메뉴 건너뛰기




Volumn 20, Issue 7, 2014, Pages 1041-1044

VEGF and colon cancer growth beyond angiogenesis: Does VEGF directly mediate colon cancer growth via a non-angiogenic mechanism?

Author keywords

Angiogenesis; Cancer cell growth; Colon cancer; VEGF

Indexed keywords

BEVACIZUMAB; MONOCLONAL ANTIBODY; VASCULOTROPIN A;

EID: 84895095447     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612819999131218175905     Document Type: Review
Times cited : (44)

References (45)
  • 1
    • 0033000342 scopus 로고    scopus 로고
    • Activation of VEGF and Ras genes in gastric mucosa during angiogenic response to ethanol injury
    • Jones MK, Itani RM, Wang H, et al. Activation of VEGF and Ras genes in gastric mucosa during angiogenic response to ethanol injury. Am J Physiol 1999; 276: (6 Pt 1), G1345-55.
    • (1999) Am J Physiol , vol.276 , Issue.6 PART 1
    • Jones, M.K.1    Itani, R.M.2    Wang, H.3
  • 2
    • 0034767707 scopus 로고    scopus 로고
    • Gene therapy for gastric ulcers with single local injection of naked DNA encoding VEGF and angiopoietin-1
    • Jones MK, Kawanaka H, Baatar D, et al. Gene therapy for gastric ulcers with single local injection of naked DNA encoding VEGF and angiopoietin-1. Gastroenterology 2001; 121: (5), 1040-7.
    • (2001) Gastroenterology , vol.121 , Issue.5 , pp. 1040-1047
    • Jones, M.K.1    Kawanaka, H.2    Baatar, D.3
  • 3
    • 84970070220 scopus 로고
    • Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer
    • Takahashi Y, Kitadai Y, Bucana CD, Cleary KR, Ellis LM. Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res 1995; 55: (18), 3964-8.
    • (1995) Cancer Res , vol.55 , Issue.18 , pp. 3964-3968
    • Takahashi, Y.1    Kitadai, Y.2    Bucana, C.D.3    Cleary, K.R.4    Ellis, L.M.5
  • 4
    • 0033963827 scopus 로고    scopus 로고
    • Enhancement of angiogenesis, tumor growth, and metastasis by transfection of vascular endothelial growth factor into LoVo human colon cancer cell line
    • Kondo Y, Arii S, Mori A, Furutani M, Chiba T, Imamura M. Enhancement of angiogenesis, tumor growth, and metastasis by transfection of vascular endothelial growth factor into LoVo human colon cancer cell line. Clin Cancer Res 2000; 6: (2), 622-30.
    • (2000) Clin Cancer Res , vol.6 , Issue.2 , pp. 622-630
    • Kondo, Y.1    Arii, S.2    Mori, A.3    Furutani, M.4    Chiba, T.5    Imamura, M.6
  • 5
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350: (23), 2335-42.
    • (2004) N Engl J Med , vol.350 , Issue.23 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 6
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • Kim KJ, Li B, Winer J, et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 1993; 362: (6423), 841-4.
    • (1993) Nature , vol.362 , Issue.6423 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3
  • 7
    • 0029949160 scopus 로고    scopus 로고
    • Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody
    • Yuan F, Chen Y, Dellian M, Safabakhsh N, Ferrara N, Jain RK. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc Natl Acad Sci USA 1996; 93: (25), 14765-70.
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.25 , pp. 14765-14770
    • Yuan, F.1    Chen, Y.2    Dellian, M.3    Safabakhsh, N.4    Ferrara, N.5    Jain, R.K.6
  • 8
    • 84867115561 scopus 로고    scopus 로고
    • Cediranib with mFOLFOX6 versus bevacizumab with mFOLFOX6 as first-line treatment for patients with advanced colorectal cancer: A double blind, randomized phase III study (HORIZON III)
    • Schmoll HJ, Cunningham D, Sobrero A, et al. Cediranib with mFOLFOX6 versus bevacizumab with mFOLFOX6 as first-line treatment for patients with advanced colorectal cancer: a double blind, randomized phase III study (HORIZON III). J Clin Oncol 2012; 30: (29), 3588-95.
    • (2012) J Clin Oncol , vol.30 , Issue.29 , pp. 3588-3595
    • Schmoll, H.J.1    Cunningham, D.2    Sobrero, A.3
  • 9
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 1983; 219: (4587), 983-5.
    • (1983) Science , vol.219 , Issue.4587 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3    Perruzzi, C.A.4    Harvey, V.S.5    Dvorak, H.F.6
  • 10
    • 0024384470 scopus 로고
    • Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    • Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 1989; 161: (2), 851-8.
