-
1
-
-
0034705207
-
Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis
-
Carsillo T, Astrinidis A, Henske EP. Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis. Proc Natl Acad Sci USA 2000; 97: 6085-6090.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 6085-6090
-
-
Carsillo, T.1
Astrinidis, A.2
Henske, E.P.3
-
2
-
-
0035888683
-
Chromosome 16 loss of heterozygosity in tuberous sclerosis and sporadic lymphangiomyomatosis
-
Yu J, Astrinidis A, Henske EP. Chromosome 16 loss of heterozygosity in tuberous sclerosis and sporadic lymphangiomyomatosis. Am J Respir Crit Care Med 2001; 164: 1537-1540.
-
(2001)
Am J Respir Crit Care Med
, vol.164
, pp. 1537-1540
-
-
Yu, J.1
Astrinidis, A.2
Henske, E.P.3
-
3
-
-
0345237920
-
Recurrent lymphangiomyomatosis after transplantation: Genetic analyses reveal a metastatic mechanism
-
Karbowniczek M, Astrinidis A, Balsara BR, et al. Recurrent lymphangiomyomatosis after transplantation: genetic analyses reveal a metastatic mechanism. Am J Respir Crit Care Med 2003; 167: 976-982.
-
(2003)
Am J Respir Crit Care Med
, vol.167
, pp. 976-982
-
-
Karbowniczek, M.1
Astrinidis, A.2
Balsara, B.R.3
-
4
-
-
84871731680
-
Lymphangioleiomyomatosis: Calling it what it is: A low-grade, destructive, metastasizing neoplasm
-
McCormack FX, Travis WD, Colby TV, et al. Lymphangioleiomyomatosis: calling it what it is: a low-grade, destructive, metastasizing neoplasm. Am J Respir Crit Care Med 2012; 186: 1210-1212.
-
(2012)
Am J Respir Crit Care Med
, vol.186
, pp. 1210-1212
-
-
McCormack, F.X.1
Travis, W.D.2
Colby, T.V.3
-
5
-
-
84868624305
-
Lymphangioleiomyomatosis-a wolf in sheep's clothing
-
Henske EP, McCormack FX. Lymphangioleiomyomatosis-a wolf in sheep's clothing. J Clin Invest 2012; 122: 3807-3816.
-
(2012)
J Clin Invest
, vol.122
, pp. 3807-3816
-
-
Henske, E.P.1
McCormack, F.X.2
-
6
-
-
79955510505
-
Efficacy and safety of sirolimus in lymphangioleiomyomatosis
-
McCormack FX, Inoue Y, Moss J, et al. Efficacy and safety of sirolimus in lymphangioleiomyomatosis. N Engl J Med 2011; 364: 1595-1606.
-
(2011)
N Engl J Med
, vol.364
, pp. 1595-1606
-
-
McCormack, F.X.1
Inoue, Y.2
Moss, J.3
-
7
-
-
38049169559
-
Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis
-
Bissler JJ, McCormack FX, Young LR, et al. Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. N Engl J Med 2008; 358: 140-151.
-
(2008)
N Engl J Med
, vol.358
, pp. 140-151
-
-
Bissler, J.J.1
McCormack, F.X.2
Young, L.R.3
-
8
-
-
84867333656
-
Genome sequencing identifies a basis for everolimus sensitivity
-
Iyer G, Hanrahan AJ, Milowsky MI, et al. Genome sequencing identifies a basis for everolimus sensitivity. Science 2012; 338: 221.
-
(2012)
Science
, vol.338
, pp. 221
-
-
Iyer, G.1
Hanrahan, A.J.2
Milowsky, M.I.3
-
9
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324: 1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
10
-
-
84864874958
-
MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
-
Martina JA, Chen Y, Gucek M, et al. MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB. Autophagy 2012; 8: 903-914.
