Synergistic efficacy of meropenem and rifampicin in a murine model of sepsis caused by multidrug-resistant Acinetobacter baumannii

European Journal of Pharmacology

Volumn 729, Issue 1, 2014, Pages 116-122

  Sun, Yuan ^a   Wang, Lei ^a   Li, Jiankang ^a   Zhao, Chongbo ^a   Zhao, Jinyi ^a   Liu, Meiyou ^a   Wang, Shan ^a   Lu, Chengtao ^a   Shang, Gangwei ^a   Jia, Yanyan ^a   Wen, Aidong ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Acinetobacter baumannii; Combination; Meropenem; Murine sepsis model; Rifampicin

Indexed keywords

AMIKACIN; AZITHROMYCIN; CEFOPERAZONE; CEFOPERAZONE PLUS SULBACTAM; CIPROFLOXACIN; INTERLEUKIN 6; MEROPENEM; RIFAMPICIN; SULBACTAM; TUMOR NECROSIS FACTOR ALPHA; ANTIINFECTIVE AGENT; THIENAMYCIN DERIVATIVE;

ACINETOBACTER INFECTION; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL COUNT; BACTERIAL STRAIN; BIOASSAY; CHECKERBOARD ASSAY; COMBINATION CHEMOTHERAPY; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG HALF LIFE; DRUG MEGADOSE; DRUG POTENTIATION; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; MALE; MAXIMUM PLASMA CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; MONOTHERAPY; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; OUTCOME ASSESSMENT; PLASMA CLEARANCE; PRIORITY JOURNAL; SEPSIS; SURVIVAL RATE; TIME KILL ASSAY; ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; ANIMAL; BAGG ALBINO MOUSE; BLOOD; DISEASE MODEL; DRUG EFFECTS; HUMAN; MICROBIAL SENSITIVITY TEST; PHYSIOLOGY; PROCEDURES; TREATMENT OUTCOME;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; ANIMALS; ANTI-BACTERIAL AGENTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE, BACTERIAL; DRUG SYNERGISM; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICROBIAL SENSITIVITY TESTS; RIFAMPIN; SEPSIS; THIENAMYCINS; TREATMENT OUTCOME;

EID: 84895156253     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.02.015     Document Type: Article

References (26)

