The effect of multivitamin/mineral supplements on age-related cataracts: A systematic review and meta-analysis

Nutrients

Volumn 6, Issue 3, 2014, Pages 931-949

  Zhao, Li Quan ^a   Li, Liang Mao ^a   Zhu, Huang ^b  

^a No 181 Hospital of PLA   (China)

^b XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Cataract; Dietary supplements; Meta analysis; Minerals; Vitamins

Indexed keywords

MINERAL; MULTIVITAMIN; PLACEBO;

DATA ANALYSIS; DIET SUPPLEMENTATION; HUMAN; INCIDENCE; LIFE EXPECTANCY; MEDICAL SUBJECT HEADINGS; META ANALYSIS; PREVALENCE; PUBLIC HEALTH; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SENILE CATARACT; SYSTEMATIC REVIEW;

AGING; ANTIOXIDANTS; CATARACT; DATABASES, FACTUAL; DIETARY SUPPLEMENTS; HUMANS; MICRONUTRIENTS; OBSERVATIONAL STUDY AS TOPIC; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RECOMMENDED DIETARY ALLOWANCES;

EID: 84895423820     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu6030931     Document Type: Review

References (56)

1. Asbell, P.A.; Dualan, I.; Mindel, J.; Brocks, D.; Ahmad, M.; Epstein, S. Age-related cataract. Lancet 2005, 365, 599-609.
2. Truscott, R.J. Age-related nuclear cataract-oxidation is the key. Exp. Eye Res. 2005, 80, 709-725.
3. Boscia, F.; Grattagliano, I.; Vendemiale, G.; Micelli-Ferrari, T.; Altomare, E. Protein oxidation and lens opacity in humans. Investig. Ophthalmol. Vis. Sci. 2000, 41, 2461-2465.
4. Varma, S.D. Scientific basis for medical therapy of cataracts by antioxidants. Am. J. Clin. Nutr. 1991, 53, 335S-345S.
5. Christen, W.G. Antioxidant vitamins and age-related eye disease. Proc. Assoc. Am. Physicians 1999, 111, 16-21.
6. Fernandez, M.M.; Afshari, N.A. Nutrition and the prevention of cataracts. Curr. Opin. Ophthalmol. 2008, 19, 66-70.
7. Lin, D.; Barnett, M.; Grauer, L.; Robben, J.; Jewell, A.; Takemoto, L.; Takemoto, D.J. Expression of superoxide dismutase in whole lens prevents cataract formation. Mol. Vis. 2005, 11, 853-858.
8. Mares-Perlman, J.A.; Lyle, B.J.; Klein, R.; Fisher, A.I.; Brady, W.E.; VandenLangenberg, G.M.; Trabulsi, J.N.; Palta, M. Vitamin supplement use and incident cataracts in a population-based study. Arch. Ophthalmol. 2000, 118, 1556-1563.
9. Klein, B.E.; Knudtson, M.D.; Lee, K.E.; Reinke, J.O.; Danforth, L.G.; Wealti, A.M.; Moore, E.; Klein, R. Supplements and age-related eye conditions: The Beaver Dam Eye Study. Ophthalmology 2008, 115, 1203-1208.
10. Kuzniarz, M.; Mitchell, P.; Cumming, R.G.; Flood, V.M. Use of vitamin supplements and cataract: The Blue Mountains Eye Study. Am. J. Ophthalmol. 2001, 132, 19-26.
11. Rautiainen, S.; Lindblad, B.E.; Morgenstern, R.; Wolk, A. Vitamin C supplements and the risk of age-related cataract: A population-based prospective cohort study in women. Am. J. Clin. Nutr. 2010, 91, 487-493.
12. Zheng, S.J.; Rautiainen, S.; Lindblad, B.E.; Morgenstern, R.; Wolk, A. High-dose supplements of vitamins C and E, low-dose multivitamins, and the risk of age-related cataract: A population-based prospective cohort study of men. Am. J. Epidemiol. 2013, 177, 548-555.
13. Milton, R.C.; Sperduto, R.D.; Clemons, T.E.; Ferris, F.L., III. Centrum use and progression of age-related cataract in the Age-Related Eye Disease Study: A propensity score approach. AREDS report No. 21. Ophthalmology 2006, 113, 1264-1270.
