Clarithromycin modulates Helicobacter pylori-induced activation of nuclear factor-κB through classical and alternative pathways in gastric epithelial cells

Clinical and Experimental Medicine

Volumn 14, Issue 1, 2014, Pages 53-59

  Peng, Yen Chun ^a,b,c   Ho, Shu Peng ^b   Shyu, Ching Lin ^b   Chang, Chi Sen ^a,d   Huang, Lan Ru ^e  

^a TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^e CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

CagA; Clarithromycin; Helicobacter pylori; Interleukin 8; NF B

Indexed keywords

ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BLOTTING, WESTERN; CELL LINE, TUMOR; CHROMATOGRAPHY, LIQUID; CLARITHROMYCIN; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; EPITHELIAL CELLS; GENE EXPRESSION PROFILING; HELICOBACTER PYLORI; HUMANS; IMMUNOLOGIC FACTORS; INTERLEUKIN-8; NF-KAPPA B; PROTEOME; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TANDEM MASS SPECTROMETRY;

EID: 84895138190     PISSN: 15918890     EISSN: 15919528     Source Type: Journal    
DOI: 10.1007/s10238-012-0217-2     Document Type: Article

References (28)

1. Watanabe T, Tada M, Nagai H, Sasaki S, Nakao M (1998) Helicobacter pylori infection induces gastric cancer in mongolian gerbils. Gastroenterology 115(3):642-648
2. Peek RM, Blaser MJ (2002) Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer 2(1):28-37. doi: 10.1038/nrc703
3. Suerbaum S, Michetti P (2002) Helicobacter pylori infection. N Engl J Med 347(15):1175-1186. doi: 10.1056/NEJMra020542
4. Ohnishi N, Yuasa H, Tanaka S, Sawa H, Miura M, Matsui A, Higashi H, Musashi M, Iwabuchi K, Suzuki M, Yamada G, Azuma T, Hatakeyama M (2008) Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. Proc Natl Acad Sci U S A 105(3):1003-1008. doi: 10.1073/pnas.0711183105
5. Leung WK, Lin SR, Ching JY, To KF, Ng EK, Chan FK, Lau JY, Sung JJ (2004) Factors predicting progression of gastric intestinal metaplasia: results of a randomised trial on Helicobacter pylori eradication. Gut 53(9):1244-1249. doi: 10.1136/gut.2003.034629
6. Wu CY, Kuo KN, Wu MS, Chen YJ, Wang CB, Lin JT (2009) Early Helicobacter pylori eradication decreases risk of gastric cancer in patients with peptic ulcer disease. Gastroenterology 137(5):1641-1648, e1641-e1642. doi: 10.1053/j.gastro.2009.07.060
7. Desaki M, Takizawa H, Ohtoshi T, Kasama T, Kobayashi K, Sunazuka T, Omura S, Yamamoto K, Ito K (2000) Erythromycin suppresses nuclear factor-κB and activator protein-1 activation in human bronchial epithelial cells. Biochem Biophys Res Commun 267(1):124-128. doi: 10.1006/bbrc.1999.1917
8. Kikuchi T (2002) Clarithromycin suppresses lipopolysaccharide-induced interleukin-8 production by human monocytes through AP-1 and NF-κB transcription factors. J Antimicrob Chemother 49(5):745-755. doi: 10.1093/jac/dkf008
9. Yamaya M, Shinya K, Hatachi Y, Kubo H, Asada M, Yasuda H, Nishimura H, Nagatomi R (2010) Clarithromycin inhibits type a seasonal influenza virus infection in human airway epithelial cells. J Pharmacol Exp Ther 333(1):81-90. doi: 10.1124/jpet.109.162149
10. Ghosh S, Karin M (2002) Missing pieces in the NF-κB puzzle. Cell 109(Suppl):S81-S96
11. Li Q, Verma IM (2002) NF-κB regulation in the immune system. Nat Rev Immunol 2(10):725-734. doi: 10.1038/nri910
12. Porta C, Riboldi E, Sica A (2011) Mechanisms linking pathogens-associated inflammation and cancer. Cancer Lett 305(2):250-262. doi: 10.1016/j.canlet. 2010.10.012