-
(2012)
Autophagy
, vol.8
, pp. 903-914
-
-
Martina, J.A.1
Chen, Y.2
Gucek, M.3
-
11
-
-
65249176304
-
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
-
Jung CH, Jun CB, Ro SH, et al. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell 2009; 20: 1992-2003.
-
(2009)
Mol Biol Cell
, vol.20
, pp. 1992-2003
-
-
Jung, C.H.1
Jun, C.B.2
Ro, S.H.3
-
12
-
-
58149478492
-
mTOR regulates autophagy-associated genes downstream of p73
-
Rosenbluth JM, Pietenpol JA. mTOR regulates autophagy-associated genes downstream of p73. Autophagy 2009; 5: 114-116.
-
(2009)
Autophagy
, vol.5
, pp. 114-116
-
-
Rosenbluth, J.M.1
Pietenpol, J.A.2
-
13
-
-
79961059959
-
Tumorigenesis in tuberous sclerosis complex is autophagy and p62/ sequestosome 1 (SQSTM1)-dependent
-
Parkhitko A, Myachina F, Morrison TA, et al. Tumorigenesis in tuberous sclerosis complex is autophagy and p62/ sequestosome 1 (SQSTM1)-dependent. Proc Natl Acad Sci USA 2011; 108: 12455-12460.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 12455-12460
-
-
Parkhitko, A.1
Myachina, F.2
Morrison, T.A.3
-
14
-
-
84893108714
-
Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide
-
Parkhitko AA, Priolo C, Coloff JL, et al. Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. Mol Cancer Res 2014; 12: 48-57.
-
(2014)
Mol Cancer Res
, vol.12
, pp. 48-57
-
-
Parkhitko, A.A.1
Priolo, C.2
Coloff, J.L.3
-
15
-
-
0031841280
-
Frequent progesterone receptor immunoreactivity in tuberous sclerosisassociated renal angiomyolipomas
-
Henske EP, Ao X, Short MP, et al. Frequent progesterone receptor immunoreactivity in tuberous sclerosisassociated renal angiomyolipomas. Mod Pathol 1998; 11: 665-668.
-
(1998)
Mod Pathol
, vol.11
, pp. 665-668
-
-
Henske, E.P.1
Ao, X.2
Short, M.P.3
-
16
-
-
0033957846
-
Frequent estrogen and progesterone receptor immunoreactivity in renal angiomyolipomas from women with pulmonary lymphangioleiomyomatosis
-
Logginidou H, Ao X, Russo I, et al. Frequent estrogen and progesterone receptor immunoreactivity in renal angiomyolipomas from women with pulmonary lymphangioleiomyomatosis. Chest 2000; 117: 25-30.
-
(2000)
Chest
, vol.117
, pp. 25-30
-
-
Logginidou, H.1
Ao, X.2
Russo, I.3
-
17
-
-
0034121340
-
Downregulation of estrogen and progesterone receptors in the abnormal smooth muscle cells in pulmonary lymphangioleiomyomatosis following therapy. An immunohistochemical study
-
Matsui K, Takeda K, Yu ZX, et al. Downregulation of estrogen and progesterone receptors in the abnormal smooth muscle cells in pulmonary lymphangioleiomyomatosis following therapy. An immunohistochemical study. Am J Respir Crit Care Med 2000; 161: 1002-1009.
-
(2000)
Am J Respir Crit Care Med
, vol.161
, pp. 1002-1009
-
-
Matsui, K.1
Takeda, K.2
Yu, Z.X.3
-
18
-
-
0031792469
-
Immunohistochemical analysis of proteins of the Bcl-2 family in pulmonary lymphangioleiomyomatosis: Association of Bcl-2 expression with hormone receptor status
-
Usuki J, Horiba K, Chu SC, et al. Immunohistochemical analysis of proteins of the Bcl-2 family in pulmonary lymphangioleiomyomatosis: association of Bcl-2 expression with hormone receptor status. Arch Pathol Lab Med 1998; 122: 895-902.