    • (1989) Biochem Biophys Res Commun , vol.161 , Issue.2 , pp. 851-858
    • Ferrara, N.1    Henzel, W.J.2
  • 11
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989; 246: (4935), 1306-9.
    • (1989) Science , vol.246 , Issue.4935 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goeddel, D.V.4    Ferrara, N.5
  • 12
    • 0031807538 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor in hu man hepatocellular carcinoma
    • Yamaguchi R, Yano H, Iemura A, Ogasawara S, Haramaki M, Kojiro M. Expression of vascular endothelial growth factor in hu man hepatocellular carcinoma. Hepatology 1998; 28: (1), 68-77.
    • (1998) Hepatology , vol.28 , Issue.1 , pp. 68-77
    • Yamaguchi, R.1    Yano, H.2    Iemura, A.3    Ogasawara, S.4    Haramaki, M.5    Kojiro, M.6
  • 13
    • 0034887583 scopus 로고    scopus 로고
    • Vascular endothelial growth factors and liver diseases
    • Shi B, Wang X, Yang Z. Vascular endothelial growth factors and liver diseases. Hepatogastroenterology 2001; 48: (40), 1145-8.
    • (2001) Hepatogastroenterology , vol.48 , Issue.40 , pp. 1145-1148
    • Shi, B.1    Wang, X.2    Yang, Z.3
  • 14
    • 0030004485 scopus 로고    scopus 로고
    • Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
    • Ferrara N, Carver-Moore K, Chen H, et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 1996; 380: (6573), 439-42.
    • (1996) Nature , vol.380 , Issue.6573 , pp. 439-442
    • Ferrara, N.1    Carver-Moore, K.2    Chen, H.3
  • 15
    • 0343920277 scopus 로고    scopus 로고
    • Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
    • Carmeliet P, Ferreira V, Breier G, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 1996; 380: (6573), 435-9.
    • (1996) Nature , vol.380 , Issue.6573 , pp. 435-439
    • Carmeliet, P.1    Ferreira, V.2    Breier, G.3
  • 16
    • 25644437787 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of gastrointestinal ulcer healing
    • Tarnawski AS. Cellular and molecular mechanisms of gastrointestinal ulcer healing. Dig Dis Sci 2005; 50 Suppl 1: S24-S33.
    • (2005) Dig Dis Sci , vol.50 , Issue.SUPPL. 1
    • Tarnawski, A.S.1
  • 17
    • 62449300644 scopus 로고    scopus 로고
    • Neutralizing antivascular endothelial growth factor (VEGF) antibody reduces severity of experimental ulcerative colitis in rats: Direct evidence for the pathogenic role of VEGF
    • Tolstanova G, Khomenko T, Deng X, et al. Neutralizing antivascular endothelial growth factor (VEGF) antibody reduces severity of experimental ulcerative colitis in rats: direct evidence for the pathogenic role of VEGF. J Pharmacol Exp Ther 2009; 328: (3), 749-57.
    • (2009) J Pharmacol Exp Ther , vol.328 , Issue.3 , pp. 749-757
    • Tolstanova, G.1    Khomenko, T.2    Deng, X.3
  • 18
    • 77956266957 scopus 로고    scopus 로고
    • New molecular mechanisms of the unexpectedly complex role of VEGF in ulcerative colitis
    • Tolstanova G, Khomenko T, Deng X, Szabo S, Sandor Z. New molecular mechanisms of the unexpectedly complex role of VEGF in ulcerative colitis. Biochem Biophys Res Commun 2010; 399: (4), 613-6.
    • (2010) Biochem Biophys Res Commun , vol.399 , Issue.4 , pp. 613-616
    • Tolstanova, G.1    Khomenko, T.2    Deng, X.3    Szabo, S.4    Sandor, Z.5
  • 19
    • 0036068479 scopus 로고    scopus 로고
    • The role of the angiogenic molecule VEGF in the pathogenesis of rheumatoid arthritis
    • Afuwape AO, Kiriakidis S, Paleolog EM. The role of the angiogenic molecule VEGF in the pathogenesis of rheumatoid arthritis. Histol Histopathol 2002; 17: (3), 961-72.
