Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit

Molecular Therapy

Volumn 22, Issue 3, 2014, Pages 522-534

  Wang, Baomei ^a   Zhuang, Xiaoying ^a   Deng, Zhong Bin ^a   Jiang, Hong ^a   Mu, Jingyao ^a   Wang, Qilong ^a   Xiang, Xiaoyu ^a   Guo, Haixun ^a   Zhang, Lifeng ^a   Dryden, Gerald ^b   Yan, Jun ^a   Miller, Donald ^a   Zhang, Huang Ge ^a,b,c  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b University of Louisville School of Medicine   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2 INHIBITOR; DEXTRAN SULFATE; GRAPEFRUIT DERIVED NANOVESICLE; HEME OXYGENASE 1; INTERLEUKIN 1BETA; METHOTREXATE; NANOPARTICLE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOCOMPATIBILITY; BIODEGRADABILITY; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG TARGETING; EXPERIMENTAL COLITIS; GRAPEFRUIT; IMMUNOMODULATION; IN VITRO STUDY; INTESTINE ABSORPTION; INTESTINE CELL; MACROPHAGE; MALE; MOUSE; NONHUMAN; PH; PROTEIN EXPRESSION; THERAPY EFFECT; UPREGULATION;

CITRUS X PARADISI; MUS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CITRUS PARADISI; COLITIS; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; GENE EXPRESSION REGULATION; HEME OXYGENASE-1; HUMANS; INFLAMMATORY BOWEL DISEASES; INTERLEUKIN-1BETA; INTESTINAL MUCOSA; MACROPHAGES; MALE; METHOTREXATE; MICE; MICE, INBRED C57BL; MOLECULAR TARGETED THERAPY; NANOSTRUCTURES; PLANT EXTRACTS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84895450873     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2013.190     Document Type: Article

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