Docetaxel-loaded chitosan microspheres as a lung targeted drug delivery system: In vitro and in vivo evaluation

International Journal of Molecular Sciences

Volumn 15, Issue 3, 2014, Pages 3519-3532

  Wang, Hao ^a   Xu, Yongdong ^b   Zhou, Xiao ^a  

^a TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^b FUDAN UNIVERSITY PUDONG MEDICAL CENTER   (China)

Author keywords

Biodistribution; Docetaxel; Microspheres; Pharmacokinetics; Release

Indexed keywords

CHITOSAN; DOCETAXEL; GLUTARALDEHYDE; MANNITOL; MICROSPHERE; PARAFFIN; PHOSPHATE BUFFERED SALINE; SORBITAN OLEATE; ANTINEOPLASTIC AGENT; DELAYED RELEASE FORMULATION; TAXOID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG RELEASE; ENCAPSULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LOADING DRUG DOSE; LUNG TARGETED DRUG DELIVERY SYSTEM; MASS SPECTROMETRY; MOUSE; NONHUMAN; PARTICLE SIZE; PLASMA CLEARANCE; PLASMA HALF LIFE; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL; ADMINISTRATION AND DOSAGE; ANIMAL; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG FORMULATION; EVALUATION STUDY; LIQUID CHROMATOGRAPHY; PHARMACOKINETICS; PROCEDURES; RAT; REPRODUCIBILITY; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

ANIMALS; ANTINEOPLASTIC AGENTS; CHITOSAN; CHROMATOGRAPHY, LIQUID; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; GLUTARAL; MICE; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSPHERES; PARTICLE SIZE; RATS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY; TAXOIDS; TISSUE DISTRIBUTION;

EID: 84895433664     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15033519     Document Type: Article

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