    • (2002) Histol Histopathol , vol.17 , Issue.3 , pp. 961-972
    • Afuwape, A.O.1    Kiriakidis, S.2    Paleolog, E.M.3
  • 20
    • 0031810231 scopus 로고    scopus 로고
    • Modulation of angiogenic vascular endothelial growth factor by tumor necrosis factor alpha and interleukin-1 in rheumatoid arthritis
    • Paleolog EM, Young S, Stark AC, McCloskey RV, Feldmann M, Maini RN. Modulation of angiogenic vascular endothelial growth factor by tumor necrosis factor alpha and interleukin-1 in rheumatoid arthritis. Arthritis Rheum 1998; 41: (7), 1258-65.
    • (1998) Arthritis Rheum , vol.41 , Issue.7 , pp. 1258-1265
    • Paleolog, E.M.1    Young, S.2    Stark, A.C.3    McCloskey, R.V.4    Feldmann, M.5    Maini, R.N.6
  • 21
    • 0034212632 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) in breast cancer: Comparison of plasma, serum, and tissue VEGF and microvessel density and effects of tamoxifen
    • Adams J, Carder PJ, Downey S, et al. Vascular endothelial growth factor (VEGF) in breast cancer: comparison of plasma, serum, and tissue VEGF and microvessel density and effects of tamoxifen. Cancer Res 2000; 60: (11), 2898-905.
    • (2000) Cancer Res , vol.60 , Issue.11 , pp. 2898-2905
    • Adams, J.1    Carder, P.J.2    Downey, S.3
  • 22
    • 0031032073 scopus 로고    scopus 로고
    • Prognostic significance of vascular endothelial growth factor protein in node-negative breast carcinoma
    • Gasparini G, Toi M, Gion M, et al. Prognostic significance of vascular endothelial growth factor protein in node-negative breast carcinoma. J Natl Cancer Inst 1997; 89: (2), 139-47.
    • (1997) J Natl Cancer Inst , vol.89 , Issue.2 , pp. 139-147
    • Gasparini, G.1    Toi, M.2    Gion, M.3
  • 23
    • 49649107704 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression in ovarian cancer: A model for targeted use of novel therapies?
    • Duncan TJ, Al Attar A, Rolland P, et al. Vascular endothelial growth factor expression in ovarian cancer: a model for targeted use of novel therapies? Clin Cancer Res 2008; 14: (10), 3030-5.
    • (2008) Clin Cancer Res , vol.14 , Issue.10 , pp. 3030-3035
    • Duncan, T.J.1    Al, A.A.2    Rolland, P.3
  • 24
    • 0030066037 scopus 로고    scopus 로고
    • Prognostic value of vascular endothelial growth factor expression in gastric carcinoma
    • Maeda K, Chung YS, Ogawa Y, et al. Prognostic value of vascular endothelial growth factor expression in gastric carcinoma. Cancer 1996; 77: (5), 858-63.
    • (1996) Cancer , vol.77 , Issue.5 , pp. 858-863
    • Maeda, K.1    Chung, Y.S.2    Ogawa, Y.3
  • 25
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971; 285: (21), 1182-6.
    • (1971) N Engl J Med , vol.285 , Issue.21 , pp. 1182-1186
    • Folkman, J.1
  • 26
    • 77949461468 scopus 로고    scopus 로고
    • Blocking effects of siRNA on VEGF expression in human colorectal cancer cells
    • Yin Y, Cao LY, Wu WQ, Li H, Jiang Y, Zhang HF. Blocking effects of siRNA on VEGF expression in human colorectal cancer cells. World J Gastroenterol 2010; 16: (9), 1086-92.
    • (2010) World J Gastroenterol , vol.16 , Issue.9 , pp. 1086-1092
    • Yin, Y.1    Cao, L.Y.2    Wu, W.Q.3    Li, H.4    Jiang, Y.5    Zhang, H.F.6
  • 27
    • 84871615399 scopus 로고    scopus 로고
    • Effects of siRNA Targeting c-Myc and VEGF on Human Colorectal Cancer Volo Cells
    • Tai J, Wang G, Liu T, Wang L, Lin C, Li F. Effects of siRNA Targeting c-Myc and VEGF on Human Colorectal Cancer Volo Cells. J Biochem Mol Toxicol 2012; 26: (12), 499-505.
    • (2012) J Biochem Mol Toxicol , vol.26 , Issue.12 , pp. 499-505
    • Tai, J.1    Wang, G.2    Liu, T.3    Wang, L.4    Lin, C.5    Li, F.6
  • 28
    • 84870557260 scopus 로고    scopus 로고
    • A novel angiogenesis inhibitor impairs lovo cell survival via targeting against human VEGFR and its signaling pathway of phosphorylation
    • Zhang YM, Dai BL, Zheng L, et al. A novel angiogenesis inhibitor impairs lovo cell survival via targeting against human VEGFR and its signaling pathway of phosphorylation. Cell Death Dis 2012; 3: e406.