-
(1998)
Arch Pathol Lab Med
, vol.122
, pp. 895-902
-
-
Usuki, J.1
Horiba, K.2
Chu, S.C.3
-
19
-
-
84892661539
-
Sirolimus decreases circulating lymphangioleiomyomatosis cells in patients with lymphangioleiomyomatosis
-
Cai X, Pacheco-Rodriguez G, Haughey M, et al. Sirolimus decreases circulating lymphangioleiomyomatosis cells in patients with lymphangioleiomyomatosis. Chest 2014; 145: 108-112.
-
(2014)
Chest
, vol.145
, pp. 108-112
-
-
Cai, X.1
Pacheco-Rodriguez, G.2
Haughey, M.3
-
20
-
-
84883196385
-
Faslodex inhibits estradiol-induced extracellular matrix dynamics and lung metastasis in a model of lymphangioleiomyomatosis
-
Li C, Zhou X, Sun Y, et al. Faslodex inhibits estradiol-induced extracellular matrix dynamics and lung metastasis in a model of lymphangioleiomyomatosis. Am J Respir Cell Mol Biol 2013; 49: 135-142.
-
(2013)
Am J Respir Cell Mol Biol
, vol.49
, pp. 135-142
-
-
Li, C.1
Zhou, X.2
Sun, Y.3
-
21
-
-
84883784055
-
Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis
-
Gu X, Yu JJ, Ilter D, et al. Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis. Proc Natl Acad Sci USA 2013; 110: 14960-14965.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 14960-14965
-
-
Gu, X.1
Yu, J.J.2
Ilter, D.3
-
22
-
-
62449318120
-
Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells
-
Yu JJ, Robb VA, Morrison TA, et al. Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells. Proc Natl Acad Sci USA 2009; 106: 2635-2640.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 2635-2640
-
-
Yu, J.J.1
Robb, V.A.2
Morrison, T.A.3
-
23
-
-
84883373329
-
Sex-specific lung diseases: Effect of oestrogen on cultured cells and in animal models
-
Shim B, Pacheco-Rodriguez G, Kato J, et al. Sex-specific lung diseases: effect of oestrogen on cultured cells and in animal models. Eur Respir Rev 2013; 22: 302-311.
-
(2013)
Eur Respir Rev
, vol.22
, pp. 302-311
-
-
Shim, B.1
Pacheco-Rodriguez, G.2
Kato, J.3
-
24
-
-
43249088754
-
Activation of the estrogen receptor contributes to the progression of pulmonary lymphangioleiomyomatosis via matrix metalloproteinase-induced cell invasiveness
-
Glassberg MK, Elliot SJ, Fritz J, et al. Activation of the estrogen receptor contributes to the progression of pulmonary lymphangioleiomyomatosis via matrix metalloproteinase-induced cell invasiveness. J Clin Endocrinol Metab 2008; 93: 1625-1633.
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 1625-1633
-
-
Glassberg, M.K.1
Elliot, S.J.2
Fritz, J.3
-
25
-
-
84863078767
-
Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
-
Baselga J, Campone M, Piccart M, et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med 2012; 366: 520-529.
-
(2012)
N Engl J Med
, vol.366
, pp. 520-529
-
-
Baselga, J.1
Campone, M.2
Piccart, M.3
-
26
-
-
79957443342
-
Abiraterone and increased survival in metastatic prostate cancer
-
de Bono JS, Logothetis CJ, Molina A, et al. Abiraterone and increased survival in metastatic prostate cancer. N Engl J Med 2011; 364: 1995-2005.
-
(2011)
N Engl J Med
, vol.364
, pp. 1995-2005
-
-
de Bono, J.S.1
Logothetis, C.J.2
Molina, A.3
-
27
-
-
1642290141
-
Estradiol and tamoxifen stimulate LAM-associated angiomyolipoma cell growth and activate both genomic and nongenomic signaling pathways
-
Yu J, Astrinidis A, Howard S, et al. Estradiol and tamoxifen stimulate LAM-associated angiomyolipoma cell growth and activate both genomic and nongenomic signaling pathways. Am J Physiol Lung Cell Mol Physiol 2004; 286: L694-L700.