14. Leske, M.C.; Chylack, L.T., Jr.; He, Q.; Wu, S.Y.; Schoenfeld, E.; Friend, J.; Wolfe, J. Antioxidant vitamins and nuclear opacities: The longitudinal study of cataract. Ophthalmology 1998, 105, 831-836.
15. Seddon, J.M.; Christen, W.G.; Manson, J.E.; LaMotte, F.S.; Glynn, R.J.; Buring, J.E.; Hennekens, C.H. The use of vitamin supplements and the risk of cataract among US male physicians. Am. J. Public Health 1994, 84, 788-792.
16. Hankinson, S.E.; Stampfer, M.J.; Seddon, J.M.; Colditz, G.A.; Rosner, B.; Speizer, F.E.; Willett, W.C. Nutrient intake and cataract extraction in women: A prospective study. BMJ 1992, 305, 335-339.
17. Chasan-Taber, L.; Willett, W.C.; Seddon, J.M.; Stampfer, M.J.; Rosner, B.; Colditz, G.A.; Hankinson, S.E. A prospective study of vitamin supplement intake and cataract extraction among U.S. women. Epidemiology 1999, 10, 679-684.
18. Taylor, A.; Jacques, P.F.; Chylack, L.T., Jr.; Hankinson, S.E.; Khu, P.M.; Rogers, G.; Friend, J.; Tung, W.; Wolfe, J.K.; Padhye, N.; et al Long-term intake of vitamins and carotenoids and odds of early age-related cortical and posterior subcapsular lens opacities. Am. J. Clin. Nutr. 2002, 75, 540-549.
19. Jacques, P.F.; Chylack, L.T., Jr.; Hankinson, S.E.; Khu, P.M.; Rogers, G.; Friend, J.; Tung, W.; Wolfe, J.K.; Padhye, N.; Willett, W.C.; et al Long-term nutrient intake and early age-related nuclear lens opacities. Arch. Ophthalmol. 2001, 119, 1009-1019.
20. Tan, A.G.; Mitchell, P.; Flood, V.M.; Burlutsky, G.; Rochtchina, E.; Cumming, R.G.; Wang, J.J. Antioxidant nutrient intake and the long-term incidence of age-related cataract: The Blue Mountains Eye Study. Am. J. Clin. Nutr. 2008, 87, 1899-1905.
21. Christen, W.G.; Liu, S.; Glynn, R.J.; Gaziano, J.M.; Buring, J.E. Dietary carotenoids, vitamins C and E, and risk of cataract in women: A prospective study. Arch. Ophthalmol. 2008, 126, 102-109.
22. Yoshida, M.; Takashima, Y.; Inoue, M.; Iwasaki, M.; Otani, T.; Sasaki, S.; Tsugane, S.; JPHC Study Group. Prospective study showing that dietary vitamin C reduced the risk of age-related cataracts in a middle-aged Japanese population. Eur. J. Nutr. 2007, 46, 118-124.
23. Brown, L.; Rimm, E.B.; Seddon, J.M.; Giovannucci, E.L.; Chasan-Taber, L.; Spiegelman, D.; Willett, W.C.; Hankinson, S.E. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am. J. Clin. Nutr. 1999, 70, 517-524.
24. Chasan-Taber, L.; Willett, W.C.; Seddon, J.M.; Stampfer, M.J.; Rosner, B.; Colditz, G.A.; Speizer, F.E.; Hankinson, S.E. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am. J. Clin. Nutr. 1999, 70, 509-516.
25. Cumming, R.G.; Mitchell, P.; Smith, W. Diet and cataract: The Blue Mountains Eye Study. Ophthalmology 2000, 107, 450-456.
26. Vu, H.T.; Robman, L.; Hodge, A.; McCarty, C.A.; Taylor, H.R. Lutein and zeaxanthin and the risk of cataract: The Melbourne visual impairment project. Investig. Ophthalmol. Vis. Sci. 2006, 47, 3783-3786.
27. Jacques, P.F.; Taylor, A.; Moeller, S.; Hankinson, S.E.; Rogers, G.; Tung, W.; Ludovico, J.; Willett, W.C.; Chylack, L.T., Jr. Long-term nutrient intake and 5-year change in nuclear lens opacities. Arch. Ophthalmol. 2005, 123, 517-526.