    • (2012) Cell Death Dis , vol.3
    • Zhang, Y.M.1    Dai, B.L.2    Zheng, L.3
  • 29
    • 84867770738 scopus 로고    scopus 로고
    • Anticancer effects of KI-10F: A novel compound affecting apoptosis, angiogenesis and cell growth in colon cancer
    • Hong SW, Jung KH, Choi MJ, et al. Anticancer effects of KI-10F: a novel compound affecting apoptosis, angiogenesis and cell growth in colon cancer. Int J Oncol 2012; 41: (5), 1715-22.
    • (2012) Int J Oncol , vol.41 , Issue.5 , pp. 1715-1722
    • Hong, S.W.1    Jung, K.H.2    Choi, M.J.3
  • 30
    • 20944441857 scopus 로고    scopus 로고
    • Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells
    • Fan F, Wey JS, McCarty MF, et al. Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells. Oncogene 2005; 24: (16), 2647-53.
    • (2005) Oncogene , vol.24 , Issue.16 , pp. 2647-2653
    • Fan, F.1    Wey, J.S.2    McCarty, M.F.3
  • 31
    • 0028935608 scopus 로고
    • Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis
    • Warren RS, Yuan H, Matli MR, Gillett NA, Ferrara N. Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. J Clin Invest 1995; 95: (4), 1789-97.
    • (1995) J Clin Invest , vol.95 , Issue.4 , pp. 1789-1797
    • Warren, R.S.1    Yuan, H.2    Matli, M.R.3    Gillett, N.A.4    Ferrara, N.5
  • 32
    • 77954722597 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptors VEGFR-2 and VEGFR-3 are localized primarily to the vasculature in human primary solid cancers
    • Smith NR, Baker D, James NH, et al. Vascular endothelial growth factor receptors VEGFR-2 and VEGFR-3 are localized primarily to the vasculature in human primary solid cancers. Clin Cancer Res 2010; 16: (14), 3548-61.
    • (2010) Clin Cancer Res , vol.16 , Issue.14 , pp. 3548-3561
    • Smith, N.R.1    Baker, D.2    James, N.H.3
  • 33
    • 0035201545 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor and its receptor KDR (kinase domain-containing receptor)/Flk-1 (fetal liver kinase-1) as prognostic factors in human colorectal cancer
    • Harada Y, Ogata Y, Shirouzu K. Expression of vascular endothelial growth factor and its receptor KDR (kinase domain-containing receptor)/Flk-1 (fetal liver kinase-1) as prognostic factors in human colorectal cancer. Int J Clin Oncol 2001; 6: (5), 221-8.
    • (2001) Int J Clin Oncol , vol.6 , Issue.5 , pp. 221-228
    • Harada, Y.1    Ogata, Y.2    Shirouzu, K.3
  • 34
    • 39149122201 scopus 로고    scopus 로고
    • Differential involvement of vascular endothelial growth factor in the survival of hypoxic colon cancer cells
    • Calvani M, Trisciuoglio D, Bergamaschi C, Shoemaker RH, Melillo G. Differential involvement of vascular endothelial growth factor in the survival of hypoxic colon cancer cells. Cancer Res 2008; 68: (1), 285-91.
    • (2008) Cancer Res , vol.68 , Issue.1 , pp. 285-291
    • Calvani, M.1    Trisciuoglio, D.2    Bergamaschi, C.3    Shoemaker, R.H.4    Melillo, G.5
  • 35
    • 84856034041 scopus 로고    scopus 로고
    • Colonic mucosal biopsies obtained during confocal endomicroscopy are pre-stained with fluorescein in vivo and are suitable for histologic evaluation
    • Coron E, Mosnier JF, Ahluwalia A, et al. Colonic mucosal biopsies obtained during confocal endomicroscopy are pre-stained with fluorescein in vivo and are suitable for histologic evaluation. Endoscopy 2012; 44: (2), 148-53.
    • (2012) Endoscopy , vol.44 , Issue.2 , pp. 148-153
    • Coron, E.1    Mosnier, J.F.2    Ahluwalia, A.3
  • 36
    • 84881547592 scopus 로고    scopus 로고
    • Aberrant, ectopic expression of VEGF and VEGF receptors 1 and 2 in malignant colonic epithelial cells. Implications for these cells growth via an autocrine mechanism
    • Ahluwalia A, Jones MK, Szabo S, et al. Aberrant, ectopic expression of VEGF and VEGF receptors 1 and 2 in malignant colonic epithelial cells. Implications for these cells growth via an autocrine mechanism. Biochem Biophys Res Commun 2013; 437: (4), 515-20.