13. Ki MR, Ghim SY, Hong IH, Park JK, Hong KS, Ji AR, Jeong KS (2010) In vitro inhibition of Helicobacter pylori growth and of adherence of cagA-positive strains to gastric epithelial cells by Lactobacillus paraplantarum KNUC25 isolated from kimchi. J Med Food 13(3):629-634. doi: 10.1089/jmf.2009.1265
14. Abdel-Latif MM, Windle H, Terres A, Eidhin DN, Kelleher D, Reynolds JV (2006) Helicobacter pylori extract induces nuclear factor-κ B, activator protein-1, and cyclooxygenase-2 in esophageal epithelial cells. J Gastrointest Surg 10(4):551-562. doi: 10.1016/j.gassur.2005.09.003
15. Covacci A, Censini S, Bugnoli M, Petracca R, Burroni D, Macchia G, Massone A, Papini E, Xiang Z, Figura N et al (1993) Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sci U S A 90(12):5791-5795
16. Censini S, Lange C, Xiang Z, Crabtree JE, Ghiara P, Borodovsky M, Rappuoli R, Covacci A (1996) cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc Natl Acad Sci U S A 93(25):14648-14653
17. Hatakeyama M (2009) Helicobacter pylori and gastric carcinogenesis. J Gastroenterol 44(4):239-248. doi: 10.1007/s00535-009-0014-1
18. Blaser MJ, Berg DE (2001) Helicobacter pylori genetic diversity and risk of human disease. J Clin Invest 107(7):767-773. doi: 10.1172/JCI12672
19. Kuipers EJ, Perez-Perez GI, Meuwissen SG, Blaser MJ (1995) Helicobacter pylori and atrophic gastritis: importance of the cagA status. J Natl Cancer Inst 87(23):1777-1780
20. Hsu PI, Hwang IR, Cittelly D, Lai KH, El-Zimaity HM, Gutierrez O, Kim JG, Osato MS, Graham DY, Yamaoka Y (2002) Clinical presentation in relation to diversity within the Helicobacter pylori cag pathogenicity island. Am J Gastroenterol 97(9):2231-2238. doi: 10.1111/j.1572-0241.2002.05977.x
21. Ando T, Peek RM Jr, Lee YC, Krishna U, Kusugami K, Blaser MJ (2002) Host cell responses to genotypically similar Helicobacter pylori isolates from United States and Japan. Clin Diagn Lab Immunol 9(1):167-175
22. Maeda S (2001) Distinct mechanism of Helicobacter pylori-mediated NF-κ B activation between gastric cancer cells and monocytic cells. J Biol Chem 276(48):44856-44864. doi: 10.1074/jbc.M105381200
23. Brandt S (2005) NF- κB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein. Proc Natl Acad Sci 102(26):9300-9305. doi: 10.1073/pnas.0409873102
24. Ng MT, Van't Hof R, Crockett JC, Hope ME, Berry S, Thomson J, McLean MH, McColl KE, El-Omar EM, Hold GL (2010) Increase in NF-κB binding affinity of the variant C allele of the toll-like receptor 9-1237T/C polymorphism is associated with Helicobacter pylori-induced gastric disease. Infect Immun 78(3):1345-1352. doi: 10.1128/IAI.01226-09
25. Hayden MS, Ghosh S (2008) Shared principles in NF-κB signaling. Cell 132(3):344-362. doi: 10.1016/j.cell.2008.01.020
26. Sun SC (2012) The noncanonical NF-κB pathway. Immunol Rev 246(1):125-140. doi: 10.1111/j.1600-065X.2011.01088.x
27. Lin CY, Huang YS, Li CH, Hsieh YT, Tsai NM, He PJ, Hsu WT, Yeh YC, Chiang FH, Wu MS, Chang CC, Liao KW (2009) Characterizing the polymeric status of Helicobacter pylori heat shock protein 60. Biochem Biophys Res Commun 388(2):283-289. doi: 10.1016/j.bbrc.2009.07.159
28. Lin CS, He PJ, Tsai NM, Li CH, Yang SC, Hsu WT, Wu MS, Wu CJ, Cheng TL, Liao KW (2010) A potential role for Helicobacter pylori heat shock protein 60 in gastric tumorigenesis. Biochem Biophys Res Commun 392(2):183-189. doi: 10.1016/j.bbrc.2010.01.010