-
(2004)
Am J Physiol Lung Cell Mol Physiol
, vol.286
-
-
Yu, J.1
Astrinidis, A.2
Howard, S.3
-
28
-
-
10444277302
-
Decline in lung function in patients with lymphangioleiomyomatosis treated with or without progesterone
-
Taveira-Da Silva AM, Stylianou MP, Hedin CJ, et al. Decline in lung function in patients with lymphangioleiomyomatosis treated with or without progesterone. Chest 2004; 126: 1867-1874.
-
(2004)
Chest
, vol.126
, pp. 1867-1874
-
-
Taveira-Da Silva, A.M.1
Stylianou, M.P.2
Hedin, C.J.3
-
29
-
-
4544315390
-
Survival and disease progression in UK patients with lymphangioleiomyomatosis
-
Johnson SR, Whale CI, Hubbard RB, et al. Survival and disease progression in UK patients with lymphangioleiomyomatosis. Thorax 2004; 59: 800-803.
-
(2004)
Thorax
, vol.59
, pp. 800-803
-
-
Johnson, S.R.1
Whale, C.I.2
Hubbard, R.B.3
-
30
-
-
84865695405
-
Intermittent androgen suppression for rising PSA level after radiotherapy
-
Crook JM, O'Callaghan CJ, Duncan G, et al. Intermittent androgen suppression for rising PSA level after radiotherapy. N Engl J Med 2012; 367: 895-903.
-
(2012)
N Engl J Med
, vol.367
, pp. 895-903
-
-
Crook, J.M.1
O'Callaghan, C.J.2
Duncan, G.3
-
31
-
-
84875793215
-
Intermittent versus continuous androgen deprivation in prostate cancer
-
Hussain M, Tangen CM, Berry DL, et al. Intermittent versus continuous androgen deprivation in prostate cancer. N Engl J Med 2013; 368: 1314-1325.
-
(2013)
N Engl J Med
, vol.368
, pp. 1314-1325
-
-
Hussain, M.1
Tangen, C.M.2
Berry, D.L.3
-
32
-
-
77956799312
-
Serum vascular endothelial growth factor-D prospectively distinguishes lymphangioleiomyomatosis from other diseases
-
Young LR, Vandyke R, Gulleman PM, et al. Serum vascular endothelial growth factor-D prospectively distinguishes lymphangioleiomyomatosis from other diseases. Chest 2010; 138: 674-681.
-
(2010)
Chest
, vol.138
, pp. 674-681
-
-
Young, L.R.1
Vandyke, R.2
Gulleman, P.M.3
-
33
-
-
84881343915
-
Serum VEGF-D concentration as a biomarker of lymphangioleiomyomatosis severity and treatment response: A prospective analysis of the Multicenter International Lymphangioleiomyomatosis Efficacy of Sirolimus (MILES) trial
-
Young LR, Lee HS, Inoue Y, et al. Serum VEGF-D concentration as a biomarker of lymphangioleiomyomatosis severity and treatment response: a prospective analysis of the Multicenter International Lymphangioleiomyomatosis Efficacy of Sirolimus (MILES) trial. Lancet Respir Med 2013; 1: 445-452.
-
(2013)
Lancet Respir Med
, vol.1
, pp. 445-452
-
-
Young, L.R.1
Lee, H.S.2
Inoue, Y.3
-
34
-
-
84895437651
-
A two year randomised placebo controlled trial of doxycycline for lymphangioleiomyomatosis
-
[In press DOI: 10.1183/09031936.00167413]
-
Chang WY, Cane JL, Kumaran M, et al. A two year randomised placebo controlled trial of doxycycline for lymphangioleiomyomatosis. Eur Respir J 2013 [In press DOI: 10.1183/09031936.00167413].