    • (2013) Biochem Biophys Res Commun , vol.437 , Issue.4 , pp. 515-520
    • Ahluwalia, A.1    Jones, M.K.2    Szabo, S.3
  • 37
    • 0029805574 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma
    • Warren RS, Yuan H, Matli MR, Ferrara N, Donner DB. Induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma. J Biol Chem 1996; 271: (46), 29483-8.
    • (1996) J Biol Chem , vol.271 , Issue.46 , pp. 29483-29488
    • Warren, R.S.1    Yuan, H.2    Matli, M.R.3    Ferrara, N.4    Donner, D.B.5
  • 38
    • 70349594194 scopus 로고    scopus 로고
    • Heregulin-induced VEGF expression via the ErbB3 signaling pathway in colon cancer
    • Yonezawa M, Wada K, Tatsuguchi A, et al. Heregulin-induced VEGF expression via the ErbB3 signaling pathway in colon cancer. Digestion 2009; 80: (4), 215-25.
    • (2009) Digestion , vol.80 , Issue.4 , pp. 215-225
    • Yonezawa, M.1    Wada, K.2    Tatsuguchi, A.3
  • 39
    • 27944490875 scopus 로고    scopus 로고
    • VEGF as a therapeutic target in cancer
    • Ferrara N. VEGF as a therapeutic target in cancer. Oncology 2005; 69 Suppl 3: 11-6.
    • (2005) Oncology , vol.69 , Issue.SUPPL. 3 , pp. 11-16
    • Ferrara, N.1
  • 40
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 2004; 25: (4), 581-611.
    • (2004) Endocr Rev , vol.25 , Issue.4 , pp. 581-611
    • Ferrara, N.1
  • 41
    • 84857535891 scopus 로고    scopus 로고
    • Critical role of hypoxia sensor-HIF-1alpha in VEGF gene activation. Implications for angiogenesis and tissue injury healing
    • Ahluwalia A, Tarnawski AS. Critical role of hypoxia sensor-HIF-1alpha in VEGF gene activation. Implications for angiogenesis and tissue injury healing. Curr Med Chem 2012; 19: (1), 90-7.
    • (2012) Curr Med Chem , vol.19 , Issue.1 , pp. 90-97
    • Ahluwalia, A.1    Tarnawski, A.S.2
  • 42
    • 38549145393 scopus 로고    scopus 로고
    • Increased VEGF165 expression in HCT116 colon cancer cells after transient transfection with a GFP vector encoding HIF-1 gene
    • Lucarini G, Zizzi A, Belvederesi L, Kyriakidou K, Mazzucchelli R, Biagini G. Increased VEGF165 expression in HCT116 colon cancer cells after transient transfection with a GFP vector encoding HIF-1 gene. J Exp Clin Cancer Res 2007; 26: (4), 515-9.
    • (2007) J Exp Clin Cancer Res , vol.26 , Issue.4 , pp. 515-519
    • Lucarini, G.1    Zizzi, A.2    Belvederesi, L.3    Kyriakidou, K.4    Mazzucchelli, R.5    Biagini, G.6
  • 43
    • 80053265664 scopus 로고    scopus 로고
    • Hypertonic stress induces VEGF production in human colon cancer cell line Caco-2: Inhibitory role of autocrine PGE(2)
    • Gentile LB, Piva B, Diaz BL. Hypertonic stress induces VEGF production in human colon cancer cell line Caco-2: inhibitory role of autocrine PGE(2). PLoS One 2011; 6: (9), e25193.
    • (2011) PLoS One , vol.6 , Issue.9
    • Gentile, L.B.1    Piva, B.2    Diaz, B.L.3
  • 44
    • 0038375038 scopus 로고    scopus 로고
    • Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1
    • Fukuda R, Kelly B, Semenza GL. Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1. Cancer Res 2003; 63: (9), 2330-4.
    • (2003) Cancer Res , vol.63 , Issue.9 , pp. 2330-2334
    • Fukuda, R.1    Kelly, B.2    Semenza, G.L.3
  • 45
    • 10344263374 scopus 로고    scopus 로고
    • N-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and-2 and HIF-1alpha induction pathway
    • Calviello G, Di Nicuolo F, Gragnoli S et al. n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and-2 and HIF-1alpha induction pathway. Carcinogenesis 2004; 25: (12), 2303-10.
    • (2004) Carcinogenesis , vol.25 , Issue.12 , pp. 2303-2310
    • Calviello, G.1    Di Nicuolo, F.2    Gragnoli, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.