marcos E, Boyer L, Maitre B, et al. Shortened telomeres in circulating leukocytes of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2009;179:566-71.
17. Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, et al. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A 2004;101:17312-5.
18. Cawthon RM, Smith KR, O'Brien E, Sivatchenko A, Kerber RA. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 2003;361:393-5.
19. Wu X, Amos CI, Zhu Y, Zhao H, Grossman BH, Shay JW, et al. Telomere dysfunction: a potential cancer predisposition factor. J Natl Cancer Inst 2003;95:1211-8.
20. Hou L, Savage SA, Blaser MJ, Perez-Perez G, Hoxha M, Dioni L, et al. Telomere length in peripheral leukocyte DNA and gastric cancer risk. Cancer Epidemiol Biomarkers Prev 2009;18: 3103-9.
21. Mirabello L, Garcia-Closas M, Cawthon R, Lissowska J, Brinton LA, Peplonska B, et al. Leukocyte telomere length in a population-based case-control study of ovarian cancer: a pilot study. Cancer Causes Control 2010;21:77-82.
22. Jang JS, Choi YY, Lee WK, Choi JE, Cha SI, Kim YJ, et al. Telomere length and the risk of lung cancer. Cancer Sci 2008; 99:1385-9.
23. Petersen VC, Baxter KJ, Love SB, Shepherd NA. Identification of objective pathological prognostic determinants and models of prognosis in Dukes' B colon cancer. Gut 2002;51:65-9.
24. Benzeval M, Der G, Ellaway A, Hunt K, Sweeting H, West P, et al. Cohort profile: west of Scotland twenty-07 study: health in the community. Int J Epidemiol 2009;38:1215-23.
25. Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acids Res 2002;30:e47.
26. Koppelstaetter C, Jennings P, Hochegger K, Perco P, Ischia R, Karkoszka H, et al. Effect of tissue fixatives on telomere length determination by quantitative PCR. Mech Ageing Dev 2005;126: 1331-3.
27. Roxburgh CS, McMillan DC. Role of systemic inflammatory response in predicting survival in patients with primary operable cancer. Future Oncol 2010;6:149-63.
28. Talwar D, Ha TK, Cooney J, Brownlee C, O'Reilly DS. A routine method for the simultaneous measurement of retinol, alpha-tocopherol and five carotenoids in human plasma by reverse phase HPLC. Clin Chim Acta 1998;270:85-100.
29. Pooley KA, Sandhu MS, Tyrer J, Shah M, Driver KE, Luben RN, et al. Telomere length in prospective and retrospective cancer case-control studies. Cancer Res 2010;70:3170-6.
30. Zee RY, Castonguay AJ, Barton NS, Buring JE. Mean telomere length and risk of incident colorectal carcinoma: a prospective, nested casecontrol approach. Cancer Epidemiol Biomarkers Prev 2009;18: 2280-2.
31. Lee IM, Lin J, Castonguay AJ, Barton NS, Buring JE, Zee RY. Mean leukocyte telomere length and risk of incident colorectal carcinoma in women: a prospective, nested case-control study. Clin Chem Lab Med 2010;48:259-62.
32. Willeit P, Willeit J, Mayr A, Weger S, Oberhollenzer F, Brandstatter A, et al. Telomere length and risk of incident cancer and cancer mortality. JAMA 2010;304:69-75.
33. Serra V, von Zglinicki T, Lorenz M, Saretzki G. Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening. J Biol Chem 2003;278:6824-30.
34. Gangneux C, Daveau M, Hiron M, Derambure C, Papaconstantinou J, Salier JP. The inflammation-induced down-regulation of plasma fetuin-A (alpha2HS-glycoprotein) in liver results from the loss of interaction between long C/EBP isoforms at two neighbouring binding sites. Nucleic Acids Res 2003;31:5957-70.
35. Hermans MM, Brandenburg V, Ketteler M, Kooman JP, van der Sande FM, Boeschoten EW, et al. Association of serum fetuin-A levels with mortality in dialysis patients. Kidney Int 2007;72: 202-7.
36. Li W, Zhu S, Li J, Huang Y, Rongrong Z, Fan X, et al. A hepatic protein, fetuin-a, occupies a protective role in lethal systemic inflammation. PLoS One 2011;6:e16945.
37. Voros K, Graf L Jr, Prohaszka Z, Graf L, Szenthe P, Kaszas E, et al. Serum fetuin-A in metabolic and inflammatory pathways in patients with myocardial infarction. Eur J Clin Invest 2011;41: 703-9.
38. Petrik V, Saadoun S, Loosemore A, Hobbs J, Opstad KS, Sheldon J, et al. Serum {alpha}2-HS glycoprotein predicts survival in patients with glioblastoma. Clin Chem 2008;54:713-22.
39. Rho JH, RoehrlMH, Wang JY. Glycoproteomic analysis of human lung adenocarcinomas using glycoarrays and tandem mass spectrometry: differential expression and glycosylation patterns of vimentin and fetuin A isoforms. Protein J 2009;28:148-60.
40. Coppe JP, Patil CK, Rodier F, Sun Y, Munoz DP, Goldstein J, et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 2008;6:2853-68.
41. Risques RA, Lai LA, Brentnall TA, Li L, Feng Z, Gallaher J, et al. Ulcerative colitis is a disease of accelerated colon aging: evidence from telomere attrition and DNA damage. Gastroenterology 2008; 135:410-8.
42. Davalos AR, Coppe JP, Campisi J, Desprez PY. Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev 2010;29:273-83.
43. Gertler R, Rosenberg R, Stricker D, Friederichs J, Hoos A, Werner M, et al. Telomere length and human telomerase reverse transcriptaseexpression as markers for progression and prognosis of colorectal carcinoma. J Clin Oncol 2004;22:1807-14.
44. Plentz RR, Wiemann SU, Flemming P, Meier PN, Kubicka S, Kreipe H, et al. Telomere shortening of epithelial cells characterises the adenoma- carcinoma transition of human colorectal cancer. Gut 2003;52: 1304-7.
45. Rampazzo E, Bertorelle R, Serra L, Terrin L, Candiotto C, Pucciarelli S, et al. Relationship between telomere shortening, genetic instability, and site of tumour origin in colorectal cancers. Br J Cancer 2010;102:1300-5.
46. Iacopetta B. Are there two sides to colorectal cancer? Int J Cancer 2002;101:403-8.