28. Christen, W.G.; Manson, J.E.; Glynn, R.J.; Gaziano, J.M.; Sperduto, R.D.; Buring, J.E.; Hennekens, C.H. A randomized trial of β carotene and age-related cataract in US physicians. Arch. Ophthalmol. 2003, 121, 372-378.
29. McNeil, J.J.; Robman, L.; Tikellis, G.; Sinclair, M.I.; McCarty, C.A.; Taylor, H.R. Vitamin E supplementation and cataract: Randomized controlled trial. Ophthalmology 2004, 111, 75-84.
30. Christen, W.G.; Glynn, R.J.; Chew, E.Y.; Buring, J.E. Vitamin E and age-related cataract in a randomized trial of women. Ophthalmology 2008, 115, 822-829.
31. Christen, W.; Glynn, R.; Sperduto, R.; Chew, E.; Buring, J. Age-related cataract in a randomized trial of β-carotene in women. Ophthalmic Epidemiol. 2004, 11, 401-412.
32. Teikari, J.M.; Rautalahti, M.; Haukka, J.; Järvinen, P.; Hartman, A.M.; Virtamo, J.; Albanes, D.; Heinonen, O. Incidence of cataract operations in Finnish male smokers unaffected by α tocopherol or β carotene supplements. J. Epidemiol. Community Health 1998, 52, 468-472.
33. Gritz, D.C.; Srinivasan, M.; Smith, S.D.; Kim, U.; Lietman, T.M.; Wilkins, J.H.; Priyadharshini, B.; John, R.K.; Aravind, S.; Prajna, N.V.; et al The antioxidants in prevention of cataracts study: Effects of antioxidant supplements on cataract progression in South India. Br. J. Ophthalmol. 2006, 90, 847-851.
34. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and β carotene for age-related cataract and vision loss: AREDS report no. 9. Arch. Ophthalmol. 2001, 119, 1439-1452.
35. Christen, W.G.; Glynn, R.J.; Sesso, H.D.; Kurth, T.; MacFadyen, J.; Bubes, V.; Buring, J.E.; Manson, J.E.; Gaziano, J.M. Age-related cataract in a randomized trial of vitamins E and C in men. Arch. Ophthalmol. 2010, 128, 1397-1405.
36. Teikari, J.M.; Virtamo, J.; Rautalahti, M.; Palmgren, J.; Liesto, K.; Heinonen, O.P. Long-term supplementation with α-tocopherol and β-carotene and age-related cataract. Acta Ophthalmol. Scand. 1997, 75, 634-640.
37. Chylack, L.T., Jr.; Brown, N.P.; Bron, A.; Hurst, M.; Köpcke, W.; Thien, U.; Schalch, W. The Roche European American Cataract Trial (REACT): A randomized clinical trial to investigate the efficacy of an oral antioxidant micronutrient mixture to slow progression of age-related cataract. Ophthalmic Epidemiol. 2002, 9, 49-48.
38. Mathew, M.C.; Ervin, A.M.; Tao, J.; Davis, R.M. Antioxidant vitamin supplementation for preventing and slowing the progression of age-related cataract. Cochrane Database Syst. Rev. 2012, 6, doi:10.1002/14651858.CD004567.pub2.
39. Radimer, K.; Bindewald, B.; Hughes, J.; Ervin, B.; Swanson, C.; Picciano, M.F. Dietary supplement use by US adults: Data from the National Health and Nutrition Examination Survey, 1999-2000. Am. J. Epidemiol. 2004, 160, 339-349.
40. Rock, C.L. Multivitamin-multimineral supplements: Who uses them? Am. J. Clin. Nutr. 2007, 85, 277S-279S.
41. Schwarzpaul, S.; Strassburg, A.; Luhrmann, P.M.; Neuhauser-Berthold, M. Intake of vitamin and mineral supplements in an elderly german population. Ann. Nutr. Metab. 2006, 50, 155-162.
42. Chen, S.Y.; Lin, J.R.; Kao, M.D.; Hang, C.M. The usage of dietary supplements among the elderly individuals in Taiwan. Asia Pac. J. Clin. Nutr. 2005, 14, 230-237.
43. Wells, G.A.; Shea, B.; O'Connell, D.; Peterson, J.; Welch, V.; Losos, M.; Tugwell, P. The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses. Available online: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp (accessed on 1 September 2013).