-
(2013)
Eur Respir J
-
-
Chang, W.Y.1
Cane, J.L.2
Kumaran, M.3
-
36
-
-
84865726294
-
Lymphatics in lymphangioleiomyomatosis and idiopathic pulmonary fibrosis
-
Glasgow CG, El-Chemaly S, Moss J. Lymphatics in lymphangioleiomyomatosis and idiopathic pulmonary fibrosis. Eur Respir Rev 2012; 21: 196-206.
-
(2012)
Eur Respir Rev
, vol.21
, pp. 196-206
-
-
Glasgow, C.G.1
El-Chemaly, S.2
Moss, J.3
-
38
-
-
0035071808
-
Prognostic significance of pulmonary lymphangioleiomyomatosis histologic score
-
Matsui K, Beasley MB, Nelson WK, et al. Prognostic significance of pulmonary lymphangioleiomyomatosis histologic score. Am J Surg Pathol 2001; 25: 479-484.
-
(2001)
Am J Surg Pathol
, vol.25
, pp. 479-484
-
-
Matsui, K.1
Beasley, M.B.2
Nelson, W.K.3
-
39
-
-
3242755680
-
Lymphangiogenesis in lymphangioleiomyomatosis: Its implication in the progression of lymphangioleiomyomatosis
-
Kumasaka T, Seyama K, Mitani K, et al. Lymphangiogenesis in lymphangioleiomyomatosis: its implication in the progression of lymphangioleiomyomatosis. Am J Surg Pathol 2004; 28: 1007-1016.
-
(2004)
Am J Surg Pathol
, vol.28
, pp. 1007-1016
-
-
Kumasaka, T.1
Seyama, K.2
Mitani, K.3
-
40
-
-
84864584731
-
Bronchoscopic diagnosis of Langerhans' cell histiocytosis and lymphangioleiomyomatosis
-
Harari S, Torre O, Cassandro R, et al. Bronchoscopic diagnosis of Langerhans' cell histiocytosis and lymphangioleiomyomatosis. Respir Med 2012; 106: 1286-1292.
-
(2012)
Respir Med
, vol.106
, pp. 1286-1292
-
-
Harari, S.1
Torre, O.2
Cassandro, R.3
-
41
-
-
84870777785
-
Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis
-
Meraj R, Wikenheiser-Brokamp KA, Young LR, et al. Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis. Front Med 2012; 6: 395-405.
-
(2012)
Front Med
, vol.6
, pp. 395-405
-
-
Meraj, R.1
Wikenheiser-Brokamp, K.A.2
Young, L.R.3
-
42
-
-
84887052370
-
Statins in lymphangioleiomyomatosis. Simvastatin and atorvastatin induce differential effects on tuberous sclerosis complex 2-null cell growth and signaling
-
Atochina-Vasserman EN, Goncharov DA, Volgina AV, et al. Statins in lymphangioleiomyomatosis. Simvastatin and atorvastatin induce differential effects on tuberous sclerosis complex 2-null cell growth and signaling. Am J Respir Cell Mol Biol 2013; 49: 704-709.
-
(2013)
Am J Respir Cell Mol Biol
, vol.49
, pp. 704-709
-
-
Atochina-Vasserman, E.N.1
Goncharov, D.A.2
Volgina, A.V.3
-
43
-
-
79958068761
-
mTORC2 is required for proliferation and survival of TSC2-null cells
-
Goncharova EA, Goncharov DA, Li H, et al. mTORC2 is required for proliferation and survival of TSC2-null cells. Mol Cell Biol 2011; 31: 2484-2498.
-
(2011)
Mol Cell Biol
, vol.31
, pp. 2484-2498
-
-
Goncharova, E.A.1
Goncharov, D.A.2
Li, H.3
|