Breast arterial calcification in chronic kidney disease: Absence of smooth muscle apoptosis and osteogenic transdifferentiation

Kidney International

Volumn 85, Issue 3, 2014, Pages 668-676

  Oneill, W Charles ^a   Adams, Amy L ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

arteriosclerosis; vascular calcification; vascular smooth muscle

Indexed keywords

TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR SOX9; TRANSGELIN; OSTEOCALCIN;

ADULT; AGED; APOPTOSIS; ARTERY CALCIFICATION; ARTERY INTIMA PROLIFERATION; ARTICLE; BREAST; BREAST ARTERY CALCIFICATION; CELL DENSITY; CELL TRANSDIFFERENTIATION; CHRONIC KIDNEY DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; MIDDLE AGED; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; VASCULAR SMOOTH MUSCLE; VERY ELDERLY; BONE DEVELOPMENT; BREAST DISEASE; COHORT ANALYSIS; END STAGE RENAL DISEASE; HEMODIALYSIS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MASTECTOMY; MINERALIZATION; PROTEIN ANALYSIS; SMOOTH MUSCLE; SMOOTH MUSCLE FIBER; ARTERY; BLOOD VESSEL CALCIFICATION; CHRONIC KIDNEY FAILURE; PATHOLOGY; VASCULARIZATION;

AGED; AGED, 80 AND OVER; APOPTOSIS; ARTERIES; BREAST; CELL TRANSDIFFERENTIATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; MUSCLE, SMOOTH, VASCULAR; OSTEOGENESIS; RENAL INSUFFICIENCY, CHRONIC; VASCULAR CALCIFICATION;

EID: 84895111042     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2013.351     Document Type: Article

References (36)