44. Liberati, A.; Altman, D.G.; Tetzlaff, J.; Mulrow, C.; Gøtzsche, P.C.; Ioannidis, J.P.; Clarke, M.; Devereaux, P.J.; Kleijnen, J.; Moher, D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: Explanation and elaboration. BMJ 2009, 339, doi:10.1371/journal.pmed.1000100.
45. O'Connor, D.; Green, S.; Higgins, J.P. Defining the Review Question and Developing Criteria for Including Studies. In Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0. Part 2: General Methods for Cochran Reviews; Higgins, J.P., Green, S., Eds.; Cochrane Collaboration: Oxford, UK, 2008; Available online: http://www.cochrane-handbook.org/ (accessed on 1 September 2013).
46. Clinical Trial of Nutritional Supplements and Age-Related Cataract Study Group; Maraini, G.; Williams, S.L.; Sperduto, R.D.; Ferris, F.; Milton, R.C.; Clemons, T.E.; Rosmini, F.; Ferrigno, L. A randomized, double-masked, placebo-controlled clinical trial of multivitamin supplementation for age-related lens opacities. Clinical trial of nutritional supplements and age-related cataract report no. 3. Ophthalmology 2008, 115, 599-607. e1.
47. Sperduto, R.D.; Hu, T.S.; Milton, R.C.; Zhao, J.L.; Everett, D.F.; Cheng, Q.F.; Blot, W.J.; Bing, L.; Taylor, P.R.; Li, J.Y.; et al The Linxian cataract studies. Two nutrition intervention trials. Arch. Ophthalmol. 1993, 111, 1246-1253.
48. Klein, B.E.; Klein, R.; Linton, K.L. Prevalence of age-related lens opacities in a population. The Beaver Dam Eye Study. Ophthalmology 1992, 99, 546-552.
49. Robman, L.; Taylor, H. External factors in the development of cataract. Eye 2005, 19, 1074-1082.
50. Delcourt, C.; Cristol, J.P.; Tessier, F.; Léger, C.L.; Michel, F.; Papoz, L. Risk factors for cortical, nuclear, and posterior subcapsular cataracts: The POLA study. Pathologies Oculaires Liées à l'Age. Am. J. Epidemiol. 2000, 151, 497-504.
51. Age-Related Eye Disease Study 2 (AREDS2) Research Group. Lutein/zeaxanthin for the treatment of age-related cataract: AREDS2 randomized trial report no. 4. JAMA Ophthalmol. 2013, 131, 843-850.
52. Maraini, G.; Williams, S.L.; Sperduto, R.D.; Ferris, F.L.; Milton, R.C.; Clemons, T.E.; Rosmini, F.; Ferrigno, L. Effects of multivitamin/mineral supplementation on plasma levels of nutrients. Report No. 4 of the Italian-American clinical trial of nutritional supplements and age-related cataract. Ann. Ist. Super. Sanita 2009, 45, 119-127.
53. Cui, Y.H.; Jing, C.X.; Pan, H.W. Association of blood antioxidants and vitamins with risk of age-related cataract: A meta-analysis of observational studies. Am. J. Clin. Nutr. 2013, 98, 778-786.
54. Jacques, P.F.; Hartz, S.C.; Chylack, L.T., Jr.; McGandy, R.B.; Sadowski, J.A. Nutritional status in persons with and without senile cataract: Blood vitamin and mineral levels. Am. J. Clin. Nutr. 1988, 48, 152-158.
55. Leske, M.C.; Wu, S.Y.; Hyman, L.; Sperduto, R.; Underwood, B.; Chylack, L.T.; Milton, R.C.; Srivastava, S.; Ansari, N. Biochemical factors in the lens opacities. Case-control study. The Lens Opacities Case-Control Study Group. Arch. Ophthalmol. 1995, 113, 1113-1119.
56. Egger, M.; Schneider, M.; Smith, G.D. Spurious precision? Meta-analysis of observational studies. BMJ 1998, 316, 140-144.