1. A. Abbo, S. Navon-Venezia, O. Hammer-Muntz, T. Krichali, Y. Siegman-Igra, and Y. Carmeli Multidrug-resistant Acinetobacter baumannii Emerg. Infect. Dis. 11 2005 22 29 (Pubitemid 40093348)
2. M. Afzal-Shah, and D.M. Livermore Worldwide emergence of carbapenem-resistant Acinetobacter spp J. Antimicrob. Chemother. 41 1998 576 577 (Pubitemid 28230316)
3. M. Bassetti, E. Righi, S. Esposito, N. Petrosillo, and L. Nicolini Drug treatment for multidrug-resistant Acinetobacter baumannii infections Future Microbiol. 3 2008 649 660
4. J. Buijs, A.S. Dofferhoff, J.W. Mouton, and J.W. van der Meer Continuous administration of PBP-2- and PBP-3-specific beta-lactams causes higher cytokine responses in murine Pseudomonas aeruginosa and Escherichia coli sepsis J. Antimicrob. Chemother. 59 2007 926 933 (Pubitemid 47073364)
5. K.C. Chang, M.F. Lin, N.T. Lin, W.J. Wu, H.Y. Kuo, T.Y. Lin, T.L. Yang, Y.C. Chen, and M.L. Liou Clonal spread of multidrug-resistant Acinetobacter baumannii in eastern Taiwan J. Microbiol. Immunol. Infect. 45 2012 37 42
6. Y.H. Chen, and P.R. Hsueh Changing bacteriology of abdominal and surgical sepsis Curr. Opin. Infect. Dis. 25 2012 590 595
7. J. Dominguez-Herrera, F. Docobo-Perez, R. Lopez-Rojas, C. Pichardo, R. Ruiz-Valderas, J.A. Lepe, and J. Pachon Efficacy of daptomycin versus vancomycin in an experimental model of foreign-body and systemic infection caused by biofilm producers and methicillin-resistant Staphylococcus epidermidis Antimicrob. Agents Chemother. 56 2012 613 617
8. J. Fernandez, D. Abbanat, W. Shang, W. He, K. Amsler, J. Hastings, A.M. Queenan, J.L. Melton, A.M. Barron, R.K. Flamm, and A.S. Lynch Synergistic activity of ceftobiprole and vancomycin in a rat model of infective endocarditis caused by methicillin-resistant and glycopeptide-intermediate Staphylococcus aureus Antimicrob. Agents Chemother. 56 2012 1476 1484
9. N.C. Gordon, K. Png, and D.W. Wareham Potent synergy and sustained bactericidal activity of a vancomycin-colistin combination versus multidrug-resistant strains of Acinetobacter baumannii Antimicrob. Agents Chemother. 54 2010 5316 5322
10. D.E. Karageorgopoulos, T. Kelesidis, I. Kelesidis, and M.E. Falagas Tigecycline for the treatment of multidrug-resistant (including carbapenem-resistant) Acinetobacter infections: a review of the scientific evidence J. Antimicrob. Chemother. 62 2008 45 55 (Pubitemid 351865873)
11. P. Kiratisin, A. Apisarnthanarak, and S. Kaewdaeng Synergistic activities between carbapenems and other antimicrobial agents against Acinetobacter baumannii including multidrug-resistant and extensively drug-resistant isolates Int. J. Antimicrob. Agents 36 2010 243 246
12. T. Kirikae, M. Nakano, and D.C. Morrison Antibiotic-induced endotoxin release from bacteria and its clinical significance Microbiol. Immunol. 41 1997 285 294 (Pubitemid 27212559)
13. C.H. Lee, Y.F. Tang, L.H. Su, C.C. Chien, and J.W. Liu Antimicrobial effects of varied combinations of meropenem, sulbactam, and colistin on a multidrug-resistant Acinetobacter baumannii isolate that caused meningitis and bacteremia Microb. Drug Resist. 14 2008 233 237
14. T.P. Lim, T.Y. Tan, W. Lee, S. Sasikala, T.T. Tan, L.Y. Hsu, and A.L. Kwa In-vitro activity of polymyxin B, rifampicin, tigecycline alone and in combination against carbapenem-resistant Acinetobacter baumannii in Singapore PLoS One 6 2011 e18485
15. A. Montero, J. Ariza, X. Corbella, A. Domenech, C. Cabellos, J. Ayats, F. Tubau, C. Ardanuy, and F. Gudiol Efficacy of colistin versus beta-lactams, aminoglycosides, and rifampin as monotherapy in a mouse model of pneumonia caused by multiresistant Acinetobacter baumannii Antimicrob. Agents Chemother. 46 2002 1946 1952 (Pubitemid 34535219)
16. V.M. Moodley, S.P. Oliver, I. Shankland, and B.G. Elisha Acinetobacter baumannii: an evaluation of five susceptibility test methods to detect tobramycin resistance in an epidemiologically related cluster J. Clin. Microbiol. 51 2013 2535 2540
17. M.E. Pachon-Ibanez, F. Docobo-Perez, R. Lopez-Rojas, J. Dominguez-Herrera, M.E. Jimenez-Mejias, A. Garcia-Curiel, C. Pichardo, L. Jimenez, and J. Pachon Efficacy of rifampin and its combinations with imipenem, sulbactam, and colistin in experimental models of infection caused by imipenem-resistant Acinetobacter baumannii Antimicrob. Agents Chemother. 54 2010 1165 1172
18. M.E. Pachon-Ibanez, F. Docobo-Perez, M.E. Jimenez-Mejias, J. Ibanez-Martinez, A. Garcia-Curiel, C. Pichardo, and J. Pachon Efficacy of rifampin, in monotherapy and in combinations, in an experimental murine pneumonia model caused by panresistant Acinetobacter baumannii strains Eur. J. Clin. Microbiol. Infect. Dis. 30 2011 895 901
19. J.M. Rae, M.D. Johnson, M.E. Lippman, and D.A. Flockhart Rifampin is a selective, pleiotropic inducer of drug metabolism genes in human hepatocytes: studies with cDNA and oligonucleotide expression arrays J. Pharmacol. Exp. Ther. 299 2001 849 857 (Pubitemid 33104951)
20. G.E. Reid, S.A. Grim, C.A. Aldeza, W.M. Janda, and N.M. Clark Rapid development of Acinetobacter baumannii resistance to tigecycline Pharmacotherapy 27 2007 1198 1201 (Pubitemid 47173663)
21. C. Shen, Q. Meng, G. Zhang, and W. Hu Rifampicin exacerbates isoniazid-induced toxicity in human but not in rat hepatocytes in tissue-like cultures Br. J. Pharmacol. 153 2008 784 791 (Pubitemid 351271758)
22. R. Silverstein, J.G. Wood, Q. Xue, M. Norimatsu, D.L. Horn, and D.C. Morrison Differential host inflammatory responses to viable versus antibiotic-killed bacteria in experimental microbial sepsis Infect. Immun. 68 2000 2301 2308 (Pubitemid 30164867)
23. J.Y. Song, S.Y. Kee, I.S. Hwang, Y.B. Seo, H.W. Jeong, W.J. Kim, and H.J. Cheong In vitro activities of carbapenem/sulbactam combination, colistin, colistin/rifampicin combination and tigecycline against carbapenem-resistant Acinetobacter baumannii J. Antimicrob. Chemother. 60 2007 317 322 (Pubitemid 47243880)
24. J.Y. Song, H.J. Cheong, J. Lee, A.K. Sung, and W.J. Kim Efficacy of monotherapy and combined antibiotic therapy for carbapenem-resistant Acinetobacter baumannii pneumonia in an immunosuppressed mouse model Int. J. Antimicrob. Agents 33 2009 33 39
25. M.M. Sopirala, J.E. Mangino, W.A. Gebreyes, B. Biller, T. Bannerman, J.M. Balada-Llasat, and P. Pancholi Synergy testing by Etest, microdilution checkerboard, and time-kill methods for pan-drug-resistant Acinetobacter baumannii Antimicrob. Agents Chemother. 54 2010 4678 4683
26. F. Timurkaynak, F. Can, O.K. Azap, M. Demirbilek, H. Arslan, and S.O. Karaman In vitro activities of non-traditional antimicrobials alone or in combination against multidrug-resistant strains of Pseudomonas aeruginosa and Acinetobacter baumannii isolated from intensive care units Int. J. Antimicrob. Agents 27 2006 224 228 (Pubitemid 43246952)