1. Blacher J, Guerin AP, Pannier B et al. Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease. Hypertension 2001; 38: 938-942.
2. London GM, Guerin AP, Marchais SJ et al. Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. Nephrol Dial Transplant 2003; 18: 1731-1740.
3. Jeziorska M, McCollum C, Woolley DE. Calcification in atherosclerotic plaque of human carotid arteries: associations with mast cells and macrophages. J Pathol 1998; 185: 10-17.
4. Amann K. Media calcification and intima calcification are distinct entities in chronic kidney disease. Clin J Am Soc Nephrol 2008; 3: 1599-1605.
5. McCullough PA, Agrawal V, Danielewicz E et al. Accelerated atherosclerotic calcification and Mönckeberg's sclerosis: a continuum of advanced vascular pathology in chronic kidney disease. Clin J Am Soc Nephrol 2008; 3: 1585-1598.
6. Duhn V, D'Orsi EM, Johnson S et al. Breast arterial calcification: a marker of medial vascular calcification in chronic kidney disease. Clin J Am Soc Nephrol 2011; 6: 377-382.
7. Abou-Hassan N, D'Orsi ET, D'Orsi CJ et al. The risk for medial arterial calcification in CKD. Clin J Am Soc Nephrol 2012; 7: 275-279.
8. Urry DW. Neutral sites for calcium ion binding to elastin and collagen: a charge neutralization theory for calcification and its relationship to atherosclerosis. Proc Natl Acad Sci USA 1971; 68: 810-814.
9. Vyavahare N, Ogle M, Schoen FJ et al. Elastin calcification and its prevention with aluminum chloride pretreatment. Am J Pathol 1999; 155: 973-982.
10. Harmey D, Hessle L, Narisawa S et al. Concerted regulation of inorganic pyrophosphate and osteopontin by Akp2, Enpp1 and Ank: an integrated model of the pathogenesis of mineralization disorders. Am J Pathol 2004; 164: 1199-1209.
11. Luo G, Ducy P, McKee MD et al. Spontaneous calcification of arteries and cartilage in mice lacking matrix Gla protein. Nature 1997; 386: 78-81.
12. Rutsch F, Vaingankar S, Johnson K et al. PC-1 nucleotide triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification. Am J Pathol 2001; 158: 543-554.
13. Meier M, Weng LP, Alexandrakis E et al. Tracheobronchial stenosis in Keutel syndrome. Eur Respir J 2001; 17: 566-569.
14. Munroe PB, Olgunturk RO, Fryns JP et al. Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome. Nature Genetics 1999; 21: 142-144.
15. Lomashvili KA, Khawandi W, O'Neill WC. Reduced plasma pyrophosphate levels in hemodialysis patients. J Am Soc Nephrol 2005; 16: 2495-2500.
16. O'Neill WC, Sigrist MK, McIntyre CW. Plasma pyrophosphate and vascular calcification in chronic kidney disease. Nephrol Dial Transplant 2010; 25: 187-191.
17. O'Neill WC, Lomashvili KA, Malluche HH et al. Treatment with pyrophosphate inhibits uremic vascular calcification. Kidney Int 2011; 79: 512-517.
18. Schurgers LJ, Teunissen KJF, Knapen MHJ et al. Novel conformationspecific antibodies against matrix g-carboxyglutamic acid (gla) protein. Undercarboxylated matrix gla protein as marker for vascular calcification. Arterioscler Thromb Vasc Biol 2005; 25: 1629-1633.
19. Murshed M, Harmey D, Millan JL et al. Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone. Genes Dev 2005; 19: 1093-1104.
20. Hessle L, Johnsson KA, Anderson HC et al. Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization. Proc Natl Acad Sci USA 2002; 99: 9445-9449.
21. Shanahan CM, Cary NRB, Salisbury JR et al. Medial localization of mineralization-regulating proteins in association with Monckeberg's sclerosis. Evidence for smooth muscle cell-mediated vascular calcification. Circulation 1999; 100: 2168-2176.
22. Moe SM, Duan D, Doehle BP et al. Uremia induces the osteoblast differentiation factor Cbfa1 in human blood vessels. Kidney Int 2003; 63: 1003-1011.
23. Shroff RC, McNair R, Figg N et al. Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis. Circulation 2008; 118: 1748-1757.
24. Reynolds JL, Joannides AJ, Skepper JN et al. Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD. J Am Soc Nephrol 2004; 15: 2857-2867.
25. Shanahan CM, Cary NRB, Salisbury JR et al. Medial localization of mineralization-regulating proteins in association with Monckeberg's sclerosis: evidence for smooth muscle cell-mediated vascular calcification. Circulation 1999; 100: 2168-2176.
26. Speer MY, Yang H-Y, Brabb T et al. Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries. Circ Res 2009; 104: 733-741.
27. Neven E, Dauwe S, De Broe ME et al. Endochondral bone formation is involved in media calcification in rats and in men. Kidney Int 2007; 72: 574-581.
28. Ewence AE, Bootman M, Roderick HL et al. Calcium phosphate crystals induce cell death in human vascular smooth muscle cells: a potential mechanism in atherosclerotic plaque destabilization. Circ Res 2008; 103: e28-e34.
29. Nielsen BB, Holm NV. Calcification in breast arteries. The frequency and severity of arterial calcification in female breast tissue without malignant changes. Acta Path Microbiol Immunol Scand A 1985; 93: 13-16.
30. Moore S. Blood vessels and lymphatics. In: Damjanov I, Linder J (eds) Anderson's Pathology, 10th edn Mosby: St. Louis, 1996, pp 1401.
31. Micheletti RG, Fishbein GA, Currier JS et al. Monckeberg sclerosis revisited. A clarification of the histologic definition of Monckeberg sclerosis. Arch Pathol Lab Med 2008; 132: 43-47.
32. Proudfoot D, Skepper JN, Hegyi L et al. Apoptosis regulates human vascular calcification in vitro: evidence for initiation of vascular calcification by apoptotic bodies. Circ Res 2000; 87: 1055-1062.
33. Amann K, Wolf B, Nichols C et al. Aortic changes in experimental renal failure. Hyperplasia or hypertrophy of smooth muscle cells? Hypertension 1997; 29: 770-775.
34. Romberg RW, Werness PG, Riggs BL et al. Inhibition of hydroxyapatite crystal growth by bone-specific and other calcium-binding proteins. Biochem 1986; 25: 1176-1180.
35. Levy RJ, Schoen FJ, Levy JT et al. Biologic determinants of dystrophic calcification and osteocalcin deposition in glutaraldehyde-preserved porcine aortic valve leaflets implanted subcutaneously in rats. Am J Pathol 1983; 113: 143-155.
36. Cameron ER, Neil JC. The Runx genes: lineage-specific oncogenes and tumor suppressors. Oncogene 2004; 23: 4308-4314.