Use of a benzimidazole derivative BF-188 in fluorescence multispectral imaging for selective visualization of tau protein fibrils in the alzheimer's disease brain

Molecular Imaging and Biology

Volumn 16, Issue 1, 2014, Pages 19-27

  Harada, Ryuichi ^a   Okamura, Nobuyuki ^a   Furumoto, Shozo ^a   Yoshikawa, Takeo ^a   Arai, Hiroyuki ^b   Yanai, Kazuhiko ^a   Kudo, Yukitsuka ^c  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c TOHOKU UNIVERSITY HOSPITAL   (Japan)

Author keywords

Alzheimer's disease; Fluorescent probes; Multispectral fluorescence imaging; Neurofibrillary tangles; Senile plaques

Indexed keywords

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID; AMYLOID BETA-PEPTIDES; ANIMALS; BENZIMIDAZOLES; BLOOD-BRAIN BARRIER; BRAIN; BUTADIENES; DIAGNOSTIC IMAGING; FEMALE; HUMANS; LEWY BODIES; MALE; MICE; NEUROFIBRILLARY TANGLES; PERMEABILITY; PHOSPHORYLATION; PLAQUE, AMYLOID; SPECTROMETRY, FLUORESCENCE; TAU PROTEINS;

EID: 84895077025     PISSN: 15361632     EISSN: 18602002     Source Type: Journal    
DOI: 10.1007/s11307-013-0667-2     Document Type: Article

References (20)

1. Clinton LK, Blurton-Jones M, Myczek K et al (2010) Synergistic interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline. J Neurosci Off J Soc Neurosci 30:7281-7289
2. Zhou L, El-Deiry WS (2009) Multispectral fluorescence imaging. J Nucl Med Off Publ Soc Nucl Med 50:1563-1566
3. Ran C, Moore A (2012) Spectral unmixing imaging of wavelength-responsive fluorescent probes: an application for the real-time report of amyloid Beta species in Alzheimer's disease. Mol Imaging Biol MIB Off Publ Acad Mol Imaging 14:293-300
4. Mishra R, Sjolander D, Hammarstrom P (2011) Spectroscopic characterization of diverse amyloid fibrils in vitro by the fluorescent dye Nile red. Mol Biosyst 7:1232-1240
5. Okamura N, Suemoto T, Furumoto S et al (2005) Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer's disease. J Neurosci Off J Soc Neurosci 25:10857-10862
6. Styren SD, Hamilton RL, Styren GC, Klunk WE (2000) X-34, a fluorescent derivative of Congo red: a novel histochemical stain for Alzheimer's disease pathology. J Histochem Cytochem Off J Histochem Soc 48:1223-1232
7. Velasco A, Fraser G, Delobel P et al (2008) Detection of filamentous tau inclusions by the fluorescent Congo red derivative FSB [(trans, trans)-1-fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene]. FEBS Lett 582:901-906
8. Murayama H, Shin RW, Higuchi J et al (1999) Interaction of aluminum with PHFtau in Alzheimer's disease neurofibrillary degeneration evidenced by desferrioxamine-assisted chelating autoclave method. Am J Pathol 155:877-885
9. Fodero-Tavoletti MT, Okamura N, Furumoto S et al (2011) (18)F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease. Brain 134:1089-1100
10. Berezin MY, Kao J, Achilefu S (2009) pH-dependent optical properties of synthetic fluorescent imidazoles. Chemistry 15:3560-3566
11. Kobayashi H, Ogawa M, Alford R et al (2010) New strategies for fluorescent probe design in medical diagnostic imaging. Chem Rev 110:2620-2640
12. Kirschner DA, Abraham C, Selkoe DJ (1986) X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation. Proc Natl Acad Sci U S A 83:503-507
13. Aslund A, Sigurdson CJ, Klingstedt T et al (2009) Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses. ACS Chem Biol 4:673-684
14. Grundke-Iqbal I, Iqbal K, Quinlan M et al (1986) Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J Biol Chem 261:6084-6089
15. Grundke-Iqbal I, Iqbal K, Tung YC et al (1986) Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci U S A 83:4913-4917
16. Fujiwara H, Hasegawa M, Dohmae N et al (2002) alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 4:160-164
17. Fodero-Tavoletti MT, Mulligan RS, Okamura N et al (2009) In vitro characterisation of BF227 binding to alpha-synuclein/Lewy bodies. Eur J Pharmacol 617:54-58
18. Neal KL, Shakerdge NB, Hou SS, et al. (2013) Development and screening of contrast agents for in vivo imaging of Parkinson's disease. Molecular imaging and biology: MIB: the Official pPublication of the Academy of Molecular Imaging
19. Berriman J, Serpell LC, Oberg KA et al (2003) Tau filaments from human brain and from in vitro assembly of recombinant protein show cross-beta structure. Proc Natl Acad Sci U S A 100:9034-9038
20. Okamura N, Mori M, Furumoto S et al (2011) In vivo detection of amyloid plaques in the mouse brain using the near-infrared fluorescence probe THK-265. J Alzheimers Dis JAD 23:37-48